WBC Review

common progenitor with monocytes:

CFU-GM

which “pool” refers to self-renewal and differentiation?

stem cell pool

which “pool” refers to high proliferation (cell division) capacity?

mitotic pool

which “pool” refers to cells not being able to divide and just continue with maturation?

storage pool

identify this cell:

myeloblast

identify this cell:

promyelocyte

identify this cell:

myelocyte

identify this cell:

myelocyte

identify this cell:

metamyelocyte

identify this cell:

band

identify this cell:

segmented neutrophil

daily production of ____ is around one billion/kbw.

neutrophils

transit time from myeloblast through myelocyte is around ____.

6 days

transit time from myeloblast to maturation pool is around ____

4-6 days

the two pools in circulation: circulating neutrophil pool (CNP) and marginated neutrophil pool (MNP) has a ____ distribution.

50:50

what is the half life of a neutrophil?

7 hours

after the 7 hour half life of a neutrophil, it will leave circulation for tissues by ____ process (either involved in inflammation/infection or spontaneous apoptosis).

diapedesis

main function is phagocytosis (recognition and attachment; ingestion):

neutrophil

functions by killing and digesting (O2 dependent and O2 independent):

neutrophil

azurophilic granules refer to ____ granules.

primary

specific granules refer to ____ granules.

secondary

vesicles refer to ____ granules.

secretory

granules that develops at promyelocyte stage and contain MPO (most important type):

primary

granule formed during myelocyte and metamyelocyte stages that contain collagenase and lactoferrin:

secondary

granule formed during metamyelocyte and band stages that contains lysozymes:

tertiary

granule formed during band and segmented neutrophil stages that contain some complement components:

secretory

eosinophils separate from myeloid lines at the ____ stage.

promyelocyte

eosinophils can already be identified as eosinophilic at ____ stage.

myelocyte

eosinophilic promyelocytes can be identified by detection of ____ protein in their primary granules.

charcot leyden crystal

____ is the specific cytokine for eosinophils.

IL-5

what is the half life of eosinophils in circulation?

18 hours

functions in immune reactions (allergies):

eosinophil

functions by killing parasites (helminths) extracellularly by secreting major basic protein (MBP):

eosinophil

identify this cell:

eosinophilic myelocyte

similar to mast cells and probably has the same progenitor:

basophil

uses blood as a transit system but is a tissue-resident cell:

mast cell

what is the half life for basophils?

30 hours

functions as an inflammatory response and produces large amount of IL-4 and IL-13 (Th2 cytokines):

basophils

basophils synthesize ____ (most important cytokine in allergic reactions):

IgE

____ have receptors for IgE by cross-linking allergens triggering granular release of histamine (degranulation).

basophil

the main cytokine responsible for development of mononuclear cells:

M-CSF

has the characteristic of light blue cytoplasm, delicate chromatin, 1-2 nucleoli, folded or indented nucleus and azurophilic granules (less than promyelocyte):

promonocyte

has the characteristic of mostly indented or folded nucleus, sometimes vacuoles, irregular in overall shape, fine (lacy) chromatin, few granules in cytoplasm (ground glass appearance):

monocyte

monocytes and macrophages have no storage pool in the BM (released immediately after maturation). true or false?

true

monocytes migrate to the tissues after ____.

3 days

term for monocytes/macrophages when in the liver:

kupffer cells

term for monocytes/macrophages when in the epidermis:

langerhans cells

term for monocytes/macrophages when in the CNS:

microglia

monocyte/macrophage functions for ____ immunity (NO production, expression of TLRs, FcyRs):

innate

monocyte/macrophage functions for ____ immunity (antigen presentation, activation of T and B cells):

adaptive

functions with housekeeping such as debris removal (dead cells at infection/inflammation site, old RBC destruction, production of many proteins (some coag factors), complement proteins, interleukins, growth factors, enzymes):

monocyte/macrophage

only mature cells that are able to proliferate/divide (blast transformation):

lymphocyte

of all lymphocytes, about ____% are B cells.

3-21%

of all lymphocytes, about ____% are T cells.

51-88%

of all lymphocytes, about ____% are NK cells.

4-29%

B cells develop in the ____ (pro-B, pre-B, immature B) and move to secondary lymphoid organs (as naive B cells).

bone marrow

T cells develop in the ____ (pro-T, pre-T, immature T) and move to secondary lymphoid organs (as naive T cells).

thymus

identify this cell:

plasma cell