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BIOL 101 Complete Study Guide Unit 1: DNA, RNA, and Genetics 1. DNA structure What is DNA? DNA stands for deoxyribonucleic acid. It stores the genetic information that tells cells how to function, grow, and reproduce. What is the shape of DNA? DNA has a double-helix shape, which looks like a twisted ladder. What are the building blocks of DNA? Nucleotides. What are the three parts of a DNA nucleotide? * A phosphate group * A five-carbon sugar called deoxyribose * A nitrogenous base What are the four nitrogenous bases in DNA? * Adenine (A) * Thymine (T) * Cytosine (C) * Guanine (G) What are the DNA base-pairing rules? * Adenine pairs with Thymine (A–T). * Cytosine pairs with Guanine (C–G). What does complementary base pairing mean? Each DNA base has a specific partner. Knowing one DNA strand allows you to determine the matching strand. Example: * Original: A T C G * Complement: T A G C What holds the two DNA strands together? Hydrogen bonds between the nitrogenous bases. 2. DNA vs. RNA What is RNA? RNA stands for ribonucleic acid. It helps use the genetic instructions stored in DNA to make proteins. What are the main differences between DNA and RNA? DNA RNA Usually double-stranded Usually single-stranded Contains deoxyribose sugar Contains ribose sugar Uses thymine (T) Uses uracil (U) Stores genetic information Helps make proteins What are the four bases in RNA? * Adenine (A) * Uracil (U) * Cytosine (C) * Guanine (G) What replaces thymine in RNA? Uracil. What are the three main types of RNA? * mRNA (messenger RNA): Carries genetic instructions from DNA to the ribosome. * tRNA (transfer RNA): Brings amino acids to the ribosome. * rRNA (ribosomal RNA): Makes up part of the ribosome and helps build proteins. 3. DNA replication What is DNA replication? DNA replication is the process of making an identical copy of DNA before a cell divides. Why is DNA replication important? It ensures that each new cell receives a copy of the genetic information. What does semiconservative replication mean? Each new DNA molecule contains one original strand and one newly made strand. What enzyme unzips DNA? Helicase. What enzyme adds new DNA nucleotides? DNA polymerase. What enzyme connects DNA fragments on the lagging strand? DNA ligase. What is the leading strand? The strand that is copied continuously in the direction of the replication fork. What is the lagging strand? The strand that is copied in short sections called Okazaki fragments. What are Okazaki fragments? Short pieces of newly made DNA that form on the lagging strand. What is the job of DNA ligase? It joins the Okazaki fragments together. What are telomeres? Protective sections of DNA found at the ends of chromosomes. What is the purpose of telomeres? They help protect important genetic information from being lost when DNA is copied. What is DNA repair? The process cells use to identify and correct mistakes or damage in DNA. 4. Transcription What is transcription? Transcription is the process of copying genetic information from DNA into mRNA. Where does transcription happen in eukaryotic cells? In the nucleus. What enzyme helps make RNA during transcription? RNA polymerase. What is the purpose of transcription? To create an mRNA copy of a gene that can be used to make a protein. What are the RNA base-pairing rules? * DNA A pairs with RNA U. * DNA T pairs with RNA A. * DNA C pairs with RNA G. * DNA G pairs with RNA C. Example: DNA: A T C G RNA: U A G C What happens to mRNA before it leaves the nucleus in eukaryotic cells? It undergoes RNA processing. What are introns? Sections of RNA that are removed during RNA processing. What are exons? Sections that remain and are joined together to form mature mRNA. What is RNA splicing? The removal of introns and joining of exons. 5. Translation What is translation? Translation is the process of using mRNA instructions to build a protein. Where does translation happen? At the ribosomes in the cytoplasm or on the rough endoplasmic reticulum. What is a codon? A group of three mRNA bases that codes for an amino acid or a stop signal. What is an anticodon? A group of three bases on tRNA that pairs with a matching mRNA codon. What is the role of tRNA? It carries amino acids to the ribosome. What is the role of the ribosome? It reads mRNA and connects amino acids to build a protein. What is the start codon? AUG. What amino acid does AUG code for? Methionine. What are the three stop codons? * UAA * UAG * UGA What happens when a stop codon is reached? Translation ends, and the completed protein is released. 6. Gene expression and regulation What is gene expression? Gene expression is the process of using information from a gene to make a functional product, such as a protein. What is gene regulation? Gene regulation controls when, where, and how much a gene is expressed. Why is gene regulation important? It allows cells to perform different functions even though many cells contain the same DNA. What is an operon? A group of genes controlled together, commonly found in bacteria. What is the lac operon? A group of bacterial genes involved in breaking down lactose. What happens when lactose is present? Lactose helps remove the repressor’s blockage, allowing the genes to be expressed. What happens when lactose is absent? The repressor binds to the operator and prevents the genes from being expressed. Unit 2: Evolution and Natural Selection 1. Understanding evolution What is evolution? Evolution is the change in inherited characteristics of a population over generations. Does an individual organism evolve during its lifetime? No. Populations evolve over generations. What is a population? A group of individuals of the same species living in the same area. What is a species? A group of organisms that can reproduce with one another and produce fertile offspring, under the biological species concept. What is natural selection? Natural selection is the process in which organisms with inherited traits that improve survival or reproduction tend to leave more offspring. Who is associated with the theory of evolution by natural selection? Charles Darwin. What is adaptation? An inherited characteristic that helps an organism survive or reproduce in its environment. What is biological fitness? An organism’s ability to survive and reproduce, measured by its contribution of offspring to the next generation. Does the strongest organism always have the highest fitness? No. Fitness depends on how well an organism’s inherited traits help it reproduce in its particular environment. 2. Natural selection What are the main requirements for natural selection? * Individuals in a population have variation. * Some variation is inherited. * Organisms produce more offspring than can survive. * Individuals with certain inherited traits reproduce more successfully. What happens to helpful inherited traits over generations? They may become more common in the population. Can natural selection create traits because organisms need them? No. Natural selection acts on existing inherited variation. It does not create a needed trait simply because an organism needs it. What is an example of natural selection? If insects vary in color and birds more easily spot one color, insects with the less visible color may survive and reproduce more often. Over generations, that color may become more common. 3. Population genetics What is an allele? An alternative version of a gene. What is a gene pool? All the alleles present in a population. What is allele frequency? The proportion of a particular allele in a population. What does it mean when allele frequencies change? The population is evolving. What is genetic variation? Differences in genetic information among individuals in a population. Why is genetic variation important? It provides the differences that natural selection can act on. 4. Mechanisms of evolution What are the five major mechanisms that can change allele frequencies? * Mutation * Gene flow * Genetic drift * Natural selection * Nonrandom mating can change genotype frequencies and, in some circumstances, influence allele frequencies indirectly through selection. What is mutation? A change in DNA sequence. How can mutations affect evolution? They can introduce new genetic variations and sometimes create new alleles. What is gene flow? The movement of alleles between populations when individuals or their reproductive cells move between them. What is genetic drift? A random change in allele frequencies, especially noticeable in small populations. What is the bottleneck effect? A type of genetic drift that happens when a population becomes much smaller due to a random event. What is the founder effect? A type of genetic drift that occurs when a small group separates from a larger population and starts a new population. What is the difference between natural selection and genetic drift? Natural selection is based on differences in reproductive success associated with inherited traits. Genetic drift changes allele frequencies randomly. 5. Hardy-Weinberg equilibrium What is Hardy-Weinberg equilibrium? A model that describes a population that is not evolving with respect to the gene being studied. What are the five Hardy-Weinberg conditions? * No mutations * Random mating * No natural selection * Very large population * No gene flow What is the Hardy-Weinberg equation? p+q=1 What does p represent? The frequency of one allele. What does q represent? The frequency of the other allele. What is the genotype frequency equation? p^2+2pq+q^2=1 What does each part represent? * : Homozygous dominant * : Heterozygous * : Homozygous recessive What does homozygous mean? Having two identical alleles for a gene. What does heterozygous mean? Having two different alleles for a gene. Practice question: If q = 0.4, what is p? Answer: p=1-0.4=0.6 Practice question: If p = 0.6 and q = 0.4, what is the frequency of homozygous dominant individuals? Answer: p^2=0.6^2=0.36 Practice question: If p = 0.6 and q = 0.4, what is the frequency of heterozygous individuals? Answer: 2pq=2(0.6)(0.4)=0.48 Practice question: If p = 0.6 and q = 0.4, what is the frequency of homozygous recessive individuals? Answer: q^2=0.4^2=0.16 6. Evidence for evolution What are some forms of evidence for evolution? * Fossil records * Comparative anatomy * Molecular similarities * Embryology * Biogeography What are fossils? Preserved remains or traces of organisms that lived in the past. What is homologous anatomy? Similar body structures inherited from a common ancestor, even if they serve different functions. What is an example of homologous structures? The forelimbs of humans, whales, bats, and cats. What is analogous anatomy? Structures that perform similar functions but evolved independently and do not come from the same ancestral structure. What is an example of analogous structures? The wings of birds and insects. What is biogeography? The study of where organisms live and how their geographic distribution relates to evolution. How can DNA provide evidence for evolution? Organisms with more similar DNA sequences often share a more recent common ancestor. 7. Speciation What is speciation? The formation of new species. What is reproductive isolation? When populations can no longer successfully reproduce with one another. What is geographic isolation? When physical barriers separate populations, such as mountains, rivers, or oceans. What is allopatric speciation? Speciation that occurs when populations are geographically separated. What is sympatric speciation? Speciation that occurs without geographic separation. Unit 3: Classification, Taxonomy, and Phylogeny 1. Classification What is taxonomy? The science of naming and classifying organisms. What is systematics? The study of biological diversity and evolutionary relationships. What is binomial nomenclature? The two-part scientific naming system for organisms. What are the two parts of a scientific name? Genus and species. How should scientific names be written? The genus is capitalized, the species name is lowercase, and both are italicized. Example: Homo sapiens. What are the main taxonomic levels from broadest to most specific? * Domain * Kingdom * Phylum * Class * Order * Family * Genus * Species What are the three domains of life? * Bacteria * Archaea * Eukarya 2. Phylogenetic trees What is a phylogenetic tree? A diagram showing evolutionary relationships among organisms. What does a branch point represent? A common ancestor where evolutionary lineages split. What is a common ancestor? An ancestral organism or population from which two or more groups evolved. What are sister taxa? Two groups that share an immediate common ancestor. What does a node represent on a phylogenetic tree? A branching point representing a common ancestor. Does being next to another organism on a tree always mean they are closely related? No. Relationships are determined by shared branch points, not simply by how close the names appear. What is a clade? An ancestor and all of its descendants. What is a derived trait? A trait that evolved in a particular lineage and can help identify relationships among organisms. Unit 4: Prokaryotes, Eukaryotes, Bacteria, and Archaea 1. Cell types What are prokaryotic cells? Cells that do not have a nucleus or membrane-bound organelles. What are eukaryotic cells? Cells that have a nucleus and membrane-bound organelles. What organisms are prokaryotes? Bacteria and Archaea. What organisms are eukaryotes? Animals, plants, fungi, and protists. What is the main difference between prokaryotic and eukaryotic cells? Eukaryotic cells have a nucleus and membrane-bound organelles. Prokaryotic cells do not. Where is DNA located in a prokaryotic cell? In a region called the nucleoid. What is the function of the cell membrane? It controls what enters and leaves the cell. What is the function of ribosomes? They make proteins. 2. Bacteria and Archaea What are bacteria? Single-celled prokaryotic organisms found in many environments. What are Archaea? Single-celled prokaryotic organisms that are genetically and chemically distinct from bacteria. What is binary fission? A form of asexual reproduction in which one cell divides into two cells. Do bacteria and archaea have a nucleus? No. What is a bacterial cell wall commonly made of? Peptidoglycan. What is peptidoglycan? A material that provides structure and support to bacterial cell walls. 3. Gram-positive and Gram-negative bacteria What are Gram-positive bacteria? Bacteria with a thick peptidoglycan cell wall that usually stain purple during Gram staining. What are Gram-negative bacteria? Bacteria with a thinner peptidoglycan layer and an outer membrane that usually stain pink or red during Gram staining. What is the major difference between Gram-positive and Gram-negative bacteria? Gram-positive bacteria have thick peptidoglycan walls, while Gram-negative bacteria have thin peptidoglycan walls and an outer membrane. 4. Endosymbiotic theory What is the endosymbiotic theory? The theory that mitochondria and chloroplasts originated from free-living bacteria that were taken into ancestral eukaryotic cells. What organelles are explained by endosymbiotic theory? Mitochondria and chloroplasts. What evidence supports endosymbiotic theory? * They contain their own DNA. * They have their own ribosomes. * They divide in a way similar to bacteria. * They have double membranes. What is the function of mitochondria? They produce most of the cell’s ATP through cellular respiration. What is the function of chloroplasts? They carry out photosynthesis in plants and some other organisms. 5. Protists and fungi What are protists? A diverse group of eukaryotic organisms that do not fit into the traditional plant, animal, or fungi kingdoms. Are all protists single-celled? No. Many are single-celled, but some are multicellular. What are fungi? Eukaryotic organisms that absorb nutrients from their surroundings. What is the cell wall of fungi made of? Chitin. What are examples of fungi? * Mushrooms * Molds * Yeasts How do fungi obtain nutrients? They release digestive enzymes into their surroundings and absorb the broken-down nutrients. What is the role of decomposers? They break down dead organisms and recycle nutrients into the environment. Unit 5: Plants 1. Plant characteristics What are the major characteristics of plants? Plants are multicellular eukaryotes that generally have chloroplasts, cellulose cell walls, and carry out photosynthesis. What is photosynthesis? The process of using light energy to convert carbon dioxide and water into sugars and oxygen. What is the function of chlorophyll? It absorbs light energy for photosynthesis. What is the function of roots? They absorb water and minerals and help anchor the plant. What is the function of stems? They support the plant and transport materials. What is the function of leaves? They are the main organs where photosynthesis occurs in most plants. 2. Alternation of generations What is alternation of generations? A plant life cycle that alternates between two multicellular stages: the haploid gametophyte and the diploid sporophyte. What is a gametophyte? The haploid stage that produces gametes. What is a sporophyte? The diploid stage that produces spores through meiosis. What does haploid mean? Having one set of chromosomes, represented by . What does diploid mean? Having two sets of chromosomes, represented by . What is fertilization? The joining of two gametes to form a diploid zygote. What is meiosis? A type of cell division that reduces the chromosome number by half and produces haploid cells. What is the difference between spores and gametes? Spores can develop into a new organism without fusing with another cell. Gametes must fuse during fertilization to form a zygote. 3. Major plant groups What are the major groups of plants? * Nonvascular plants * Seedless vascular plants * Gymnosperms * Angiosperms What are nonvascular plants? Plants that lack specialized vascular tissues for transporting water and nutrients. What are examples of nonvascular plants? Mosses and liverworts. What are vascular plants? Plants that have specialized tissues to transport water, minerals, and sugars. What are the two major vascular tissues? * Xylem * Phloem What is the function of xylem? It transports water and minerals from the roots toward the rest of the plant. What is the function of phloem? It transports sugars and other organic nutrients throughout the plant. What are seedless vascular plants? Vascular plants that reproduce using spores instead of seeds. What is an example of a seedless vascular plant? Ferns. What are gymnosperms? Seed-producing plants with seeds that are not enclosed within fruits. What is an example of a gymnosperm? Pine trees. What are angiosperms? Flowering plants that produce seeds enclosed within fruits. What is the main difference between gymnosperms and angiosperms? Gymnosperms have exposed seeds, while angiosperms produce seeds enclosed in fruits. 4. Plant reproduction What is pollination? The transfer of pollen from the male reproductive structure to the female reproductive structure of a plant. What is pollen? A structure that carries the male gametophyte in seed plants. What is the purpose of flowers? Flowers are reproductive structures of angiosperms. What develops into a fruit? The ovary of a flower. What develops into a seed? The ovule after fertilization. What is the purpose of seeds? They protect and provide resources for the developing plant embryo. Unit 6: Animals 1. Animal characteristics What are the major characteristics of animals? Animals are multicellular eukaryotes that obtain nutrients by consuming other organisms or organic material. They do not have cell walls. Are animals prokaryotic or eukaryotic? Eukaryotic. Are animals unicellular or multicellular? Multicellular. Are animals autotrophs or heterotrophs? Heterotrophs. What is a heterotroph? An organism that obtains energy and nutrients by consuming other organisms or organic material. 2. Animal body plans What is symmetry? The arrangement of body parts around an axis or center. What is asymmetry? A body shape that cannot be divided into matching halves. What is radial symmetry? A body arrangement in which body parts are organized around a central axis. What is an example of an animal with radial symmetry? A jellyfish. What is bilateral symmetry? A body arrangement that can be divided into approximately equal left and right halves. What is an example of an animal with bilateral symmetry? A human. What is cephalization? The concentration of sensory organs and nervous tissue toward the front or head region of an animal. What is a body cavity? A fluid-filled space within an animal’s body that can contain and protect internal organs. 3. Major animal groups What are sponges? Simple aquatic animals that lack true tissues and organs. What is the scientific phylum for sponges? Porifera. How do sponges obtain food? They filter small food particles from water flowing through their bodies. What are cnidarians? Aquatic animals with specialized stinging cells. What is the scientific phylum for cnidarians? Cnidaria. What are examples of cnidarians? * Jellyfish * Corals * Sea anemones What are cnidocytes? Specialized stinging cells used for capturing prey and defense. What are arthropods? Animals with segmented bodies, jointed appendages, and an external skeleton. What is an exoskeleton? A hard external structure that supports and protects an animal’s body. What are examples of arthropods? * Insects * Spiders * Crabs * Lobsters What is molting? The process of shedding an old exoskeleton so an arthropod can grow. What are the major animal groups covered in this section? * Porifera: Sponges * Cnidaria: Jellyfish, corals, and sea anemones * Arthropoda: Insects, spiders, and crustaceans Note: Your lecture material did not provide a complete list of characteristics for every animal phylum, so I have not added unsupported details to those sections. Unit 7: Biotechnology 1. Biotechnology basics What is biotechnology? The use of living organisms, cells, or biological processes to develop useful products and technologies. What is genetic engineering? The process of directly changing an organism’s DNA. What is recombinant DNA? DNA made by combining genetic material from different sources. What is a plasmid? A small circular DNA molecule commonly found in bacteria. Why are plasmids useful in biotechnology? They can be used to carry selected genes into cells. 2. PCR What does PCR stand for? Polymerase chain reaction. What is PCR used for? To make many copies of a specific DNA segment. What are the three main stages of PCR? * Denaturation * Annealing * Extension What happens during denaturation? The DNA strands separate. What happens during annealing? Primers attach to complementary DNA sequences. What happens during extension? DNA polymerase adds nucleotides to build new DNA strands. 3. Gel electrophoresis What is gel electrophoresis? A laboratory technique used to separate DNA fragments based on size. How does gel electrophoresis separate DNA? An electric current moves DNA fragments through a gel. Smaller fragments generally travel farther than larger fragments. Why does DNA move toward the positive end of the gel? DNA has a negatively charged phosphate backbone. What can gel electrophoresis help scientists do? Compare DNA fragments and examine DNA samples. 4. Restriction enzymes and cloning What are restriction enzymes? Enzymes that cut DNA at specific sequences. What is DNA cloning? The process of making copies of a DNA segment or gene. What is a GMO? A genetically modified organism whose genetic material has been altered using genetic engineering or other genetic modification methods. What is a transgenic organism? An organism that contains genetic material introduced from another species. What is CRISPR? A gene-editing technology that allows scientists to make targeted changes to DNA. What is gene therapy? A medical approach that aims to treat or prevent disease by changing genetic material in a person’s cells. What is genomics? The study of an organism’s entire genome. What is proteomics? The study of the proteins produced by a cell, tissue, or organism. Practice Questions: Multiple Choice The answer is immediately underneath each question. Try answering before reading it. 1. What is the basic building block of DNA? A. Amino acid B. Nucleotide C. Protein D. Lipid Answer: B. Nucleotide 2. Which base pairs with adenine in DNA? A. Guanine B. Cytosine C. Thymine D. Uracil Answer: C. Thymine 3. Which enzyme separates DNA strands during replication? A. Ligase B. Helicase C. RNA polymerase D. Ribosome Answer: B. Helicase 4. What is the purpose of DNA replication? A. To create proteins B. To make RNA C. To copy DNA before cell division D. To destroy old DNA Answer: C. To copy DNA before cell division 5. What is the process of making mRNA from DNA called? A. Translation B. Transcription C. Replication D. Mutation Answer: B. Transcription 6. Where does translation occur? A. Nucleus B. Ribosome C. Cell membrane D. Golgi apparatus Answer: B. Ribosome 7. What does tRNA carry? A. DNA B. Glucose C. Amino acids D. Lipids Answer: C. Amino acids 8. What is the start codon? A. UAA B. AUG C. UGA D. UAG Answer: B. AUG 9. What is evolution? A. An individual changing during its lifetime B. A population changing genetically over generations C. An organism growing larger D. A cell dividing Answer: B. A population changing genetically over generations 10. Who is associated with evolution by natural selection? A. Gregor Mendel B. Charles Darwin C. Louis Pasteur D. Robert Hooke Answer: B. Charles Darwin 11. What is genetic drift? A. A random change in allele frequencies B. The movement of water C. The creation of proteins D. The copying of DNA Answer: A. A random change in allele frequencies 12. What is gene flow? A. DNA replication B. Movement of alleles between populations C. Protein synthesis D. Natural death Answer: B. Movement of alleles between populations 13. Which equation represents Hardy-Weinberg allele frequencies? A. B. C. D. Answer: B. 14. What are the three domains of life? A. Plants, animals, fungi B. Bacteria, Archaea, Eukarya C. Mammals, reptiles, birds D. Protists, fungi, plants Answer: B. Bacteria, Archaea, Eukarya 15. Which cells do not have a nucleus? A. Eukaryotic B. Prokaryotic C. Animal D. Plant Answer: B. Prokaryotic 16. What is the function of mitochondria? A. Protein storage B. ATP production C. DNA protection D. Photosynthesis Answer: B. ATP production 17. What is the cell wall of fungi made of? A. Cellulose B. Peptidoglycan C. Chitin D. Starch Answer: C. Chitin 18. What tissue transports water in plants? A. Phloem B. Xylem C. Epidermis D. Pollen Answer: B. Xylem 19. What is the function of phloem? A. Transport sugars B. Absorb sunlight C. Produce pollen D. Protect seeds Answer: A. Transport sugars 20. Which plants produce flowers? A. Mosses B. Ferns C. Gymnosperms D. Angiosperms Answer: D. Angiosperms 21. What is the scientific phylum for sponges? A. Cnidaria B. Porifera C. Arthropoda D. Chordata Answer: B. Porifera 22. What do arthropods have? A. Jointed appendages and an exoskeleton B. No body structure C. Only soft bodies D. Chloroplasts Answer: A. Jointed appendages and an exoskeleton 23. What is PCR used for? A. Separating proteins B. Copying DNA C. Producing ATP D. Growing plants Answer: B. Copying DNA 24. What does gel electrophoresis separate DNA by? A. Color B. Shape only C. Fragment size D. Temperature Answer: C. Fragment size 25. What is CRISPR used for? A. Editing DNA B. Separating cells C. Making ATP D. Producing pollen Answer: A. Editing DNA Fill-in-the-Blank Practice 1. DNA stands for __________. Answer: Deoxyribonucleic acid. 2. RNA uses __________ instead of thymine. Answer: Uracil. 3. The enzyme that unzips DNA is __________. Answer: Helicase. 4. The enzyme that connects Okazaki fragments is __________. Answer: DNA ligase. 5. The process of making RNA from DNA is called __________. Answer: Transcription. 6. The process of making proteins from mRNA is called __________. Answer: Translation. 7. A group of three mRNA bases is called a __________. Answer: Codon. 8. The movement of alleles between populations is called __________. Answer: Gene flow. 9. Random changes in allele frequencies are called __________. Answer: Genetic drift. 10. The formation of new species is called __________. Answer: Speciation. 11. The three domains are Bacteria, Archaea, and __________. Answer: Eukarya. 12. The cell wall of fungi contains __________. Answer: Chitin. 13. The plant tissue that transports water is __________. Answer: Xylem. 14. The plant tissue that transports sugars is __________. Answer: Phloem. 15. Flowering plants are called __________. Answer: Angiosperms. 16. The haploid plant stage is called the __________. Answer: Gametophyte. 17. The diploid plant stage is called the __________. Answer: Sporophyte. 18. Sponges belong to the phylum __________. Answer: Porifera. 19. Jellyfish belong to the phylum __________. Answer: Cnidaria. 20. The process used to make many copies of DNA is called __________. Answer: PCR. Important Terms to Memorize Term Meaning DNA Stores genetic information RNA Helps make proteins Nucleotide Building block of DNA and RNA Helicase Separates DNA strands DNA polymerase Builds new DNA DNA ligase Connects DNA fragments Transcription DNA to RNA Translation RNA to protein Codon Three mRNA bases Mutation Change in DNA Evolution Change in inherited traits in a population over generations Natural selection Differences in reproductive success based on inherited traits Genetic drift Random allele frequency change Gene flow Movement of alleles between populations Speciation Formation of new species Taxonomy Naming and classifying organisms Phylogeny Evolutionary relationships Prokaryote Cell without a nucleus Eukaryote Cell with a nucleus Mitochondria ATP production Chloroplast Photosynthesis Xylem Transports water Phloem Transports sugars Gametophyte Haploid plant generation Sporophyte Diploid plant generation Angiosperm Flowering plant Gymnosperm Plant with exposed seeds PCR Makes copies of DNA Gel electrophoresis Separates DNA fragments by size CRISPR Gene-editing technology Final Cram Sheet: What You Should Know Before Your Exam DNA and genetics * DNA: A–T and C–G * RNA: A–U and C–G * Helicase: unzips DNA * DNA polymerase: builds DNA * Ligase: joins DNA fragments * Transcription: DNA → RNA * Translation: RNA → protein * AUG: start codon * UAA, UAG, UGA: stop codons Evolution * Darwin: natural selection * Mutation: changes DNA * Genetic drift: random change * Gene flow: movement between populations * Bottleneck: population becomes much smaller * Founder effect: small group starts a population * Speciation: new species form * Hardy-Weinberg: , Classification and cells * Three domains: Bacteria, Archaea, Eukarya * Prokaryotes: no nucleus * Eukaryotes: have a nucleus * Mitochondria: ATP * Chloroplasts: photosynthesis * Fungi: chitin cell walls * Bacteria: peptidoglycan cell walls Plants * Xylem: water * Phloem: sugar * Gametophyte: haploid * Sporophyte: diploid * Gymnosperms: exposed seeds * Angiosperms: flowers and enclosed seeds * Mosses: nonvascular * Ferns: seedless vascular Animals and biotechnology * Porifera: sponges * Cnidaria: jellyfish, corals, sea anemones * Arthropoda: jointed appendages and exoskeleton * PCR: copies DNA * Gel electrophoresis: separates DNA by size * Restriction enzymes: cut DNA * CRISPR: edits DNA Study tip: Cover the answers with a piece of paper and try to answer every question from memory. Then uncover the answer and check yourself. Focus especially on DNA replication, transcription versus translation, Hardy-Weinberg equations, evolution mechanisms, plant life cycles, and the differences between prokaryotic and eukaryotic cells.
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Like my friend Kylie read this to me "**Civil Disobedience** By Henry David Thoreau 1849 I heartily accept the motto, "That government is best which governs least"; and I should like to see it acted up to more rapidly and systematically. Carried out, it finally amounts to this, which also I believe- "That government is best which governs not at all"; and when men are prepared for it, that will be the kind of government which they will have. Government is at best but an expedient; but most governments are usually, and all governments are sometimes, inexpedient. The objections which have been brought against a standing army, and they are many and weighty, and deserve to prevail, may also at last be brought against a standing government. The standing army is only an arm of the standing government. The government itself, which is only the mode which the people have chosen to execute their will, is equally liable to be abused and perverted before the people can act through it. Witness the present Mexican war, the work of comparatively a few individuals using the standing government as their tool; for, in the outset, the people would not have consented to this measure. This American government- what is it but a tradition, though a recent one, endeavoring to transmit itself unimpaired to posterity, but each instant losing some of its integrity? It has not the vitality and force of a single living man; for a single man can bend it to his will. It is a sort of wooden gun to the people themselves. But it is not the less necessary for this; for the people must have some complicated machinery or other, and hear its din, to satisfy that idea of government which they have. Governments show thus how successfully men can be imposed on, even impose on themselves, for their own advantage. It is excellent, we must all allow. Yet this government never of itself furthered any enterprise, but by the alacrity with which it got out of its way. It does not keep the country free. It does not settle the West. It does not educate. The character inherent in the American people has done all that has been accomplished; and it would have done somewhat more, if the government had not sometimes got in its way. For government is an expedient by which men would fain succeed in letting one another alone; and, as has been said, when it is most expedient, the governed are most let alone by it. Trade and commerce, if they were not made of india-rubber, would never manage to bounce over the obstacles which legislators are continually putting in their way; and, if one were to judge these men wholly by the effects of their actions and not partly by their intentions, they would deserve to be classed and punished with those mischievous persons who put obstructions on the railroads. But, to speak practically and as a citizen, unlike those who call themselves no- government men, I ask for, not at once no government, but at once a better government. Let every man make known what kind of government would command his respect, and that will be one step toward obtaining it. After all, the practical reason why, when the power is once in the hands of the people, a majority are permitted, and for a long period continue, to rule is not because they are most likely to be in the right, nor because this seems fairest to the minority, but because they are physically the strongest. But a government in which the majority rule in all cases cannot be based on justice, even as far as men understand it. Can there not be a government in which majorities do not virtually decide right and wrong, but conscience?- in which majorities decide only those questions to which the rule of expediency is applicable? Must the citizen ever for a moment, or in the least degree, resign his conscience to the legislation? Why has every man a conscience, then? I think that we should be men first, and subjects afterward. It is not desirable to cultivate a respect for the law, so much as for the right. The only obligation which I have a right to assume is to do at any time what I think right. It is truly enough said that a corporation has no conscience; but a corporation of conscientious men is a corporation with a conscience. Law never made men a whit more just; and, by means of their respect for it, even the well-disposed are daily made the agents of injustice. A common and natural result of an undue respect for law is, that you may see a file of soldiers, colonel, captain, corporal, privates, powder- monkeys, and all, marching in admirable order over hill and dale to the wars, against their wills, ay, against their common sense and consciences, which makes it very steep marching indeed, and produces a palpitation of the heart. They have no doubt that it is a damnable business in which they are concerned; they are all peaceably inclined. Now, what are they? Men at all? or small movable forts and magazines, at the service of some unscrupulous man in power? Visit the Navy-Yard, and behold a marine, such a man as an American government can make, or such as it can make a man with its black arts- a mere shadow and reminiscence of humanity, a man laid out alive and standing, and already, as one may say, buried under arms with funeral accompaniments, though it may be, "Not a drum was heard, not a funeral note, As his corse to the rampart we hurried; Not a soldier discharged his farewell shot O'er the grave where our hero we buried." The mass of men serve the state thus, not as men mainly, but as machines, with their bodies. They are the standing army, and the militia, jailers, constables, posse comitatus, etc. In most cases there is no free exercise whatever of the judgment or of the moral sense; but they put themselves on a level with wood and earth and stones; and wooden men can perhaps be manufactured that will serve the purpose as well. Such command no more respect than men of straw or a lump of dirt. They have the same sort of worth only as horses and dogs. Yet such as these even are commonly esteemed good citizens. Others- as most legislators, politicians, lawyers, ministers, and office-holders- serve the state chiefly with their heads; and, as they rarely make any moral distinctions, they are as likely to serve the devil, without intending it, as God. A very few- as heroes, patriots, martyrs, reformers in the great sense, and men- serve the state with their consciences also, and so necessarily resist it for the most part; and they are commonly treated as enemies by it. A wise man will only be useful as a man, and will not submit to be "clay," and "stop a hole to keep the wind away," but leave that office to his dust at least: "I am too high-born to be propertied, To be a secondary at control, Or useful serving-man and instrument To any sovereign state throughout the world." He who gives himself entirely to his fellow-men appears to them useless and selfish; but he who gives himself partially to them is pronounced a benefactor and philanthropist. How does it become a man to behave toward this American government today? I answer, that he cannot without disgrace be associated with it. I cannot for an instant recognize that political organization as my government which is the slave's government also. All men recognize the right of revolution; that is, the right to refuse allegiance to, and to resist, the government, when its tyranny or its inefficiency are great and unendurable. But almost all say that such is not the case now. But such was the case, they think, in the Revolution Of '75. If one were to tell me that this was a bad government because it taxed certain foreign commodities brought to its ports, it is most probable that I should not make an ado about it, for I can do without them. All machines have their friction; and possibly this does enough good to counterbalance the evil. At any rate, it is a great evil to make a stir about it. But when the friction comes to have its machine, and oppression and robbery are organized, I say, let us not have such a machine any longer. In other words, when a sixth of the population of a nation which has undertaken to be the refuge of liberty are slaves, and a whole country is unjustly overrun and conquered by a foreign army, and subjected to military law, I think that it is not too soon for honest men to rebel and revolutionize. What makes this duty the more urgent is the fact that the country so overrun is not our own, but ours is the invading army. Paley, a common authority with many on moral questions, in his chapter on the "Duty of Submission to Civil Government," resolves all civil obligation into expediency; and he proceeds to say that "so long as the interest of the whole society requires it, that is, so long as the established government cannot be resisted or changed without public inconveniency, it is the will of God... that the established government be obeyed- and no longer. This principle being admitted, the justice of every particular case of resistance is reduced to a computation of the quantity of the danger and grievance on the one side, and of the probability and expense of redressing it on the other." Of this, he says, every man shall judge for himself. But Paley appears never to have contemplated those cases to which the rule of expediency does not apply, in which a people, as well as an individual, must do justice, cost what it may. If I have unjustly wrested a plank from a drowning man, I must restore it to him though I drown myself. This, according to Paley, would be inconvenient. But he that would save his life, in such a case, shall lose it. This people must cease to hold slaves, and to make war on Mexico, though it cost them their existence as a people. In their practice, nations agree with Paley; but does any one think that Massachusetts does exactly what is right at the present crisis? "A drab of state, a cloth-o'-silver slut, To have her train borne up, and her soul trail in the dirt." Practically speaking, the opponents to a reform in Massachusetts are not a hundred thousand politicians at the South, but a hundred thousand merchants and farmers here, who are more interested in commerce and agriculture than they are in humanity, and are not prepared to do justice to the slave and to Mexico, cost what it may. I quarrel not with far-off foes, but with those who, near at home, cooperate with, and do the bidding of those far away, and without whom the latter would be harmless. We are accustomed to say, that the mass of men are unprepared; but improvement is slow, because the few are not materially wiser or better than the many. It is not so important that many should be as good as you, as that there be some absolute goodness somewhere; for that will leaven the whole lump. There are thousands who are in opinion opposed to slavery and to the war, who yet in effect do nothing to put an end to them; who, esteeming themselves children of Washington and Franklin, sit down with their hands in their pockets, and say that they know not what to do, and do nothing; who even postpone the question of freedom to the question of free trade, and quietly read the prices-current along with the latest advices from Mexico, after dinner, and, it may be, fall asleep over them both. What is the price-current of an honest man and patriot today? They hesitate, and they regret, and sometimes they petition; but they do nothing in earnest and with effect. They will wait, well disposed, for others to remedy the evil, that they may no longer have it to regret. At most, they give only a cheap vote, and a feeble countenance and God-speed, to the right, as it goes by them. There are nine hundred and ninety-nine patrons of virtue to one virtuous man. But it is easier to deal with the real possessor of a thing than with the temporary guardian of it. All voting is a sort of gaming, like checkers or backgammon, with a slight moral tinge to it, a playing with right and wrong, with moral questions; and betting naturally accompanies it. The character of the voters is not staked. I cast my vote, perchance, as I think right; but I am not vitally concerned that that right should prevail. I am willing to leave it to the majority. Its obligation, therefore, never exceeds that of expediency. Even voting for the right is doing nothing for it. It is only expressing to men feebly your desire that it should prevail. A wise man will not leave the right to the mercy of chance, nor wish it to prevail through the power of the majority. There is but little virtue in the action of masses of men. When the majority shall at length vote for the abolition of slavery, it will be because they are indifferent to slavery, or because there is but little slavery left to be abolished by their vote. They will then be the only slaves. Only his vote can hasten the abolition of slavery who asserts his own freedom by his vote. I hear of a convention to be held at Baltimore, or elsewhere, for the selection of a candidate for the Presidency, made up chiefly of editors, and men who are politicians by profession; but I think, what is it to any independent, intelligent, and respectable man what decision they may come to? Shall we not have the advantage of his wisdom and honesty, nevertheless? Can we not count upon some independent votes? Are there not many individuals in the country who do not attend conventions? But no: I find that the respectable man, so called, has immediately drifted from his position, and despairs of his country, when his country has more reason to despair of him. He forthwith adopts one of the candidates thus selected as the only available one, thus proving that he is himself available for any purposes of the demagogue. His vote is of no more worth than that of any unprincipled foreigner or hireling native, who may have been bought. O for a man who is a man, and, as my neighbor says, has a bone in his back which you cannot pass your hand through! Our statistics are at fault: the population has been returned too large. How many men are there to a square thousand miles in this country? Hardly one. Does not America offer any inducement for men to settle here? The American has dwindled into an Odd Fellow-one who may be known by the development of his organ of gregariousness, and a manifest lack of intellect and cheerful self-reliance; whose first and chief concern, on coming into the world, is to see that the almshouses are in good repair; and, before yet he has lawfully donned the virile garb, to collect a fund for the support of the widows and orphans that may be; who, in short, ventures to live only by the aid of the Mutual Insurance company, which has promised to bury him decently. It is not a man's duty, as a matter of course, to devote himself to the eradication of any, even the most enormous, wrong; he may still properly have other concerns to engage him; but it is his duty, at least, to wash his hands of it, and, if he gives it no thought longer, not to give it practically his support. If I devote myself to other pursuits and contemplations, I must first see, at least, that I do not pursue them sitting upon another man's shoulders. I must get off him first, that he may pursue his contemplations too. See what gross inconsistency is tolerated. I have heard some of my townsmen say, "I should like to have them order me out to help put down an insurrection of the slaves, or to march to Mexico;- see if I would go"; and yet these very men have each, directly by their allegiance, and so indirectly, at least, by their money, furnished a substitute. The soldier is applauded who refuses to serve in an unjust war by those who do not refuse to sustain the unjust government which makes the war; is applauded by those whose own act and authority he disregards and sets at naught; as if the state were penitent to that degree that it differed one to scourge it while it sinned, but not to that degree that it left off sinning for a moment. Thus, under the name of Order and Civil Government, we are all made at last to pay homage to and support our own meanness. After the first blush of sin comes its indifference; and from immoral it becomes, as it were, unmoral, and not quite unnecessary to that life which we have made. The broadest and most prevalent error requires the most disinterested virtue to sustain it. The slight reproach to which the virtue of patriotism is commonly liable, the noble are most likely to incur. Those who, while they disapprove of the character and measures of a government, yield to it their allegiance and support are undoubtedly its most conscientious supporters, and so frequently the most serious obstacles to reform. Some are petitioning the State to dissolve the Union, to disregard the requisitions of the President. Why do they not dissolve it themselves- the union between themselves and the State- and refuse to pay their quota into its treasury? Do not they stand in the same relation to the State that the State does to the Union? And have not the same reasons prevented the State from resisting the Union which have prevented them from resisting the State? How can a man be satisfied to entertain an opinion merely, and enjoy it? Is there any enjoyment in it, if his opinion is that he is aggrieved? If you are cheated out of a single dollar by your neighbor, you do not rest satisfied with knowing that you are cheated, or with saying that you are cheated, or even with petitioning him to pay you your due; but you take effectual steps at once to obtain the full amount, and see that you are never cheated again. Action from principle, the perception and the performance of right, changes things and relations; it is essentially revolutionary, and does not consist wholly with anything which was. It not only divides States and churches, it divides families; ay, it divides the individual, separating the diabolical in him from the divine. Unjust laws exist: shall we be content to obey them, or shall we endeavor to amend them, and obey them until we have succeeded, or shall we transgress them at once? Men generally, under such a government as this, think that they ought to wait until they have persuaded the majority to alter them. They think that, if they should resist, the remedy would be worse than the evil. But it is the fault of the government itself that the remedy is worse than the evil. It makes it worse. Why is it not more apt to anticipate and provide for reform? Why does it not cherish its wise minority? Why does it cry and resist before it is hurt? Why does it not encourage its citizens to be on the alert to point out its faults, and do better than it would have them? Why does it always crucify Christ, and excommunicate Copernicus and Luther, and pronounce Washington and Franklin rebels? One would think, that a deliberate and practical denial of its authority was the only offence never contemplated by government; else, why has it not assigned its definite, its suitable and proportionate, penalty? If a man who has no property refuses but once to earn nine shillings for the State, he is put in prison for a period unlimited by any law that I know, and determined only by the discretion of those who placed him there; but if he should steal ninety times nine shillings from the State, he is soon permitted to go at large again. If the injustice is part of the necessary friction of the machine of government, let it go, let it go: perchance it will wear smooth- certainly the machine will wear out. If the injustice has a spring, or a pulley, or a rope, or a crank, exclusively for itself, then perhaps you may consider whether the remedy will not be worse than the evil; but if it is of such a nature that it requires you to be the agent of injustice to another, then, I say, break the law. Let your life be a counter-friction to stop the machine. What I have to do is to see, at any rate, that I do not lend myself to the wrong which I condemn. As for adopting the ways which the State has provided for remedying the evil, I know not of such ways. They take too much time, and a man's life will be gone. I have other affairs to attend to. I came into this world, not chiefly to make this a good place to live in, but to live in it, be it good or bad. A man has not everything to do, but something; and because he cannot do everything, it is not necessary that he should do something wrong. It is not my business to be petitioning the Governor or the Legislature any more than it is theirs to petition me; and if they should not bear my petition, what should I do then? But in this case the State has provided no way: its very Constitution is the evil. This may seem to be harsh and stubborn and unconciliatory; but it is to treat with the utmost kindness and consideration the only spirit that can appreciate or deserves it. So is an change for the better, like birth and death, which convulse the body. I do not hesitate to say, that those who call themselves Abolitionists should at once effectually withdraw their support, both in person and property, from the government of Massachusetts, and not wait till they constitute a majority of one, before they suffer the right to prevail through them. I think that it is enough if they have God on their side, without waiting for that other one. Moreover, any man more right than his neighbors constitutes a majority of one already. I meet this American government, or its representative, the State government, directly, and face to face, once a year- no more- in the person of its tax- gatherer; this is the only mode in which a man situated as I am necessarily meets it; and it then says distinctly, Recognize me; and the simplest, the most effectual, and, in the present posture of affairs, the indispensablest mode of treating with it on this head, of expressing your little satisfaction with and love for it, is to deny it then. My civil neighbor, the tax-gatherer, is the very man I have to deal with- for it is, after all, with men and not with parchment that I quarrel- and he has voluntarily chosen to be an agent of the government. How shall he ever know well what he is and does as an officer of the government, or as a man, until he is obliged to consider whether he shall treat me, his neighbor, for whom he has respect, as a neighbor and well-disposed man, or as a maniac and disturber of the peace, and see if he can get over this obstruction to his neighborliness without a ruder and more impetuous thought or speech corresponding with his action. I know this well, that if one thousand, if one hundred, if ten men whom I could name- if ten honest men only- ay, if one HONEST man, in this State of Massachusetts, ceasing to hold slaves, were actually to withdraw from this copartnership, and be locked up in the county jail therefor, it would be the abolition of slavery in America. For it matters not how small the beginning may seem to be: what is once well done is done forever. But we love better to talk about it: that we say is our mission, Reform keeps many scores of newspapers in its service, but not one man. If my esteemed neighbor, the State's ambassador, who will devote his days to the settlement of the question of human rights in the Council Chamber, instead of being threatened with the prisons of Carolina, were to sit down the prisoner of Massachusetts, that State which is so anxious to foist the sin of slavery upon her sister- though at present she can discover only an act of inhospitality to be the ground of a quarrel with her- the Legislature would not wholly waive the subject the following winter. Under a government which imprisons any unjustly, the true place for a just man is also a prison. The proper place today, the only place which Massachusetts has provided for her freer and less desponding spirits, is in her prisons, to be put out and locked out of the State by her own act, as they have already put themselves out by their principles. It is there that the fugitive slave, and the Mexican prisoner on parole, and the Indian come to plead the wrongs of his race should find them; on that separate, but more free and honorable, ground, where the State places those who are not with her, but against her- the only house in a slave State in which a free man can abide with honor. If any think that their influence would be lost there, and their voices no longer afflict the ear of the State, that they would not be as an enemy within its walls, they do not know by how much truth is stronger than error, nor how much more eloquently and effectively he can combat injustice who has experienced a little in his own person. Cast your whole vote, not a strip of paper merely, but your whole influence. A minority is powerless while it conforms to the majority; it is not even a minority then; but it is irresistible when it clogs by its whole weight. If the alternative is to keep all just men in prison, or give up war and slavery, the State will not hesitate which to choose. If a thousand men were not to pay their tax-bills this year, that would not be a violent and bloody measure, as it would be to pay them, and enable the State to commit violence and shed innocent blood. This is, in fact, the definition of a peaceable revolution, if any such is possible. If the tax-gatherer, or any other public officer, asks me, as one has done, "But what shall I do?" my answer is, "If you really wish to do anything, resign your office." When the subject has refused allegiance, and the officer has resigned his office, then the revolution is accomplished. But even suppose blood should flow. Is there not a sort of blood shed when the conscience is wounded? Through this wound a man's real manhood and immortality flow out, and he bleeds to an everlasting death. I see this blood flowing now. I have contemplated the imprisonment of the offender, rather than the seizure of his goods- though both will serve the same purpose- because they who assert the purest right, and consequently are most dangerous to a corrupt State, commonly have not spent much time in accumulating property. To such the State renders comparatively small service, and a slight tax is wont to appear exorbitant, particularly if they are obliged to earn it by special labor with their hands. If there were one who lived wholly without the use of money, the State itself would hesitate to demand it of him. But the rich man- not to make any invidious comparison- is always sold to the institution which makes him rich. Absolutely speaking, the more money, the less virtue; for money comes between a man and his objects, and obtains them for him; and it was certainly no great virtue to obtain it. It puts to rest many questions which he would otherwise be taxed to answer; while the only new question which it puts is the hard but superfluous one, how to spend it. Thus his moral ground is taken from under his feet. The opportunities of living are diminished in proportion as what are called the "means" are increased. The best thing a man can do for his culture when he is rich is to endeavor to carry out those schemes which he entertained when he was poor. Christ answered the Herodians according to their condition. "Show me the tribute-money," said he;- and one took a penny out of his pocket;- if you use money which has the image of Caesar on it, and which he has made current and valuable, that is, if you are men of the State, and gladly enjoy the advantages of Caesar's government, then pay him back some of his own when he demands it. "Render therefore to Caesar that which is Caesar's, and to God those things which are God's"- leaving them no wiser than before as to which was which; for they did not wish to know. When I converse with the freest of my neighbors, I perceive that, whatever they may say about the magnitude and seriousness of the question, and their regard for the public tranquillity, the long and the short of the matter is, that they cannot spare the protection of the existing government, and they dread the consequences to their property and families of disobedience to it. For my own part, I should not like to think that I ever rely on the protection of the State. But, if I deny the authority of the State when it presents its tax-bill, it will soon take and waste all my property, and so harass me and my children without end. This is hard. This makes it impossible for a man to live honestly, and at the same time comfortably, in outward respects. It will not be worth the while to accumulate property; that would be sure to go again. You must hire or squat somewhere, and raise but a small crop, and eat that soon. You must live within yourself, and depend upon yourself always tucked up and ready for a start, and not have many affairs. A man may grow rich in Turkey even, if he will be in all respects a good subject of the Turkish government. Confucius said: "If a state is governed by the principles of reason, poverty and misery are subjects of shame; if a state is not governed by the principles of reason, riches and honors are the subjects of shame." No: until I want the protection of Massachusetts to be extended to me in some distant Southern port, where my liberty is endangered, or until I am bent solely on building up an estate at home by peaceful enterprise, I can afford to refuse allegiance to Massachusetts, and her right to my property and life. It costs me less in every sense to incur the penalty of disobedience to the State than it would to obey. I should feel as if I were worth less in that case. Some years ago, the State met me in behalf of the Church, and commanded me to pay a certain sum toward the support of a clergyman whose preaching my father attended, but never I myself. "Pay," it said, "or be locked up in the jail." I declined to pay. But, unfortunately, another man saw fit to pay it. I did not see why the schoolmaster should be taxed to support the priest, and not the priest the schoolmaster; for I was not the State's schoolmaster, but I supported myself by voluntary subscription. I did not see why the lyceum should not present its tax-bill, and have the State to back its demand, as well as the Church. However, at the request of the selectmen, I condescended to make some such statement as this in writing:- "Know all men by these presents, that I, Henry Thoreau, do not wish to be regarded as a member of any incorporated society which I have not joined." This I gave to the town clerk; and he has it. The State, having thus learned that I did not wish to be regarded as a member of that church, has never made a like demand on me since; though it said that it must adhere to its original presumption that time. If I had known how to name them, I should then have signed off in detail from all the societies which I never signed on to; but I did not know where to find a complete list. I have paid no poll-tax for six years. I was put into a jail once on this account, for one night; and, as I stood considering the walls of solid stone, two or three feet thick, the door of wood and iron, a foot thick, and the iron grating which strained the light, I could not help being struck with the foolishness of that institution which treated me as if I were mere flesh and blood and bones, to be locked up. I wondered that it should have concluded at length that this was the best use it could put me to, and had never thought to avail itself of my services in some way. I saw that, if there was a wall of stone between me and my townsmen, there was a still more difficult one to climb or break through before they could get to be as free as I was. I did not for a moment feel confined, and the walls seemed a great waste of stone and mortar. I felt as if I alone of all my townsmen had paid my tax. They plainly did not know how to treat me, but behaved like persons who are underbred. In every threat and in every compliment there was a blunder; for they thought that my chief desire was to stand the other side of that stone wall. I could not but smile to see how industriously they locked the door on my meditations, which followed them out again without let or hindrance, and they were really all that was dangerous. As they could not reach me, they had resolved to punish my body; just as boys, if they cannot come at some person against whom they have a spite, will abuse his dog. I saw that the State was half-witted, that it was timid as a lone woman with her silver spoons, and that it did not know its friends from its foes, and I lost all my remaining respect for it, and pitied it. Thus the State never intentionally confronts a man's sense, intellectual or moral, but only his body, his senses. It is not armed with superior wit or honesty, but with superior physical strength. I was not born to be forced. I will breathe after my own fashion. Let us see who is the strongest. What force has a multitude? They only can force me who obey a higher law than I. They force me to become like themselves. I do not hear of men being forced to have this way or that by masses of men. What sort of life were that to live? When I meet a government which says to me, "Your money or your life," why should I be in haste to give it my money? It may be in a great strait, and not know what to do: I cannot help that. It must help itself; do as I do. It is not worth the while to snivel about it. I am not responsible for the successful working of the machinery of society. I am not the son of the engineer. I perceive that, when an acorn and a chestnut fall side by side, the one does not remain inert to make way for the other, but both obey their own laws, and spring and grow and flourish as best they can, till one, perchance, overshadows and destroys the other. If a plant cannot live according to its nature, it dies; and so a man. The night in prison was novel and interesting enough. The prisoners in their shirt-sleeves were enjoying a chat and the evening air in the doorway, when I entered. But the jailer said, "Come, boys, it is time to lock up"; and so they dispersed, and I heard the sound of their steps returning into the hollow apartments. My room-mate was introduced to me by the jailer as "a first-rate fellow and a clever man." When the door was locked, he showed me where to hang my hat, and how he managed matters there. The rooms were whitewashed once a month; and this one, at least, was the whitest, most simply furnished, and probably the neatest apartment in the town. He naturally wanted to know where I came from, and what brought me there; and, when I had told him, I asked him in my turn how he came there, presuming him to be an honest man, of course; and, as the world goes, I believe he was. "Why," said he, "they accuse me of burning a barn; but I never did it." As near as I could discover, he had probably gone to bed in a barn when drunk, and smoked his pipe there; and so a barn was burnt. He had the reputation of being a clever man, had been there some three months waiting for his trial to come on, and would have to wait as much longer; but he was quite domesticated and contented, since he got his board for nothing, and thought that he was well treated. He occupied one window, and I the other; and I saw that if one stayed there long, his principal business would be to look out the window. I had soon read all the tracts that were left there, and examined where former prisoners had broken out, and where a grate had been sawed off, and heard the history of the various occupants of that room; for I found that even here there was a history and a gossip which never circulated beyond the walls of the jail. Probably this is the only house in the town where verses are composed, which are afterward printed in a circular form, but not published. I was shown quite a long list of verses which were composed by some young men who had been detected in an attempt to escape, who avenged themselves by singing them. I pumped my fellow-prisoner as dry as I could, for fear I should never see him again; but at length he showed me which was my bed, and left me to blow out the lamp. It was like travelling into a far country, such as I had never expected to behold, to lie there for one night. It seemed to me that I never had heard the town clock strike before, nor the evening sounds of the village; for we slept with the windows open, which were inside the grating. It was to see my native village in the light of the Middle Ages, and our Concord was turned into a Rhine stream, and visions of knights and castles passed before me. They were the voices of old burghers that I heard in the streets. I was an involuntary spectator and auditor of whatever was done and said in the kitchen of the adjacent village inn- a wholly new and rare experience to me. It was a closer view of my native town. I was fairly inside of it. I never had seen its institutions before. This is one of its peculiar institutions; for it is a shire town. I began to comprehend what its inhabitants were about. In the morning, our breakfasts were put through the hole in the door, in small oblong-square tin pans, made to fit, and holding a pint of chocolate, with brown bread, and an iron spoon. When they called for the vessels again, I was green enough to return what bread I had left; but my comrade seized it, and said that I should lay that up for lunch or dinner. Soon after he was let out to work at haying in a neighboring field, whither he went every day, and would not be back till noon; so he bade me good-day, saying that he doubted if he should see me again. When I came out of prison- for some one interfered, and paid that tax- I did not perceive that great changes had taken place on the common, such as he observed who went in a youth and emerged a tottering and gray-headed man; and yet a change had to my eyes come over the scene- the town, and State, and country- greater than any that mere time could effect. I saw yet more distinctly the State in which I lived. I saw to what extent the people among whom I lived could be trusted as good neighbors and friends; that their friendship was for summer weather only; that they did not greatly propose to do right; that they were a distinct race from me by their prejudices and superstitions, as the Chinamen and Malays are; that in their sacrifices to humanity they ran no risks, not even to their property; that after all they were not so noble but they treated the thief as he had treated them, and hoped, by a certain outward observance and a few prayers, and by walking in a particular straight though useless path from time to time, to save their souls. This may be to judge my neighbors harshly; for I believe that many of them are not aware that they have such an institution as the jail in their village. It was formerly the custom in our village, when a poor debtor came out of jail, for his acquaintances to salute him, looking through their fingers, which were crossed to represent the grating of a jail window, "How do ye do?" My neighbors did not thus salute me, but first looked at me, and then at one another, as if I had returned from a long journey. I was put into jail as I was going to the shoemaker's to get a shoe which was mended. When I was let out the next morning, I proceeded to finish my errand, and, having put on my mended shoe, joined a huckleberry party, who were impatient to put themselves under my conduct; and in half an hour- for the horse was soon tackled- was in the midst of a huckleberry field, on one of our highest hills, two miles off, and then the State was nowhere to be seen. This is the whole history of "My Prisons." I have never declined paying the highway tax, because I am as desirous of being a good neighbor as I am of being a bad subject; and as for supporting schools, I am doing my part to educate my fellow-countrymen now. It is for no particular item in the tax-bill that I refuse to pay it. I simply wish to refuse allegiance to the State, to withdraw and stand aloof from it effectually. I do not care to trace the course of my dollar, if I could, till it buys a man or a musket to shoot one with- the dollar is innocent- but I am concerned to trace the effects of my allegiance. In fact, I quietly declare war with the State, after my fashion, though I will still make what use and get what advantage of her I can, as is usual in such cases. If others pay the tax which is demanded of me, from a sympathy with the State, they do but what they have already done in their own case, or rather they abet injustice to a greater extent than the State requires. If they pay the tax from a mistaken interest in the individual taxed, to save his property, or prevent his going to jail, it is because they have not considered wisely how far they let their private feelings interfere with the public good. This, then, is my position at present. But one cannot be too much on his guard in such a case, lest his action be biased by obstinacy or an undue regard for the opinions of men. Let him see that he does only what belongs to himself and to the hour. I think sometimes, Why, this people mean well, they are only ignorant; they would do better if they knew how: why give your neighbors this pain to treat you as they are not inclined to? But I think again, This is no reason why I should do as they do, or permit others to suffer much greater pain of a different kind. Again, I sometimes say to myself, When many millions of men, without heat, without ill will, without personal feeling of any kind, demand of you a few shillings only, without the possibility, such is their constitution, of retracting or altering their present demand, and without the possibility, on your side, of appeal to any other millions, why expose yourself to this overwhelming brute force? You do not resist cold and hunger, the winds and the waves, thus obstinately; you quietly submit to a thousand similar necessities. You do not put your head into the fire. But just in proportion as I regard this as not wholly a brute force, but partly a human force, and consider that I have relations to those millions as to so many millions of men, and not of mere brute or inanimate things, I see that appeal is possible, first and instantaneously, from them to the Maker of them, and, secondly, from them to themselves. But if I put my head deliberately into the fire, there is no appeal to fire or to the Maker of fire, and I have only myself to blame. If I could convince myself that I have any right to be satisfied with men as they are, and to treat them accordingly, and not according, in some respects, to my requisitions and expectations of what they and I ought to be, then, like a good Mussulman and fatalist, I should endeavor to be satisfied with things as they are, and say it is the will of God. And, above all, there is this difference between resisting this and a purely brute or natural force, that I can resist this with some effect; but I cannot expect, like Orpheus, to change the nature of the rocks and trees and beasts. I do not wish to quarrel with any man or nation. I do not wish to split hairs, to make fine distinctions, or set myself up as better than my neighbors. I seek rather, I may say, even an excuse for conforming to the laws of the land. I am but too ready to conform to them. Indeed, I have reason to suspect myself on this head; and each year, as the tax-gatherer comes round, I find myself disposed to review the acts and position of the general and State governments, and the spirit of the people, to discover a pretext for conformity. "We must affect our country as our parents, And if at any time we alienate Our love or industry from doing it honor, We must respect effects and teach the soul Matter of conscience and religion, And not desire of rule or benefit." I believe that the State will soon be able to take all my work of this sort out of my hands, and then I shall be no better a patriot than my fellow-countrymen. Seen from a lower point of view, the Constitution, with all its faults, is very good; the law and the courts are very respectable; even this State and this American government are, in many respects, very admirable, and rare things, to be thankful for, such as a great many have described them; but seen from a point of view a little higher, they are what I have described them; seen from a higher still, and the highest, who shall say what they are, or that they are worth looking at or thinking of at all? However, the government does not concern me much, and I shall bestow the fewest possible thoughts on it. It is not many moments that I live under a government, even in this world. If a man is thought-free, fancy-free, imagination-free, that which is not never for a long time appearing to be to him, unwise rulers or reformers cannot fatally interrupt him. I know that most men think differently from myself; but those whose lives are by profession devoted to the study of these or kindred subjects content me as little as any. Statesmen and legislators, standing so completely within the institution, never distinctly and nakedly behold it. They speak of moving society, but have no resting-place without it. They may be men of a certain experience and discrimination, and have no doubt invented ingenious and even useful systems, for which we sincerely thank them; but all their wit and usefulness lie within certain not very wide limits. They are wont to forget that the world is not governed by policy and expediency. Webster never goes behind government, and so cannot speak with authority about it. His words are wisdom to those legislators who contemplate no essential reform in the existing government; but for thinkers, and those who legislate for all time, he never once glances at the subject. I know of those whose serene and wise speculations on this theme would soon reveal the limits of his mind's range and hospitality. Yet, compared with the cheap professions of most reformers, and the still cheaper wisdom and eloquence of politicians in general, his are almost the only sensible and valuable words, and we thank Heaven for him. Comparatively, he is always strong, original, and, above all, practical. Still, his quality is not wisdom, but prudence. The lawyer's truth is not Truth, but consistency or a consistent expediency. Truth is always in harmony with herself, and is not concerned chiefly to reveal the justice that may consist with wrong-doing. He well deserves to be called, as he has been called, the Defender of the Constitution. There are really no blows to be given by him but defensive ones. He is not a leader, but a follower. His leaders are the men of '87- "I have never made an effort," he says, "and never propose to make an effort; I have never countenanced an effort, and never mean to countenance an effort, to disturb the arrangement as originally made, by which the various States came into the Union." Still thinking of the sanction which the Constitution gives to slavery, he says, "Because it was a part of the original compact- let it stand." Notwithstanding his special acuteness and ability, he is unable to take a fact out of its merely political relations, and behold it as it lies absolutely to be disposed of by the intellect- what, for instance, it behooves a man to do here in America today with regard to slavery- but ventures, or is driven, to make some such desperate answer as the following, while professing to speak absolutely, and as a private man- from which what new and singular code of social duties might be inferred? "The manner," says he, "in which the governments of those States where slavery exists are to regulate it is for their own consideration, under their responsibility to their constituents, to the general laws of propriety, humanity, and justice, and to God. Associations formed elsewhere, springing from a feeling of humanity, or any other cause, have nothing whatever to do with it. They have never received any encouragement from me, and they never will." They who know of no purer sources of truth, who have traced up its stream no higher, stand, and wisely stand, by the Bible and the Constitution, and drink at it there with reverence and humility; but they who behold where it comes trickling into this lake or that pool, gird up their loins once more, and continue their pilgrimage toward its fountain-head. No man with a genius for legislation has appeared in America. They are rare in the history of the world. There are orators, politicians, and eloquent men, by the thousand; but the speaker has not yet opened his mouth to speak who is capable of settling the much-vexed questions of the day. We love eloquence for its own sake, and not for any truth which it may utter, or any heroism it may inspire. Our legislators have not yet learned the comparative value of free trade and of freedom, of union, and of rectitude, to a nation. They have no genius or talent for comparatively humble questions of taxation and finance, commerce and manufactures and agriculture. If we were left solely to the wordy wit of legislators in Congress for our guidance, uncorrected by the seasonable experience and the effectual complaints of the people, America would not long retain her rank among the nations. For eighteen hundred years, though perchance I have no right to say it, the New Testament has been written; yet where is the legislator who has wisdom and practical talent enough to avail himself of the light which it sheds on the science of legislation? The authority of government, even such as I am willing to submit to- for I will cheerfully obey those who know and can do better than I, and in many things even those who neither know nor can do so well- is still an impure one: to be strictly just, it must have the sanction and consent of the governed. It can have no pure right over my person and property but what I concede to it. The progress from an absolute to a limited monarchy, from a limited monarchy to a democracy, is a progress toward a true respect for the individual. Even the Chinese philosopher was wise enough to regard the individual as the basis of the empire. Is a democracy, such as we know it, the last improvement possible in government? Is it not possible to take a step further towards recognizing and organizing the rights of man? There will never be a really free and enlightened State until the State comes to recognize the individual as a higher and independent power, from which all its own power and authority are derived, and treats him accordingly. I please myself with imagining a State at least which can afford to be just to all men, and to treat the individual with respect as a neighbor; which even would not think it inconsistent with its own repose if a few were to live aloof from it, not meddling with it, nor embraced by it, who fulfilled all the duties of neighbors and fellow-men. A State which bore this kind of fruit, and suffered it to drop off as fast as it ripened, would prepare the way for a still more perfect and glorious State, which also I have imagined, but not yet anywhere seen. THE END"
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