Anergy & Stringency of negative selection

What happens to self-reactive B cells that recognize soluble monovalent antigens but are not removed through clonal deletion or receptor editing?

They are placed into an arrested state known as anergy.

What is the characteristic of B cells in anergy?

They do not respond to antigen.

How does the stringency of negative selection for B cells compare to T cells?

Negative selection of B cells is less stringent than T cells.

Why is negative selection of B cells less stringent than that of T cells?

B-cell activation depends on help from T cells.

For both B and T cells to become self-reactive, what must happen?

Both B and T cells would have to react to the same self-antigen.

Why is T-cell negative selection more stringent than B-cell negative selection?

It is much harder for a self-reactive T cell to be released into the circulation.