4 - Antibody Structure & Generation of B-Cell Diversity

The ____ enzyme mediates somatic hypermutation & class switching.

AID (Activation-Induced Cytidine Deaminase)

T/F: Only monoclonal antibodies are used as therapeutics.

False, both polyclonal & monoclonal antibodies are used

Which 2 classes of antibodies have membrane-bound forms?

A) IgE & IgG

B) IgM & IgG

C) IgM & IgD

D) IgG & IgA

C) IgM & IgD

Which part of the variable region has the most number of gene segments?

Heavy chain V segment

Which of the following enzymes are only expressed during VDJ recombination? (multiple answers)

A) TdT

B) NHEJ complex

C) RAG1

D) RAG2

TdT, RAG 1 & 2

Which portion of an antibody binds host molecules?

A) variable region

B) Fab region

C) Fc region

D) light chain

C) Fc region

T/F: A 12 spacer RSS can recombine with an RSS with a 12 nucleotide spacer.

False, a 12 spacer RSS can only recombine with a 23 spacer