PHAR 308 Unit1-2 Intravenous Anesthetics 힌트 얻기

IV Anesthetics

MOA of IV anesthetics

GABBA receptors

Potency of IV anesthetics

free plasma [ ] at EQB that produces loss of reponse to surgical incisions in 50% of subjects

Q. What chemical characteristics would affect free plasma concentration

size (small)

hydrophobicity (phobic)

protein binding

IV anesthesia drugs usual perfused in?

lipohillic tissues in brain + spinal cord

Onset & Duration definition

Onset: how long it takes to reach brain (BBB)

Duration: depends on redistribution rate from brain — tissues

Question: What are some drug factors that may impact onset and duration?

BP + heart rate

Question: What are some patient factors that would influence t1/2

kidney f(x)

what does Propofol (IV anesthetics) do?

• allosteric modulator (rapid)

• inhibits GABAa R + NMDA glutamate R

Ketamine does?

antagonist NMDA receptors

analgesia + anesthesia

ADRs

dissociation (responsive but X awake), dysphoria

depressents, decreases contract F