chapter 27 - introduction to hematologic neoplasms

solid tumors

lymphomas differ from leukemias in that they are

HTLV-1

virus known to cause lymphoid neoplasms in humans?

allowing cells with damaged DNA to progress through the cell cycle

loss of function of tumor suppressor genes increase the risk of hematologic neoplasms by

a mutation in only one allele is sufficient to promote a malignant phenotype

oncogenes are said to act in a dominant fashion because

acceleration of DNA catabolism

which is NOT one of the cellular abnormalities produced by oncogenes?

• constitutive activation of a growth factor receptor

• constitutive activation of a signaling protein

• acceleration of DNA catabolism

• dysregulation of apoptosis

TP53

example of tumor suppressor gene

reduce risk of infection

G-CSF is provided as supportive treatment during leukemia treatment regimens to

targeted therapy

imatinib is an example of what type of leukemia treatment

hypermethylation of CpG islands in gene promoters results in their overactivation

statement that is FALSE about epigenetic mechanisms

• epigenetic mechanisms control how genes are expressed & silenced

• microRNAs can bind to specific mRNAs & block their translation

• hypermethylation of CpG islands in gene promoters results in their overactivation

• histone deacetylases keep chromatin of target genes in a closed, inactive state

spleen

not a source of hematopoietic stem cells for transplantation