Central Dogma & DNA Replication: Key Concepts for Biology

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Last updated 9:56 PM on 3/21/26
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25 Terms

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Central Dogma

DNA → RNA → Protein

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DNA vs RNA

DNA has deoxyribose; RNA has ribose

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Bonds

Hydrogen bonds hold base pairs

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Helicase

Unwinds DNA

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Primase

Makes RNA primers

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DNA Polymerase III

Builds DNA

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DNA Polymerase I

Replaces primers

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Ligase

Joins fragments

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DNA gyrase

Relieves tension

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Leading strand

Is continuous

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Lagging strand

Forms Okazaki fragments

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Silent mutation

No change

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Missense mutation

Different amino acid

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Nonsense mutation

Stop codon

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Frameshift mutation

Insertion/deletion shifts reading frame

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mRNA

Carries info

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tRNA

Brings amino acids

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rRNA

Forms ribosome

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Post-transcription

5' cap, poly-A tail, splicing

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Leptin

Fullness

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Ghrelin

Hunger

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Insulin

Regulates blood sugar

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Prions

Misfolded proteins causing brain disease

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Creutzfeld-Jakob Disease

Example of prion disease

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Meselson-Stahl experiment

Proved semi-conservative replication using nitrogen isotopes

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