Cell Compatibility and Organ Transplant Investigation

Flashcards about cell compatibility, organ transplants, and the donation process.

Sialic acid

Sugar chains attached to the cell surface.

Glycoproteins in the cell membrane

Identify what kind of cell it is (e.g., liver cell). Carbohydrate branching chain patterns identify each cell as belonging to you.

What are carbohydrate chains

Human Leukocyte Antigens (HLA); inherited from parents, making family members the most compatible matches.

What happens if a cell has a different pattern of markers?

The immune system attacks and kills cells with different patterns of HLA markers.

Examples of living organ donation

Kidney, liver section.

Deceased donor

A person is clinically brain dead but organs are kept viable by keeping the person on a ventilator and cardiac machine while the recipients prepare for surgery.

Factors that have to match for an organ to be transplanted:

Matching carbohydrate branching patterns, compatible blood type, and size and weight.

Transplant or organ rejection

The immune system recognizes foreign tissue cells are different and attacks the newly received transplant.

What happens if you don't have the protein on your RBC

If you don't have the "protein" on your RBC, you cannot receive that type of blood; the immune system recognizes foreign proteins & attacks the newly received transplant.

Universal donor blood type

O-

Universal recipient blood type

AB+

Size & Weight

The donor should be approximately the same size as the recipient; the organ would be too small for the recipient.

Age for transplants

Any aged person can donate or receive organs; some medical conditions could prevent someone from being a living donor.

How long different organs can live outside the body:

Heart: 4-6 hrs., lungs: less than 2hrs, liver: 12 hrs., kidneys: 36 hrs.

Goal of the Lab assignment

To make your own personal carbohydrate chains extending off the glycolipid and glycoprotein components of the cell membrane.

Typical storage times for organs:

30 hours or less for a kidney, less than 12 hours for a pancreas or liver, and less than 6 hours for a heart or lungs.

What do immunosuppressive medications do?

Medications suppress the immune system by weakening it but do not completely destroy all of the T and B cells.

How to become an organ donor

Register on the organ donor website (www.organdonor.gov) and Drivers License.

Do Now! Or Exit Ticket!

Name at least three body parts that can be transplanted. Describe the job of the immune system. What will immunosuppression medication do to the immune system & why? Name two compatible factors that are considered when choosing an organ donor match for a recipient. What are the two type of organ donors?

Reason to be eligible must be an organ donor or has been the recipient of an organ

They can receive scholarship money.

Name at least three body parts that can be transplanted.

Lung, Heart, Liver, Kidney, Pancreas, Intestine.

What different people had which blood types in need of donors

A+, O-, AB-, B+.