Lipid lowering drugs

simvastatin moa

inhibit HMG-CoA reductase (liver uses that enzyme to produce cholesterol) -> lower rate of cholesterol production

simvastatin (2) indications

hypercholesterolemia, CVD risk reduction

simvastatin (3) side/adverse effects

myopathy, rhabdomyolysis, elevations in liver enzymes

simvastatin (3) drug interactions

erythromycin, Azole antifungals, grapefruit juice

Niacin moa

increase activity of lipase -> breaks down lipids -> reduces metabolism of cholesterol

Niacin (2) side effects

flushing (caused by histamine release), rhabdomyolysis

Niacin what to do to decrease some of the side effects

flushing can be decreased if niacin is started on a smaller dose and slowly increased. Premedication with a small dose of aspirin or NSAID 30 min before taking med and taking niacin with meals helps decrease side effects

Gemfibrozil indications

hypertriglyceridemia

Gemfibrozil (4) side effects

abdominal discomfort, diarrhea, nausea, increased risk of gallstones

Ezetimibe moa

inhibits absorption of cholesterol from small intestine -> reduced total cholesterol, LDL, and triglyceride levels

Ezetimibe indication

hypercholesterolemia

Ezetimibe (3) side effects

GI issues, joint pain, elevated liver enzymes