Week 5 - Lymphatic System + Innate/Non Specific

Leukocyte Types

Neutrophils

Monocytes - macrophages

Lymphocytes

Basophils/mast cells

Eosinophils

Primary Lymphoid Organs

Pluripotent stem cells

Produce/mature B/T

Red bone marrow

Thymus

Secondary Lymphoid Organs

Immune response

Lymphocytes activated by antigens

Recirculation

Lymphoid Organs - Capsulated

Lymph nodes

Spleen

Lymphoid Tissue - Non-capsulated

Tonsils

Lymphatic nodules

Appendix

Peyer’s patches

MALT

Mucosa associated lymphoid tissue

GI tract

Anchoring Filaments

Elastic fibres that attach lymph vessels to surrounding connective tissue

Albumin

Most abundant protein in plasma

Produced in liver

Maintain fluid balance + transport

1st Line - Skin

Normal flora - competition

Physical/impermeable barrier

Sebum - pH 5

1st line - Antimicrobial peptides

Produced by skin/immune cells

Kill microbes - disrupt cell walls

1st line - Lactoperoxidase

Enzyme in milk that produces antibacterial chemicals

1st line - Spermine/Zinc

Antimicrobial semen

3 Inflammation Functions

Prevent spread

Remove debris

Begin repair

Chemical Mediators

Histamine

Heparin

Prostaglandins - pain

Kinins - swelling/pain

Complement proteins

Complement Proteins

Attract immune cells

Secrete cytokines

Pain

Inflammation Process

Mechanical damage/pathogens

Mast cells detect

Chemical mediators released

Leukotactic agents released

Phagocytosis

Healing

Leukotactic Agents

Chemical that attract leukocytes

Chemotaxis - use chemical gradient

Leukocytosis inducing factor - stimulate production/release from bone marrow

2nd line - Serum

Plasma without clotting factors/blood cells

Complement system - 20

Opsonisation

Trigger inflammation

Kill - lysis/antibodies

Serum Contain

Interferons - anti viral

Acute phase proteins - produced by liver + enhance inflammation