G-Protein Coupled Receptors (GPCRs)
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Why are GPCRs important?
They mediate smell
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How many GPCR isoforms exist?
Over 800 in humans
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What is the structure of GPCRs?
Seven transmembrane alpha helices
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How do GPCRs activate G proteins?
Ligand binding induces conformational change
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What makes G proteins molecular switches?
GTP binding activates them
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How is the signal amplified?
One GPCR activates multiple G proteins
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Flashcards (103)