BME chapter 2 - Biomolecular Principles

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47 Terms

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biological molecules used in biomedical engineering

proteins, nucleic acids, carbohydrates, and lipids

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liposomes

lipid molecules assembled to aid in anticancer drugs.

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Ions

molecules with a net charge

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Ionic bonds

electrons being transferred from one atom to another

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cation

positively charged ion

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anion

negatively charged ion

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covalent bonds

sharing of electrons

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what are the charges of a H2O molecule?

oxygen is slightly negative, hydrogen is slightly positive

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gene delivery

act of transferring foreign DNA into a cell

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hydrogen bonds

when a partially positive hydrogen atom in a polar bond is attracted to a slightly negative atom (O, N, F) in a neighboring molecule, holds large molecules together

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what holds together macromolecules?

all atoms are held together by covalent or ionic bonds

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molecular complex

collections of molecules held together often by weak bonds (ie. hydrogen bonds) held together in a single unit

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enzymes

type of molecular complex that speeds up chemical conversions

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van der Waals interactions

weak noncovalent attraction, usually results from temporary and unequal electron distributions around atoms

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aqueous

water-rich

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hydrophobic effect

when hydrophobic molecules aggregate together to exclude water as best as they can, driving force in protein folding

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amphiphilic

molecules that contain both hydrophilic and hydrophobic groups (ie. phospholipids used to make liposomes)

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acidosis

excess of acid in the body fluids, as may occur in kidney disease or diabetes

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adenosine 5’ triphosphate (ATP)

nucleotide that is the most important molecule for capturing and transferring free energy in cells, hydrolysis of each of the two high-energy phosphoanydride bonds in ATP is accompanied by a large energy change

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aquaporin

a water channel protein that allows water molecules to cross the cell membrane much more rapidly than through the phospholipid bilayer

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base

a compound usually containing nitrogen that can accept a proton

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chemical equilibrium

the state of a reaction when the forward and reverse reaction are occurring at the same time

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complementary sequence

a sequence the nucleotide bases of which match or hybridize (mirror image) with original sequence

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condensation

opposite of hydrolysis

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deoxyribose

5 carbon sugar of DNA

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endothermic

referring to a chemical concentration that absorbs heat

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enthalpy

a thermodynamic property of chemicals that indicates the amount of internal energy

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facilitated diffusion

protein-aided transport of molecules across a membrane down its concentration gradient

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first-order reaction

a reaction where all of the reaction rates are equal to the rate constant x concentration

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flux

rate of transfer fluid, particles, or energy across a given surface

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formation reaction

a chemical reaction that describes the formation of a compound from the most stable form of its components

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fructose

hexose sugar especially found in fruits

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galactose

hexose sugar that is a constituent of lactose and other polysaccharides

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genetic information

hereditary info that is carried by nucleic acids

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glucose

G6 H12 O6

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glycolipid

two hydrocarbon chains linked to a polar head group containing carbs

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glycoprotein

protein linked to oligosaccharides

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hybridization

the process of two single strands of DNA assembling into double-stranded DNA

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messenger RNA (mRNA)

a form of RNA in which genetic information transcribed from RNA is transferred to the ribosome

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neutral

pH 7

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passive diffusion

water and small uncharged molecules (O2 and CO2) passing through the plasma membrane

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pentose

five-carbon sugar

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peptide

small polymer containing less than 30 amino acids

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polymerization

making polymers from a collection of monomers

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ribose

five-carbon sugar part of RNA

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transcription

process where genetic info contained represented as DNA nucleotides is copied into newly synthesized strands of RNA

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translation

process where a sequence of nucleotide triplets in mRNA gives rise to a specific sequence of amino acids during protein synthesis