Top 300 Quiz 9

AMIODARONE

brand

Cordarone

Pacerone (INJ)

Nexterone

AMIODARONE

Dosage Forms

Tablet

AMIODARONE

Tablet

100 mg, 200 mg, 400 mg

AMIODARONE

Common FDA Label Indication, Dosing, and Titration

Secondary prophylaxis of ventricular arrhythmias

AMIODARONE

MOA

Type III antiarrhythmic

AMIODARONE

Box Warnings

Hepatotoxicity

proarrhythmic effects

pulmonary toxicity

AMIODARONE

Contraindications

severe bradycardia

severe sinus node dysfunction

2/3 AV block

cardiogenic shock

AMIODARONE

Adverse Reaction

N/V

hypotension

phospholipidemia

Blindness

hepatotoxicity

pulmonary fibrosis

ventricular arrhythmias

AMIODARONE

Key Patient Counseling Points

Use sunscreen

DDI

consistently + meals

avoid grapefruit

medication guide must be dispensed

AMIODARONE

Dosage Forms

INJ

Single-Use Vial

Premixed Infusion

AMIODARONE

Single-Use Vial

INJ

150 mg/3 mL, 450 mg/9 mL, 900 mg/18 mL

AMIODARONE
Premixed Infusion

INJ

150 mg/100 mL

360 mg/200 mL

AMIODARONE

Common FDA Label Indication, Dosing, and Titration

INJ

Pulseless ventricular tachycardia or ventricular fibrillation

QUETIAPINE

brand

Seroquel, Seroquel XR

QUETIAPINE

Dosage Forms

Tablet

Tablet, ER

QUETIAPINE

Tablet

25 mg, 50 mg, 100 mg, 200 mg, 300 mg, 400 mg

QUETIAPINE

Tablet, Extended Release

50 mg, 150 mg, 200 mg, 300 mg, 400 mg

QUETIAPINE

Common FDA Label Indication, Dosing, and Titration

Bipolar disorder

schizophrenia

MDD

QUETIAPINE

MOA

antagonizes serotonin 5-HT_1A / 5-HT₂

D₁ / D₂,

H₁

α₁ and α₂ receptors

QUETIAPINE

Box Warnings

Mortality in elderly with dementia

suicidality

not approved for children <10 y of age

QUETIAPINE

Contraindications

Hypersensitivity to quetiapine

QUETIAPINE

Adverse Reactions

Agitation,

HTN

weight gain

Neuroleptic malignant syndrome, neutropenia, pancreatitis, sudden cardiac death, syncope, tardive dyskinesia, slowed or difficult breathing when used in combination with opioids

QUETIAPINE

Key Patient Counseling Points

Take IR / ER tablet with or without food

Avoid alcohol

Avoid activities requiring mental alertness

Rise slowly from a sitting

RIZATRIPTAN

brand

Maxalt

RIZATRIPTAN

Dosage Forms

Tablet

Disintegrating Tablet

RIZATRIPTAN

Common FDA Label Indication, Dosing, and Titration

Migraine

RIZATRIPTAN

MOA

5HT 1B / 1D

RIZATRIPTAN

Contraindications

Cerebrovascular syndromes

hemiplegic or basilar migraine

ischemic bowel disease/heart disease

peripheral vascular disease

severe hepatic impairment

uncontrolled HTN

MAOI

ergot alkaloids

RIZATRIPTAN

Adverse Reactions

None known

chest pain, jaw pain

HTN

heart block

RIZATRIPTAN

Key Patient Counseling Point

avoid alcohol, CNS depressants

Caution with driving

disintegrating tablet to dissolve on tongue

ROPINIROLE

brand

Requip, Requip XL

ROPINIROLE

Dosage Forms

Tablet

Tablet, Extended Release 24 h

ROPINIROLE

Common FDA Label Indication, Dosing, and Titration

Parkinson disease

Restless legs syndrome

ROPINIROLE

Tablet

0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg, 5 mg

ROPINIROLE

Tablet, Extended Release 24 h

2 mg, 4 mg, 6 mg, 8 mg, 12 mg

ROPINIROLE

MOA

postsynaptic D2-type receptor

ROPINIROLE

Dose Adjustment Renal

yes

ROPINIROLE

Adverse Reactions

Dizziness, dyskinesia, nausea, orthostatic hypotension, somnolence, vomiting, hallucinations

Sinus node dysfunction, neuroleptic malignancy syndrome, impulse control/compulsive behaviors

ROPINIROLE

Key Patient Counseling Points

Take with food

Rise slowly from sitting

Avoid driving

Avoid sudden discontinuation

Do not drink alcohol or take other CNS depressants

TAMSULOSIN

brand

Flomax

TAMSULOSIN

Dosage Forms

Capsule

TAMSULOSIN

Capsule

0.4 mg

TAMSULOSIN

Common FDA Label Indication, Dosing, and Titration

Benign prostatic hyperplasia

TAMSULOSIN

MOA

selectively block postsynaptic α1-adrenergic receptors

TAMSULOSIN

Contraindications

Hypersensitivity

TAMSULOSIN

Adverse Reactions

Dizziness, headache, abnormal ejaculation, rhinitis, positional hypotension

Angioedema, retinal detachment, priapism

TAMSULOSIN

Key Patient Counseling Points

30 min after same meal daily

Avoid activities requiring coordination

Rise slowly from a sitting

Syncope is possible with 1st dose or dose increases

TERAZOSIN

brand

Hytrin, Tezruly

TERAZOSIN

Dosage Forms

Capsule

Solution

TERAZOSIN

Capsule

1 mg, 2 mg, 5 mg, 10 mg

TERAZOSIN

Solution

1 mg/mL

TERAZOSIN

Common FDA Label Indication, Dosing, and Titration

Benign prostatic hyperplasia

HTN

TERAZOSIN

MOA

selectively blocks postsynaptic α1-adrenergic receptors

TERAZOSIN

Contraindications

Hypersensitivity

TERAZOSIN

Adverse Reactions

Asthenia

dizziness

fatigue

Hepatotoxicity

TERAZOSIN

Key Patient Counseling Points

Avoid driving

Rise slowly from a sitting

Syncope - 1st dose

Bedtime

Avoid sudden discontinuation of drug

Avoid alcohol