Pulmonary ventilation (breathing)
movement of air in and out of the lungs
External respiration
movement of oxygen from the lungs into the blood; movement of carbon dioxide from the blood into the lungs; exchange between alveoli and deoxygenated blood in pulmonary capillaries
Depends on partial pressure gradients, matching alveolar ventilation & pulmonary perfusion (blood flow), and respiratory membrane structure
Transport of gases
transportation of oxygen to the body tissues and carbon dioxide from the tissues by the blood
Internal respiration
movement of oxygen from the blood into the tissues; movement of carbon dioxide from the tissues into the blood
External nares
The nostrils
Internal nares
two small openings to the throat
Paranasal sinuses
lighten the skull and warm the air that is breathed in provides an airway, warms, moistens, and filters the air breathed in, olfactory receptor cells, and modifies sound for speech
Nasopharynx
superior portion that lies behind the nasal cavity, extends down to the soft palate (for air only)
During swallowing, the ____________ is closed off by the soft palate and uvula, preventing food from entering the nasal cavity (doesn’t work very well when you laugh)
Oropharynx
middle portion extending from the soft palate to the hyoid bone (for food and air)
Laryngopharynx
inferior portion extending from the hyoid down to the larynx and esophagus (for food and air)
Larynx (voice box)
Provides an airway, Channels food and air into the proper tube (i.e. esophagus and trachea respectively), Voice production
Thyroid cartilage (Adam’s apple)
front wall of larynx
Epiglottis cartilage
elastic cartilage, closes off the glottis walls during swallowing
Glottis
mucous membranes & vocal cords
Arytenoids cartilage
involved in vocal cord function
Cricoids cartilage
forms inferior larynx
Corniculate & Cuneiform cartilage
forms lateral & posterior walls
Vestibular folds
false vocal cords - Mucosal folds
Vocal folds
true vocal cords — Ligaments that vibrate
Phonation
sound production
Occurs by moving air across the vocal cords
Tighter cords – high sounds
Relaxed cords – low sounds
Trachea
Also called the “windpipe”
Is 5 inches long, 1 inch in diameter
Mucosa
Inner layer of trachea
ciliated epithelium
Filters out things we don’t want in our lungs
Submucosa
Connective tissue
Houses glands that secrete mucus
“Tracheal cartilage”
hyaline, C-shaped rings
Carina
where the trachea branches
Tracheotomy
making an incision in the trachea to open the airway
Intrapulmonary Pressure
pressure inside the alveoli
Between breaths = atmospheric pressure (760 mmHg)
During inspiration it is less than atmospheric pressure
During expiration it is greater than atmospheric press.
Intraplueral pressure
pressure in the pleural cavity
Must always be less than intrapulmonary pressure (creates a negative pressure)
This keeps the lungs inflated and working
Boyle’s Law
pressure of a gas (air) in a closed container (lungs) is inversely proportional to the volume of the container (with temperature constant)
Airway Resistance
friction encountered by the air as it enters
Alveolar surface tension
Causes difficulty breathing
Compliance
Ease at which the lungs expand
Tidal Volume
(tv) volume of one breath 500mL
Inspiratory reserve volume
(IRV) – maximum amount of air you can forcibly inspire beyond the tidal volume
Expiratory reserve volume
maximum amount of air you can expire after normal tidal volume expiration (1000-1200 mL)
Residual volume
(RV) – amount of air remaining in the lungs after you forcibly exhale (1200 mL) – keeps the alveoli open
Inspiratory capacity
(IC) = TV + IRV
Max. you can inhale
Functional residual capacity
(FRC) = RV + ERV
Air left in lungs after normal expiration
Vital capacity
(VC) = TV + IRV + ERV
Max. you can exhale after you max. inhale
Spirometer
measures lung volumes and capacities
Eupnea
normal quiet breathing (12 breaths per minute in normal, healthy adults)
Dalton’s Law of Partial Pressures
In a mixture of gases (i.e. air), each individual gas has its own partial pressure (i.e. oxygen and carbon dioxide)
Henry’s Law
When a gas is in contact with a liquid, the gas will dissolve in the liquid in proportion to its partial pressure
The greater the gas concentration, the more and faster it will go into solution in the liquid
Bohr Effect
Refers to the physiological phenomenon where increased levels of carbon dioxide or decreased pH (higher acidity) in the blood lead to a reduction in hemoglobin's affinity for oxygen, facilitating oxygen release to tissues.
Haldane Effect
The physiological phenomenon where deoxygenation of hemoglobin increases its affinity for carbon dioxide, facilitating the removal of carbon dioxide from tissues. (Similar to the Bohr Effect)
Hypoxia
Lack of oxygen