pharmacology

What is the mechanism of action for Baclofen?

GABA-B receptor agonist

What is the primary use of Baclofen?

Skeletal muscle relaxant; inhibits reflexes at the spinal cord level

What are some adverse effects of Baclofen?

Sedation and dizziness

Is Baclofen associated with serotonin syndrome?

No, it is not associated with serotonin syndrome.

What is the mechanism of Celecoxib?

Selective COX-2 inhibitor (NSAID)

What is the use of Celecoxib?

Pain and inflammation, including acute low back pain

Is Celecoxib associated with serotonin syndrome?

No, it is not associated with serotonin syndrome.

What is the mechanism of Diazepam?

Binds to GABA-A receptors (benzodiazepine)

What effects does Diazepam have?

Sedative, anxiolytic, anticonvulsant, muscle relaxant

What are some adverse effects of Diazepam?

Psychomotor impairment, amnesia, dependence

Is Diazepam serotonergic?

No, it is not serotonergic, so not linked to serotonin syndrome.

What is the mechanism of Naproxen?

Nonselective COX-1 and COX-2 inhibitor (NSAID)

What is the primary use of Naproxen?

Common first-line for acute low back pain

Is Naproxen associated with serotonin syndrome?

No, it is not associated with serotonin syndrome.

What is the mechanism of Tramadol?

Weak opioid receptor agonist; inhibits serotonin & norepinephrine reuptake

What is a risk associated with Tramadol?

May cause serotonin syndrome, especially when combined with SSRIs.

What are warning symptoms of serotonin syndrome with Tramadol?

Diaphoresis, restlessness, tremors, diarrhea.