PCT

PCT

The ________ is characterized by a brush border of microvilli protruding into the lumen of the tubule.

Na K ATPase

In the proximal convoluted tubule (PCT), Na+ ions are actively transported from the filtrate to the intracellular space against their concentration gradient through the ________ pump.

tubule

The proximal convoluted ________ (PCT) is a specialized segment of the kidney nephron responsible for reabsorbing a majority of the filtered load from the glomerulus.

ATP

The pump utilizes the energy stored in ________ molecules to perform this task and is a crucial factor in the body's ability to regulate blood pressure, extracellular fluid volume, and pH.

Glucose

________ and amino acids are reabsorbed at 100 % via a co- transport mechanism alongside sodium ions.

percentage of reabsorption varies

The ________ depending on the substance.

proper electrolyte balance

It maintains the ________ in the body by actively transporting Na+ and K+ ions across the plasma membrane against their concentration gradients.

reabsorption process

The microfilaments also interact with myosin, allowing the microvilli to contract and expand, further enhancing the ________.

concentration gradients

The pump works by utilizing the energy stored in ATP molecules to pump Na+ and K+ ions against their ________.

Na K pump

The ________, also known as the sodium- potassium pump, is an essential driver for the process in the proximal convoluted tubule (PCT) of the nephron.

hyperosmotic extracellular area

The ________ surrounding the PCT is driven by the solute concentration within the tubule.

ion movement

Overall, the Na+ ________ across the nephron, from the lumen to the interstitial space, and into the peritubular capillary network, is a tightly regulated process that ensures the net reabsorption of Na+ and solutes and the maintenance of body fluid and electrolyte balance.

microvilli

The ________ are supported by an underlying network of microfilaments made up of actin.

PCT

The ________ is lined with a single layer of cuboidal epithelial cells that contain various transporters responsible for moving solutes across the cell membrane.

tubule

In the proximal convoluted ________ (PCT), there is an active transport of solutes and water reabsorption.

ATP

________ is hydrolyzed by the pump to release energy, which is used to change the conformation of the pump, allowing it to transport Na+ and K+ ions across the plasma membrane.

PCT

Additionally, the ________ contains a high density of mitochondria, which provide the energy required for active transport of solutes against their concentration gradients.

PCT

In the ________, the Na /K pump plays a crucial role in maintaining the proper electrolyte balance in the body.

PCT

In the ________, aquaporins are found on both the apical and basolateral membranes.

The Na/K pump is a membrane-spanning protein that contains three subunits

α, β, and γ

The PCT absorbs:

large proportion of filtered water and solutes (glucose/amino acids)

The PCT is permeable to

water and electrolytes

The PCT plays a critical role in

maintaining the body’s fluid and electrolyte balance