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Absolutely — this is your AP U.S. Government Unit 1 test review, covering Chapters 1–3. I can turn this into a study guide with simple definitions + what you actually need to know for the test. 🇺🇸 AP Government Unit 1 Test Review 1. Foundational Documents Declaration of Independence Main idea: Government exists to protect people’s natural rights, and people can change/remove a government that violates those rights. Know: * Natural rights: life, liberty, and the pursuit of happiness * Consent of the governed: government gets its power from the people * Social contract: people give government authority in exchange for protection of rights * Influenced by John Locke * Justified the colonies’ separation from Britain Test connection: Popular sovereignty + social contract + limited government. ⸻ Articles of Confederation The first U.S. governing document. Strength: States had significant power. Problems: * Weak national government * Congress couldn’t directly tax * No executive branch * No national court system * Difficult to pass laws * Difficult to amend * Weak ability to regulate interstate commerce Why it matters: Its weaknesses helped lead to the Constitutional Convention. ⸻ U.S. Constitution Created a stronger federal government while limiting its power. Know: * Separation of powers * Checks and balances * Federalism * Popular sovereignty * Republicanism * Limited government ⸻ Federalist No. 10 Written by James Madison. Main issue: factions. Madison argued that a large republic could help control the effects of factions because there would be many competing interests. Key idea: Pluralism/competing factions can prevent one group from completely dominating government. ⸻ Federalist No. 39 Written by James Madison. Main question: Is the Constitution republican and federal? * Republican: people elect representatives * Federal: power is divided between national and state governments Madison argued that the Constitution created a system combining national and federal characteristics. ⸻ Federalist No. 51 Written by James Madison. Main idea: Checks and balances and separation of powers prevent government from becoming too powerful. Famous concept: “Ambition must be made to counteract ambition.” In simple terms: Give each branch enough power to check the others. ⸻ Brutus No. 1 Written by an Anti-Federalist. Main concern: The proposed Constitution gave too much power to the national government. Brutus feared: * Federal government would become too powerful * States would lose power * Necessary and Proper Clause could expand federal authority * Large republic might not adequately represent citizens Federalist vs. Brutus: Federalist Brutus Stronger national government Stronger state governments Large republic can control factions Large republic may be difficult to represent Constitution protects liberty Constitution could threaten liberty ⸻ 2. Court Cases McCulloch v. Maryland (1819) Issue: Could Congress create a national bank, and could Maryland tax it? Decision: No, Maryland could not tax the national bank. Why? The Constitution’s Necessary and Proper Clause gives Congress implied powers. This case strengthened: * Federal power * Implied powers * Supremacy of federal law Remember: McCulloch = Federal government wins over state government. ⸻ United States v. Lopez (1995) Issue: Could Congress use the Commerce Clause to prohibit guns near schools? Decision: No. The Supreme Court ruled that Congress had gone beyond its Commerce Clause authority. Why it matters: It limited federal power under the Commerce Clause. Easy comparison: McCulloch → expands federal power Lopez → limits federal power ⸻ 3. Constitutional Clauses Necessary and Proper Clause Also called the Elastic Clause. Allows Congress to make laws necessary and proper for carrying out its constitutional powers. Connection: Implied powers. ⸻ Supremacy Clause Federal law is generally supreme over conflicting state law. Think: Federal law > conflicting state law This was important in McCulloch v. Maryland. ⸻ Commerce Clause Gives Congress power to regulate interstate commerce. “Interstate” = between states. It has historically been an important source of federal power. Connection: United States v. Lopez. ⸻ Full Faith and Credit Clause States generally must recognize the public acts, records, and judicial proceedings of other states. Example: A court judgment from one state may need to be recognized in another state. ⸻ 4. Amendment Process — Article V The Constitution has a deliberately difficult amendment process. Proposal An amendment can be proposed by: * 2/3 of both houses of Congress OR * A convention called by Congress after 2/3 of state legislatures request one. Ratification It must then be ratified by: * 3/4 of the states Memorize: 2/3 → propose 3/4 → ratify ⸻ 5. Amendments 10th Amendment Powers not given to the federal government by the Constitution, and not prohibited to the states, are generally reserved to the states or the people. Think: Reserved powers. ⸻ 14th Amendment Very important for federalism and civil rights. Know: * Citizenship * Due process * Equal protection Equal Protection Clause States cannot deny people equal protection of the laws. Due Process Clause States must follow fair legal procedures and respect protected rights. Big connection: The 14th Amendment has been used to apply many constitutional rights to the states. ⸻ 6. Democracy Vocabulary Limited Government Government’s power is restricted by laws and the Constitution. Think: Government officials aren’t above the law. ⸻ Popular Sovereignty The people are the ultimate source of governmental power. Easy: People → government. ⸻ Republicanism People govern indirectly through elected representatives. ⸻ Social Contract The idea that people agree to give government some authority in exchange for protection and order. ⸻ Participatory Democracy Citizens are actively involved in government. Examples: * Voting * Protesting * Contacting representatives * Political campaigns * Community activism ⸻ Elite Democracy A relatively small group of influential individuals makes major political decisions. Think: Political power concentrated among elites. ⸻ Pluralist Democracy Different interest groups compete to influence government. Think: Many groups → competing interests → government responds Federalist No. 10 connects strongly to this concept. ⸻ 7. Legislature Structures Bicameral A legislature with two chambers. U.S. Congress: * House of Representatives * Senate Unicameral A legislature with one chamber. Easy: Bi = 2 Uni = 1 ⸻ 8. Plans for the Constitution Virginia Plan Wanted: * Strong national government * Three branches * Bicameral legislature * Representation based on population Favored larger states. ⸻ New Jersey Plan Wanted: * Stronger national government * Unicameral legislature * Equal representation for states Favored smaller states. ⸻ Great Compromise Solved the disagreement between the Virginia and New Jersey Plans. Created a bicameral Congress: House Representation based on population. Senate Each state gets 2 senators. Easy: House = population Senate = equal states ⸻ 9. Electoral College The system used to formally elect the president. Each state gets electoral votes based on its: * House representatives * 2 senators Total = House members + 2 senators Most states use a winner-take-all system for allocating electoral votes. Important: The president is not directly elected through one nationwide popular vote. ⸻ 10. Three-Fifths Compromise An agreement during the Constitutional Convention concerning how enslaved people would be counted for representation and taxation. For those purposes, enslaved people were counted as three-fifths of a person. This compromise was part of the Constitution’s original structure and reflected the institution of slavery. ⸻ 11. Separation of Powers Power is divided among three branches. Branch Main Function Legislative Makes laws Executive Enforces laws Judicial Interprets laws Think: Divide power. ⸻ 12. Checks and Balances Each branch can limit the power of the other branches. Examples: President → vetoes legislation Congress → overrides veto Senate → confirms presidential appointments Courts → judicial review Congress → can impeach federal officials Difference: Separation of powers = divide government power Checks and balances = branches limit each other ⸻ 13. Federalism Power is divided between: National government ↔ State governments This is different from separation of powers. Separation of powers: Between branches Federalism: Between levels of government ⸻ 14. Types of Federalism Layer Cake Federalism Also called dual federalism. Federal and state governments have separate areas of responsibility. Think: 🟫 National 🟨 State Separate layers. ⸻ Marble Cake Federalism Also called cooperative federalism. Federal and state governments work together and share responsibilities. Think: Swirled together. ⸻ 15. Preemption When federal law takes priority over conflicting state law. Connected to the Supremacy Clause. Think: Federal law can “preempt” state law. ⸻ 16. Types of Powers Exclusive Powers Powers belonging only to one level of government. Example: * Coining money → federal government ⸻ Delegated Powers Powers given to the federal government by the Constitution. Also called enumerated powers when specifically listed. Examples: * Declare war * Coin money * Regulate interstate commerce ⸻ Reserved Powers Powers reserved for states. Connected to the 10th Amendment. Examples: * Education * Local governments * Many licensing rules ⸻ Concurrent Powers Powers shared by federal and state governments. Examples: * Taxation * Courts * Law enforcement Memorize: Delegated → Federal Reserved → States Concurrent → Both ⸻ Implied Powers Powers that aren’t specifically written but are reasonably connected to Congress’s enumerated powers. Source: Necessary and Proper Clause. McCulloch v. Maryland = huge connection. ⸻ Inherent Powers Powers the national government is understood to possess because it is a sovereign nation. Example: * Conducting foreign relations ⸻ 17. Fiscal Federalism The use of federal money to influence state and local governments. Basically: Federal government → money → states/local governments ⸻ 18. Revenue Sharing The federal government gives states/local governments money with few restrictions on how it can be spent. States have significant flexibility. ⸻ 19. Incentives The federal government encourages states to do something by offering benefits, usually money. Example: Federal government: “Do X, and we’ll give you funding.” ⸻ 20. Categorical Grants Federal money given to states/local governments for a specific purpose. Very specific. Example: Federal government provides money specifically for a school nutrition program. Think: Categorical = category ⸻ 21. Block Grants Federal money given to states for a broad purpose, giving states more flexibility. Example: Money for healthcare rather than one extremely specific program. Difference: Categorical = specific Block = broad/flexible ⸻ 22. Mandates Requirements imposed by the federal government on state/local governments. Think: Federal government → “You MUST do this.” Some mandates come with funding; others may be unfunded mandates, meaning governments must comply without receiving enough federal money to cover the costs. ⸻ 23. Devolution The process of transferring power/responsibility from the federal government → state governments. Think: Federal → States ⸻ ⭐ THE BIG CONNECTIONS TO MEMORIZE These are especially useful because AP Gov questions often make you connect concepts. McCulloch v. Maryland Necessary & Proper Clause → implied powers → stronger federal government → Supremacy Clause U.S. v. Lopez Commerce Clause → limits federal power Federalist 10 Factions → large republic → competing interests → pluralism Federalist 51 Separation of powers → checks and balances → prevent tyranny Brutus 1 Fear of powerful national government → concern about federalism and individual liberty 10th Amendment Reserved powers → states 14th Amendment Equal protection + due process → limits state governments Great Compromise Virginia Plan + New Jersey Plan → bicameral Congress Fiscal Federalism Federal money → states → grants/incentives/mandates ⸻ 🧠 15 Things I Would Memorize FIRST If you’re short on time, know these cold: 1. Popular sovereignty = people have power 2. Republicanism = elected representatives 3. Limited government = government power is restricted 4. Federalism = national + state power 5. Separation of powers = three branches 6. Checks and balances = branches check each other 7. 10th Amendment = reserved powers 8. Necessary & Proper = implied powers 9. Supremacy Clause = federal law takes priority over conflicting state law 10. Commerce Clause = Congress regulates interstate commerce 11. McCulloch = expands federal power 12. Lopez = limits federal Commerce Clause power 13. Great Compromise = House by population, Senate equal 14. Categorical grant = specific 15. Block grant = broad/flexible The fastest memory trick: Federalism = levels Separation = branches Checks = limits 10th = states Necessary & Proper = implied Supremacy = federal wins Commerce = interstate McCulloch = expand Lopez = limit Categorical = specific Block = broad
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Chapter 4 Skin and Body Membranes Body Membranes Functions of body membranes Cover body surfaces Line body cavities Form protective sheets around organs Classified according to tissue types Body Membranes Two major categories Epithelial membranes Cutaneous membranes Mucous membranes Serous membranes Connective tissue membranes Synovial membranes Epithelial Membranes Epithelial membranes are simple organs Also called covering and lining membranes These membranes contain both: Epithelial tissue layer Connective tissue layer Epithelial Membranes Cutaneous membrane = skin Dry membrane Outermost protective boundary Consists of two layers Epidermis is composed of keratinized stratified squamous epithelium Dermis is mostly dense (fibrous) connective tissue Epithelial Membranes • Mucous membranes (mucosae) • I Moist membranes Some mucosae secrete protective, lubricating mucus Line all body cavities that open to the exterior body surface • Adapted for absorption or secretion • ' Consists of two layers • Epithelium type depends on site • Loose connective tissue (lamina propria) Epithelial Membranes Serous membranes (serosae) Line compartments in the ventral body cavity that are ciosed to the exterior of the body Occur in pairs, separated by serous fluid, with a visceral and parietal layer Consists of two layers Simple squamous epithelium Areolar connective tissue Epithelial Membranes Specific serous membranes Peritoneum Cover organs in the abdominal cavity Pleurae Surround the lungs Pericardia Surround the heart Connective Tissue Membranes Synovial membranes Loose areolar connective tissue only (no epithelial tissue) Line fibrous capsules surrounding joints Line bursae Line tendon sheaths Secrete a lubricating fluid to cushion organs moving against each other during muscle activity Integumentary System Integumentary system consists of the: Skin (cutaneous membrane) Skin appendages Sweat glands Oil glands Hair Nails Functions of the Integumentary System Insulates and cushion deeper body organs Protects the entire body from: Mechanical damage (bumps and cuts) Chemical damage (acids and bases) Thermal damage (heat or cold) Ultraviolet (UV) radiation (sunlight) Microbes (bacteria) • Water loss Functions of the Integumentary System Regulates heat loss as controlled by the nervous system Acts as a mini-excretory system; sweat aids in the loss of Urea Salts Water Synthesizes vitamin D Secretions create a protective acid mantle Structure of the Skin Two kinds of tissue compose the skin Epidermis Dermis Subcutaneous tissue (hypodermis) Anchors the skin to underlying organs Not technically part of the integumentary system Composed mostly of adipose tissue Serves as a shock absorber and insulates deeper tissues Structure of the Skin Epidermisouter layer Composed of stratified squamous epithelium Most cells are keratinocytes which produce a fibrous protein called keratin Keratinization makes the epidermis tough Desmosomes connect keratinocytes together Avascular Composed of five layers (strata) Structure of the Skin Summary of strata (layers) of the epidermis from deepest to most superficial Stratum basale Stratum spinosum Stratum granulosum Stratum lucidum (thick, hairless skin only) Stratum corneum Structure of the Skin Stratum basale (stratum germinativum) Deepest layer of epidermis Lies next to dermis Wavy borderline with the dermis anchors the two together Cells undergoing mitosis Daughter cells are pushed upward to become the more superficial layers Stratum spinosum Cells become increasingly flatter and more keratinized Structure of the Skin Stratum granulosum Stratum lucidum Formed from dead cells of the deeper strata Occurs only in thick, hairless skin of the palms of hands and soles of feet Stratum corneum Outermost layer of epidermis Shingle-like dead cells are filled with keratin (protective protein prevents wat loss from skin Structure of the Skin Melanin Melanin is a pigment produced by melanocytes Melanocytes are mostly in the stratum basale of the epidermis Color is yellow to brown to black Structure of the Skin Epidermal dendritic cells Alert and activate immune cells to a threat (bacterial or viral invasion) Merkel cells Associated with sensory nerve endings Serve as touch receptors called Merkel discs Structure of the Skin Dermis Connective tissue Underlies the epidermis Two regions Papillary Reticular Structure of the Skin Two regions of the dermis Papillary layer (upper dermal region) contain projections called dermal papillae Areolar connective tissue Indent the epidermis above Many projections contain capillary loops, and others house pain and touch receptors On palm and sole surfaces, papillae increase friction and gripping ability Fingerprints are identifying films of sweat Structure of the Skin Two regions of the dermis Reticular layer (deepest skin layer) Dense irregular connective tissue Blood vessels Sweat and oil glands Deep pressure receptors (lamellar corpuscles) Structure of the Skin Other dermal features Cutaneous sensory receptors Phagocytes Collagen and elastic fibers Blood vessels I Nerve supply Skin Color • Three pigments contribute to skin color 1. Melanin • Yellow, reddish brown, or black pigments 2. Carotene • Orange-yellow pigment (also found in some vegetables) 3. Hemoglobin Red coloring from blood cells in dermal capillaries Oxygen content determines the extent of red coloring Skin Color Redness (erythema) due to embarrassment, inflammation, hypertension, fever, or allergy Pallor (blanching) due to emotional stress (such as fear), anemia, low blood pressure, impaired blood flow to an area Jaundice (yellow cast)-indicates a liver disorder • Bruises (black and blue marks)-hematomas Appendages of the Skin Cutaneous glands are all exocrine glands Sebaceous glands Sweat glands Hair and hair follicles Nails Appendages of the Skin Sebaceous (oil) glands Located all over the skin except for palms and soles Produce sebum (oil) Makes skin soft and moist Prevents hair from becoming brittle Kills bacteria Most have ducts that empty into hair follicles; others open directly onto skin surface Glands are activated at puberty with increased androgens Appendages of the Skin Sweat (sudoriferous) glands Produce sweat Widely distributed in skin Two types of sudoriferous glands Eccrine glands Apocrine glands Appendages of the Skin Eccrine glands More numerous, located all over the body Open via duct to sweat pores on the skin's surface Produce acidic sweat Water, salts, vitamin C, traces of metabolic waste Function in body temperature regulation Appendages of the Skin Apocrine glands Ducts empty into hair follicles in the armpit and genitals Begin to function at puberty Release sweat that also contains fatty acids and proteins (milky or yellowish color) • Play a minimal role in body temperature regulation Appendages of the Skin Hair Located body-wide except for palms, soles, nipples, lips Produced by hair follicle Root is enclosed in the follicle Shaft projects from the surface of the scalp or skin Consists of hard keratinized epithelial cells Melanocytes provide pigment for hair color Hair grows in the matrix of the hair bulb in stratum basale Appendages of the Skin Hair anatomy Central medulla Cortex surrounds medulla Cuticle on outside of cortex Most heavily keratinized region of the hair Melanin provides color Appendages of the Skin Associated hair structures Hair follicle Composed of an inner epithelial root sheath andan outer fibrous sheath Dermal region provides a blood supply to the hair bulb (deepest part of the follicle) Arrector pili muscle connects to the hair follicle to pull hairs upright when we are cold or frightened Appendages of the Skin Nails Heavily keratinized, scalelike modifications of the epidermis Stratum basale extends beneath the nail bed, which is responsible for growth Lack of pigment makes nails colorless Appendages of the Skin Parts of a nail Free edge Body is the visible attached portion Nail folds are skin folds that overlap the edges of the nail; the cuticle is the proximal edge Root of nail is embedded in skin Growth of the nail occurs from nail matrix of nail bed Homeostatic Imbalances of Skin Infections and allergies Athlete's foot Caused by fungal infection (Tinea pedis) Itchy, red peeling skin between the toes Boils (furuncles) and carbuncles Caused by inflammation of hair follicles Carbuncles are clusters of boils caused by bacteria Cold sores (fever blisters) Caused by human herpesvirus 1 Blisters itch and sting Homeostatic Imbalances of Skin Infections and allergies Contact dermatitis Caused by exposure to chemicals that provoke allergic responses Itching, redness, and swelling of the skin Impetigo Caused by bacterial infection Pink, fluid-filled raised lesions around mouth/nose Psoriasis Triggered by trauma, infection, hormonal changes, or stress Red, epidermal lesions covered with dry, silvery scales that itch, burn, Crack, or sometimes bleed Homeostatic Imbalances of Skin • Burns Tissue damage and cell death caused by heat, electricity, UV radiation, or chemicals Associated dangers Protein denaturation and cell death Dehydration and electrolyte imbalance Circulatory shock Result in loss of body fluids and infection from the invasion of bacteria Homeostatic Imbalances of Skin Extent of a burn is estimated using the rule of nines Body is divided into 11 areas for quick estimation Each area represents about 9 percent of total body surface area The area surrounding the genitals (the perineum) represents 1 percent of body surface area Homeostatic Imbalances of Skin . First-degree burn (superficial burn) Only epidermis is damaged Skin is red and swollen Second-degree burn (superficial partial-thickness burn) Epidermis and superficial part of dermis are damaged Skin is red, painful, and blistered Regrowth of the epithelium can occur Homeostatic Imbalances of Skin Third-degree burn (full-thickness burn) Destroys epidermis and dermis; burned area is painless Requires skin grafts, as regeneration is not possible Burned area is blanched (gray-white) or black Fourth-degree burn (full-thickness burn) Extends into deeper tissues (bone, muscle, tendons) Appears dry and leathery Requires surgery and grafting May require amputation Homeostatic Imbalances of Skin Criteria for deeming burns critical (if any one is met): Over 30 percent of body has second-degree burns Over 10 percent of the body has third-or fourth-degree burns Third-or fourth-degree burns of the face, hands, feet, or genitals Burns affect the airways Circumferential (around the body or limb) burns have occurred Homeostatic Imbalances of Skin Skin cancer Most common form of cancer in humans Most important risk factor is overexposure to ultraviolet (V) radiation in sunlight and tanning beds Cancer can be classified two ways Benign means the neoplasm (tumor) has not spread Malignant means the neoplasm has invaded other body areas Concept Link Recall that mitosis gone wild is the basis for cancer (Chapter 3, pp. 82-83). These cells lack normal control of cell division and divide quickly, resulting in errors during DNA replication, mitosis, or both. Cells experiencing rapid, uncontrolled growth become cancerous and can metastasize (spread) to other parts of the body. Homeostatic Imbalances of Skin . First-degree burn (superficial burn) Only epidermis is damaged Skin is red and swollen Second-degree burn (superficial partial-thickness burn) Epidermis and superficial part of dermis are damaged Skin is red, painful, and blistered Regrowth of the epithelium can occur Homeostatic Imbalances of Skin Third-degree burn (full-thickness burn) Destroys epidermis and dermis; burned area is painless Requires skin grafts, as regeneration is not possible Burned area is blanched (gray-white) or black Fourth-degree burn (full-thickness burn) Extends into deeper tissues (bone, muscle, tendons) Appears dry and leathery Requires surgery and grafting May require amputation Homeostatic Imbalances of Skin Criteria for deeming burns critical (if any one is met): Over 30 percent of body has second-degree burns Over 10 percent of the body has third-or fourth-degree burns Third-or fourth-degree burns of the face, hands, feet, or genitals Burns affect the airways Circumferential (around the body or limb) burns have occurred Homeostatic Imbalances of Skin Skin cancer Most common form of cancer in humans Most important risk factor is overexposure to ultraviolet (V) radiation in sunlight and tanning beds Cancer can be classified two ways Benign means the neoplasm (tumor) has not spread Malignant means the neoplasm has invaded other body areas Concept Link Recall that mitosis gone wild is the basis for cancer (Chapter 3, pp. 82-83). These cells lack normal control of cell division and divide quickly, resulting in errors during DNA • One or more of the ABCD characteristics is evolving Developmental Aspects of Skin and Body Membranes Lanugo, a downy hair, covers the body by the fifth or sixth month of fetal development but disappears by birth Vernix caseosa, an oily covering, is apparent at birth Milia, small white spots, are common at birth and disappear by the third week Acne may appear during adolescence Pimples, scales, and dermatitis are more common with aging skin Developmental Aspects of Skin and Body Membranes In youth, skin is thick, resilient, and well hydrated With aging, skin loses elasticity and thins Skin cancer is a major threat to skin exposed to excessive sunlight Balding (alopecia) and/or graying occurs with aging; both are genetically determined other factors that may contribute include drugs and emotional stress
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Chapter 1 : Cell Biology The study of cells, their structures, and their functions. Cell Theory All living organisms are composed of one or more cells; cells are the smallest living things and basic units of organization; cells arise only from previously existing cells. Fundamental Unit of Life The cell. Plasma Membrane A structure found in all cells that surrounds the cell. Cytoplasm The area of the cell that includes the cytosol. Cytosol The fluid portion of the cell outside the organelles. Genetic Material The DNA contained within cells. Prokaryote An organism whose cells do not have a true nucleus. Eukaryote An organism whose cells have a true nucleus. Prokaryotes Bacteria and Archaea. Eukaryotes Animals, plants, fungi, and protists. Prokaryotic Cell Usually a single cell with no true nucleus and typically one circular chromosome. Eukaryotic Cell A cell with a true nucleus and membrane-bound organelles. True Nucleus A nucleus that contains DNA and is enclosed by a nuclear envelope. Virus A non-cellular entity that requires cells to survive and reproduce. Obligate Intracellular Parasite An organism or entity that requires a cell to survive and reproduce; viruses are sometimes called this. Light Microscope A microscope that can be used to view live or dead cells and can show structures such as the membrane, nucleus, cytoplasm, and larger organelles. Electron Microscope A microscope with much higher resolution than a light microscope; specimens must be fixed (dead). TEM Transmission Electron Microscopy; used to examine thin sections of tissues and internal structures. SEM Scanning Electron Microscopy; used to examine surfaces of cells or tissues. Fluorescence Microscopy Microscopy that uses fluorescent labels to see specific tagged cell structures. Cell Resolution The human eye resolves about 200 µm, while typical cells are about 5–20 µm. Nucleus Contains DNA and is involved in DNA replication. Mitochondria Organelles that make ATP through aerobic cellular respiration. ATP The energy-containing molecule produced by mitochondria. Aerobic Cellular Respiration The process carried out by mitochondria to make ATP. Chloroplast An organelle involved in photosynthesis and found in plant cells. Photosynthesis The process in which light energy and CO2 are used to produce food. Rough ER The organelle involved in making proteins; it has ribosomes attached to it. Ribosomes Structures associated with the rough ER that are involved in protein production. Smooth ER An organelle involved in making lipids, storage, and modifying carbohydrates. Golgi Apparatus Modifies and sorts proteins and helps transport them. Vesicle A membrane-bound structure involved in transporting materials between organelles and to the plasma membrane. Exocytosis The process involving vesicles releasing materials through the plasma membrane. Cytoskeleton A system of filaments important for cell organization, structure, and movement. Actin Filaments Cytoskeletal structures involved in muscle contraction, cell crawling, cell shape, and pseudopodial cell extension. Microtubules Cytoskeletal structures involved in vesicle transport, chromosome movement, cilia, flagella, and the mitotic spindle. Intermediate Filaments Cytoskeletal structures important for stability and structural support. Mitotic Spindle A structure made of microtubules that helps move chromosomes during cell division. Cell Wall A structure found in plant cells and many prokaryotes that provides support. Vacuole A structure found in plant cells; plant cells have vacuoles in addition to their other organelles. Endosymbiosis The engulfment of bacteria by a larger cell. Endosymbiont Theory The theory that mitochondria and chloroplasts evolved from bacteria that were engulfed by ancestral cells. Mitochondrial Origin According to endosymbiont theory, mitochondria arose from an aerobic bacterium taken up by an anaerobic bacteria-like ancestor of eukaryotic cells. Chloroplast Origin According to endosymbiont theory, chloroplasts arose from photosynthetic bacteria taken up by an aerobic eukaryotic ancestor of plants. Evidence for Endosymbiont Theory Mitochondria and chloroplasts are bacteria-sized, have two membranes, have bacterial-like ribosomes, contain their own DNA, and divide similarly to bacteria. Mitochondrial DNA Mitochondria contain their own DNA, including a single circular chromosome similar to bacteria. Chloroplast DNA Chloroplasts contain their own DNA, including a single circular chromosome similar to bacteria. Double Membrane Mitochondria and chloroplasts have two membranes, supporting the endosymbiont theory. Common Ancestor Hypothesis The hypothesis that organisms descended from an ancestral prokaryote called LUCA or LUA. LUCA The Last Universal Common Ancestor; an ancestral prokaryote in the common ancestor hypothesis. Genome The genetic material of an organism, containing protein-coding genes and regulatory regions.y
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Chapter 1 : Cell Biology The study of cells, their structures, and their functions. Cell Theory All living organisms are composed of one or more cells; cells are the smallest living things and basic units of organization; cells arise only from previously existing cells. Fundamental Unit of Life The cell. Plasma Membrane A structure found in all cells that surrounds the cell. Cytoplasm The area of the cell that includes the cytosol. Cytosol The fluid portion of the cell outside the organelles. Genetic Material The DNA contained within cells. Prokaryote An organism whose cells do not have a true nucleus. Eukaryote An organism whose cells have a true nucleus. Prokaryotes Bacteria and Archaea. Eukaryotes Animals, plants, fungi, and protists. Prokaryotic Cell Usually a single cell with no true nucleus and typically one circular chromosome. Eukaryotic Cell A cell with a true nucleus and membrane-bound organelles. True Nucleus A nucleus that contains DNA and is enclosed by a nuclear envelope. Virus A non-cellular entity that requires cells to survive and reproduce. Obligate Intracellular Parasite An organism or entity that requires a cell to survive and reproduce; viruses are sometimes called this. Light Microscope A microscope that can be used to view live or dead cells and can show structures such as the membrane, nucleus, cytoplasm, and larger organelles. Electron Microscope A microscope with much higher resolution than a light microscope; specimens must be fixed (dead). TEM Transmission Electron Microscopy; used to examine thin sections of tissues and internal structures. SEM Scanning Electron Microscopy; used to examine surfaces of cells or tissues. Fluorescence Microscopy Microscopy that uses fluorescent labels to see specific tagged cell structures. Cell Resolution The human eye resolves about 200 µm, while typical cells are about 5–20 µm. Nucleus Contains DNA and is involved in DNA replication. Mitochondria Organelles that make ATP through aerobic cellular respiration. ATP The energy-containing molecule produced by mitochondria. Aerobic Cellular Respiration The process carried out by mitochondria to make ATP. Chloroplast An organelle involved in photosynthesis and found in plant cells. Photosynthesis The process in which light energy and CO2 are used to produce food. Rough ER The organelle involved in making proteins; it has ribosomes attached to it. Ribosomes Structures associated with the rough ER that are involved in protein production. Smooth ER An organelle involved in making lipids, storage, and modifying carbohydrates. Golgi Apparatus Modifies and sorts proteins and helps transport them. Vesicle A membrane-bound structure involved in transporting materials between organelles and to the plasma membrane. Exocytosis The process involving vesicles releasing materials through the plasma membrane. Cytoskeleton A system of filaments important for cell organization, structure, and movement. Actin Filaments Cytoskeletal structures involved in muscle contraction, cell crawling, cell shape, and pseudopodial cell extension. Microtubules Cytoskeletal structures involved in vesicle transport, chromosome movement, cilia, flagella, and the mitotic spindle. Intermediate Filaments Cytoskeletal structures important for stability and structural support. Mitotic Spindle A structure made of microtubules that helps move chromosomes during cell division. Cell Wall A structure found in plant cells and many prokaryotes that provides support. Vacuole A structure found in plant cells; plant cells have vacuoles in addition to their other organelles. Endosymbiosis The engulfment of bacteria by a larger cell. Endosymbiont Theory The theory that mitochondria and chloroplasts evolved from bacteria that were engulfed by ancestral cells. Mitochondrial Origin According to endosymbiont theory, mitochondria arose from an aerobic bacterium taken up by an anaerobic bacteria-like ancestor of eukaryotic cells. Chloroplast Origin According to endosymbiont theory, chloroplasts arose from photosynthetic bacteria taken up by an aerobic eukaryotic ancestor of plants. Evidence for Endosymbiont Theory Mitochondria and chloroplasts are bacteria-sized, have two membranes, have bacterial-like ribosomes, contain their own DNA, and divide similarly to bacteria. Mitochondrial DNA Mitochondria contain their own DNA, including a single circular chromosome similar to bacteria. Chloroplast DNA Chloroplasts contain their own DNA, including a single circular chromosome similar to bacteria. Double Membrane Mitochondria and chloroplasts have two membranes, supporting the endosymbiont theory. Common Ancestor Hypothesis The hypothesis that organisms descended from an ancestral prokaryote called LUCA or LUA. LUCA The Last Universal Common Ancestor; an ancestral prokaryote in the common ancestor hypothesis. Genome The genetic material of an organism, containing protein-coding genes and regulatory regions.
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🇺🇸 APUSH CRAM SHEET PERIOD 1: 1491–1607 — Native America & Exploration Native American Societies * Iroquois Confederacy → political alliance of Native nations * Pueblo peoples → Southwest; agriculture, irrigation * Mississippian societies → Cahokia; agriculture and complex societies Columbian Exchange Americas → Europe * Corn * Potatoes * Tomatoes * Tobacco * Cacao Europe/Africa → Americas * Horses * Cattle * Sugar * Wheat * Diseases ⚠️ Major consequence: Native populations dramatically declined because of European diseases. Exploration * Christopher Columbus (1492) → opened sustained European contact * Treaty of Tordesillas (1494) → Spain/Portugal divided claims in the Americas * Encomienda System → Spanish forced Native labor ⸻ PERIOD 2: 1607–1754 — Colonies Jamestown — 1607 * First permanent English settlement * Virginia Company * John Smith → helped colony survive * Tobacco → major cash crop * John Rolfe → tobacco cultivation Important Virginia Developments * House of Burgesses (1619) → representative government * Headright System → encouraged immigration by giving land * Growth of slavery Plymouth & Massachusetts * Pilgrims → Plymouth, 1620 * Mayflower Compact → self-government * Puritans → Massachusetts Bay * John Winthrop → “city upon a hill” Religion Puritans: wanted to reform the Church of England Quakers: * Religious tolerance * Equality * Pennsylvania * William Penn Bacon’s Rebellion — 1676 * Nathaniel Bacon led frontier farmers against Virginia government * Showed conflict between wealthy elites and poorer colonists * Contributed to increased reliance on enslaved labor Colonial Economies New England * Fishing * Shipbuilding * Trade * Small farms Middle Colonies * Grain * Trade * Diverse population Southern Colonies * Tobacco * Rice * Indigo * Plantation agriculture * Slavery ⸻ PERIOD 3: 1754–1800 — Revolution & Constitution French & Indian War — 1754–1763 Britain vs. France + Native allies Consequences * Britain wins * Britain gains territory * Britain has massive debt * Britain begins taxing colonies Proclamation of 1763 * Colonists prohibited from settling west of Appalachian Mountains * Angered colonists ⸻ Road to Revolution Tax Acts Stamp Act (1765) * Tax on printed materials * “No taxation without representation” Townshend Acts (1767) * Taxes on imports * Led to colonial resistance Boston Massacre (1770) * British soldiers killed colonists * Patriot propaganda Boston Tea Party (1773) * Colonists protested Tea Act Intolerable Acts (1774) * Punished Massachusetts * Helped unite colonies ⸻ Declaration of Independence — 1776 Thomas Jefferson Main ideas: * Natural rights * Life, liberty, pursuit of happiness * Government gets power from the people * People can overthrow an abusive government ⸻ Revolutionary War Turning Points Saratoga (1777) → Major American victory → France joins American side Yorktown (1781) → Cornwallis surrendered → Major fighting effectively ended Treaty of Paris (1783) → Britain recognized U.S. independence ⸻ Articles of Confederation Strengths * Won Revolutionary War * Land Ordinance of 1785 * Northwest Ordinance of 1787 Weaknesses * No power to tax * No executive branch * No national court system * Weak central government ⸻ Constitution Great Compromise * House of Representatives → population * Senate → equal representation 3/5 Compromise * Enslaved people counted as 3/5 for representation and taxation Federalists vs. Anti-Federalists Federalists * Strong national government * Hamilton * Madison * Jay Anti-Federalists * Feared centralized power * Wanted Bill of Rights Bill of Rights — 1791 First 10 amendments ⸻ PERIOD 4: 1800–1848 — Expansion & Democracy Jefferson Election of 1800 * Peaceful transfer of power * Jefferson becomes president Louisiana Purchase — 1803 * Bought from France * Doubled U.S. territory Lewis & Clark * Explored western territory ⸻ War of 1812 Causes: * British impressment * British interference with trade * British support for Native resistance Effects * Increased nationalism * Weakened Federalist Party * Encouraged American manufacturing ⸻ Market Revolution Transportation * Canals * Roads * Railroads * Steamboats Industrialization * Factories grew * Wage labor expanded * Cities grew Erie Canal → connected Great Lakes to Hudson River ⸻ Jacksonian Democracy Andrew Jackson * Expanded voting for white men * Spoils system * Popular democracy Indian Removal Act — 1830 * Forced Native Americans west * Trail of Tears * Major example of U.S. expansion and Native displacement Bank War Jackson opposed the national bank. ⸻ Manifest Destiny Belief that the U.S. was destined to expand across North America. Texas * Texas declared independence from Mexico * Alamo * Texas becomes U.S. state in 1845 Mexican-American War — 1846–1848 U.S. victory → Mexican Cession Treaty of Guadalupe Hidalgo * U.S. gained California, New Mexico and huge western territory ⸻ PERIOD 5: 1844–1877 — Civil War & Reconstruction Sectionalism North * Industry * Free labor * Railroads * Growing cities South * Plantation economy * Cotton * Slavery West * Competition over whether slavery would expand ⸻ Slavery Cotton Gin * Eli Whitney * Made cotton processing faster * Increased demand for enslaved labor Missouri Compromise — 1820 * Missouri → slave * Maine → free * 36°30′ line Compromise of 1850 * California → free * Popular sovereignty in Utah/New Mexico * Fugitive Slave Act strengthened Kansas-Nebraska Act — 1854 * Popular sovereignty * Repealed Missouri Compromise * Led to Bleeding Kansas Dred Scott v. Sandford — 1857 Supreme Court ruled: * African Americans were not citizens * Congress couldn’t prohibit slavery in territories Lincoln-Douglas Debates Major issue → slavery’s expansion ⸻ Civil War Election of 1860 Abraham Lincoln wins Southern states secede. Emancipation Proclamation — 1863 * Freed enslaved people in rebelling states * Changed war aims toward ending slavery Gettysburg — 1863 Major Union victory Gettysburg Address * Equality * Democracy * “new birth of freedom” Appomattox — 1865 Lee surrendered to Grant. ⸻ Reconstruction — 1865–1877 13th Amendment Abolished slavery 14th Amendment Citizenship + equal protection 15th Amendment Voting rights for Black men Freedmen’s Bureau * Helped formerly enslaved people * Education * Employment * Food/housing assistance Black Codes Southern laws restricting African Americans after the Civil War. Ku Klux Klan Used violence and intimidation to suppress Black political participation. Compromise of 1877 * Ended disputed 1876 election * Federal troops withdrawn from South * Reconstruction effectively ended ⚠️ APUSH connection: Reconstruction achieved major constitutional changes but failed to permanently protect many of those gains. ⸻ PERIOD 6: 1865–1898 — Gilded Age Industrialization Important Industrialists * Andrew Carnegie → steel * John D. Rockefeller → oil * J.P. Morgan → banking/finance Robber Barons vs. Captains of Industry Robber Baron → exploited workers, monopolies Captain of Industry → created jobs/industry and sometimes philanthropy Social Darwinism Applied survival-of-the-fittest ideas to society/economics. ⸻ Labor Knights of Labor * Broad membership * Wanted better working conditions AFL * Samuel Gompers * Skilled workers * Higher wages * Shorter hours Major Strikes Haymarket Affair → labor unrest + anarchism Homestead Strike → Carnegie Steel Pullman Strike → railroad workers → federal government intervened ⸻ Immigration Old Immigration Mostly: * Northern/Western Europe New Immigration Mostly: * Southern/Eastern Europe * Italians * Poles * Russians Chinese Exclusion Act — 1882 Restricted Chinese immigration. ⸻ Urbanization Problems: * Tenements * Disease * Crime * Poor sanitation Political machines * Ex: Tammany Hall * Provided services in exchange for votes ⸻ PERIOD 7: 1890–1945 — Progressive Era & World Wars Progressivism Goals: * Reduce corruption * Regulate corporations * Improve working conditions * Consumer protection * Women’s suffrage Muckrakers Investigative journalists exposing problems. Upton Sinclair → The Jungle → exposed meatpacking conditions → helped inspire Meat Inspection Act & Pure Food and Drug Act Theodore Roosevelt Square Deal * Trust busting * Conservation * Consumer protection 16th Amendment → Federal income tax 17th Amendment → Direct election of senators 18th Amendment → Prohibition 19th Amendment → Women’s suffrage ⸻ Imperialism Spanish-American War — 1898 U.S. victory U.S. gains influence over: * Puerto Rico * Guam * Philippines Open Door Policy U.S. wanted equal trade access in China. Roosevelt Corollary U.S. claimed right to intervene in Latin America. ⸻ World War I Causes Think MAIN * Militarism * Alliance system * Imperialism * Nationalism U.S. enters in 1917. Wilson’s Fourteen Points * Self-determination * League of Nations * International cooperation Treaty of Versailles Senate rejected it. ⸻ 1920s Consumer Culture * Cars * Radios * Movies * Advertising Harlem Renaissance African American cultural movement. Important figures: * Langston Hughes * Zora Neale Hurston * Duke Ellington Great Migration African Americans moved from South → Northern/Western cities. ⸻ Great Depression Causes * Stock market speculation * Bank failures * Unequal wealth * Overproduction * Consumer debt FDR’s New Deal Relief → help people now Recovery → rebuild economy Reform → prevent future depression Important Programs CCC → jobs for young men WPA → public works/jobs Social Security Act → retirement assistance FDIC → protects bank deposits SEC → regulates stock market ⸻ World War II Pearl Harbor — 1941 Japan attacks U.S. U.S. enters WWII. Japanese American Internment Executive Order 9066 → forced relocation/internment D-Day — 1944 Allied invasion of Europe. Manhattan Project Developed atomic bomb. Hiroshima & Nagasaki Atomic bombs used against Japan. Japan surrenders → 1945 ⸻ PERIOD 8: 1945–1980 — Cold War & Civil Rights Cold War U.S. vs. USSR Capitalism vs. Communism Truman Doctrine Contain communism. Marshall Plan Economic aid to rebuild Europe. NATO Western military alliance. Korean War U.S. supports South Korea against communist North Korea. ⸻ Civil Rights Movement Brown v. Board — 1954 School segregation unconstitutional. Rosa Parks Montgomery Bus Boycott Martin Luther King Jr. * Nonviolent protest * Civil rights Civil Rights Act — 1964 Banned segregation/discrimination in many public settings. Voting Rights Act — 1965 Protected voting rights. Malcolm X Initially promoted Black nationalism/self-defense; later shifted views toward broader cooperation. ⸻ Vietnam War Domino Theory If one country becomes communist, nearby countries may follow. Gulf of Tonkin Resolution Expanded presidential power in Vietnam. Vietnamization Nixon’s policy of reducing U.S. troops while South Vietnam took more responsibility. Effects * Antiwar movement * Distrust of government * War Powers Act ⸻ PERIOD 9: 1980–Present Reagan Reaganomics Tax cuts + deregulation + reduced government spending Conservative Movement * Lower taxes * Smaller government * Anti-communism * Traditional social values Cold War Ends 1989 → Berlin Wall falls 1991 → USSR collapses ⸻ ⭐ MUST-KNOW APUSH THEMES 1. Federal Power Articles → weak government ↓ Constitution → stronger government ↓ Civil War → massive federal expansion ↓ New Deal → federal government expands economically ↓ Great Society → federal government expands social programs ⸻ 2. Race Colonial slavery ↓ Expansion of slavery ↓ Civil War ↓ 13th/14th/15th Amendments ↓ Jim Crow ↓ Civil Rights Movement ↓ Civil Rights Act + Voting Rights Act ⸻ 3. Expansion Louisiana Purchase ↓ Manifest Destiny ↓ Mexican-American War ↓ Westward expansion ↓ Imperialism ↓ Overseas influence ⸻ 4. Economy Agricultural colonies ↓ Market Revolution ↓ Industrial Revolution ↓ Gilded Age corporations ↓ Great Depression ↓ New Deal ↓ Modern consumer economy ⸻ 🔥 20 EVENTS YOU ABSOLUTELY NEED TO KNOW Date Event 1492 Columbus 1607 Jamestown 1620 Plymouth 1754–63 French & Indian War 1776 Declaration of Independence 1781 Articles/ Yorktown 1787 Constitution 1803 Louisiana Purchase 1812 War of 1812 1820 Missouri Compromise 1830 Indian Removal Act 1846–48 Mexican-American War 1854 Kansas-Nebraska Act 1861–65 Civil War 1863 Emancipation Proclamation 1865 13th Amendment 1898 Spanish-American War 1929 Great Depression begins 1941 Pearl Harbor 1954 Brown v. Board 1964 Civil Rights Act 1965 Voting Rights Act 🧠 APUSH Essay Formula For LEQs/DBQs, remember: Claim → Evidence → Explain → Connect Don’t just say what happened. Instead: Evidence: The Kansas-Nebraska Act repealed the Missouri Compromise. Analysis: This increased sectional tensions because it allowed slavery to potentially expand into territories previously closed to it, contributing to the breakdown of political compromise before the Civil War. APUSH loves CAUSATION, CHANGE/CONTINUITY, and COMPARISON. Ask yourself: * Why did this happen? * What did it cause? * What changed? * What stayed the same? * Who benefited? * Who was harmed? * How does this connect to another period
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Cell cycle is a 4-stage process that takes place in a cell as the cell grows and divides. Each complete cell division will result in two daughter cells. The four stages of cell division are Gap 1 ( G₁ phase ), Synthesis (S phase), Gap 2 ( G₂ phase ) and mitosis. Figure 3 Figure 3 - The G₁, S and G₂ phases are also known as interphase. The process of mitosis and cytokinesis are also called M phase. Stages of cell division Mitosis Mitosis is a process where a single cell divides to form two new identical daughter cells. The two daughter cells contain the same number of chromosomes and genetic content as their parent cell. Mitosis can be divided into 4 phases: Prophase Metaphase Anaphase Telophase Figure 4 Figure 4 - 1. During prophase, chromatin condenses and becomes tightly coiled to form chromosome structure. Each chromosome consists of two sister chromatids joined together at the centromere. At the end of prophase, nucleolus disappear and nuclear membrane disintegrates. Figure 5 Figure 5 - 2. Metaphase follows after prophase. Centrioles migrate to the opposite poles of the cell. The mitotic spindle/spindle fibres are fully formed. All the chromosomes are lined up randomly at the metaphase/equatorial plate. Metaphase ends when the centromeres divide. Figure 6 Figure 6 - 3. Anaphase begins when the sister chromatids separate at the centromere. Shortening of the spindle fibres pull the sister chromatids apart to the opposite poles. The separated chromatids are referred to as daughter chromosomes. Anaphase ends when the chromosomes reach the poles of the cell. Figure 7 Figure 7 - 4. Telophase begins when the sets of chromosomes reach the opposite poles of the cell respectively. The chromosomes then start to uncoil to become their original fine chromatin threads again. Nucleoli and nuclear membrane are reformed. Spindle fibres disappear and the process of mitosis is now complete. Cytokinesis follows after the telophase stage. The Differences between Mitosis and Cytokinesis in Animal and Plant Cells In plant cells, the spindle fibres form even though they do not have centrioles. The differences in the cytokinesis process in animal and plant cells can be seen in the figures below. Figure 8 Figure 8 - 1. In animal cells, the microfilaments in the cytoplasm contract pull a ring of plasma membrane inwards. The cytoplasm is constricted in the middle of the cell between two nuclei. Figure 9 Figure 9 - 2. The formation of cleavage furrow pinches at the equator of the cell. Figure 10 Figure 10 - 3. The cleavage furrow deepens progressively until the cell separates, forming two daughter cells. Figure 11 Figure 11 - 1. In plant cells, membrane-enclosed vesicles form and gather at the equator of the cell. Figure 12 Figure 12. - 2. The vesicles join together to form a cell plate. Figure 13 Figure 13 - 3. The cell plate divides the cell into two daughter cells. Cellulose produced by the cell strengthens the newly formed cell wall. The Necessity of Mitosis Controlled mitosis is important because the genetic information carried by the chromosomes is necessary for proper functioning of an organism. Mitosis is important in cell repair and regeneration. Here are some examples where mitosis plays an important role: Lizards grow new tail if their tails break Starfish replaces lost arms by mitosis Liver cells divide to replace damaged and injured tissues Stem cells culture to produce meats Animal cloning (Dolly, the sheep)
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bio Genetics is the study of heredity and how traits are passed from parents to offspring. Gregor Mendel is known as the “Father of Genetics.” Why did Mendel use pea plants? * Easy to grow * Short generation time * Many visible traits * Can self-pollinate or cross-pollinate * Produce many offspring Examples of traits studied: * Flower colour * Seed shape * Plant height ⸻ VOCABULARY Gene * A segment of DNA that controls a trait. Allele * Different forms of the same gene. Example: P = purple flowers p = white flowers Dominant Allele * Expressed whenever it is present. * Represented by a capital letter. Example: P = purple Recessive Allele * Only expressed when two copies are present. * Represented by a lowercase letter. Example: p = white Genotype * Genetic makeup of an organism. Examples: PP Pp pp Phenotype * Physical appearance of an organism. Examples: Purple flower White flower Homozygous * Two identical alleles. Examples: PP pp Heterozygous * Two different alleles. Example: Pp Pure Breeding * Homozygous for a trait. Gamete * Sex cell (sperm or egg). ⸻ MENDEL’S LAWS Law of Dominance * A dominant allele masks a recessive allele. Example: Pp = Purple flower Law of Segregation * Alleles separate during gamete formation. * Each gamete receives only one allele. Example: Parent = Pp Gametes: P p Law of Independent Assortment * Different genes assort independently during meiosis. ⸻ MONOHYBRID CROSSES A monohybrid cross studies one trait. Example: P = Purple p = White Cross: Pp × Pp Punnett Square INCOMPLETE DOMINANCE Neither allele completely dominates. Example: Snapdragons RR = Red WW = White RW = Pink Cross: RW × RW Genotype Ratio: 1 RR : 2 RW : 1 WW Phenotype Ratio: 1 Red : 2 Pink : 1 White CODOMINANCE Both alleles are expressed equally. Example: AB Blood Type Genotype: IAIB Phenotype: AB MULTIPLE ALLELES More than two alleles exist in a population. Example: ABO Blood Group Alleles: IA IB i BLOOD TYPES Type A Genotypes: IAIA or IAi Type B Genotypes: IBIB or IBi Type AB Genotype: IAIB Type O Genotype: ii Can Type A and Type B Parents Have a Type O Child? Yes. If: Father = IAi Mother = IBi Possible Blood Types: AB A B O CELL CYCLE Purpose: * Growth * Repair * Replacement of cells Stages: G1 S G2 Mitosis Cytokinesis INTERPHASE G1 Phase Cell grows and carries out normal functions. S Phase DNA replication occurs. G2 Phase Cell prepares for division. MITOSIS Purpose: Growth and repair. Produces: 2 genetically identical diploid cells. PROPHASE Events: * Chromosomes condense * Nuclear membrane disappears * Nucleolus disappears * Spindle fibres form METAPHASE Events: * Chromosomes line up at the equator ANAPHASE Events: * Sister chromatids separate TELOPHASE Events: * Nuclear membranes reform * Chromosomes uncoil CYTOKINESIS Division of the cytoplasm. Animal Cells: Cleavage furrow forms. Plant Cells: Cell plate forms. CHROMOSOME STRUCTURE Chromosome consists of: * Two sister chromatids * One centromere DIPLOID VS HAPLOID Diploid (2n) * Two sets of chromosomes * Human body cells * 46 chromosomes Haploid (n) * One set of chromosomes * Human gametes * 23 chromosomes HOMOLOGOUS CHROMOSOMES Chromosome pairs that: * Carry the same genes * One comes from the mother * One comes from the father Humans have 23 homologous pairs. MEIOSIS Purpose: Produce gametes. Produces: 4 genetically unique haploid cells. MEIOSIS I Separates homologous chromosomes. CROSSING OVER Occurs during Prophase I. Definition: Exchange of DNA between homologous chromosomes. Importance: Creates genetic variation. RANDOM ASSORTMENT Occurs during Metaphase I. Definition: Homologous pairs line up randomly. Importance: Creates unique chromosome combinations. MEIOSIS II Separates sister chromatids. MITOSIS VS MEIOSIS Mitosis * 2 cells produced * Diploid * Genetically identical * Growth and repair Meiosis * 4 cells produced * Haploid * Genetically different * Produces gametes NONDISJUNCTION Failure of chromosomes to separate properly during meiosis. Can result in extra or missing chromosomes. DOWN SYNDROME Cause: Extra chromosome 21. Chromosome Number: 47 Usually caused by nondisjunction during meiosis. DNA DNA = Deoxyribonucleic Acid Shape: Double Helix Function: Stores genetic information. NUCLEOTIDE Three Components: * Phosphate Group * Deoxyribose Sugar * Nitrogenous Base NITROGENOUS BASES Adenine (A) Thymine (T) Cytosine (C) Guanine (G) COMPLEMENTARY BASE PAIRING A pairs with T C pairs with G DNA REPLICATION Purpose: Make identical copies of DNA. Location: Nucleus Result: Two identical DNA molecules. TRANSCRIPTION Purpose: Create mRNA from DNA. Location: Nucleus DNA → mRNA Remember: RNA uses Uracil (U) instead of Thymine (T). TRANSLATION Purpose: Make proteins. Location: Ribosome mRNA is read and amino acids are joined together to form a protein. MUTATIONS A mutation is a change in DNA sequence. Types: * Deletion * Duplication * Inversion * Translocation DELETION DNA segment removed. DUPLICATION DNA segment repeated. INVERSION DNA segment reversed. TRANSLOCATION DNA segment moves to another chromosome. SEX-LINKED TRAITS Traits located on sex chromosomes. Most are located on the X chromosome. RED-GREEN COLOUR BLINDNESS Inheritance: X-linked recessive. XC = Normal Vision Xc = Colour Blind Male: XcY Colour blind boys inherit the allele from their mother because fathers pass a Y chromosome to their sons. TAY-SACHS DISEASE Cause: Missing enzyme that breaks down lipids in nerve cells. Inheritance: Autosomal recessive. Treatment: No cure currently available. SICKLE CELL ANEMIA Cause: Mutation in hemoglobin gene. Effects: * Sickle-shaped red blood cells * Reduced oxygen transport * Blocked blood vessels Inheritance: Autosomal recessive. HUNTINGTON’S DISEASE Cause: Dominant mutation. Effects: * Nervous system degeneration * Loss of motor control * Cognitive decline Inheritance: Autosomal dominant. KARYOTYPE A photograph of chromosomes arranged in pairs. Used to: * Determine sex * Detect chromosome abnormalities * Diagnose genetic disorders PEDIGREE A family tree used to track inheritance patterns. Symbols: Square = Male Circle = Female Shaded = Has trait CLONING Producing genetically identical organisms. Uses: * Research * Agriculture * Medicine * Conservation GENETIC COUNSELLING Provides information about: * Inherited disorders * Family risk * Testing options AMNIOCENTESIS Prenatal test in which amniotic fluid is sampled and fetal cells are analyzed. Can detect: * Genetic disorders * Chromosomal disorders GMOs Genetically Modified Organisms. Definition: Organisms whose DNA has been altered through biotechnology. Advantages: * Increased crop yield * Disease resistance * Pest resistance Disadvantages: * Ethical concerns * Environmental concerns DNA REPLICATION → TRANSCRIPTION → TRANSLATION DNA (Nucleus) ↓ Replication DNA Copy DNA ↓ Transcription mRNA mRNA ↓ Translation Protein Final Product: Protein RESPIRATORY SYSTEM Function: * Brings oxygen into the body * Removes carbon dioxide * Works with the circulatory system to supply cells with oxygen Why do organisms require oxygen and produce carbon dioxide? Oxygen is required for cellular respiration. Cellular Respiration: Glucose + Oxygen → Energy (ATP) + Carbon Dioxide + Water Cells use oxygen to release energy from food. Carbon dioxide is produced as a waste product and must be removed. ⸻ PATHWAY OF AIR Nasal Cavity ↓ Pharynx ↓ Larynx ↓ Trachea ↓ Bronchi ↓ Bronchioles ↓ Alveoli ⸻ NASAL CAVITY Functions: * Warms air * Moistens air * Filters air Nasal Hairs: * Trap large particles Mucus: * Traps dust and microorganisms Blood Capillaries: * Warm incoming air ⸻ PHARYNX Common passageway for: * Air * Food Also called the throat. ⸻ UVULA Functions: * Prevents food from entering nasal cavity * Helps with speech ⸻ EPIGLOTTIS Functions: * Covers trachea during swallowing * Prevents choking ⸻ LARYNX Also called the voice box. Contains vocal cords. ⸻ TRACHEA Also called the windpipe. Contains cartilage rings that prevent collapse. Lined with: * Cilia * Mucus ⸻ CILIA Tiny hair-like structures. Function: * Sweep mucus upward toward throat ⸻ BRONCHI Two branches of the trachea leading to lungs. Right Bronchus → Right Lung Left Bronchus → Left Lung ⸻ BRONCHIOLES Smaller branches inside lungs. Lead to alveoli. ⸻ ALVEOLI Tiny air sacs. Site of gas exchange. Adaptations: * Thin walls * Moist surface * Large surface area * Rich blood supply Gas Exchange: Oxygen moves: Alveoli → Blood Carbon Dioxide moves: Blood → Alveoli By diffusion. ⸻ BREATHING MECHANICS Two main muscles: 1. Diaphragm 2. Intercostal Muscles ⸻ INHALATION (INSPIRATION) Diaphragm: * Contracts * Moves downward Intercostal Muscles: * Contract * Lift ribs upward Result: * Chest cavity volume increases * Pressure decreases * Air enters lungs ⸻ EXHALATION (EXPIRATION) Diaphragm: * Relaxes * Moves upward Intercostal Muscles: * Relax Result: * Chest cavity volume decreases * Pressure increases * Air leaves lungs ⸻ MEDULLA OBLONGATA Located in the brainstem. Function: * Controls breathing rate Responds to: * Carbon dioxide levels More CO₂: * Faster breathing Less CO₂: * Slower breathing ⸻ LUNG VOLUMES Tidal Volume * Normal amount of air breathed in and out Inspiratory Reserve Volume * Extra air inhaled after normal breath Expiratory Reserve Volume * Extra air exhaled after normal breath Residual Volume * Air remaining in lungs after maximum exhalation Vital Capacity * Maximum amount of air exhaled after deepest breath Total Lung Capacity * Total amount of air lungs can hold ⸻ CIRCULATORY SYSTEM Functions: * Transport oxygen * Transport nutrients * Remove wastes * Maintain homeostasis * Transport hormones Humans have a CLOSED circulatory system. Blood remains inside vessels. ⸻ BLOOD VESSELS ARTERIES Function: * Carry blood away from heart Characteristics: * Thick walls * High pressure * Small lumen * No valves Usually oxygen-rich Exception: Pulmonary artery ⸻ VEINS Function: * Carry blood toward heart Characteristics: * Thin walls * Low pressure * Large lumen * Valves present Usually oxygen-poor Exception: Pulmonary vein ⸻ CAPILLARIES Smallest blood vessels. Functions: * Gas exchange * Nutrient exchange * Waste exchange Walls are one cell thick. ⸻ HEART STRUCTURE Blood Flow: Body ↓ Vena Cava ↓ Right Atrium ↓ Right Ventricle ↓ Pulmonary Artery ↓ Lungs ↓ Pulmonary Vein ↓ Left Atrium ↓ Left Ventricle ↓ Aorta ↓ Body ⸻ HEART CHAMBERS Right Atrium * Receives deoxygenated blood Right Ventricle * Pumps blood to lungs Left Atrium * Receives oxygenated blood Left Ventricle * Pumps blood to body ⸻ SEPTUM Wall separating left and right sides of heart. Prevents mixing of blood. ⸻ HEART VALVES Function: * Prevent backflow of blood Types: Atrioventricular (AV) Valves Pulmonary Semilunar Valve Aortic Semilunar Valve ⸻ SA NODE Sinoatrial Node Known as: * Natural pacemaker Initiates heartbeat. ⸻ AV NODE Atrioventricular Node Receives signal from SA node. Delays impulse slightly. Allows ventricles to fill before contraction. ⸻ BLOOD Components: 1. Plasma 2. Red Blood Cells 3. White Blood Cells 4. Platelets ⸻ PLASMA Liquid component of blood. Functions: * Transport nutrients * Transport hormones * Transport wastes ⸻ RED BLOOD CELLS (ERYTHROCYTES) Function: * Carry oxygen Contain: * Hemoglobin ⸻ HEMOGLOBIN Protein in red blood cells. Function: * Binds oxygen Allows oxygen transport. ⸻ WHITE BLOOD CELLS (LEUKOCYTES) Function: * Fight infection * Defend body Part of immune system. ⸻ PLATELETS Function: * Blood clotting Prevent blood loss. ⸻ BLOOD PRESSURE Force of blood against artery walls. Measured using: Sphygmomanometer Example: 120/80 120 = Systolic Pressure 80 = Diastolic Pressure ⸻ SYSTOLIC PRESSURE Pressure when heart contracts. ⸻ DIASTOLIC PRESSURE Pressure when heart relaxes. ⸻ HYPERTENSION High blood pressure. Can increase risk of: * Stroke * Heart attack * Kidney disease ⸻ STROKE VOLUME Amount of blood pumped per heartbeat. ⸻ CARDIAC OUTPUT Amount of blood pumped per minute. Formula: Cardiac Output = Heart Rate × Stroke Volume ⸻ ECG Electrocardiogram Measures electrical activity of heart. Used to detect: * Irregular heartbeat * Heart damage ⸻ PULMONARY CIRCULATION Heart → Lungs → Heart Purpose: * Oxygenate blood ⸻ SYSTEMIC CIRCULATION Heart → Body → Heart Purpose: * Deliver oxygen to tissues ⸻ HOMEOSTASIS DURING EXERCISE Body responds by: * Increasing heart rate * Increasing breathing rate * Increasing cardiac output * Redirecting blood to muscles * Sweating to cool body Purpose: Maintain stable internal conditions. ⸻ DIGESTIVE SYSTEM Functions: * Break down food * Absorb nutrients * Eliminate waste ⸻ DIGESTIVE TRACT Mouth ↓ Pharynx ↓ Esophagus ↓ Stomach ↓ Small Intestine ↓ Large Intestine ↓ Rectum ↓ Anus ⸻ MECHANICAL DIGESTION Physical breakdown of food. Examples: * Chewing * Churning ⸻ CHEMICAL DIGESTION Chemical breakdown of food using enzymes. Examples: * Amylase * Pepsin ⸻ SALIVA Functions: 1. Moistens food 2. Contains amylase Amylase begins carbohydrate digestion. ⸻ TONGUE Functions: 1. Forms bolus 2. Pushes food for swallowing ⸻ ESOPHAGUS Moves food to stomach. Uses: Peristalsis ⸻ PERISTALSIS Wave-like muscular contractions. Move food through digestive tract. ⸻ STOMACH Functions: * Stores food * Mixes food * Begins protein digestion Produces: * HCl * Pepsin * Mucus ⸻ HCl Hydrochloric Acid Functions: * Kills bacteria * Activates pepsin ⸻ PEPSIN Function: * Digests proteins ⸻ MUCUS Function: * Protects stomach lining ⸻ CHYME Semi-liquid food mixture leaving stomach. ⸻ HEARTBURN Cause: Stomach acid enters esophagus. Usually caused by weakened cardiac sphincter. ⸻ SMALL INTESTINE Main site of: * Digestion * Absorption Adaptations: * Long length * Folds * Villi * Microvilli Large surface area increases absorption. ⸻ DUODENUM First section. Functions: * Receives bile * Receives pancreatic enzymes * Most chemical digestion ⸻ JEJUNUM Main nutrient absorption. ⸻ ILEUM Final nutrient absorption. ⸻ VILLI Finger-like projections. Function: Increase surface area. ⸻ LIVER Functions: * Produces bile * Processes nutrients * Detoxifies blood ⸻ GALL BLADDER Functions: * Stores bile * Releases bile into small intestine ⸻ PANCREAS Functions: * Produces digestive enzymes * Produces bicarbonate ⸻ BILE Function: Emulsifies fats. Breaks large fat droplets into smaller droplets. Makes fat digestion easier. ⸻ DIGESTION OF CARBOHYDRATES Mouth: * Amylase begins digestion Small Intestine: * Pancreatic amylase continues digestion End Product: Glucose ⸻ DIGESTION OF PROTEINS Stomach: * Pepsin begins digestion Small Intestine: * Trypsin continues digestion End Product: Amino Acids ⸻ DIGESTION OF LIPIDS Small Intestine: * Bile emulsifies fats * Lipase digests fats End Product: Fatty Acids + Glycerol ⸻ EVOLUTION Evolution: Change in populations over time. Individuals do NOT evolve. Populations evolve. ⸻ DARWIN Proposed: Natural Selection Book: On the Origin of Species ⸻ WALLACE Independently developed theory of natural selection. ⸻ LAMARCK Proposed: Inheritance of acquired characteristics Example: Giraffes stretch necks and pass longer necks to offspring. This theory is incorrect. ⸻ NATURAL SELECTION Requirements: 1. Variation 2. Overproduction 3. Competition 4. Differential Survival 5. Reproduction Result: Adaptation ⸻ ADAPTATION Inherited characteristic that increases survival and reproduction. ⸻ SELECTIVE ADVANTAGE A characteristic that improves survival or reproduction. Example: Antibiotic resistance ⸻ SELECTIVE PRESSURE Environmental factor that influences survival. Examples: * Predators * Disease * Climate * Competition ⸻ VARIATION Differences among individuals in a population. Sources: * Mutation * Crossing Over * Random Assortment ⸻ MUTATION Ultimate source of new alleles. Creates genetic variation. ⸻ FOSSIL Preserved remains or traces of organisms. ⸻ FOSSIL RECORD Collection of fossils showing evolutionary history. Provides evidence for evolution. ⸻ RADIOACTIVE DATING Uses radioactive isotopes to determine fossil age. ⸻ UNIFORMITARIANISM Proposed by Lyell. Earth changes gradually over long periods of time. ⸻ CATASTROPHISM Proposed by Cuvier. Earth shaped by sudden catastrophic events. ⸻ BIOGEOGRAPHY Study of species distribution around Earth. Provides evidence for evolution. ⸻ EMBRYOLOGY Study of embryos. Similar embryos suggest common ancestry. ⸻ HOMOLOGOUS STRUCTURES Same evolutionary origin. Different functions. Example: Human arm Whale flipper Bat wing Evidence of common ancestry. ⸻ ANALOGOUS STRUCTURES Different origins. Same function. Example: Bird wing Insect wing Not evidence of close ancestry. ⸻ VESTIGIAL STRUCTURES Structures with little or no function. Examples: * Human appendix * Whale pelvis Evidence of evolution. ⸻ MIMICRY One species resembles another. Example: Syrphid fly resembles wasp. Provides protection. ⸻ ARTIFICIAL SELECTION Humans select traits. Examples: * Dog breeding * Crop breeding ⸻ DIRECTIONAL SELECTION One extreme phenotype favored. Graph shifts in one direction. ⸻ STABILIZING SELECTION Average phenotype favored. Extremes selected against. ⸻ DISRUPTIVE SELECTION Both extremes favored. Middle selected against. ⸻ GENETIC DRIFT Random change in allele frequencies. Most significant in small populations. ⸻ FOUNDER EFFECT Small group starts new population. Different allele frequencies from original population. ⸻ BOTTLENECK EFFECT Population drastically reduced. Loss of genetic variation. ⸻ GENE FLOW Movement of alleles between populations. Occurs through migration. ⸻ NON-RANDOM MATING Individuals choose specific mates. Can reduce variation. ⸻ SPECIES A group of organisms that can interbreed in nature and produce fertile offspring. ⸻ SPECIATION Formation of new species. ⸻ ALLOPATRIC SPECIATION Requires: Geographic isolation Example: Mountain separates populations. ⸻ SYMPATRIC SPECIATION Occurs without geographic isolation. ⸻ PRE-ZYGOTIC ISOLATION Prevents fertilization. Examples: * Different mating seasons * Different mating songs * Different habitats ⸻ POST-ZYGOTIC ISOLATION Occurs after fertilization. Example: Sterile hybrids Example: Mule DIVERSITY Prokaryotes vs Eukaryotes PROKARYOTES * No nucleus * No membrane-bound organelles * Circular DNA * Smaller * Examples: Eubacteria, Archaebacteria EUKARYOTES * Nucleus present * Membrane-bound organelles * Linear chromosomes * Larger * Examples: Protists, Fungi, Plants, Animals Three Differences: 1. Nucleus vs no nucleus 2. Organelles vs no organelles 3. Larger vs smaller ⸻ Taxonomy Kingdom Phylum Class Order Family Genus Species Mnemonic: King Philip Came Over For Good Soup ⸻ Binomial Nomenclature Genus + Species Example: Homo sapiens Rules: * Genus capitalized * Species lowercase * Italicized Purpose: * Universal naming system * Avoids confusion * Shows relationships ⸻ Dichotomous Key Used to identify organisms using paired choices. Example: 1a Has wings → Step 2 1b No wings → Step 3 ⸻ Six Kingdoms 1. Archaebacteria 2. Eubacteria 3. Protista 4. Fungi 5. Plantae 6. Animalia ⸻ VIRUSES Virus Structure: * DNA or RNA * Capsid * Attachment proteins * Sometimes envelope Why Viruses Are Not Living: * Not made of cells * Cannot reproduce independently * No metabolism * Need host cell ⸻ DNA Virus vs RNA Virus DNA Virus: * Contains DNA * More stable RNA Virus: * Contains RNA * Mutates faster ⸻ Lytic Cycle Attachment ↓ Penetration ↓ Replication ↓ Assembly ↓ Lysis Host cell bursts. ⸻ Lysogenic Cycle Attachment ↓ Penetration ↓ Integration into host DNA ↓ Host reproduces ↓ Virus DNA copied Cell survives initially. ⸻ ARCHAEBACTERIA Characteristics: * Prokaryotic * Unicellular * Extreme environments Three Groups: Methanogens * Produce methane Halophiles * Salt-loving Thermoacidophiles * Hot acidic environments ⸻ EUBACTERIA Characteristics: * Prokaryotic * Peptidoglycan cell wall * Binary fission Examples: * E. coli * Streptococcus ⸻ Binary Fission DNA Replication ↓ Cell Growth ↓ Cell Division ↓ Two Identical Cells ⸻ Conjugation DNA transfer through pilus. Importance: * Genetic variation * Antibiotic resistance ⸻ Antibiotic Resistance Mutation ↓ Antibiotic kills susceptible bacteria ↓ Resistant bacteria survive ↓ Resistant bacteria reproduce Natural Selection ⸻ PROTISTS Characteristics: * Eukaryotic * Mostly unicellular * Aquatic Three Groups: Animal-like * Amoeba * Paramecium Plant-like * Algae * Euglena Fungus-like * Slime molds ⸻ Amoeba * Uses pseudopods * Phagocytosis ⸻ Algae * Photosynthetic * Oxygen producer ⸻ Euglena * Chloroplasts * Flagellum * Photosynthesis * Can also feed heterotrophically ⸻ Malaria Cause: Plasmodium Kingdom: Protista ⸻ FUNGI Characteristics: * Eukaryotic * Heterotrophic * Chitin cell walls * Reproduce with spores Examples: * Mushrooms * Mold * Yeast ⸻ External Digestion Release enzymes ↓ Digest food outside body ↓ Absorb nutrients ⸻ Fungi vs Plants FUNGI * Heterotrophic * Chitin * No chloroplasts PLANTS * Autotrophic * Cellulose * Chloroplasts ⸻ PLANTS Biodiversity vs Monoculture BIODIVERSITY * Many species * Stable ecosystem * Disease resistance MONOCULTURE * One crop species * Low diversity * Disease risk ⸻ Bryophytes Definition: Nonvascular plants Examples: * Mosses * Liverworts Characteristics: * No xylem * No phloem * Need water for reproduction ⸻ Vascular Plants Contain: * Xylem * Phloem ⸻ Xylem Function: Water and minerals Direction: Roots → Leaves ⸻ Phloem Function: Sugars Direction: Throughout plant ⸻ Alternation of Generations Sporophyte (2n) ↓ meiosis Spores (n) ↓ Gametophyte (n) ↓ Gametes ↓ fertilization Zygote (2n) ↓ Sporophyte ⸻ Moss Life Cycle Spores ↓ Gametophyte ↓ Egg + Sperm ↓ Zygote ↓ Sporophyte ↓ Capsule ↓ Spores Know: * Capsule * Sporophyte * Gametophyte * Spores ⸻ Fern Life Cycle Fern ↓ Sori ↓ Spores ↓ Prothallus ↓ Gametes ↓ Fertilization ↓ Young Fern Know: * Frond * Sori * Sporangia * Prothallus ⸻ Gymnosperms Characteristics: * Naked seeds * Cones * Wind pollination * Evergreen Examples: * Pine * Spruce * Fir ⸻ Angiosperms Characteristics: * Flowers * Fruit * Seeds enclosed Examples: * Apple tree * Rose * Maple ⸻ Flower Structure Anther * Produces pollen Pollen Grain * Male gamete Stigma * Receives pollen Style * Connects stigma and ovary Ovary * Contains ovules Ovule * Female gamete Petals * Attract pollinators ⸻ Plant Tissues Meristematic * Growth Dermal * Protection Ground * Photosynthesis * Storage Vascular * Transport ⸻ Leaf Structure Blade * Main leaf surface Petiole * Connects leaf to stem Cuticle * Reduces water loss Palisade Mesophyll * Photosynthesis Spongy Mesophyll * Gas exchange Veins * Xylem + Phloem ⸻ Stomata Openings in leaves. Functions: * Gas exchange * Water loss ⸻ Guard Cells Control opening and closing of stomata. ⸻ Transpiration Water loss from leaves. Functions: * Pulls water upward * Cools plant * Moves minerals ⸻ Simple vs Compound Leaves Simple: * One blade Compound: * Multiple leaflets ⸻ Monocots vs Dicots MONOCOTS * 1 cotyledon * Parallel veins * Fibrous roots * Flower parts in 3s Examples: Corn Grass DICOTS * 2 cotyledons * Net veins * Taproot * Flower parts in 4s or 5s Examples: Bean Maple ⸻ Seeds Contain: * Embryo * Stored food * Seed coat Functions: * Protection * Survival * Dispersal ⸻ Seed Dispersal Wind * Dandelion Water * Coconut Animals * Burrs Explosive * Touch-me-not ⸻ Fruit vs Vegetable Fruit: * Comes from ovary * Contains seeds Examples: Tomato Apple Pepper Vegetable: * Root, stem, leaf, or flower Examples: Carrot Celery Broccoli ⸻ Factors Affecting Plant Growth 1. Light 2. Water 3. Carbon dioxide 4. Temperature 5. Soil nutrients 6. Oxygen 7. Soil pH 8. Space 9. Pollinators 10. 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