Nervous System

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Development of the Nervous System

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1

Development of the Nervous System

  • begins as a tube along the axis of the body

  • folds over during development and is hollow as a result

  • starts as 3 swellings after 4 weeks in the uterus (turns into 5)

  • neural tube becomes the spinal cord

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Rhombencephalon

Hindbrain

<p>Hindbrain</p>
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3

Mesencephalon

Midbrain

<p>Midbrain</p>
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4

Prosencephalon

Forebrain

<p>Forebrain</p>
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5

spina bifida

when the neural tube doesn't completely close at the caudal end

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Central Nervous System

  • brain

  • spinal cord

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Peripheral Nervous System

  • neural tissue outside of the CNS

  • sensory and motor neurons

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8

Sensory Nervous System

contains receptors that transmit information to the CNS

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9

Motor Nervous System

  • transmits information for the CNS to the rest of the body

  • sends motor information to effectors

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10

Somatic Sensory

  • apart of the sensory nervous system

  • voluntary actions

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11

Visceral Sensory

  • apart of the sensory nervous system

  • involuntary actions

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12

Somatic Motor

  • apart of the motor nervous system

  • voluntary actions

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13

Autonomic Motor

  • apart of the motor nervous system

  • involuntary actions

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14

Gray Matter

  • consists of neural and glial cell bodies

  • outer portion of the brain

  • inner portion of the spinal cord

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15

White Matter

  • consists of axons

  • inner portion of the brain

  • outer portion of the spinal cord

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16

Nerves

  • cable like bundle of parallel axons

  • surrounded by three layers of connective tissue

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17

Endoneurium

delicate connective tissue around individual axons in nerve

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Perineurium

the sheath of connective tissue that covers a bundle of nerve fibers (fascicles)

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Epineurium

connective tissue surrounding the entire nerve

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20

Synapse

  • junction between two neurons that is responsible for unidirectional transmission of nerve impulses

  • can make contact with cell bodies, dendrites or other axons

  • release neurotransmitters

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Excitatory

  • type of synapse

  • activity promotes impulses

  • depolarizes the next cell membrane

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Inhibitory

  • type of synapse

  • inhibits impulse transmission

  • hyperpolarizes next cell membrane

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Acetylcholine

  • neurotransmitter that is released at all neuromuscular junctions

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24

Multipolar Neuron

  • has several dendrites

  • one axon

  • majority of the neurons in the CNS

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Unipolar Neuron

  • one long axon with dendrites at the end

  • touch and stretching

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Bipolar Neurons

  • one dendrite and one axon

  • makes up many sensory nerves

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27

Pyramid Neuron

  • type of multipolar neuron

  • triangular shaped bodies

  • found in the cerebral cortex, hippocampus and amygdala

  • linked to cognitive ability

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28

Neuroglia

  • glial cells

  • CNS and PNS

  • physically protect and nourish the neuron

  • higher amount compared to the amount of neurons

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Oligodendrocytes

  • CNS axons only

  • extensions of cytoplasm that wrap around the axon

  • produce myelin to insulate the electrical activity and produce rapid nerve impulses

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Schwann Cells

  • PNS only

  • whole cell that wraps around an axon

  • insulate electrical activity by myelinating the axons for rapid nerve impulses

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Astrocytes

  • most common glial cell

  • regulation of the environment around axons and synapses

  • repairs damage of neurons

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Microglia

  • type of macrophage associated with the immune system

  • clean-up cell

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33

Multiple Sclerosis

  • results from the destruction of the myelin sheath and axons

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34

Meninges

  • three layers of connective tissue that surround the spinal cord and brain

  • protection

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Pia Mater

  • innermost layer of meninges

  • adheres to surfaces

  • highly vascular

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Arachnoid Mater

  • middle layer of meninges

  • weblike and avascular

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Dura Mater

  • outer layer of meninges

  • dense, irregular connective tissue

  • 2 layers in the brain

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38

Epidural Space

  • area between the vertebral column/cranium and dura mater

  • blood vessels, fat and connective tissue

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Subdural Space

  • area between the arachnoid and dura mater

  • contains interstitial fluid

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40

Subarachnoid Space

  • area between the pia and arachnoid mater

  • contains cerebralspinal fluid

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41

Severe Head Trauma Cases

  • can create bleeding between the meninges

  • cause pressure that can destroy neurons and glia cells

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Epidural Block

  • regional anesthesia that numbs the lower body

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Spinal Tap

  • needle inserted between the lumbar vertebrae into subarachnoid space

  • withdraws cerebrospinal fluid and can introduce substances

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44

Cerebrospinal Fluid

  • produced in the choroid plexuses of each of the four brain ventricles

  • found in the subarachnoid space of the brain and spinal cord

  • protection of the brain; brain floats in it and provides cushioning

  • transports nutrients and removes wastes

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45

Hydrocephalus

  • cerebrospinal fluid accumulates in the brain ventricles

  • babies heads with swell

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46

Blood-Brain Barrier

  • barrier that strictly regulates which substances can enter the interstitial fluid in the brain

  • capillaries in the brain are selectively permeable

  • glial cells surround the capillaries to catch things that get through the barrier

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47

Bone

  • most important physical defense for the CNS

  • not applicable for the PNS

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48

Spinal Cord

  • pathway for sensory and motor impulses to and from the brain

  • responsible for the quickest reflex reactions to a stimulus

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External Spinal Cord Anatomy

  • from medulla oblongata to second lumbar vertebra

  • cervical enlargement consists of nerves from the upper limbs

  • lumbosacral enlargement consists of nerves from the lower limbs

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Internal Spinal Cord Anatomy

  • grey matter consisting of unmyelinated axons and glial cells, butterfly shape

  • white matter consisting of myelinated axons

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51

Anterior Horns

  • grey matter in spinal cord

  • contain cell bodies of somatic motor neurons which innervate skeletal muscle

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52

Posterior Horns

  • grey matter in spinal cord

  • contain axons of sensory neurons

  • cell bodies of interneurons

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53

Lateral Horn

  • grey matter in spinal cord

  • found in T1-L2

  • cell bodies of autonomic motor neurons

  • innervate cardiac and smooth muscle and glands

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54

Grey Commissure

  • grey matter in spinal cord

  • unmyelinated axons

  • communication route between the right and left side

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55

Spinal Nerves

  • make up PNS

  • connect the CNS to sensory receptors, muscles and glands

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Meningeal Branch

  • branch of spinal nerves

  • returns through vertebral foramen to innervate meninges, vertebrae and ligaments

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Rami Communications

  • two branches in the spinal nerves that function within the autonomic nervous system

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58

Dorsal Ramus

  • branch of spinal nerves

  • innervate deep muscles and skin of the back

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Ventral Ramus

  • branch of spinal nerves

  • innervate superficial back muscles, lateral and ventral muscles and skins and muscles of upper and lower limbs

  • do not go directly to body structures and form networks on both sides of the body

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60

Cervical Plexus

  • portion of anterior rami of the C1-C4 and part of C5

  • positioned laterally

  • head, neck, upper shoulders and chest

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61

Phrenic Nerve

  • C3-C5

  • innervate the diaphragm

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62

Brachial Plexus

  • positioned lateral from C5-T1

  • extends downward under the clavicle into axilla

  • part of shoulders and all upper limbs

  • 5 major nerves

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63

Axillary Nerve

  • from brachial plexus

  • sensory from skin of shoulder

  • motion to some shoulder muscles

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64

Musculocutaneous Nerve

  • from brachial plexus

  • flexors of the arm

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Radial Nerve

  • from brachial plexus

  • extensors of the arm and forearm

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66

Median Nerve

  • from brachial plexus

  • anterior forearm and portion of the hand

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67

Ulnar Nerve

  • from brachial plexus

  • anterior/medial forearm and majority of the hand

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68

Lumbar Plexus

  • side of anterior rami of L1-L4

  • anterolateral abdominal walls, external genitals and parts of lower limbs

  • 2 major nerves

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69

Femoral Nerve

  • from lumbar plexus

  • anterior muscles of the thigh

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70

Obturator Nerve

  • from lumbar plexus

  • medial (adductor) muscles of the thigh

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71

Sacral Plexus

  • immediately caudal to lumbar plexus

  • formed by L4-S5

  • lower back, pelvis, posterior thigh, parts of the foot

  • one main nerve

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72

Sciatic Nerves

  • largest nerve extending the length of each leg

  • irritation can cause crippling pain and discomfort, pinching of the nerve (sciatica), arthritic inflammation, bulging disk, vitamin deficiencies

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Dermatomes

  • area of skin supplied by a single spinal nerve (all but C1 innervate single portion)

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74

Reflexes

  • rapide involuntary reactions to a stimulus

  • required to initiate a response

  • few neurons must be involved and synaptic delay must be minimal

  • occurs the same way everytime

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75

Reflex Arc

  1. stimulus

  2. sensory neuron activated

  3. processed in the CNS

  4. motor neuron activated

  5. response by effector

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76

Telencephalon

  • the anterior division of the forebrain consisting of the cerebrum

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77

Diencephalon

  • the posterior division of the forebrain consisting of the thalamus, epithalamus and hypothalamus

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Mesencephalon

  • midbrain

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79

Metencephalon

  • the part of the hindbrain that develops into the pons and the cerebellum

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80

Myelencephalon

  • the posterior part of the hindbrain that forms the medulla oblongata

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81

Medulla Oblongata

  • last portion of the brain before the spinal cord

  • contains sensory and motor tracts to and from the brain

  • controls heart rate and breathing

  • vomiting, coughing and sneezing reflexes

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Pons

  • contains sensory and motor tracts that connect the brain and spinal cord (bridge)

  • helps to regulate the breathing rate

  • involved in sound localization

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83

Cerebellum

  • second largest part of the brain

  • highly convoluted surfaced covered in folds

  • coordinates and fine tunes skeletal muscle movement

  • monitors position of joints and muscles

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84

Midbrain

  • between pons and diencephalon

  • controls various sub or unconscious movement of the eye

  • contains elements of the auditory pathway

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Diencephalon

  • contains the thalamus, epithalamus and hypothalamus

  • surrounds the third ventricle

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86

Thalamus

  • paired oval masses of grey matter, each consisting of a dozen thalamic nuclei

  • division of the diencephalon

  • all sensory signals pass through here (excluding smell)

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87

Hypothalamus

  • division of the diencephalon

  • involved in hormone production

  • regulation of emotions, eating, drinking and body temperature

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88

Epithalamus

  • connects the limbic system to the rest of the brain

  • division of the diencephalon

  • main component is the pineal gland

  • important for sleep regulation

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89

Cerebrum

  • location of conscious thought processes and the origin of intellectual functions

  • formed from the telencephalon

  • surface folds into elevated ridges

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Gyri

  • adjacent gyri are separated by shallow grooves (sulci) or deeper grooves (fissures)

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Cerebral Hemispheres

  • 2 components of the cerebrum

  • divided by a longitudinal fissure extends along the midsagittal plane

  • memory and consciousness can not be assigned to particular regions

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92

Corpus Callosum

  • main tract connecting the right and left cerebral hemispheres

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93

Olfactory Nerve

  • cranial nerve that carries impulses to the brain from the olfactory epithelium

  • (I)

  • sensory only

  • only type of nervous tissue to regenerate

  • anosmia is partial or total loss of smell

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94

Optic Nerve

  • (II) cranial nerve that carries impulses from the retina

  • sensory only

  • left and right optic nerves unite at optic chiasma

  • information passes through thalamus on way to occipital lobe of cerebrum

  • anopsia is visual defects

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95

Oculomotor Nerve

  • (III) cranial nerve that controls pupil size

  • motor fibers to four extrinsic eye muscles and upper eyelid

  • sensory fibers from proprioceptors

  • damage causes upper eyelid droop, paralysis of eye muscles, double vision or difficulty focusing

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96

Trochlear Nerve

  • (IV) cranial nerve

  • motor fibers to the fifth eye muscle

  • sensory fibers from proprioceptors

  • damage can cause paralysis of superior oblique muscle leading to visual issues

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Trigeminal Nerve

  • (V) cranial nerve

  • motor fibers innervate muscles of mastication

  • motor sensory fibers from the face

  • divides into three branches

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98

Ophthalmic Branch

  • part of the trigeminal nerve

  • motor fibers to tear gland

  • sensory fibers from cornea, nose, forehead and anterior scalp

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Maxillary Branch

  • part of the trigeminal nerve

  • sensory fibers from nasal mucosa, gums and cheek

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100

Mandibular Branch

  • part of the trigeminal nerve

  • sensory fibers from the lower jaw and teeth and part of the tongue

  • motor fibers to the temporalis, masseter and pterygoid muscles

  • damage causes trigeminal neuralgia (inflammation of sensory components)

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