just hallucinogens i and ii

all plant sources of hallucinogens

lophophora williamsii/peyote, ayahuasca, anadenanthera peregrine, virola tree, tabernanthe iboga, ipomea nil/morning glory, atropa belladonna, datura, henbane, mandrake

what chemical is from Lophophora williamsii / peyote ?

mescaline

what chemicals are from ayahuasca vines?

DMT harmine harmaline

what chemicals are from anadenanthera peregrine?

DMT bufotenin

what chemical is from Tabernanthe iboga?

ibogaine

what chemicals are from Myristica fragrans / nutmeg and mace?

myristicin elemicin

what chemical is from Ipomea nil/morning glory seed?

LA amide/ergine

what chemical is from Atropa belladonna, Datura, Henbane Mandrake?

atropine, scopolamine, hyoscyamine

what chemical is from Claviceps purpea?

lysergic acid

psilocybe, Panaeolus conoscybe spp. chemical?

psilocybin

amanita muscaria chems?

ibotenic acid, muscimol

different nucleus/bases?

indole amine, phenethylamine, catechol nucleus

LSD ADME

onset 30-90m TI>1000

liver duration 5-12h

kidneys gi tract

ingest 90-100BA

inhale, inject

LSD unique effects

synesthesia

animals will not self admin

bias agonism for what in LSD

5HT2a agonist

psilocybin info

ingest 3-6h duration milder LSD

no flashback or lethality

liver and gut meta into psilocin

5HT2a agonist

sympathomimetic

not addict rapid tol

DMT info

snort smoke inject destroy in GUT worms

5HT2a/c 1a agonist no tol

connection

harmine and harmaline info helps w what diseases

B carboline chems
MAO and AChase inhibitors = alheimers

DA release = parkinsons

bufotenin is similar to what chem
effs?

5HT
drooling heart palp BP o2 depletion blur headache toad breath

toxic glycosides = dysrhythmia

ibogaine info

block addiction circuits and up GDNF in midbrain

GDNF in VTA decr drug cravings (but cause cerebellum damage)