HIV Quiz

What is the global trend for HIV since its peak?

Globally down -38, but up in Latin America, East Europe, and Middle East

Describe the variants of HIV

A-F, B is dominant globally but the other variants (namely C) overtake it in Africa

Describe the structure and function of the HIV envelope

Outer membrane stolen from host cells

Dotted in glycoprotein spikes

GP120 recognizes and attaches to CD4 in helper T Complexes

Complexes to bring GP41 close to bind CCR5

What is the T Cell count required to diagnosis AIDS?

Less than 200 cells per uL

What actions of HIV drug exist?

Entrance Inhibitors

RNA Inhibitors

Integrase Inhibitors

Protease Inhibitors

Describe the Course of HIV

Acute HIV: Right off the bat, viral load skyrockets and CD4 count gets cut in half, lasts weeks

Chronic HIV: Antibody response develops, viral load gets cut and the CD4 count is able to recover somewhat, lasts months to years

AIDS: Eventually the CD4 count is weakened, and it eventually kills the host

Describe the Interplay of HIV Development

High load, High count: Rare

High load, Low count: AIDS

Low load, High count, Asymptomatic

Low load, Low count Rare (late in life)

What methods are used for HIV Detection

ELISA and Western Blot (more specific)

Describe the current HIV Statistics

91.4 million infections total

44.1 million deaths, 40.8 million survivors

Of those, 31.6 million on ART (77%)

630,000 new deaths in 2024, on the down

1.3 million new infections in 2024, on the down

87% of patients aware of their status, 5.3 million don’t know