Lecture 13 - Follicles & Folliculogenesis

folliculogenesis

process of follicles developing

on the ovary

Where does folliculogenesis occur?

in the ovary

Where does folliculogenesis occur in equids?

oocyte (female germ cell)

What does a follicle contain?

finite

Females are born with _____ number of follicles

primordial follicle

follicle with single layer of squamous-shaped follicular cells that surround an oogonia

mitosis

Once an oogonia is surrounded by follicular cells, it can NO longer go through what?

meiosis

Once an oogonia is surrounded by follicular cells, it begins what?

cAMP

What do follicular cells produce?

prophase I

The oocyte is arrested in what stage of meiosis?

primary follicle

follicle with single layer of cuboidal cells (granulosa cells)

primordial follicle

Females are born with their oocyte inside what follicle?

secondary follicle

follicle with more than one layer of granulosa cells, layer of theca cells, and appearance of the zona pellucida

antral follicle

follicle that can be seen by the naked eye & contains a cavity

antrum

fluid filled cavity in a follicle

cumulus cells

granulosa cells that surround the oocyte & leave with the oocyte

LH

What hormone activates theca cells?

testosterone

Theca cells make what?

FSH

What hormone activates granulosa cells?

estradiol

Granulosa cells make what?

aromatase

When FSH binds to a receptor & activates cAMP, what enzyme is activated?

1) brain

2) reproductive tract

What 2 places does estradiol go to in the body?

monotocous

species with one offspring, one follicle, & one ovulation

polytocous

Species that are litter bearers & multiple follicles ovulate

gonadotropin-independent growth

follicular growth that does NOT depend on LH & FSH; instead depends on environmental factors, nutrition, etc.

preantral (primordial, primary, & secondary)

Which follicles experience gonadotropin-independent growth?

gonadotropin-dependent growth

follicular growth that depends on LH & FSH; follicles die without them

antral

Which follicles experience gonadotropin-dependent growth?

1) Recruitment

2) Selection

3) Dominance

3 phases of folliculogenesis

recruitment & selection

Which follicular phases are FSH dependent?

selection & dominance

Which follicular phases are LH dependent?

recruitment

phase where follicle enters into gonadotropin sensitive pool

selection

phase where ovulatory follicles emerge

dominance

phase where final growth of ovulatory follicles occurs & inhibition of other follicles

inhibin

What do granulosa cells produce?

FSH

Inhibin suppresses the release of what from the anterior pituitary gland?

atresia

“death” of a follicle

positive

What type of feedback loop does estradiol have on the hypothalamus?