1.6 metabolic pathways

What is a metabolic pathway?

metabolic pathway’s are integrated and cotrolled pathways of enzyme-catalysed reactions within a cell

What type of steps can metabolic pathways have?

Reverisble steps, irriversible steps and alternative routes.

What type of reaction’s can occur within a metabolic pathway?

Anabolic reactions and catabolic reactions

What is an anabolic reaction?

Anabolic reactions build up large molecules from small molecules and require energy.

What are catabolic reaction?

Catabolic reactions break down large molecules into smaller ones and release energy.

How are metabolic pathways controlled?

metabolic pathways are controlled by the presence or absence of particular enzymes and the the regulation of the rate of reaction of key enzymes

When does induced fit occur and what are affects of it?

Induced fit occurs when the active site changes shape to better fit the substrate after the substrate binds and it lowers the activation energy allowing the reaction to take place more easily

What is the affinty of substrate molecules and the subsequent product?

The substrate molecules have a high affinity for the active site and trh subsequent products have a low affinity allowing them to leave the active site

What determines the direction of a metabolic reaction?

Some metabolic reactions are reversible and the presence of a substrate or the removal a product will drive a sequnce of reactions in a particular direction.

what is competitve inhibiton?

competitive inhibitors bind at the active site preventing the substrate from binding. Competitive inhibiton can be reversed by an increasing substrate concentration.

What is Non-competitive inhibitors?

Non-competitive inhibitors bind away from the active site but change the shape of the active site preventing the substrate from binding. Non-competitive inhibiton cannot be reversed by increasing substrate concentration.

What is feeback inhibiton?

Feedback inhibition occurs when the end-product in the metabolic pathway reaches a critical concentration. The end-product then inhibits an earlier enzyme, blocking the pathway, and so prevents further synthesis of the end-product.