Drug Receptor Interaction

covalent alkylation reaction

nucleophilic target attacks a highly electrophilic atom/ group present on the drug

covalent acylation reaction

nucleophilic atom/ group on a protein attacks an ester, lactone, amide, lactam, or carbamate on a drug.

covalent phosphorylation reaction

covalent bond formed with organophosphates

ionic bonds

between ionized acidic and basic functional groups OR between ionized acidic and quaternary ammonium functional groups.

what is the strongest non-covalent interaction?

ionic bonds

what is a hydrogen bond donor?

the atom that is covalently bound to the hydrogen atom.

what is the hydrogen bond acceptor?

the atom that is non-covalently bound to the hydrogen atom. via a hydrogen bond.

why is pyrrole not a hydrogen bond acceptor?

the nitrogen lone pair is delocalized within the aromatic ring.

what are Debye forces?

forces that occur between a permanent dipole and an induced dipole

what are London dispersion forces?

forces that occur between two induced dipoles

what is chelation

when two distinct electron donating groups bind to a metal ion and form a ring structure.