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Drug induced SIADH
SSRIs: citalopram, escitalopram, fluoxetine, paroxetine
SNRIs: desvenla, venla, duloxetine
carbamazepines
opiates
Vasopressein Antagonists
demeclocycline
tolvaptan
conivaptan
Demeclocycline
induces diabetes inispidus
AE: AKI, renal tubular damage
CI: kids, pregnancy
Tolvaptan
V2 antagonist
indicated for hyper- and euvolemic hyponatremia due to HF, cirrhosis, or SIADH
AE: thirst, polyuria, constipation
BBW: hepatotoxicity
CYP3A4 and P-glycoprotein substrate = lots of DDIs