Ligand-gated channels

Activates and inactivates quickly.

AMPA

Relies on AMPA to activate first and inactivates slower.

NMDA

Glutamate has 3 selective receptors, name them

AMPA

KA

NMDA

T/F Glutamate mediates epilepsy

T

Most potent AMPA agonist used to destroy neurons

Quisqualate

Glutamate Metabolism

1. Gln-T--→ L-glutamine
2. L-glutamine---→L-glutamate using glutaminase
3. ==L-glutamate ---→ alpha-ketoglutarate using AA==
4. ==alpha-ketoglutarate---→== alpha-ketoglutarate using dicarboxylate carrier
5. alpha-ketoglutarate---→L-glutamate using AA

Turn L-glutamate to GABA using what enzyme

(GAD) glutamate decarboxylase

Turn L-glutamate to L-glutamine using what enzyme

glutamine synthase

Stabilizes AMPA to synapses

GRIP (a protein)

T/F AMPA is the most abundant receptor in the CNS

T

Where do you primarily find KARs

inhibitory neurons

T/F GLuRs are found only in post synaptic neurons.

F

GLuRs are found in post and pre-synaptic neurons

In KA receptors, which channels are not functional by themselves

GluK (4&5)

AMPAR Modulators do what?

enhance affinity & function of AMPARs

responsible for most glutamate reuptake in glial cells

EAAT

transports glutamine into the cell

Gln-T

vGlu-T is dependent on what ions

hydrogen and magnesium

Look at notes on GluR biology to refresh on GluR 2 and GluR 5/6

Blocks AMPA receptors

CNQX