Transplantation Immunology

Which of the following responses is the type of allograft rejection associated with vascular and parenchymal injury with lymphocyte infiltrates?

Acute cellular rejection

Antigen receptors on T lymphocytes bind HLA class II + peptide complexes with the help of which accessory molecule?

CD4

Patients who have received the following types of grafts are at risk for graft-versus-host disease (GVHD) except for recipients of

irradiated leukocytes

Which of the following properties is not exhibited by HLA molecules?

There are monomorphic

Kidney allograft loss from intravascular thrombosis without cellular infiltration 5 days post-transplant may indicate which primary rejection mechanism?

Accelerated humoral rejection

Which reagents would be used in a donor–recipient crossmatch test?

Recipient serum and donor lymphocytes + rabbit serum complement

The indirect allorecognition pathway involves which one of the following mechanisms?

Processed peptides from polymorphic donor proteins restricted by recipient HLA class II molecules

Which immunosuppressive agent selectively inhibits IL-2 receptor- mediated activation of T cells?

Basiliximab

Phenotyping for HLA class II antigens requires B lymphocytes because

B lymphocytes express HLA class II antigens

A renal transplant candidate was crossmatched with a donor who was mismatched for only the HLA-B35 antigen. The candidate was known to have an antibody specific for HLA-B35. Which of the following combinations of T- and B-cell flow cytometric crossmatch results would be expected?

T cell positive, B cell positive

Which of the following HLA alleles differs from A*02:01:02 by a synonymous nucleotide substitution?

A*02:01:03

Which one of the following donors would be expected to elicit a positive mixed lymphocyte response in lymphocytes from a patient who has the HLA-DRB1*01:01, 01:03 alleles?

DRB1*01:01, 01:05

Which of the following donors would be the most appropriate, based on ABO compatibility, for a renal transplant candidate with the ABO type = O?

O

Which of the following HLA antigens would be expected to elicit an HLA antibody response in a kidney transplant recipient with the following HLA type: HLA-A*01,03; B*07,14; C*01,04N; DRB1*16,07?

HLA-C*04

Suppose a 30-year-old man was found to be a suitable donor for a kidney transplant to his younger sister. This transplant would be an example of a(an)

allograft