schizophrenia and antipsychotic drugs - jos

based on his kahoot (jcpharmacy_2003) but he did say it would be more case based questions this time

which of the following G-proteins is coupled with D2 receptor?

a. Gs

b. Gi

c. Gq

d. G12/13

b.

which of the following is a typical antipsychotic drug?

a. clozapine

b. trifluperidol

c. risperidone

d. aripiprazole

b.

what is the major mechanism of first generation antipsychotic drugs?

a. incr. cAMP

b. decr. cAMP

c. block 5HT receptors

d. activate 5HT receptors

a.

which of the following is the major beneficial effect of the typical antipsychotic drugs?

a. improve positive symptoms

b. improve cognitive symptoms

c. improve negative symptoms

d. none of these

a.

which of the following is the major mechanism of action of haloperidol?

a. dopamine receptor agonism

b. 5HT receptor agonism

c. D2 receptor antagonist

d. 5HT receptor antagonist

c.

SAR studies showed that addition of fluorine in first generation antipsychotic drug:

a. decr. the potency

b. enhance the potency

c. modulates PK activity

d. reduced the antipsychotic activity

b.

which of the following first generation antipsychotic drug has the longest half life and is good for maintenance therapy?

a. haloperidol

b. thiothixene

c. triflupromazine

d. pimozide

d.

which of the following dopamine pathways is affected by antipsychotic drugs to cause EPS?

a. mesolimbic pathway

b. mesocortical pathway

c. nigrostriatal pathway

d. tuberoinfundibular pathway

c.

which of the following dopamine pathways is affected by antipsychotic drugs to cause hyperprolactinemia?

a. mesolimbic pathway

b. tuberoinfundibular pathway

c. mesocortical pathway

d. nigrostriatal pathway

b.

which of the following dopamine pathways is responsible for gynecomastia and amenorrhea by antipsychotic drugs?

a. tuberoinfundibular pathway

b. mesocortical pathway

c. nigrostriatal pathway

d. mesolimbic pathway

a.

which of the following is the boxed warning for typical antipsychotic drugs?

a. incr. menstrual irregularities/infertility

b. incr. mortality in elderly with dementia

c. incr. metabolic disorder and weight gain

d. incr. hemodynamic effects

b.

which of the following is the mechanism of atypical antipsychotics? (SATA)

a. weak D2 receptor antagonist

b. potent dopamine receptor blocker

c. none of these

d. potent 5HT antagonist

a. d.

which of the following is the beneficial effects of atypical antipsychotics over typical antipsychotics?

a. reduced risk of EPS

b. lower risk of tardive dyskinesia

c. improve the impaired cognition

d. all of these

d.

which of the following drugs is an atypical antipsychotic?

a. risperidone

b. penfluridol

c. haloperidol

d. molindone

a.

which of the following receptor’s activity is the reason for orthostatic hypotension by antipsychotic drugs?

a. beta adrenergic receptor antagonist

b. alpha adrenergic receptor antagonist

c. alpha adrenergic receptor agonist

d. ACh receptor agonism

b.

which of the following antipsychotic drugs leads to agranulocytosis and requires hematological monitoring?

a. haloperidol

b. thioridazine

c. aripiprazole

d. clozapine

d.

which of the following drugs may increase sedative effects of antipsychotic drugs?

a. chlorpheniramine

b. phenytoin

c. atenolol

d. prazosin

a.

in which of the following cases should the antipsychotic drug be stopped immediately and a dopamine agonist provided?

a. NMS

b. agranulocytosis

c. orthostatic hypotension

d. akathisia

a.