Section 14: Drug Toxicity Chapter 57

Female offspring of women who received stilbestrol during pregnancy have an increased risk of

lung cancer

breast cancer

vaginal cancer

endometrial cancer

heart valve defects

vaginal cancer

The toxic metabolite of paracetamol, N-acetyl-p-benzoquinone imine, is believed to cause liver failure by

inhibiting cytochrome P450 enzymes

inhibiting lipid peroxidation

depleting reactive oxygen species

depleting reduced glutathione

activating Ca2+ ATPases

depleting reduced glutathione

Promoters are substances that increase the likelihood of cancer when administered

alone

before a co-carcinogen

after a co-carcinogen

before a primary carcinogen

after a primary carcinogen

after a primary carcinogen

Exposure to mercury during pregnancy primarily causes abnormal development of the fetal

brain

bones

face

kidneys

limbs

brain