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amyloid plaques
fragments of the protein beta-amyloid that accumulates into insoluble plaques that inhibit neural comminication betweeen neurons
neurofibrillary tangles
accumulation of the protein tau that forms insoluble tangles WITHIN neurosn which then inhibits the transportation of essentual substances and eventually kills the neuron entirely
long term depression in memory
Long-term memory has a relatively permanent duration.
This duration may be impacted by long-term depression which refers to the long-lasting weakening of unused synaptic connections due to repeated low0intensity stimulation
Therefore, long-term depression may at times affect the information stored in long-term memory by reducing the duration of long-term memory, causing some memories which become lost rather than be permanent due to the weakening of synaptic connections associated with this memory