Solid organ transplant tolerance

Why might solid organ transplants between dizygotic twins be better tolerated?

Because of blood chimerism—shared blood circulation during development.

What is blood chimerism?

It’s the presence of cells from one individual in the blood of another, often from shared circulation during development or prior transplants.

How can prior organ transplantation affect future transplant tolerance?

It may lead to blood chimerism, which can promote tolerance to future transplants.

How do donor hematopoietic stem cells help prevent solid organ graft rejection?

They can induce immune tolerance in the recipient, reducing the risk of rejection.