Biology Study Guide Complete review of your notes • Vocabulary + concepts to know • No tables This guide covers the vocabulary, nitrogen cycle, phosphorus cycle, water cycle, energy transfer, food chains, organisms, and ecological processes from all your notes. I combined repeated information and clarified a few definitions to help you prepare for tomorrow’s test. Part 1: Vocabulary 1. Ecology and ecosystem organization Ecology — The study of interactions between organisms and their environment. Biosphere — All parts of Earth where life exists. Population — Members of the same species living in the same area. Community — Different populations living and interacting in the same area. Ecosystem — A community of organisms and the nonliving environment they interact with. Biomass — The total mass of living organisms in a particular area or trophic level. Trophic level — An organism’s feeding position in a food chain. 2. Types of organisms Autotroph — An organism that makes its own food using light energy or chemical energy. * Examples: plants, algae and some bacteria. * Autotrophs are also called producers. Heterotroph — An organism that obtains energy and nutrients by consuming or absorbing organic matter from other organisms. - Examples: animals and fungi. Producer — An organism that makes its own organic food. Consumer — An organism that obtains energy by eating other organisms. Herbivore — An organism that eats plants or other producers. Examples: deer, cows and caterpillars. Carnivore — An organism that eats other animals. Examples: lions, hawks and sharks. Omnivore — An organism that eats both plants and animals. Examples: humans, bears and crows. Scavenger — An organism that feeds on dead animals. Example: a vulture. Detritivore — A heterotroph that obtains nutrients by ingesting detritus. Detritus — Dead and decomposing plant and animal material, including organic waste. Decomposer — An organism that breaks down organic matter externally using enzymes and absorbs the released nutrients. - Examples: fungi, mushrooms and bacteria. Phytoplankton — Tiny photosynthetic organisms, including algae, that drift in aquatic environments and form the base of many aquatic food webs. 3. Food and energy vocabulary Food chain — A single pathway showing how energy passes from one organism to another. Food web — A network of interconnected food chains showing feeding relationships in an ecosystem. Energy transfer — The movement of energy from one organism to another. Photosynthesis — The process that uses light energy to make sugars from carbon dioxide and water. Cellular respiration — The process of breaking down molecules such as glucose to release usable energy. Chemosynthesis — The process of using energy from chemical reactions to make organic molecules. 4. Nitrogen cycle vocabulary Nitrogen fixation — The conversion of atmospheric nitrogen gas into usable nitrogen compounds. Assimilation — The process in which plants absorb nitrogen compounds and use the nitrogen to build organic molecules. Consumption — Animals obtain nitrogen and other nutrients by eating plants or other animals. Ammonification — Decomposers convert nitrogen in organic matter into ammonia or ammonium. Nitrification — Bacteria convert ammonium into nitrite and then nitrate. Denitrification — Bacteria convert nitrate into nitrogen gas, returning nitrogen to the atmosphere. Ammonia — A nitrogen-containing compound with the formula . Ammonium — A positively charged nitrogen ion with the formula . Nitrite — A nitrogen-containing ion with the formula . Nitrate — A nitrogen-containing ion with the formula , which plants can absorb. 5. Water cycle vocabulary Evaporation — Liquid water absorbs energy and changes into water vapor. Condensation — Water vapor cools and changes into liquid droplets. Transpiration — The release of water vapor from plants, mainly through their leaves. Precipitation — Water falling from clouds as rain, snow, sleet or hail. 6. Nutrients and other vocabulary Phosphorus — An essential nutrient used to build DNA, RNA, ATP and cell membranes. It also supports plant growth and root development. Limiting nutrient — A nutrient whose limited availability restricts the growth of organisms. Eutrophication — The process in which excess nutrients enter a body of water, promoting excessive algae growth and potentially reducing dissolved oxygen. Amino acids — The building blocks of proteins. Proteins — Molecules made of amino acids that perform many functions in living organisms. Nucleic acids — Molecules such as DNA and RNA that store and transmit genetic information. External digestion — The breakdown of food outside an organism’s cells or body using enzymes, as fungi do. Decomposition — The breakdown of dead organic matter and waste, returning nutrients to the environment. Part 2: Things You Need to Know 1. The nitrogen cycle The nitrogen cycle describes how nitrogen moves between the atmosphere, soil, water and living organisms. Nitrogen is essential for making proteins, amino acids and nucleic acids such as DNA and RNA. Although the atmosphere contains a lot of nitrogen gas, most plants cannot use atmospheric nitrogen gas directly. The main processes 1. Nitrogen fixation Atmospheric nitrogen gas () is converted into usable nitrogen compounds. * Mainly carried out by nitrogen-fixing bacteria. * Lightning also helps convert atmospheric nitrogen into compounds that enter the soil. 2. Assimilation Plants absorb nitrate () or ammonium () from the soil and use the nitrogen to make proteins and nucleic acids. 3. Consumption Animals obtain nitrogen by eating plants or other animals. 4. Ammonification Decomposers break down nitrogen-containing material in dead organisms and waste, releasing ammonia or ammonium into the environment. 5. Nitrification Bacteria convert ammonium into nitrite and then nitrate. NH_4^+ \rightarrow NO_2^- \rightarrow NO_3^- 6. Denitrification Bacteria convert nitrate into nitrogen gas, returning nitrogen to the atmosphere. Important things to remember * Nitrogen fixation starts with atmospheric nitrogen gas, . * Nitrogen fixation is carried out mainly by bacteria, but lightning also contributes. * Plants need nitrogen to build proteins and nucleic acids. * Animals obtain nitrogen through food. * Decomposers recycle nitrogen from dead organisms and waste. * Nitrification produces nitrite and then nitrate. * Denitrification returns nitrogen to the atmosphere. The nitrogen cycle is a cycle, so nitrogen can enter through several pathways. The processes do not always occur in one simple sequence. 2. Nitrogen formulas to memorize * = nitrogen gas * = ammonia * = ammonium * = nitrite * = nitrate Pay special attention to the difference between ammonia, ammonium, nitrite and nitrate. 3. The phosphorus cycle Phosphorus is an essential nutrient that organisms need to survive. How it moves through the environment * Weathering breaks down rocks and releases phosphorus into soil and water. * Plants absorb phosphorus through their roots. * Animals obtain phosphorus by eating plants or other animals. * Waste and dead organisms are broken down by decomposers. * Phosphorus returns to soil and water, where it can be used again. Why phosphorus matters * It is needed to build DNA and RNA. * It is part of ATP, which cells use to transfer energy. * It is a component of cell membranes. * It helps plants grow and develop strong roots. * It is often a limiting nutrient in soils and aquatic ecosystems. Important difference: Unlike the nitrogen cycle, the phosphorus cycle does not have a major atmospheric gas phase. 4. Eutrophication Eutrophication happens when too many nutrients enter a body of water. This can occur when fertilizers or sewage enter lakes and rivers. Know the steps: * Excess nutrients enter the water. * Algae grow rapidly, creating an algal bloom. * Algae die and decomposers break down the dead material. * Decomposers use dissolved oxygen during decomposition. * Oxygen levels decrease, which can harm or kill fish and other aquatic organisms. Remember that the problem is not simply that algae grow. The decomposition of dead algae can use up the oxygen aquatic organisms need. 5. The water cycle The water cycle describes how water moves between Earth’s surface and the atmosphere. The four main processes * Evaporation: Liquid water absorbs heat and becomes water vapor. * Condensation: Water vapor cools and forms liquid droplets, helping create clouds. * Precipitation: Water falls from clouds as rain, snow, sleet or hail. * Transpiration: Plants release water vapor through their leaves. Water also collects in rivers, lakes and oceans, while some infiltrates the soil and becomes groundwater. Make sure you can explain the difference between evaporation and condensation: * Evaporation: liquid to gas. * Condensation: gas to liquid. 6. Photosynthesis, respiration and chemosynthesis Photosynthesis * Uses light energy to produce sugars. * Takes in carbon dioxide and water. * Releases oxygen in typical plant photosynthesis. * Stores energy in chemical bonds. Cellular respiration * Breaks down glucose and other molecules to release usable energy. * Happens in plants, animals and many other organisms. * Most of the energy organisms obtain is eventually released as heat. Chemosynthesis * Uses energy from chemical reactions instead of sunlight. * Allows certain organisms, such as some bacteria, to produce organic molecules. How they differ Photosynthesis uses light energy, cellular respiration releases usable energy from molecules, and chemosynthesis uses chemical energy to make organic molecules. 7. Carbon and energy in ecosystems Your notes include these important ideas about carbon and energy. * Carbon enters the atmosphere through processes such as respiration, decomposition and the burning of fossil fuels. * Vehicles release carbon dioxide when they burn gasoline or other fossil fuels. * Plants remove carbon dioxide from the atmosphere during photosynthesis. * Energy moves through food chains and food webs. * Most energy obtained by organisms is eventually released as heat. * Unlike nutrients, energy does not continuously recycle through an ecosystem; it flows through the ecosystem. 8. Food chains and food webs A food chain shows one pathway of energy transfer, while a food web shows many connected feeding relationships. For example: Grass — Producer Grasshopper — Primary consumer Frog — Secondary consumer Snake — Tertiary consumer Arrows point from the organism being eaten to the organism receiving the energy. Know these facts * Producers make their own food. * Primary consumers eat producers. * Secondary consumers eat primary consumers. * Tertiary consumers eat secondary consumers. * Food webs connect multiple food chains. * Less energy is available at higher trophic levels because energy is used for life processes and much is released as heat. 9. Autotrophs versus heterotrophs Autotrophs: * Make their own organic food. * Use light energy or chemical energy. * Include plants, algae and certain bacteria. Heterotrophs: * Obtain organic food from other organisms or organic matter. * Include animals and fungi. * Depend directly or indirectly on producers for energy. Remember that not every heterotroph eats another living organism. Decomposers, for example, absorb nutrients from dead organic matter. 10. Detritivores, decomposers and scavengers These three types of organisms are easy to confuse. Scavengers eat dead animals. Examples include vultures and some crabs. Detritivores ingest dead organic matter and waste. Examples include earthworms, woodlice and some aquatic organisms. Decomposers break down organic matter externally by releasing enzymes, then absorb the nutrients. Examples include fungi and bacteria. Where they live * Terrestrial means land-based. Examples of detritivores include earthworms and woodlice. * Aquatic means water-based. Some crabs and other aquatic organisms feed on detritus. Why they matter They help recycle nutrients back into the environment, allowing those nutrients to be used by other organisms. 11. Ecosystem organization Know the difference between these four terms: * Population: One species living in a particular area. * Community: Multiple populations living in an area. * Ecosystem: The community and its nonliving environment. * Biosphere: All parts of Earth where life exists. A community consists of different populations. An ecosystem includes both living and nonliving components. 12. Phosphorus transfer through food webs * Plants absorb phosphorus from soil or water. * Heterotrophs obtain phosphorus by eating plants or other animals. * Phosphorus moves between organisms through feeding. * Decomposition and waste return phosphorus to the environment. Phosphorus is important for plant growth and for building molecules that all living organisms need. Part 3: What to memorize before the test If you’re short on time, make sure you can answer these questions without looking at your notes. Final review checklist 0 of 13 Define ecology, biosphere, population, community and biomass. Explain the differences between autotrophs and heterotrophs. Distinguish herbivores, carnivores, omnivores, scavengers, detritivores and decomposers. Explain the nitrogen cycle processes and put them in context. Memorize N₂, NH₃, NH₄⁺, NO₂⁻ and NO₃⁻. Explain the phosphorus cycle and why phosphorus matters. Explain the steps of eutrophication and why oxygen decreases. Define evaporation, condensation, precipitation and transpiration. Compare photosynthesis, cellular respiration and chemosynthesis. Explain the difference between food chains and food webs. Explain why energy decreases at higher trophic levels. Explain how decomposers recycle nutrients. Describe how carbon enters and leaves the atmosphere. My advice for tonight: Study the vocabulary first, draw the nitrogen cycle from memory, and then explain eutrophication and the water cycle out loud. Finish by testing yourself on the checklist. If you can explain each item without looking, you’re in a good position for your test.

# Neuro Exam Essentials Only what your instructor said to know: lectures, live class, slides, and the assigned book pages (with the "do not read" parts left out). Read in book = a part your instructor told you to read in the textbook. How to use this ## One tab. One chunk. Then flip cards. - Read the colored **60-second box** first. That's the big idea. - Open **one** chunk at a time. Close it when done (it'll say ✓ seen). - Do the **tap-to-flip cards**, then the **quiz**. - Hit **Mark done** at the bottom. Take a break between tabs. **Your instructor's study advice:** the nursing care **overlaps** across all these diseases. Eye problem → protect the eye. Can't swallow → nutrition support (weights, calorie counts, prealbumin). Weak or stiff → mobility and fall prevention. **Don't memorize slide by slide. Understand the idea.** But do notice how brain, spinal cord, and peripheral nerve problems look different. The nervous system map Think of a house. The brain is the electrical panel. The spinal cord is the main cable running down the wall. Peripheral nerves are the wires going out to every room. | Central (CNS) | Peripheral (PNS) | | --- | --- | | Brain + spinal cord | Spinal nerves (from the spine) · **12 cranial nerves** (from the brain) · autonomic system | **Autonomic system** = automatic, not under your control: - **Sympathetic** = "fight or flight." Speeds things up (heart rate, breathing). - **Parasympathetic** = "rest and digest." Slows things down. Word bank (terms that show up everywhere) | Word | Plain meaning | | --- | --- | | **intracranial pressure (ICP)** | Intracranial pressure: pressure inside the skull | | **level of consciousness (LOC)** | Level of consciousness: how awake and aware | | **Glasgow Coma Scale (GCS)** | Glasgow Coma Scale: scores LOC from 3 (no response) to 15 (normal) | | **Aura** | A warning sign right before a migraine or seizure | | **Dysphagia** | Trouble swallowing → aspiration risk | | **Dysarthria** | Trouble speaking clearly (slurred) | | **Diplopia** | Double vision | | **Nystagmus** | Eyes jerk side to side on their own | | **Ptosis** | Drooping eyelid | | **Photophobia** / **phonophobia** | Light hurts / sound hurts | | **Paresthesia** | Numbness or tingling | | **Acetylcholine (ACh)** | The "go" chemical that makes muscles move | | **Dopamine** | The "brake" chemical that smooths movement (also pleasure) | Your instructor's 15 neuro terms have their own tab: **Terms**. Review class: exam breakdown + how to study Review class From the in-class exam review (Joline case study + NCLEX questions). | Exam section | Points | | --- | --- | | Peripheral nervous system (PNS) | 28 | | Trauma: stroke, head injury, intracranial pressure (ICP) | 32 | | Renal: acute and chronic kidney disease (lecture recordings) | 18 | | Michelle's content (use her posted study guide) | 10 | | **Total** | **90** · about 1 hr 35 min. Don't rush. | - You only need what she **did not cross off** in the book + what's in the **lecture recordings** and **PowerPoint**. Some lecture content isn't in the book. That's okay, it still counts. - Use the **outline in the syllabus** as quiz questions. - Studying alone? **Record yourself answering out loud** on your phone, then play it back next to your notes. Saying it out loud moves it to long-term memory. - On her big day-one med chart, write **only the "exception to the rule"** facts. Those are what get tested. - Stuck? **Email her** instead of going down a YouTube rabbit hole. Quick recall · tap to flip The 60-second version ## 15 words. Break them into pieces and they explain themselves. - **a-** = without · **dys-** = hard or bad · **hemi-** = half (one side) - **-plegia** = paralyzed (can't move) · **-paresis** = weak (can move a little) - **-phasia** = speech/language · **-lexia** = reading · **-graphia** = writing - **-opia / -opsia** = vision · **gnosia** = knowing/recognizing · **praxia** = doing From your instructor's "Neurology – Medical Terminology" list Talking, reading & writing (4) ### 1. Aphasia **Word parts:** a- (without) + phasia (speech) **Means:** trouble with **language**. The brain can't make or understand words. The brain's dictionary is broken. The mouth works fine; the words don't come out right, or what you hear makes no sense. **Example:** a stroke patient wants water but says "chair," or can't understand "squeeze my hand." **3 types:** **Expressive (Broca)** = understands, can't speak · **Receptive (Wernicke)** = can't understand · **Global (mixed)** = both. ### 2. Dysarthria **Word parts:** dys- (hard) + arthr (joint/articulate) **Means:** **slurred speech** because the mouth, tongue, or face muscles are weak. The words are right, but the mouth is clumsy, like talking after a dentist numbs you. **Example:** the patient knows exactly what to say, but it sounds mumbled. **Don't mix up:** **Aphasia = a word problem** (brain's language center). **Dysarthria = a muscle problem** (words are right, just slurred). ### 3. Alexia **Word parts:** a- (without) + lexia (reading) **Means:** **can't read**, even though they could before and their eyes work. **Example:** the patient looks at a menu but the letters mean nothing. ### 5. Agraphia **Word parts:** a- (without) + graphia (writing) **Means:** **can't write**, even though the hand can hold the pen. **Example:** asked to sign a consent form, they can't form the letters of their name. Eyes & vision (4) ### 4. Papilledema (choked disc) **Word parts:** papilla (optic disc) + edema (swelling) **Means:** the **optic disc** (where the eye nerve connects, at the back of the eye) is **swollen**. The provider sees it with an ophthalmoscope. Pressure in the skull pushes on the eye nerve and "chokes" it, like a garden hose swelling when the water can't get out. **Key point:** papilledema = **always a sign of ↑intracranial pressure (ICP)**. ### 9. Nystagmus **Means:** the eyes **jerk or bounce side to side** (or up and down) on their own. Like the eyes are watching a fast tennis match that isn't there. **Seen in:** multiple sclerosis (MS), meningitis, stroke, brainstem problems. ### 12. Ptosis **Means:** a **drooping upper eyelid**. Ptosis sounds like "toe-sis": the lid falls down toward your toes. **Seen in:** myasthenia gravis, uncal herniation (CN III), stroke. ### 13. Diplopia **Word parts:** dipl (double) + opia (vision) **Means:** **double vision**. Sees two of everything. **Nursing:** eye patch, switched between eyes every few hours. ### 14. Homonymous hemianopsia **Word parts:** homonymous (same) + hemi (half) + an (without) + opsia (vision) **Means:** blind in the **same half** of the vision field **in both eyes**. For example, they can't see anything to their left. Like someone put tape over the left half of both lenses of their glasses. **Nursing:** teach to **turn the head side to side (scan)**. Put food and items on the side they can see. They may eat only half the plate. Movement & coordination (5) ### 7. Hemiparesis **Word parts:** hemi (half/one side) + paresis (weakness) **Means:** **weakness** on one side of the body. They can still move it, just not strongly. **Example:** weak right hand grip and right leg after a left-brain stroke. ### 15. Hemiplegia **Word parts:** hemi (one side) + plegia (paralysis) **Means:** **paralysis** on one side of the body. Can't move it at all. **Memory trick:** **Paresis = Partial** (weak). **Plegia = Paralyzed** (can't move). Both are on the side **opposite** the brain injury. ### 8. Apraxia **Word parts:** a- (without) + praxia (doing/action) **Means:** can't do **learned, planned movements**, even though the muscles are strong and they understand the request. The muscles work, but the brain lost the "instructions" for the task. **Example:** handed a toothbrush, they don't know the steps to brush their teeth. **Nursing:** simple, short, one-step directions; be patient. ### 10. Ataxia **Word parts:** a- (without) + taxia (order/coordination) **Means:** **poor coordination and balance**. Wobbly, unsteady walking; clumsy movements. Walking like you're on a moving boat. **Nursing:** **fall precautions**. ### 6. Proprioception **Means:** your body's sense of **where its parts are** without looking (body position sense). It's how you can touch your nose with your eyes closed. **If lost:** the patient doesn't know where their arm or foot is → falls, injuries. Watch the affected limb. Recognizing things (1) ### 11. Agnosia **Word parts:** a- (without) + gnosia (knowing) **Means:** can't **recognize** familiar objects, people, or sounds, even though their senses work. The eyes see a fork, but the brain can't name it or tell what it's for. **Nursing:** safety. They might misuse objects. **The "A" trio:** **Apraxia** = can't **do** (action) · **Agnosia** = can't **know** (recognize) · **Ataxia** = can't **coordinate** (wobbly). All 15 at a glance | # | Term | Simple meaning | | --- | --- | --- | | 1 | **Aphasia** | Trouble with language (words) | | 2 | **Dysarthria** | Slurred speech (weak mouth muscles) | | 3 | **Alexia** | Can't read | | 4 | **Papilledema** | Swollen optic disc = ↑intracranial pressure (ICP) | | 5 | **Agraphia** | Can't write | | 6 | **Proprioception** | Sense of where your body is | | 7 | **Hemiparesis** | One-sided weakness | | 8 | **Apraxia** | Can't do learned movements | | 9 | **Nystagmus** | Jerky, bouncing eyes | | 10 | **Ataxia** | Poor coordination/balance | | 11 | **Agnosia** | Can't recognize things | | 12 | **Ptosis** | Droopy eyelid | | 13 | **Diplopia** | Double vision | | 14 | **Homonymous hemianopsia** | Blind in the same half of both eyes | | 15 | **Hemiplegia** | One-sided paralysis | Flashcards · tap to flip Practice A client clearly says "I want my glasses," but the words are mumbled and hard to understand. This is: The right words, but slurred = a muscle problem = dysarthria. Practice A client eats only the food on the right side of the plate. The nurse suspects: They can't see the left half of their field. Teach head scanning; turn the plate. Practice A client holds a comb but can't figure out how to use it, even though the arm is strong. This is: Strong muscles, lost "how-to" for a learned task = apraxia. Practice The provider documents papilledema. The nurse knows this means: A swollen optic disc is always a sign of ↑ICP. Practice A client after a stroke can lift the right arm a little but it's weak. Correct term? Paresis = partial (weak). Plegia = paralyzed. Practice A client walks with a wide, wobbly gait and loses balance. Priority nursing action? Ataxia = poor coordination → fall risk. The 60-second version ## Stroke = a "brain attack." Time is brain. - **transient ischemic attack (TIA)** = mini warning stroke; symptoms gone in 30–60 min. Prevent the real one. - **\~90% are ischemic** (clot). The rest are **hemorrhagic** (bleed). - **computed tomography (CT) head WITHOUT contrast first**, to rule out a bleed. - **tissue plasminogen activator (tPA) (alteplase)** within **3 to 4.5 hrs** of when symptoms started, only for ischemic. - First sign of trouble (↑intracranial pressure (ICP)) = **change in mental status**. A stroke is a heart attack of the brain. Ischemic = a clogged pipe (no blood gets through). Hemorrhagic = a burst pipe (blood leaks where it shouldn't). The treatment for one is dangerous for the other, which is why the computed tomography (CT) comes first. transient ischemic attack (TIA): the warning sign - Brief drop in blood flow to the brain → **temporary** stroke-like symptoms. - Usually gone in **30–60 minutes**, often before reaching the emergency room (ER). Many people never go. - Symptoms are **one-sided**: numbness or weakness of face/arm, blurred or double vision, slurred speech, trouble swallowing. - It's a **red flag**: high risk of an ischemic stroke soon. **Prevention is the key intervention:** - #1 risk factor = **hypertension**. Control blood pressure (BP). - **Diabetes**: keep glucose in range. Exercise, healthy food. - **Antiplatelets**: **aspirin** and **clopidogrel**. Both together = **dual antiplatelet therapy** (same as after a myocardial infarction (MI)). **Don't mix up the classes:** **Antiplatelets** = aspirin, clopidogrel (stop platelets sticking). **Anticoagulants** = heparin, warfarin, direct oral anticoagulants (DOACs) like apixaban, rivaroxaban, dabigatran. Ischemic vs. hemorrhagic Blood flow cut off for more than a few minutes → brain cells starve of oxygen → **brain infarction** (like a myocardial infarction (MI), but in the brain). | Type | Cause | Onset | | --- | --- | --- | | **Thrombotic** (ischemic) | Clot builds slowly from **atherosclerosis**, often where arteries split (carotids, circle of Willis) | **Slow/gradual**: symptoms come and go, or slowly worsen. Body grows **collateral circulation**. | | **Embolic** (ischemic) | Clot travels, usually from the **left side of the heart**. Big risk: **A-fib**, valve disease | **Sudden**; often improves quickly too | | **Hemorrhagic** | Vessel breaks: **severe hypertension (HTN)** (incl. **cocaine**), ruptured **aneurysm**, or an ischemic stroke that turned into a bleed | Sudden or slow (depends on the bleed) | Right-heart clot → lungs (PE). Left-heart clot → brain (stroke). Left vs. right brain stroke The brain controls the **opposite** side of the body. Left brain stroke → **right** side weak. Right brain stroke → **left** side weak. | Left hemisphere (dominant) | Right hemisphere | | --- | --- | | Language, math, analytical thinking | Visual and spatial awareness | | Trouble **understanding and using language** (aphasia) | **Unilateral neglect**: ignores the left side of the body | | **Slow, cautious**; anxious with new tasks | **Impulsive**, poor judgment, unaware of deficits, denial | | Depressed, guilty, quickly angry and frustrated (they know something's wrong) | Memory loss, disoriented | | Right-side weakness | Left-side weakness · top priority: **risk for injury** | Brain-area map slide: your instructor said **do not memorize it**. BE FAST: teach the public B**Balance**: loss of balance or coordination, dizzy E**Eyes**: blurred or double vision F**Face**: smile. One side drooping? A**Arms**: raise both. One weak or drifting down? S**Speech**: repeat "You can't teach an old dog new tricks." Slurred? Garbled? T**Time**: call **911** right away. Note the **exact time symptoms started**. **Why call 911 instead of driving?** The ambulance **calls ahead**: computed tomography (CT) room ready, stroke scale started, tissue plasminogen activator (tPA) prepared, oxygen and glucose checked. In the emergency room (ER): assessment & computed tomography (CT) - Priority = get them to a **stroke center**. Not the time for a full head-to-toe. - **airway, breathing, circulation (ABCs) first**, then a rapid neuro (stroke) assessment. - **National Institutes of Health (NIH) Stroke Scale**: trained, certified staff; checks level of consciousness (LOC), movement, feeling, speech, understanding. Broader than BE FAST. **Don't memorize its parts**; just know it's a valid, reliable, evidence-based tool for consistent tracking. **CT of the head WITHOUT contrast** (or magnetic resonance imaging (MRI)) is one of the first tests. Why no contrast? Contrast would look like a bleed. CT shows a **hemorrhage**, sets a **baseline**, rules out tumors. An ischemic stroke often **doesn't show for 24 hrs**, so a negative CT doesn't rule it out. tissue plasminogen activator (tPA) (alteplase): clot buster - For **ischemic only**. **Never** for hemorrhagic. - Must start within **3 hours** of symptom onset (often extended to **4.5 hrs**). Counted from when symptoms **started at home**, not emergency room (ER) arrival. You don't need the extension criteria. - Not everyone qualifies: check bleeding risk. **Before you hang tPA:** make sure the **head computed tomography (CT) is done** and shows no bleed. Not ordered? Get it ordered. - Big risk = **bleeding** → bleeding precautions. - Keep blood pressure (BP) controlled so ischemic doesn't turn hemorrhagic. - **Repeat CT** after the infusion to check for a new bleed. **Other procedures (know the name and idea only):** - **Intra-arterial thrombolysis**: tPA put directly into the clot; up to **6 hrs**. - **Endovascular thrombectomy**: catheter pulls the clot out. - **Prevent future strokes:** angioplasty with **stent** (filter catches pieces) or **carotid endarterectomy** (neck incision to remove plaque). **After any of these:** check the site for bleeding, vital signs, **neuro checks** (new stroke from loose clots?), **hoarseness and trouble swallowing** (nerves in the neck, like the vagus), and **cerebral hyperperfusion** (a rush of blood into an area used to low flow → can bleed). Signs to assess - **Cognition**: restless, confused, memory, focus. level of consciousness (LOC) drop = late. - **Motor**: hand grips, push/pull feet. Equal both sides? - **Flaccid** paralysis = limp, can't beat gravity (e.g., **foot drop**). **Spastic** = constant contraction → **contractures**. - **Sensory**: touch, pain, numbness, neglect. - **Eyes**: pupils equal, round, reactive to light and accommodation (PERRLA) *plus* the whole visual field (lost side vision?). - **Heart**: usually hypertensive; **murmur** (clot on a valve?); **rhythm** (A-fib). - Psychosocial: personality and emotion changes. Nursing priorities (acute stroke) 1. **Oxygen first.** oxygen saturation (SpO₂) under 94%? Think: **partial airway obstruction** (tongue), **hypoventilation**, **aspiration** (most common). 2. **intravenous (IV)** (emergency meds; they may not swallow). 3. **Cardiac monitor** (A-fib). 4. **nothing by mouth (NPO) until a swallow screen.** The registered nurse (RN) does the bedside screen. Coughing, pocketing food, slurred speech → **speech therapy** consult. 5. **Glucose under 140** (high sugar blocks reperfusion). 6. **blood pressure (BP) slightly high** to push blood to the brain. Book guideline **≤150 systolic**, but follow the patient's own orders and baseline. 7. Watch for **↑intracranial pressure (ICP)**. Neuro checks **every 15–30 min** acutely; BP at least every 15 min. **Never skip pupils.** **Patient declining 24 hrs after a stroke** (more lethargic, vitals changed, sluggish pupils)? **Call Rapid Response** and the provider. Expect a computed tomography (CT). - Most likely complication = **↑ICP** (→ seizures, respiratory failure, ↓level of consciousness (LOC)). - Don't take BP on the **affected arm**: inaccurate (less vascular tone). Aspirin & stroke core measures **Why no aspirin right away (unlike a myocardial infarction (MI))?** Could be a **bleed**, may be getting **tissue plasminogen activator (tPA)**, may have **dysphagia**. Giving it early doesn't improve stroke outcomes. - Give aspirin **325 mg within 24–48 hrs** after onset. - **No aspirin within 24 hrs of tPA.** **Core measures** (hospital must do + document to get paid): 1. **tPA** if they qualify (3–4.5 hrs). 2. **venous thromboembolism (VTE) prevention**: sequential compression devices (SCDs), enoxaparin/heparin, walking. 3. By end of **day 2**: **antiplatelet** or **anticoagulant** (A-fib/flutter → anticoagulant). Discharged on it. 4. Discharged on a **statin** (cholesterol med). 5. **Stroke education** documented (signs, 911, meds). 6. **physical therapy (PT)/occupational therapy (OT) rehab** assessment. Tests & swallow nerves (Mr. Stokes case) | Test | Why | | --- | --- | | Non-contrast computed tomography (CT) head | Rule out bleed, baseline, rule out tumor | | Cardiac monitor | A-fib (with rapid ventricular response (RVR)) | | **Echocardiogram** | Shows **heart valves** (clots?) and ejection fraction | | **Carotid ultrasound** | **% of plaque** blocking the carotids | | Swallow study | Diet texture (thickened liquids, pudding, no water) | **The 2 cranial nerves you MUST know:** **cranial nerve (CN) IX (glossopharyngeal)** and **CN X (vagus)**, the swallowing nerves. They must be intact before the patient eats or drinks. "If you don't know, pick vagus." **Delegation tip** from class: licensed practical nurse (LPN) can give **routine injections** (like insulin). Hygiene → **unlicensed assistive personnel (UAP)**. NCLEX wants you to use each person's role wisely. Hemorrhagic stroke treatment Goal: **stop the bleeding** and **lower pressure on the brain**. - Stop any meds that cause bleeding; may need blood products. - Anti-seizure meds (a seizure raises intracranial pressure (ICP)). - **Bed rest** and supportive care so the body can absorb the blood. Don't push them up to the chair. **Surgery:** - **Aneurysm** → **coiling** (coils fill the bulge) or **clipping** (clip at its base). - **arteriovenous malformation (AVM)** (arteriovenous malformation: tangled weak vessels, often in kids) → surgically removed. Read in book Iggy Ch. 38, pp. 941–955 · skipped per your list: National Institutes of Health Stroke Scale (NIHSS) table, Box 38.3, alteplase dosing, calcium channel blocker paragraph transient ischemic attack (TIA) workup (book)Read in book - Symptoms usually resolve in **30–60 min** but can last up to **24 hrs**. - Box 38.2 signs: blurred/double vision, tunnel vision, one-eye blindness; arm/leg weakness, **ataxia**; numbness, **vertigo**; aphasia, dysarthria. - Workup: National Institutes of Health Stroke Scale (NIHSS), labs (**prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT)**, lipids), electrocardiogram (ECG), **head computed tomography (CT)** then magnetic resonance imaging (MRI), computed tomography angiography (CTA)/magnetic resonance angiography (MRA) of brain and neck. - Common causes: **carotid stenosis** (narrowed artery from plaque) and **A-fib**. - **ABCD2 score** predicts stroke risk: **A**ge ≥60 · **B**P ≥140/90 · **C**linical signs (one-sided weakness, speech) · **D**uration · **D**iabetes. - Treatment: carotid endarterectomy or stent, **aspirin/clopidogrel**, lower blood pressure (BP). Stroke types & risk (book)Read in book Brain can't store oxygen or glucose. Blood flow cut for **a few minutes** → infarction. "Brain attack" = treat like a myocardial infarction (MI). | | Thrombotic | Embolic | Hemorrhagic | | --- | --- | --- | --- | | Onset | Gradual; steps/worsening | Sudden | Sudden (gradual if from hypertension (HTN)) | | level of consciousness (LOC) | Awake | Awake | Deepening lethargy → coma | | Linked to | HTN, atherosclerosis; transient ischemic attack (TIA) first | Heart disease (A-fib) | HTN, vessel problems, genetics | | Headache | Slight | — | **Severe**; seizures common | | Recovery | Weeks–months | Usually rapid | Variable; often permanent deficits | - **Intracerebral hemorrhage (ICH)**: bleeding into brain tissue, usually from **severe HTN**; cocaine can trigger it. - **Subarachnoid hemorrhage (SAH)**: bleeding between pia and arachnoid, usually a ruptured **aneurysm** or **arteriovenous malformation (AVM)**. **Vasospasm** (artery clamps down) afterward → more ischemia. - Leading causes: **smoking, obesity, HTN, diabetes, high cholesterol**. Also cocaine, heavy alcohol, birth control pills in at-risk women, family history. - 5th leading cause of death; #1 cause of long-term disability. "Stroke belt" = 8 southeastern states. - Prevent with the **ABCS**: **A**spirin when appropriate, **B**lood pressure, **C**holesterol, **S**moking cessation. Assessment (book)Read in book - First priority: get to a **stroke center**. Assess within **10 minutes** of arrival (ABCs, neuro). - History: **exact time symptoms started**, did they get better or worse, meds (anticoagulants), drug use. - Sudden drop in level of consciousness (LOC)? Rule out **low blood sugar or low oxygen** first. They look like a stroke but are easy to fix. - **subarachnoid hemorrhage (SAH)**: "worst headache of my life," nausea/vomiting, photophobia, stiff neck. - Most important ongoing check = **LOC** (GCS or National Institutes of Health Stroke Scale (NIHSS)). - **Impaired airway defense**: weak cough + dysphagia → aspiration pneumonia. Screen swallowing. - Heart: murmur, A-fib, heart failure, endocarditis. - **blood pressure (BP)**: often 180–200/110–120 on arrival. A somewhat high BP (about **150/100**) keeps the brain perfused; higher can extend the stroke. - **Psychosocial**: body image, coping, money worries; screen for **depression**. **Emotional lability** = sudden laughing or crying for no reason (frontal lobe or right brain). Tell the family it's the stroke, not them. - Labs: no test confirms stroke. High **Hgb/Hct** = severe stroke; high white blood cell count (WBC) = infection or stress; glucose and **hemoglobin A1C (A1C)** check diabetes. NIHSS (Table 38.2): your instructor said don't memorize it, just be familiar. It scores 0 (normal) to 42 (worst) and helps decide who gets tissue plasminogen activator (tPA). tissue plasminogen activator (tPA) (alteplase) rules (book)Read in book - Explain to patient/family and get **informed consent**. - Door-to-needle goal: **45 minutes** from emergency department (ED) arrival. - If blood pressure (BP) is too high, give a fast antihypertensive first. BP must be **below 185/110** to start, and kept there. **Box 38.4: care during and after alteplase** - Admit to critical care or a stroke unit. **Double-check** the drug. - Give with a **programmable pump** over 60 min (10% as a 1-minute bolus). **Never push it by hand.** - Neuro checks + vitals: **every 10–15 min during the infusion**, then **every 30 min for at least 6 hrs**, then **hourly for 24 hrs**. - Use the **same BP device** each time (manual vs. automatic vs. arterial line readings differ). - BP **≥185/110 before** tPA, or **>180/105 after** (first 24 hrs) → give antihypertensive as ordered, e.g., **intravenous (IV) labetalol**. - **No invasive tubes** (NG tube, Foley) until stable, usually **24 hrs** (bleeding). - **Stop the infusion** and call for severe headache, sudden high BP, nausea/vomiting. - Follow-up computed tomography (CT)/magnetic resonance imaging (MRI) **before** starting anticoagulants or antiplatelets. **Drug Alert:** watch closely for bleeding: brain bleed (headache, level of consciousness (LOC) change) and any other site. Procedures & intracranial pressure (ICP) after stroke (book)Read in book - **Endovascular**: intraarterial tissue plasminogen activator (tPA) (within **6 hrs**), mechanical embolectomy (pull clot out), carotid stent. - After a **carotid stent**, teach to report: severe headache, level of consciousness (LOC) change (drowsy), muscle weakness, severe neck pain, **neck swelling**, **hoarseness or trouble swallowing** (nerve damage). - Hemorrhagic from arteriovenous malformation (AVM)/aneurysm: procedure to stop bleeding. - **↑ICP risk is highest the first 72 hrs**. Reassess every 1–4 hrs. **Critical Rescue:** the **first sign of ↑ICP is a declining LOC**. Report any decline to the provider or Rapid Response right away. **Prevent ↑ICP:** - **head of bed (HOB) up** per protocol. **Head midline**, neutral. - O₂ if oxygen saturation (SpO₂) **under 95%**. - No sharp hip or neck bending. - **Don't cluster care** (bath right after linen change spikes ICP). - **Hyperoxygenate** before and after suctioning; avoid unneeded suctioning and coughing. - Quiet room, **dim lights**. - Watch blood pressure (BP), rhythm, SpO₂, glucose, temperature. **Box 38.5 signs of ↑ICP:** ↓LOC (earliest), restless/irritable/confused, headache, vomiting (may be projectile), speech changes, pupil changes (dilated nonreactive = "blown"), seizures, Cushing's triad and posturing (very late). Meds, blood pressure (BP) & swallowing (book)Read in book **BP Critical Rescue:** no tissue plasminogen activator (tPA) or embolectomy → BP may be allowed up to **220** systolic. After tPA/embolectomy → report systolic **above 180**. Avoid a sudden BP drop: it can cause brain ischemia. - **Aspirin and clopidogrel** = standard for ischemic stroke and preventing the next one. - **Anticoagulants** (heparin, warfarin, direct oral anticoagulants (DOACs)) for **A-fib**. High-alert: bleeding risk. - Low-dose **aspirin within 24–48 hrs**; **not within 24 hrs of tPA**. Teach to report bruising or bleeding. - Stool softeners (no straining = no intracranial pressure (ICP) spike), pain and anxiety meds. - **nothing by mouth (NPO) until a swallow screen**. Positive screen → speech-language pathologist. - Weigh daily; check prealbumin; dietitian. - **Flaccid arm**: support it on a pillow so the shoulder doesn't dislocate (subluxation). Don't pull on it. - Early mobility; prevent deep vein thrombosis (DVT) with **compression devices**. Aphasia & communication (book)Read in book | Expressive (Broca) | Receptive (Wernicke) | Global (mixed) | | --- | --- | --- | | **Frontal** lobe. Understands but **can't speak** (or write). Knows it → frustrated, angry. | **Temporoparietal**. **Can't understand**. Can talk, but words are often meaningless. | **Both**: can't speak **and** can't understand. Reading and writing are affected the same way. Usually a large stroke involving the **left** (dominant) side. | "Broca = broken speech. Wernicke = words wacky. Global = gone both ways." - One idea at a time. Simple one-step commands. - Speak **slowly, not loudly**. Use gestures. - Yes/no questions for expressive aphasia. - **Global aphasia**: rely on **gestures, pictures, touch, and facial expression**. Keep a calm tone; watch body language for needs. - Picture boards, tablets, flash cards. **Don't rush**. - Work with the speech-language pathologist. Vision, neglect & left vs. right (book)Read in book **Right-brain stroke** (trouble with space and distance, right vs. left): - Use frequent verbal and touch cues; break tasks into small steps. - **Approach from the unaffected side.** Patient faces the door. **Unilateral neglect** (usually right-brain stroke): ignores one side. - Teach to **touch and use both sides**. Dress the **affected side first**. - **Homonymous hemianopsia**: teach to **turn the head side to side (scan)** while eating and walking. Put objects in the field of vision. - **Diplopia**: patch the affected eye; switch every 2–4 hrs. **Left-brain stroke** (memory problems): - Reorient to day and time; **structured routine** with repetition. - **Apraxia**: give simple, short directions; be patient. Core measures & going home (book)Read in book **Core measures (ischemic stroke):** venous thromboembolism (VTE) prevention · discharged on antithrombotic · anticoagulant for A-fib/flutter · tissue plasminogen activator (tPA) when eligible · antithrombotic by end of day 2 · discharged on statin · stroke education · rehab assessed. **Box 38.6 discharge teaching:** - Drugs: name, purpose, dose, timing, side effects. - Climbing stairs, getting in and out of bed, chair, and car safely; using mobility aids. - Who to call with questions; what to do in an emergency. - They're **at risk for another stroke**. Teach **FAST** (face drooping, arm weakness, speech difficulty, time to call 911). - Watch for **depression or dementia within 3 months** (poststroke depression). - Caregivers get overwhelmed → **respite**, social services, American Stroke Association. - Return demonstrations to check family skills. Book · NCLEX Challenge 38.1 · Select all A client has a **left middle cerebral artery** embolic stroke. Which findings does the nurse expect? Left brain → right side of the body. The left side controls speech, so dysarthria fits. Ataxia and vertigo point to the back of the brain (vertebrobasilar). Book · NCLEX Challenge 38.2 A client was just admitted to the emergency department (ED) with new-onset ischemic stroke. Which drug does the nurse anticipate? New ischemic stroke in the time window = tPA (after the CT shows no bleed). Aspirin waits 24–48 hrs. Book · Mastery Q1 A client with an acute ischemic stroke is receiving alteplase. Priority nursing action? Bleeding (especially into the brain) is the biggest danger with tPA. Book · NGN Challenge 38.1 **Case:** 74-year-old with diabetes in the ED. Right arm felt weak and tingly; now feels "more normal." **Bilateral carotid bruits.** blood pressure (BP) 168/92, heart rate (HR) 88, oxygen saturation (SpO₂) 96%. History: type 2 diabetes, hypertension (HTN), alcohol, **69 pack-year smoking**. Glucose 231. Quick recall · tap to flip NCLEX The nurse has an order to start alteplase for a client with stroke symptoms. What must the nurse confirm first? tPA in a hemorrhagic stroke could be fatal. CT first, every time. NCLEX A client just admitted with an ischemic stroke asks for water. What does the nurse do? Aspiration is the most common cause of hypoxia in stroke. Screen first; refer to speech if any concern. NCLEX A client with a right-hemisphere stroke keeps trying to get out of bed alone. Priority problem? Right-brain strokes cause impulsivity and poor judgment. Safety first. NCLEX A client's wife says his face drooped "about 2 hours ago, then got better, now it's back." Most important info for the nurse? tPA eligibility is timed from first symptom onset. The 60-second version ## The skull is a closed box. Swelling has nowhere to go. - Normal **intracranial pressure (ICP) 10–15**. Over **20** = brain cells die. - **cerebral perfusion pressure (CPP) = mean arterial pressure (MAP) − ICP**. Keep it **above 70**. - First sign of ↑ICP = **mental status change**. Late = **Cushing's triad**, posturing. - **Glasgow Coma Scale (GCS) 8 or less → intubate.** A **2-point drop** = call. - Head injury → **assume neck injury** too (jaw thrust). The skull holds 3 things: brain, blood, and cerebrospinal fluid (CSF). It's a full suitcase that can't stretch. If one thing gets bigger (swelling, a bleed, extra fluid), something gets crushed, starting with the blood vessels. Types of brain injury **Primary injury** = direct damage from the hit. Most common causes: **car crashes** and **falls** (teach seat belts, helmets, fall prevention). | Term | Meaning | | --- | --- | | **Open** head injury | Skull broken/pierced (e.g., gunshot) → **infection risk** | | **Closed** head injury | Blunt hit, skull intact. **More dangerous**: swelling has no escape → ↑intracranial pressure (ICP) | | Contusion | Bruised brain | | Laceration | Torn vessels (inside of skull is bumpy and sharp) | | Diffuse axonal injury | Widespread damage from high-speed crash (speed up, sudden stop) | | Severity | Glasgow Coma Scale (GCS) | Unconscious for | | --- | --- | --- | | **Mild** (= concussion) | — | Usually sent home | | **Moderate** | **9–12** | 30 min – 6 hrs | | **Severe** | **8 or less** | Over 6 hrs → intensive care unit (ICU) | Concussion discharge teaching Your instructor: "Don't memorize the list, but know it. You'll get yes/no examples." - **Acetaminophen** for pain is OK. **No nonsteroidal anti-inflammatory drugs (NSAIDs)** (Motrin, Advil): bleeding risk. - Return to the emergency room (ER) for signs of **↑intracranial pressure (ICP)** (swelling or bleed): worse headache, vomiting, confusion, hard to wake, weakness, seizures, vision changes. - **Clear fluid from the nose or ears** → return. Could be a **cerebrospinal fluid (CSF) leak** or **skull fracture**. The full book list (Box 38.8) is in the "Mild traumatic brain injury (TBI) teaching" chunk below. Secondary injury: hypoxia & ↑intracranial pressure (ICP) Happens **after** the first hit and makes it worse. End result: brain tissue damaged, blood flow interrupted. - **Post-concussion syndrome** (mild injury): headaches, dizziness, foggy thinking for weeks to months. - **Cerebral hypoxia**: from clots, respiratory failure, **low blood pressure (BP)**. Risk for **neurogenic shock**. Brain perfusion drops when **mean arterial pressure (MAP) is under 65–70**. **↑ICP numbers:** - Normal ICP = **10–15 mmHg**. Coughing, sneezing, straining (Valsalva) raise it briefly. OK. - **Over 20** for long = **neurons die**. - **cerebral perfusion pressure (CPP)** (blood flow to the brain) = **MAP − ICP**. Goal **above 70**. Example: MAP 85, ICP 25 → CPP = 60. Too low! The brain isn't getting enough blood. **ICP monitors** (just recognize the names): **ventriculostomy** (intraventricular catheter, can also drain cerebrospinal fluid (CSF)) and **subarachnoid screw / ICP bolt** (placed through a **burr hole**). Signs of ↑intracranial pressure (ICP) - **First: mental status change** (restless, confused). level of consciousness (LOC) drop comes later. - Pupil changes: unequal, dilated, **non-reactive**. **Cushing's triad** (late sign; near death). Really 4 parts:\ 1\. **Severe hypertension**\ 2\. **Bradycardia**\ 3\. **Widened pulse pressure**\ 4\. **Irregular breathing** (Cheyne-Stokes) | Decorticate | Decerebrate | | --- | --- | | Abnormal **flexion**: arms bent in toward the "core" | Abnormal **extension**: arms straight out. **Worse** | Both are late signs. Brain bleeds (hematomas) No room in the skull → life-threatening. Your instructor: "kind of something you just have to memorize." | Type | Where | Key sign | | --- | --- | --- | | **Epidural** | **Above** the dura ("epi" = above) | **Lucid interval**: knocked out → wakes up and talks (seems better) → **rapidly declines**. Emergency surgery. Neuro checks every 5–10 min. | | **Subdural** | **Below** the dura ("sub" = below) | **Slow**: weeks to months. Easy to miss. | | **Subarachnoid** | Subarachnoid space | **"Worst headache of my life,"** sudden | | **Intracerebral** | Deep in brain tissue | — | Hydrocephalus & herniation **Hydrocephalus** = too much cerebrospinal fluid (CSF) (not absorbed, or blocked) → big ventricles → ↑intracranial pressure (ICP). **Herniation** = brain shifts to make room: - **Uncal**: sideways (temporal lobe). - **Central**: downward onto the **brainstem**. Don't memorize which pupil means which. Know: pupils change (unequal, dilated), **always non-reactive** → call **Rapid Response** and the provider. level of consciousness (LOC) drops, Cheyne-Stokes breathing. Assessment after head injury - **airway, breathing, circulation (ABCs) first.** Assume a **cervical spine injury** → spinal precautions; open airway with **jaw thrust**. - **Autoregulation is lost**: blood pressure (BP) and heart rate (HR) can swing **either way**. Get a baseline; may seem stable then crash. - Do the **neuro exam BEFORE sedatives** or paralytics. - **Pupils**: any change → call right away. - **Motor**: deficit on the **opposite side** of the lesion. **Skull fracture signs:** - cerebrospinal fluid (CSF) leak: clear fluid from nose/ears; **positive glucose** on dipstick; **halo sign**. - **Battle sign**: bruising behind the ear (mastoid). - **Raccoon eyes**: bruising around the eyes. Glasgow Coma Scale practice Your instructor: **don't memorize the scale**. You'll be given it; know how to **apply** it. - Highest = **15**. Lowest = **3**. - **7 or less** = coma. "**Less than 8, intubate.**" - A **2-point drop** = clinically significant → Rapid Response / provider. Eyes open Verbal Motor Preloaded with the class example: opens eyes to pain (2) + withdraws (4) + moans (2) = **8**. Interventions to lower intracranial pressure (ICP) **Respiratory:** prevent low oxygen, and keep **carbon dioxide (CO₂) 35–45**. **"High CO₂ dilates, low CO₂ constricts."** High → brain vessels swell → ↑ICP. Low → vessels clamp → poor blood flow. Both bad. - **Cardiovascular:** know the patient's blood pressure (BP) range; call if above or below. **Cardiac monitor** (lost autoregulation → dysrhythmias). - **Therapeutic hypothermia:** cooling lowers the brain's oxygen demand. **Mannitol** (osmotic diuretic): - Pulls water **out of brain tissue into the blood** → kidneys pee it out → less swelling, lower ICP. - Dosed by **serum osmolality**; goal **310–320** (normal \~300), slightly "salty" blood. - Watch: **dehydration**, electrolyte imbalance, **acute kidney injury**. **Foley + hourly I&O** (an exception to avoiding Foleys). - Often given with **furosemide**: mannitol pulls fluid from the brain, furosemide removes it from the body. **Hypertonic saline (3% or 5%)** works like mannitol. intensive care unit (ICU) only, and it shows why it's dangerous for regular patients. Your instructor said a case study (due next week, from the book) covers ICP prevention in detail, plus post-op craniotomy care. Brain tumors & craniotomy - **Primary** = starts in the brain. **Secondary** = spread from elsewhere (lung, breast). - Any tumor → **↑intracranial pressure (ICP)** and squeezes brain tissue and vessels. - **Meningioma** (benign, common) → usually removed with a good outcome. Malignant → surgery + radiation/chemo. - Common signs: **headache, seizures**, dizziness, memory loss. | Craniotomy | Decompressive craniectomy | | --- | --- | | Skull opened, fixed, closed right away | Piece of skull **removed** and frozen; put back weeks/months later. Leaves room to swell. Patient wears a **helmet**. | Read in book Iggy Ch. 38, pp. 956–973 · skipped per your list: chronic traumatic encephalopathy (CTE) paragraph, pinpoint/ovoid pupil sentences, supra/infratentorial paragraph, chemo & direct drug delivery traumatic brain injury (TBI) basics (book)Read in book - **TBI** = brain damage from an outside force. Affects cognition, movement, senses, and emotions. - **Acceleration** injury = something hits the still head. **Deceleration** = moving head hits something still. Shearing → diffuse axonal injury. - **Open** = skull or dura broken (infection risk). **Closed** = skull intact. - Top causes: **falls**, self-harm, car crashes, assaults. Alcohol/drugs contribute. Young men most; **falls** most in older adults and kids. | Mild (concussion) | Moderate | Severe | | --- | --- | --- | | Blow to the head + brief confusion or feeling dazed, plus one or more: out **up to 30 min**, memory loss right before/after, focal neuro deficit. **Doesn't need** loss of consciousness. **computed tomography (CT)/magnetic resonance imaging (MRI) normal.** Symptoms usually gone in **72 hrs**. | Out **30 min–6 hrs**; Glasgow Coma Scale (GCS) **9–12**. CT/MRI often shows injury. Memory loss up to **24 hrs**. Short acute/critical care stay to watch for swelling, bleeding. | GCS **3–8**; out **over 6 hrs**. Critical care: hemodynamic, neuro, possibly **intracranial pressure (ICP) monitoring**. High risk for secondary injury. | - **Postconcussion syndrome** (most common secondary injury after mild TBI): headache, foggy thinking, dizziness for **4+ weeks**. Also posttraumatic headaches or vertigo; irritability, depression, anxiety, mood swings; insomnia; trouble concentrating or memory loss; **lower alcohol tolerance**. - **Second-impact syndrome**: a second hit before the brain heals → rapid brain swelling, can be catastrophic. Mostly athletes. Teach return-to-play rules. Secondary injury numbers (book)Read in book - **Hypotension** = mean arterial pressure (MAP) **under 70**. **Hypoxemia** = partial pressure of arterial oxygen (PaO₂) **under 80**. Both starve the brain → swelling → worse perfusion (vicious cycle). - intracranial pressure (ICP) normal **10–15**; coughing or straining spikes are OK. Sustained **over 20** → neurons die. - Body compensates: shifts cerebrospinal fluid (CSF), absorbs more CSF, moves venous blood out. When it can't, ICP rises → herniation. - **↑ICP is the leading cause of death** in head-trauma patients who reach the hospital alive. Bleeds & herniation (book)Read in book | Bleed | Book detail | | --- | --- | | **Epidural** | **Arterial** (middle meningeal artery), often a temporal skull fracture. Brief unconsciousness → **lucid interval** (awake, talking for minutes) → rapid decline. **Critical Rescue:** neuro checks **every 5–10 min**; loss of consciousness = **neurosurgical emergency** → provider/Rapid Response now. Document trends. | | **Subdural (SDH)** | **Venous**, slower. Acute (within 48 hrs), subacute (48 hrs–2 wks), chronic (weeks–months). Common in **older adults** and people on **anticoagulants/antiplatelets**. Signs: worsening headache, confusion, ↓level of consciousness (LOC). | | **Intracerebral (ICH)** | Bleeding into brain tissue; may appear up to 10 days later. | - **Uncal herniation**: pushes on **cranial nerve (CN) III** → dilated nonreactive pupil, **ptosis**, fast LOC decline. - **Central herniation**: downward onto the brainstem → **Cheyne-Stokes** breathing, then nonreactive pupils, unstable vitals. - All herniations are life-threatening → **Rapid Response / provider immediately**. - **Hydrocephalus**: **communicating** = cerebrospinal fluid (CSF) not absorbed (after subarachnoid hemorrhage (SAH) or meningitis); **noncommunicating** = outflow blocked (swelling, tumor, debris). traumatic brain injury (TBI) assessment (book)Read in book - History: **when, where, how**; lost consciousness, and how long? Get it from witnesses if needed. Amnesia is common. Older adults: screen for abuse/neglect. - **carbon dioxide (CO₂)**: high (over 45) → vasodilation → ↑intracranial pressure (ICP). Low (under 35, from hyperventilating) → vasoconstriction → ischemia. Track with **end-tidal carbon dioxide (ETCO₂)**. - Treat as a **cervical spine injury** until x-rays prove otherwise. **Rigid collar**; spine precautions: bed rest, no neck or back bending or twisting, **log roll**, check skin under the collar. Spine "clearance" is the provider's call. - Brainstem injury → Cheyne-Stokes or apnea; may need a ventilator. - **Cushing's triad** = severe hypertension (HTN), widened pulse pressure, bradycardia → **death is near**. - **Glasgow Coma Scale (GCS) change of 2 points** = report. **level of consciousness (LOC) is the most important thing to assess**; a change is the **first sign** of worsening. - Pupils: unequal, sluggish, or dilated = herniation until proven otherwise. **Fixed and dilated ("blown") = poor prognosis**. - Check vision (read your name tag, count fingers). - Late ↑ICP signs: severe headache, vomiting (often projectile), seizures. **Papilledema = always ↑ICP**. - Highest ICP risk: first hours, up to **3–4 days** after injury. - Motor loss is on the **opposite** side. - **cerebrospinal fluid (CSF) leak**: clear fluid from nose/ear, **positive glucose**, **halo sign** on white gauze. **Raccoon eyes**, **Battle sign** = basilar skull fracture. - **computed tomography (CT) first**. magnetic resonance imaging (MRI) shows diffuse axonal injury but **not with ICP monitors**. **Critical Rescue:** check pupils (size, shape, reaction) often, especially if they can't follow directions. Report any change to Rapid Response; it may mean ↑ICP. traumatic brain injury (TBI) interventions (book)Read in book - Vitals every **1–2 hrs** or more. Report dysrhythmias, high or low blood pressure (BP); get target ranges from the provider. - **Fever** = worse outcomes. Goal is **normal temperature** (targeted temperature monitoring). - Keep partial pressure of arterial carbon dioxide (PaCO₂) normal; avoid over-hyperventilating. **Positioning Action Alert:** head **midline**, no extreme neck flexion/extension. **Log roll**. head of bed (HOB) **at least 30°** (or as ordered). Avoid sudden HOB changes; a big BP drop when sitting up can hurt the brain. **Mannitol** (book adds): - Pulls water out of swollen brain tissue. Works best as **boluses**, not a continuous drip. - Give through a **filter** in the intravenous (IV) tubing, or draw up with a **filtered needle** for IV push (removes tiny crystals). - Serum **electrolytes and osmolarity every 6 hrs**; goal osmolarity **310–320**. Serum and urine osmolarity and sodium checked **at least daily**. - **Strict hourly urine output**, I&O. Watch for **severe dehydration**, **acute kidney failure**, weakness, edema, urine output changes. - **Furosemide** (loop diuretic) is often added: prevents mannitol "rebound," boosts its effect, lowers edema and blood volume, and **reduces cerebrospinal fluid (CSF) production**. **Hypertonic saline (HTS)**: draws fluid out like mannitol. Usually **3%** sodium chloride (NaCl) (can be up to 23%). Nursing: constant neuro checks, **serial sodium levels**, fluid status, watch for **pulmonary edema** (especially heart or kidney disease). Some hospitals require **intensive care unit (ICU) + central line**. Evidence box: HTS is at least as effective as mannitol for lowering intracranial pressure (ICP); some studies say better. Choice depends on the patient. **Opioids** (fentanyl, morphine) and sedation (propofol, dexmedetomidine) may help ventilated patients; check neuro first. **Brain death** requires: coma of known cause, temp **above 96.8°F (36°C)**, systolic **≥100**, at least 1 neuro exam. Before it's declared, call the **organ procurement** agency (the nurse doesn't bring up donation alone). Support grieving families; ethics, chaplain, social work. Cognition, seizures & trauma-informed care (book)Read in book - **Memory and thinking**: cognitive rehab; reorient; hazard-free room. - **Sensory stimulation** for comatose patients: one stimulus at a time (show a family photo and say who it is). Audio no longer than **10–15 min** or it becomes "white noise." - Seizure precautions and antiepileptic drugs (AEDs) as ordered. - **Trauma-informed care** (6 principles): **safety**, **trust and transparency** (plain language), **peer support**, **collaboration**, **empowerment** (patient has a voice), **cultural and historical sensitivity**. Mild traumatic brain injury (TBI) teaching: Box 38.8Read in book - Headache → **acetaminophen every 4 hrs** as needed (no nonsteroidal anti-inflammatory drugs (NSAIDs)). - **No sedatives, sleeping pills, or alcohol** for at least **24 hrs** (unless the provider says otherwise). - **No strenuous activity** for at least **48 hrs**. - Caregiver: balance problems can cause falls; plan safe movement. - **Call 911 / return** for: seizure, severe or worsening headache, persistent vomiting, blurred vision, **clear drainage from ear or nose**, increasing weakness, slurred speech, **progressive sleepiness**, **unequal pupils**. - Keep follow-up appointments. Home care after traumatic brain injury (TBI) (book)Read in book - Rehab goal: **highest possible function** (OT, physical therapy (PT), speech). - Home safety: working **smoke and fire alarms**; brain injury often takes away the **sense of smell**. - Dietitian: many gain weight within a year (inactivity, stress eating). - Personality and behavior changes: **structured, consistent routine** with repetition. Reinforce **positive** behavior. - Expect fatigue, irritability, temper outbursts, depression, memory problems. Some need constant supervision. - Families feel isolated → regular **respite**, support groups (Brain Injury Association of America). Brain tumors (book)Read in book - **Primary** tumors start in the central nervous system (CNS) and rarely spread out of it. **Secondary** tumors spread from lung, breast, kidney, skin, gastrointestinal (GI). - Any tumor → swelling, ↑intracranial pressure (ICP), possible herniation. Pituitary tumors can cause **syndrome of inappropriate antidiuretic hormone (SIADH)** or **diabetes insipidus** (fluid and sodium problems). - **Meningiomas** (benign) can usually be removed with a good outcome. - Malignant tumors mostly at ages **40–70**. **Signs:** **headache worse on waking**, nausea/vomiting, seizures, numbness or vision changes, dizziness, one-sided weakness, trouble speaking, personality changes. **Diagnosis:** computed tomography (CT) first, then magnetic resonance imaging (MRI) for detail. **Symptom meds:** - Codeine/acetaminophen for headache. - **Dexamethasone** (steroid) for brain swelling. - **Levetiracetam** or other antiepileptic drugs (AEDs) to prevent seizures. - proton pump inhibitors (PPIs) to prevent **stress ulcers**. **Gamma Knife / CyberKnife** (stereotactic radiosurgery): focused radiation, no incision, for hard-to-reach tumors or arteriovenous malformations (AVMs). **Tumor Treating Fields**: electric fields through skin pads. **Glioblastoma** = most aggressive; few survive 5 years. Craniotomy care (book)Read in book **Before surgery:** very anxious (head opened, hair shaved, fear of new deficits). Reassure; teach what to expect after. **Action Alert:** neuro checks + vitals **every 15–30 min for 4–6 hrs**, then **hourly**. Stable 24 hrs → every 2–4 hrs. Report: ↓level of consciousness (LOC), new weakness or paralysis, aphasia, less feeling, **sluggish pupils**, agitation, personality change. | Supratentorial (top of brain) | Infratentorial (brainstem/back) | | --- | --- | | **head of bed (HOB) 30°** (venous drainage). Head midline; no extreme hip or neck bending. Turn side to side or supine. | Keep **flat or 10°**. **Side-lying**, alternating every 2 hrs, for 24–48 hrs. **nothing by mouth (NPO) until fully awake** (swelling near medulla → vomiting, aspiration). | - Check the head **dressing every 1–2 hrs**; mark drainage once a shift. - Drain (Hemovac/Jackson-Pratt (JP)): measure every 8 hrs; usually **30–50 mL / 8 hrs**. **Critical Rescue:** report a **saturated dressing** or drainage **over 50 mL in 8 hrs** right away. Watch for ↑intracranial pressure (ICP). - Swollen, bruised eyes are normal → **cool compresses**; rinse with warm saline or artificial tears. - Cardiac monitor (dysrhythmias). Strict **I&O for 24 hrs**; fluid limit \~**1500 mL/day** if the pituitary is involved. - Labs: complete blood count (CBC), electrolytes, osmolality, clotting. Watch for **low sodium** (SIADH, steroids) → confusion, weakness. **High sodium** (DI, dehydration) → thirst, restlessness. - venous thromboembolism (VTE): compression devices until walking. Deep breathing every 2 hrs. **Box 38.9 complications:** - **Early:** ↑ICP, hematomas, subarachnoid hemorrhage (SAH), hypovolemic shock, hydrocephalus, breathing problems (atelectasis, pneumonia, neurogenic pulmonary edema). - **Late:** wound infection, meningitis, fluid/electrolyte problems, seizures, **cerebrospinal fluid (CSF) leak**, cerebral edema. Book · NCLEX Challenge 38.4 A client just returned from an open craniotomy for a frontal lobe tumor. Which finding needs immediate report to the surgeon or Rapid Response? ↓level of consciousness (LOC) = possible ↑intracranial pressure (ICP) or bleeding. Headache and eye swelling are expected; 25 mL is under the 50 mL limit. Book · NCLEX Challenge 38.3 A client with a mild traumatic brain injury (TBI) is learning about home care. Which statement shows a need for **more teaching**? Box 38.8: no strenuous activity for at least 48 hrs, and balance problems make construction work unsafe. The others are correct teaching. Book · Mastery Q3 Which finding is an **early** change in LOC in a client with a mild TBI? Behavior changes (irritable, restless) come first. Posturing and lost reflexes are late. Book · Mastery Q2 · Select all The nurse is giving mannitol to a client with a severe TBI. Which actions are appropriate? Only A is wrong: urine output is measured **every hour**, not every 4–8. Filtered needle, electrolytes, osmolarity, and dehydration watch all match p. 964. (My answer; check your book's key.) Book · NGN Challenge 38.2 **Case:** 79-year-old fell at home 2 days ago and broke her right arm. Over 2 days: Glasgow Coma Scale (GCS) **15 → 14**, headache **4 → 5 → 8/10**, blood pressure (BP) and pulse creeping up. Review class: Joline head-injury case (what she stressed) Review class From the in-class exam review (Joline case study + NCLEX questions). Joline fell from a third-story balcony. Think: head injury **and** spine injury until proven otherwise. 1. **Most important thing to monitor: level of consciousness (LOC).** First sign of trouble = changes in behavior. 2. **Cushing's triad** (the "triad" that has **4** parts): severe hypertension, widened pulse pressure, **bradycardia**, irregular breathing. Normally high blood pressure makes the heart speed up, so slow heart rate + high blood pressure is the weird exception. It is a **late** sign of increased intracranial pressure. **Be able to apply it:** "blood pressure 200/80, heart rate 40" = Cushing's. 3. **Neuro assessment, know what's wrong AND how you check it:** pupils equal, round, reactive to light and accommodation (PERRLA), LOC, Glasgow Coma Scale (GCS), motor (squeeze my hands, push/pull feet, raise arms), sensory, reflexes, cranial nerves, vital signs (which part is off and why), breathing pattern. 4. **Orogastric (OG) tube, not nasogastric (NG)**, with severe facial trauma or skull fracture (like basal skull fracture). A tube through the nose could go up through the fracture into the brain. Going through the mouth avoids that. 5. **Blood alcohol** makes the neuro assessment **unreliable**. 6. **When she wakes up:** first tell her where she is and what happened ("You're in the hospital. You were in an accident."). This lowers fear. **Then** check orientation. (Students often pick "ask where she is." That's second.) 7. **Epidural hematoma:** knocked out right away → **lucid interval** (seems better, "it's a trick") → then crashes. 8. **Bruising and swelling around the eyes** (periorbital edema and ecchymosis) is expected with this injury. Apply **cold compresses** (decrease swelling) and **artificial tears** (comfort). Assess, and notify the provider as needed. 9. **3 reasons for a fever:** infection, inflammation (body's response to brain injury), and damage to the **hypothalamus** (the body's thermostat). **Glasgow Coma Scale:** don't memorize the scale. The test will give it to you. Just know how to apply it. The tricky part is motor: **withdraws / pulls in = 4**. **Pushes the stimulus away = 5** (localizes pain). Her examples: eyes to pain 2 + verbal none 1 + withdraws 4 = **7**. Eyes to sound 3 + incomprehensible sounds 2 + localizes 5 = **10**. Review class: spinal precautions + preventing ↑intracranial pressure (ICP) Review class From the in-class exam review (Joline case study + NCLEX questions). **Backboard and cervical collar:** used because spinal cord injury and head injury go together. They stay until spinal cord injury is ruled out. - **Spinal precautions:** supine (bed rest), spine in **neutral** position. No twisting, no neck flexion forward or back, **no pillow**. - **Remove the long backboard as soon as possible**: go back to basics: a hard board causes **skin breakdown**. - **Repositioning = log roll** as a unit, with help. - **Every time the patient is moved** (turns every 2 hrs, trip to head computed tomography (CT) scan), do **another neuro assessment**. - **Head of bed position depends on cerebral perfusion pressure (CPP).** Up can pull blood away from the brain; flat can send too much and raise ICP. It's individualized. **Don't memorize** the book's exact rules; just know CPP guides the choice. **Nursing care to avoid increasing ICP:** 1. **Quiet, calm room.** Noise, bright light, anxiety, agitation all raise ICP. Limit upsetting visitors (a screaming parent may need to step out). 2. **No Valsalva** (bearing down): give **stool softeners**; manage coughing. 3. **Suction only if you must** (airway, breathing, circulation (ABCs) come first). Try repositioning and other measures first. If you suction, **hyperoxygenate first**. 4. **Keep the whole body straight:** no head flexion, **no pillow under the knees** (bent knees block blood flow back from the head). 5. **Frequent vital signs + neuro checks.** 6. **Arterial blood gas (ABG): watch carbon dioxide (CO₂)** closely. CO₂ is a **potent vasodilator** → more blood in the brain → ↑ICP. 7. **Do NOT cluster care.** Exception to the rule! Repositioning + bath + linen change + suppository all at once = ICP spike. **Space activities out.** 8. **Control fever.** Fever → shivering → more oxygen demand → more CO₂ → vasodilation → ↑ICP. 9. **Mannitol** (see below). | Mannitol: know it cold | | | --- | --- | | Class | Osmotic diuretic | | How it works | Treats brain swelling. Pulls water out of the brain tissue into the blood vessels → kidneys excrete it. Sometimes given with **furosemide** (loop diuretic) to work together. | | Dosing guide | **Serum osmolality.** Normal ≈ 300 (just remember 300). Goal = slightly hypertonic, **310–320**. Pump rate is adjusted to stay there. | | Filter needle | **Always.** It has microscopic crystals. Any time you read "use a filter needle," remember it. | | Monitor | Intake and output (I&O); urinary catheter is often used here (an exception, we usually avoid catheters); dehydration; blood pressure; labs: **sodium, potassium, serum osmolality** | **Legal/ethical (organ donation):** Joline is an adult whose **driver's license** says organ donor. In **Michigan, Ohio, and Kentucky** that is **legally binding**, so the hospital follows it even if family disagrees (it varies by state). Help the grandmother: let her express feelings; involve the **chaplain, social services, organ donation team**, and possibly the **ethics committee**. Quick recall · tap to flip NCLEX A client hit his head, was knocked out, then woke up talking normally. An hour later he's hard to wake. The nurse suspects: Lucid interval then rapid decline = epidural. Emergency surgery. NCLEX MAP 80, ICP 22. What is the CPP, and what does the nurse do? 80 − 22 = 58. Under 70 means poor brain perfusion, and ICP over 20 is dangerous. NCLEX A client's GCS dropped from 13 to 11. Best action? A 2-point drop is clinically significant. NCLEX Which finding in a client on mannitol needs follow-up first? Mannitol should cause big diuresis. Very low output suggests acute kidney injury. NCLEX Clear fluid is draining from a head-injury client's nose. Best assessment? CSF contains glucose and forms a halo on gauze. Possible skull fracture. The 60-second version ## Migraine = overexcited nerves + swollen, widened brain blood vessels - One-sided, **throbbing** pain. Nausea. Light and sound hurt. Some get an **aura** first. - **Pain management is the priority.** First step: avoid triggers. - Most migraine meds work by **narrowing the blood vessels**. - **Triptans:** NO for heart disease, high blood pressure (BP), peripheral vascular disease (PVD), or with selective serotonin reuptake inhibitors (SSRIs). The vessels are like a garden hose that's swollen too wide and throbbing. The fixes squeeze the hose back down: caffeine, triptans, even a cool cloth. Signs & finding the cause - Usually **one-sided**, throbbing. - Nausea, **photophobia**, **phonophobia**. - **Aura** = warning before it hits (vision changes). **Nurse's job:** detailed interview. How often? How long? What sets it off? **Headache diary** → finds patterns and triggers. Common triggers: **caffeine, red wine, monosodium glutamate (MSG)** (a food flavor additive). Treatment step 1 & 2: triggers + comfort 1. **Avoid triggers.** 2. **Comfort measures:** lie down in a **dark room**, **cool cloth** on the forehead, relaxation, yoga, massage, acupuncture. 3. **Medications** if still needed. Abortive meds (stop it now) Take **as soon as symptoms start**, ideally during the aura. - **First:** acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, naproxen), or over-the-counter (OTC) combos with **caffeine** (like Excedrin). Caffeine narrows blood vessels. - **Next: triptans**, like **sumatriptan (Imitrex)** and **rizatriptan (Maxalt)**. They activate serotonin → narrow brain arteries → less pain. **Triptan safety:** they narrow vessels *everywhere*, not just the brain.\ • Think twice with **high blood pressure (BP)** or **heart disease**.\ • **Peripheral vascular disease: absolutely not.**\ • Teach: report **chest pain** right away (heart not getting enough blood).\ • Don't mix with **selective serotonin reuptake inhibitors (SSRIs)** (sertraline, fluoxetine) or **St. John's wort** → **serotonin syndrome**. **Lasmiditan:** newer, doesn't narrow vessels outside the brain, so safer. Side effects: **sleepiness, dizziness**. **Rebound headache:** a new headache after the first one goes away. Caused by taking the medicine **too often or too much**. Preventive meds (stop it from coming) For migraines that are **frequent** or **severe**: - nonsteroidal anti-inflammatory drugs (NSAIDs) - **Beta blockers** - **Topiramate** (an anti-seizure drug) Read in book Iggy Ch. 36, pp. 899–902 · crossed-out parts skipped Migraine basics (book)Read in book - Recurrent attacks of head pain that serve **no protective purpose**. - Throbbing, unilateral. Nausea + sensitivity to **light, sound, or head movement**. - Lasts **4 to 72 hours**. Runs in families. **Women** more than men. - Linked to **major depression**, and higher risk of **stroke** and **epilepsy**. **How the pain happens:** cerebral arteries dilate → **prostaglandins** released → inflammation, swelling, leaking → throbbing pain. Full trigger listRead in book - **Caffeine**, **red wine**, **monosodium glutamate (MSG)** - High-intensity light, stress, excessive fatigue, change in weather - **Tyramine**: pickled foods, aged cheese, smoked sausage, beer - Preservatives, artificial sweeteners Triggers set off **hyperexcitable neurons**. Each patient's triggers are different. Types & phases (Box 36.8)Read in book | With aura ("classic") | Without aura ("common") | | --- | --- | | Aura right before the headache | **Most migraines** are this type | **Chronic** = 15+ days a month. **Episodic** = less often. 1. **Prodrome** (1–2 days before): yawning a lot, constipation, mood changes, food cravings. 2. **Aura** (5–60 min, usually one-sided): flashing lights, spots, zigzag lights; numb or tingling lips/tongue, confusion, aphasia, vertigo, one-sided weakness, drowsiness. 3. **Migraine phase**: nausea/vomiting; one-sided throbbing pain, often worse **behind one eye or ear**; photophobia, phonophobia. Without aura: pain gets worse with routine activity; often early morning, with stress, or premenstrual. **Diagnosis:** history + physical, neuro, and psych assessment. Patients tend to have the same symptoms each time. **Women over 50 with migraines:** teach cardiovascular risk factors. **Call 911** for facial drooping, arm weakness, or trouble speaking (stroke). Abortive drugs: the full lineupRead in book **Priority of care = pain management.** | Severity | Drugs | | --- | --- | | Mild | Acetaminophen; nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, naproxen); over-the-counter (OTC) nonsteroidal anti-inflammatory drug (NSAID) + caffeine | | Nausea | Antiemetics; **metoclopramide** with NSAIDs (speeds stomach emptying) | | Severe | Triptans, ditans | **Caffeine** narrows vessels by blocking **adenosine** (which widens vessels and adds inflammation). **Triptans** (sumatriptan, eletriptan, naratriptan, almotriptan) activate **5-HT (serotonin)** receptors → vasoconstriction. Sumatriptan comes as a pill, injection, or nasal spray. **Contraindicated:** ischemic heart disease, cerebrovascular ischemia, hypertension (HTN), peripheral vascular disease (PVD), **Prinzmetal angina** (coronary vasospasm risk). **Triptan teaching (Drug Alert):** take as soon as symptoms start · report chest pain right away · **use birth control** (not safe in pregnancy) · expect **flushing, tingling, hot feeling** that fades · no selective serotonin reuptake inhibitors (SSRIs) or St. John's wort. **Ditans (lasmiditan):** block one serotonin receptor **without** constricting vessels → safer and more effective than triptans. When to start preventive drugsRead in book Start prevention when **any** of these is true: - More than **2 migraines a month** - Headache lasts more than **24 hours** - Interferes with activities of daily living (ADLs) for **3+ days** - Abortive meds used more than **twice a week** - Not relieved by acute treatment | Drug | Key point | | --- | --- | | **Beta blockers** (propranolol, timolol) | Calm hyperexcitable neurons, block vasodilation. **Lower blood pressure (BP) and heart rate (HR).** | | **Calcium channel blocker** (verapamil) | | | **Topiramate** (AED) | Use in **low doses** | | **Nortriptyline** (TCA) | Dry mouth, urinary retention, constipation. **Not for older adults** (delirium). | **beta blocker (BB) / calcium channel blocker (CCB) teaching:** take your **pulse** · report **bradycardia**, fatigue, shortness of breath · change position slowly (orthostatic hypotension). Diary, comfort & complementary careRead in book - **Headache diary**: type of headache + response to meds. - Report if the headache **changes** in quality or intensity, has **new visual changes**, or the drug stops working. - At onset: lie down, dark room, **both eyes covered**, cool cloth, undisturbed. - **Cannabis:** cannabidiol (CBD) eases pain better; tetrahydrocannabinol (THC) is the mind-altering part. Tolerance can develop. - Yoga, meditation, massage, exercise, **biofeedback**, acupuncture/acupressure. - Riboflavin and **magnesium** supplements may help prevent migraines. - All herbs must be **approved by the provider** first (drug interactions). Heads-up: the book prints "vitamin B12 (riboflavin)," but riboflavin is actually **vitamin B2**. Book · NCLEX Challenge 36.4 · Select all Client prescribed propranolol (prevention) and sumatriptan (acute). Which teaching statements should the nurse include? Beta blockers cause **bradycardia** (report a LOW pulse, not >100) and orthostatic hypotension. Triptans go in early, and chest pain = possible ischemia. Vitamin D isn't part of this plan. Review class: migraine meds (prevent vs. abortive) Review class From the in-class exam review (Joline case study + NCLEX questions). | Goal | Drug | Key point | | --- | --- | --- | | **Prevent** migraines | **Propranolol** (beta blocker) | Taken regularly to prevent attacks | | **Abortive** (once headache starts) | **Triptans** (sumatriptan): "triptan" is in the name | Activates serotonin → **vasoconstriction** of the dilated brain vessels | Triptans squeeze blood vessels. They don't only squeeze the brain's vessels, they squeeze them **everywhere**. **Do NOT give triptans with:** - **Hypertension**, **peripheral vascular disease** (vessels already narrowed) - **Angina / heart disease**: chest pain after a triptan = coronary vasoconstriction - **Selective serotonin reuptake inhibitors (SSRIs)** like fluoxetine (Prozac), paroxetine → too much serotonin = **serotonin syndrome** - **St. John's wort** (and grapefruit) interact with lots of meds. If it shows up as an answer choice, don't pick it. Quick recall · tap to flip NCLEX A client is prescribed sumatriptan. Which history should the nurse report first? Triptans narrow blood vessels, which makes PVD worse. NCLEX After taking a triptan, the client says "my chest feels tight." What does the nurse do? Narrowed vessels can starve the heart of oxygen. Chest pain is a red flag. NCLEX Which statement shows the client understands migraine self-care? The diary finds triggers. Meds go early, daily use causes rebound headaches, and red wine is a trigger. The 60-second version ## A seizure is an electrical storm in the brain - Seizure with a clear cause (fever, electrolytes, alcohol withdrawal, brain injury) = **NOT epilepsy**. Treat the cause. - **Epilepsy** = seizures that keep coming back on their own. - During a seizure: **turn to side, move objects, never restrain, nothing in the mouth**. - **Status epilepticus** (>5 min) = emergency → **airway** first, then **lorazepam intravenous (IV)**. Think of a power surge in a house. Anti-seizure meds are surge protectors: they keep surges from happening, but they don't rewire the house (no cure). **Caption alert:** the video captions say "fentanyl," but your instructor means **phenytoin** (Dilantin). "Phosphantinoin" = **fosphenytoin**. Seizure vs. epilepsy **Seizure** = sudden, uncontrolled burst of electrical activity in brain cells. **Secondary causes** (fix these first): **high fever, electrolyte imbalance, alcohol withdrawal, brain injury**. These are NOT epilepsy. **Epilepsy** = chronic, **recurrent, unprovoked** seizures. Cause: abnormal brain cells or a chemical imbalance (like **gamma-aminobutyric acid (GABA)**, the brain's calming chemical). Diagnosis starts with a detailed **history and physical**. Seizure types (slides)Slides Your instructor said these are **review from Peds**. You won't be tested on each type directly, but the words may show up in a question. **Generalized** = **both** sides of the brain: - **Tonic-clonic** (2–5 min): stiffening + level of consciousness (LOC) (tonic), then rhythmic jerking (clonic). Tongue biting, incontinence. - **Myoclonic:** quick jerks of arms or legs. - **Atonic:** suddenly goes limp → falls → injury. - **Absence:** brief blank stare; lip smacking or picking (automatisms). **Partial (focal)** = **one** side: **complex** (blacks out 1–3 min, no memory after) or **simple** (stays awake, has an aura). electroencephalogram (EEG) test prep EEG records the brain's electrical activity. Electrodes are glued to the scalp. - **Clean hair**: no conditioner, gel, or spray (electrodes won't stick). - **Eat before the test.** Low blood sugar changes the reading. - **No sedatives, stimulants, or caffeine.** - Quiet room, sign on the door. We want a picture of the brain's normal self. Anything that speeds it up, slows it down, or starves it ruins the picture. Anti-seizure meds **Slide drugs:** phenytoin (Dilantin), carbamazepine (Tegretol), valproic acid (Depakote), topiramate (Topamax). You don't need to know which drug is for which seizure type. Know these rules: - They slow the brain → **drowsiness**. - Can cause **depression and suicidal thoughts**. Screen mood. - **Liver damage** → check liver enzymes. **Low white blood cells (WBCs)** → infection risk. - **Narrow safe range** → regular **blood levels**. - **Phenytoin** → **gums overgrow** (gingival hyperplasia). Teach: soft toothbrush, regular dentist visits. **Never stop suddenly.** Seizures come back and can turn into status epilepticus. - **Pregnancy category D**: can cause birth defects, but uncontrolled seizures hurt the baby too. Tough decision with the provider. - **Birth control pills** work less well → use a **second method**. - **Warfarin** needs close monitoring. **No grapefruit** (toxicity). Vagal nerve stimulator (VNS) For seizures meds can't control. A device in the **left chest** (like a pacemaker) sends pulses up the **vagus nerve** to the brain. - Feels an **aura**? **Swipe the magnet** over the device to stop the seizure. - Like a pacemaker: **magnetic resonance imaging (MRI) can be dangerous**, sets off airport metal detectors, wear a **medical alert bracelet**, carry a wallet card. Before: seizure precautions - **Suction + oxygen** at the bedside. - **intravenous (IV) access** (saline lock). They can't swallow pills during a seizure. - **Padded side rails?** Debated (could count as a restraint). **Follow hospital policy.** Some use a mattress on the floor. - Keep them **active and independent**. Don't keep them stuck in bed. **NO padded tongue blades.** A chipped tooth can be breathed in, or the blade can block the airway. During a seizure **Patient safety is the priority.** 1. Turn to the **side** so spit drains out → no aspiration. 2. **Move objects** away so they don't get hurt. 3. **Never restrain.** Nothing in the mouth. 4. **Watch and document** what happens, in order. It tells the provider the seizure type → which drug. Status epilepticus: emergency Seizure lasting **longer than 5 minutes**, or seizures back-to-back over 30 minutes. Over 10 minutes can be deadly. **Call the Rapid Response Team.** 1. **Airway** (may need intubation) + **oxygen**. 2. **intravenous (IV) with normal saline**. Draw blood: **arterial blood gases (ABGs), electrolytes, drug levels**. 3. **Stop it:** **lorazepam (Ativan)** or diazepam (Valium) IV push. 4. **Prevent the next one:** **fosphenytoin** (preferred, safer) or phenytoin. Firefighter first (lorazepam puts out the fire). Then the sprinkler system (fosphenytoin stops the next fire). Patient & family teaching - Meds: take every dose, know interactions, keep blood level appointments. - Family knows what to do during and after a seizure, and when to call 911. - **Seizure diary.** Medical alert bracelet or card. - **Driving laws** by state: **Michigan = 6 months** seizure-free · Wisconsin = 3 months · Ohio = no waiting period. - Employment concerns → refer to **social services / case manager**. - Support groups: Epilepsy Foundation. Read in book Iggy Ch. 36, pp. 902–907 · crossed-out parts skipped (seizure types, Table 36.2) Definitions & secondary causesRead in book **Seizure** = sudden, excessive, uncontrolled electrical discharge of neurons → changes in level of consciousness (LOC), motor/sensory ability, or behavior. **Epilepsy** = chronic, **repeated, unprovoked** seizures. Cause: abnormal electrical activity and/or neurotransmitter imbalance, especially **gamma-aminobutyric acid (GABA)**. **Primary (idiopathic)**: no clear cause, likely genetic. **Secondary**: from a brain lesion (tumor, trauma) or: - Metabolic disorders, **electrolyte problems** (hyperkalemia, water intoxication, hypoglycemia) - Acute alcohol withdrawal, substance abuse - High fever, stroke, head injury, heart disease **Triggers:** more physical activity, stress, fatigue, alcohol or caffeine, certain foods or chemicals. Assessment & diagnosisRead in book - How many seizures, how long, any **pattern**? Have family describe them. - Any **aura** before (the **preictal phase**)? - Meds, herbs, head trauma, high fever, alcohol or drug use, past stroke or hypertension (HTN). - New seizures: ask about any past **loss of consciousness or brain injury**, even in childhood. **Tests:** electroencephalogram (EEG), computed tomography (CT), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT)/positron emission tomography (PET). antiepileptic drug (AED) teaching (book adds)Read in book - Provider adds **one AED at a time**. - Keep lab appointments: **complete blood count (CBC) + liver enzymes** (most antiepileptic drugs (AEDs) cause **leukopenia** and liver dysfunction) + drug levels. - Take on time. Sensitivity can build with age ("drug decline and sensitivity") → frequent levels. - **Phenytoin + warfarin** = don't combine. - **Grapefruit juice** raises drug levels → toxicity. **Women with epilepsy:** hormones and birth control pills change AED effects → monitor more often. AEDs can add to **osteoporosis** after menopause. During a seizure: Box 36.9Read in book - Protect from injury; **nothing forced in the mouth**. - Turn to the **side** (prevents aspiration, keeps airway clear). - Remove objects; **suction gently** if possible; **loosen clothing**. - **Don't restrain**; guide movements if needed. - **Record start and end time.** **After:** vital signs, neuro checks, keep on side, let them rest. **Document:** pupils and eye deviation, level of consciousness (LOC), apnea/cyanosis/salivation, incontinence, eye fluttering, how motor activity spread, lip smacking, tongue biting, length, aura, behavior after, time to return to baseline. **Cyanosis** during tonic-clonic seizures is common and usually self-limiting. High-risk patients may get O₂ postictally. Status epilepticus: book detailsRead in book **Acute seizures** (more intense, more often, or in clusters) → lorazepam or diazepam to **prevent** status. **Common causes of status:** **suddenly stopping antiepileptic drugs (AEDs)**, infection, alcohol/drug withdrawal, traumatic brain injury (TBI), cerebral edema, metabolic problems. **Critical Rescue:** **airway is the priority** → call provider / Rapid Response → O₂ → **large-bore intravenous (IV)** with 0.9% sodium chloride (NaCl) → usually intensive care unit (ICU). **Untreated:** hypoxia, hypotension, hypoglycemia, dysrhythmias, lactic acidosis. Muscle breakdown → **myoglobin → acute kidney injury** (especially older adults). - **Lorazepam IV push over 2 minutes** (may repeat). Diazepam rectal gel is an option. - **Phenytoin IV:** infusion pump · **normal saline only** (precipitates in other fluids) · flush normal saline (NS) before and after · then oral doses. - **Fosphenytoin:** water-soluble, works with most IV fluids **including dextrose**, fewer heart complications. vagal nerve stimulator (VNS): book detailsRead in book - Device in the **left chest wall**, lead on the **left vagus nerve**. \~2 hrs under general anesthesia. - Turned on in the operating room (OR) or, more often, **2 weeks after surgery**. Runs continuously. - **Voice change** = the nerve is being stimulated (expected). - Complications: **hoarseness (most common)**, cough, dyspnea, neck pain, dysphagia. - Avoid **magnetic resonance imaging scans (MRIs), microwaves, shortwave radios, ultrasound diathermy**. Patient & family teaching: Box 36.10Read in book - Know drug name, dose, timing, side effects, what to do if a dose is missed. - **Never stop antiepileptic drugs (AEDs)**, even if seizures stop. - Keep blood-level appointments. No over-the-counter (OTC) drugs without asking. - Wear a **medical alert** bracelet or carry an ID card. - Family knows how to help during a seizure and **when to call emergency medical services (EMS)**. - Follow **state driving and machinery laws**. - Avoid **alcohol and excessive fatigue**. Balanced diet, rest, stress reduction. **Seizure diary.** - Can't afford meds? Refer to **social services** / case manager. - Discrimination is illegal, but risky jobs (construction, heavy equipment, pilots) may need to change. Book · Mastery Q3 · Select all A hospitalized client has a tonic-clonic seizure. Which actions are most appropriate *during* the seizure? During: suction gently, remove hazards. Nothing goes in the mouth. Vitals come **after**. Benzos are for status or clusters, not every single seizure. Book · NGN Challenge 36.1 **Case:** 54-year-old had **3 tonic-clonic seizures** (2–3 min each) in the past hour. Got intravenous (IV) lorazepam; fosphenytoin infusing; O₂ 2 L. Now back to baseline, A&O ×4, vitals normal. Review class: seizure priorities + meds Review class From the in-class exam review (Joline case study + NCLEX questions). - **Tonic-clonic seizure, loses consciousness → priority: turn to the side** (aspiration risk). If there's no trauma/fall in the story, you're not worried about spinal injury. - **Status epilepticus** = seizure that keeps going. **Stop it** with a benzodiazepine ending in **-pam**: **diazepam** or lorazepam. - **Phenytoin / fosphenytoin** (fosphenytoin more common) **do NOT stop** a seizure in progress. They **prevent future** seizures. Quick recall · tap to flip NCLEX A client is having a tonic-clonic seizure in bed. What should the nurse do first? Side-lying protects the airway. Never restrain, never put anything in the mouth, never leave. NCLEX A client has been seizing for 6 minutes. Priority action? Over 5 minutes = status epilepticus. Airway first. Nothing by mouth. NCLEX A client on an anti-seizure drug takes birth control pills. Best teaching? These drugs make the pill less effective. Never stop them suddenly, and no grapefruit. NCLEX Which finding in a client on long-term anti-seizure meds needs follow-up first? These drugs can cause depression and suicidal thoughts. Safety first. The 60-second version ## Infected brain covering = pressure + sepsis danger - **Meningitis** = inflamed **meninges** (the wrapping around brain and spinal cord). - **Viral** = more common, gets better in 7–10 days. **Bacterial** = emergency, can kill in 24 hrs. - **Meningococcal** (bacterial) → **droplet precautions**. - Diagnose with a **lumbar puncture**, but **computed tomography (CT) first** if signs of ↑intracranial pressure (ICP). - Top 3 checks: **neuro, vital signs, circulation**. The brain sits in a sealed jar. Swelling raises the pressure inside. Opening the bottom of the jar (lumbar puncture) can make the brain shift down. Check the pressure with a computed tomography (CT) before you open it. How it gets in A germ gets into the blood and **crosses the blood-brain barrier**. - Sources: **brain or spine surgery**, **ear or sinus infection**, **flu or pneumonia**. - Prevention = **vaccines**: flu, pneumonia, meningococcal. - **Meningococcal vaccine: age 11–12, booster at 16.** Viral vs. bacterial | | Viral | Bacterial (meningococcal) | | --- | --- | --- | | How common | **More common** | Less common | | How bad | Most recover in **7–10 days** | **Emergency.** Can kill within **24 hrs** | | Spread | — | Highly contagious; outbreaks in **dorms**, group homes | | Isolation | **Standard** | **Droplet** | **Encephalitis** = inflamed **brain tissue** itself. Same signs, but more **long-term brain damage**. Signs & symptoms - **Nuchal rigidity**: stiff, sore neck. - **Severe headache**, **photophobia**, **nystagmus**, pupil changes. - Altered mental status, **seizures**, **↑intracranial pressure (ICP)**, **positive Babinski**, **sepsis**. **Fever may be missing. Why?**\ 1\. **Older adults** run cooler, so 98.6°F might already be a fever for them.\ 2\. They're **already on antibiotics** for the first infection (like sinusitis). The drug didn't kill the germ, and it reached the brain. Babinski reflex **How:** stroke the bottom of the foot from the **heel up to the toes**. | Toes do… | Name | Adult meaning | | --- | --- | --- | | **Curl down** | Absent Babinski | **Normal** (what we want) | | Big toe **up**, others **fan out** | Positive Babinski | **Problem in the brain or spinal cord** | **Exception:** positive Babinski is **normal under age 2**. Their nervous system isn't mature yet. Lumbar puncture (spinal tap) Meningitis is diagnosed by testing **cerebrospinal fluid (CSF)**. - Position: **side-lying, knees to chest** (fetal position). - Patient must stay **very still** (may need help holding or sedation). **Danger:** if there are signs of ↑intracranial pressure (ICP), letting CSF out fast can make pressure worse. **computed tomography (CT) scan first.** Cultures & antibiotics: the exception **Normal rule:** get cultures first, then antibiotics. **Exception** (signs of ↑intracranial pressure (ICP), no time for computed tomography (CT) + lumbar puncture (LP)): 1. Draw **blood cultures** immediately. 2. Start a **broad-spectrum antibiotic right away**. 3. Skip the cerebrospinal fluid (CSF) culture (LP too risky). 4. Germ identified → switch to a **narrow-spectrum** antibiotic. Top 3 nursing priorities 1. **Neuro status.** **First sign of ↑intracranial pressure (ICP) = change in behavior** (restless, irritable, "something's off"). Seizure precautions. 2. **Vital signs**: clues to rising ICP. 3. **Circulation check**: color, temperature, cap refill, pulses in hands and feet. Watch for **bleeding** (gums, urine, intravenous (IV) site). **Why bleeding?** Sepsis makes tons of tiny clots. They use up all the platelets and clotting factors, so none are left for normal clotting → bleeding. This is **disseminated intravascular coagulation (DIC)** (disseminated intravascular coagulation). Read in book Iggy Ch. 36, pp. 907–909 · crossed-out parts skipped What & how it enters (book)Read in book Infection of the **pia mater and arachnoid mater**. Usually bacterial or viral; also fungal or protozoal. **Sterile meningitis** can come from cancer, nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, intravenous (IV) immunoglobulin. **Ways in:** bloodstream, or directly through penetrating trauma, brain/spine surgery, ruptured brain abscess. **Basilar skull fracture:** clear "runny nose" (**rhinorrhea**) or ear drainage (**otorrhea**) may actually be **cerebrospinal fluid (CSF)** → path for infection. **Higher risk:** head/neck infections (otitis media, sinusitis, tooth abscess, even tongue piercing); immunocompromised (no spleen, immunosuppressants, transplant, cancer); older adults. Can cause permanent cranial/spinal nerve damage and **↑intracranial pressure (ICP)**. Organisms & vaccinesRead in book **Viral = "aseptic" meningitis** (no organism grows in cerebrospinal fluid (CSF) culture): enterovirus, herpes simplex virus (HSV)-2, varicella zoster, mumps, human immunodeficiency virus (HIV). **Bacterial:** *Streptococcus pneumoniae* and *Neisseria meningitidis* (= meningococcal). Outbreaks: dorms, **military barracks**, crowded housing. **Vaccine schedule (CDC):** highest risk = **ages 16–21**. First meningococcal dose at **11–12**, booster at **16**. Adults: shared housing, travel, or no spleen. Booster OK as early as 8 weeks after first dose. Other vaccines that prevent meningitis: **Hib**, pneumococcal, mumps, varicella, meningococcal. Key features: Box 36.11Read in book - **↓level of consciousness (LOC)**, disorientation - **Photophobia**, **nystagmus** (jerky repetitive eye movements) - Motor normal early → later hemiparesis/hemiplegia - Cranial nerve problems: **cranial nerve (CN) III, intravenous (IV), VI, VII, VIII** - Short attention span, personality changes - Severe, unrelenting headache; myalgia; N/V; fever, chills; tachycardia - **Red macular rash** = meningococcal Nuchal rigidity, **Kernig** and **Brudzinski** signs show up in only a **small percentage**. Diagnostics (book)Read in book **computed tomography (CT) before lumbar puncture (LP)** for: age **over 60**, immunocompromised, or signs of ↑intracranial pressure (ICP). - LP delayed? Draw **blood cultures** (C&S) first. - Broad-spectrum antibiotic **right after the LP** (or right away if LP is delayed). - cerebrospinal fluid (CSF) tested for cell count, differential, protein, glucose, culture, Gram stain. - **complete blood count (CBC):** white blood cell count (WBC) well above normal. Electrolytes checked. - X-rays of chest, sinuses, mastoids (find the infection source). - CT/magnetic resonance imaging (MRI): ↑ICP, hydrocephalus, abscess. Treatment & isolationRead in book - Broad-spectrum antibiotic until culture and Gram stain return. - Bacterial: usually a **2-week intravenous (IV) antibiotic course**. Start within **1–2 hours** of the order. - **Mannitol** for ↑intracranial pressure (ICP); antiepileptic drugs (AEDs) for seizures. **Droplet Precautions** (in addition to Standard) for *N. meningitidis* and *H. influenzae*: private room · stay **3 feet** away without a mask · patient wears a mask outside the room · teach visitors. All other meningitis: **Standard Precautions**. Nursing care: Box 36.12Read in book **Most important nursing action:** accurately monitor and document **neuro status**. Neuro checks + vital signs (VS) **every 2–4 hours**. - airway, breathing, circulation (ABCs) first. Cranial nerve checks. - **Vascular check every 4 hrs**, especially the **hands**: temp, color, pulses, nail cap refill. Missed compromise → gangrene → loss of the arm. - Strict I&O, prevent fluid overload; **daily weight**. - Quiet room, **dim lights** (photophobia). - Bed rest, **head of bed (HOB) 30°**. Reposition (pressure injuries); range of motion (ROM) every 4 hrs. - Watch for: ↑intracranial pressure (ICP), vascular problems, fluid/electrolyte imbalance, seizures, shock. Also septic shock, clotting disorders, acute respiratory distress syndrome (ARDS), septic arthritis. Book · NGN Challenge 36.2 **Case:** 21-year-old with suspected bacterial meningitis. Temp 101.6 → **102.4°F** → 100.8°F. white blood cell count (WBC) **18,000**. At 0600: A&O ×4, headache 8/10. At 0700: **drowsy, oriented ×2**, unsure of day and time, "very sleepy," headache 5/10. Review class: bacterial meningitis: order of actions Review class From the in-class exam review (Joline case study + NCLEX questions). 1. **Isolation first** (protect yourself and the team). **Droplet** precautions: regular **surgical mask**, private room. No negative-pressure room needed. 2. **Insert an intravenous (IV) line** (circulation; emergency meds). 3. **Computed tomography (CT) of the head before the lumbar puncture**: rule out ↑intracranial pressure (ICP). A lumbar puncture with high ICP pushes it even higher. 4. **Broad-spectrum antibiotic** right away while waiting on the culture and sensitivity (C&S). 5. Once the organism is identified → switch to a **narrow-spectrum** antibiotic. **NCLEX mindset:** even if the patient is blue, you don't skip your own protection. Quick recall · tap to flip NCLEX A client with suspected bacterial meningitis becomes newly restless and irritable. Priority? Behavior change is the earliest sign of ↑ICP. Sedation would hide the neuro exam. NCLEX A college student has meningococcal meningitis. Which precautions? Meningococcal spreads by droplets. Viral meningitis uses standard precautions. NCLEX Stroking an adult's sole makes the big toe go up and the toes fan out. This means: In adults, toes should curl down. Fanning up signals a brain or spinal cord problem. The 60-second version ## Not enough dopamine → movement gets shaky, stiff, and slow - Progressive brain disease that affects **movement**. - Signs = **TRAP** + low blood pressure (BP) when standing, drooling, peeing at night. - Main drug: **carbidopa-levodopa (Sinemet)**. Take with carbs, **not protein**. - Biggest nursing job: **fall prevention** and nutrition. Acetylcholine is the gas pedal. Dopamine is the brake. In Parkinson's the brake wears out but the gas stays the same → shaky, jerky, hard-to-control movement. Signs: TRAP T**Tremor**: "pill rolling" (thumb rubs finger) at rest. Handwriting gets tiny and squiggly. R**Rigidity**: muscles can't relax → **mask-like face**, less blinking/smiling, trouble speaking, **trouble swallowing**, drooling. A**Akinesia/bradykinesia**: slow movement. Eating, writing, shaving get hard. P**Postural instability**: stooped, shuffling, **freezing gait** ("feet stuck to the floor") → **falls**. Automatic-body problems Dopamine also helps run the "fight or flight" system. Less dopamine → it underperforms: - **Orthostatic hypotension**: blood pressure (BP) drops on standing → dizzy → falls. - **Drooling**: less automatic swallowing. - **Nocturia**: peeing at night. Meds: carbidopa-levodopa (Sinemet) Your instructor said these are the most common Parkinson's meds and **the only ones you need to know**. Replaces the missing dopamine (the brake). - **Nausea** is common → take with food, but **carbs, not protein** (protein blocks absorption). - Long-term: **dyskinesia** (uncontrolled movements). - **"On-off"**: symptoms controlled (on), then back (off), several times a day. Meds: dopamine agonists Copy dopamine. Side effects are less common but **more serious** → often **not safe for older adults**. - **Impulse control problems**: gambling, hypersexuality (dopamine = pleasure). - Mood changes. Tolerance, toxicity & drug holiday | Tolerance | Toxicity | | --- | --- | | Med just isn't working as well | **Delirium** (sudden confusion) | **Delirium = sudden. Dementia = slow and long-term.** **Fix for both:** lower the dose or frequency, change meds, or a **drug holiday** (off the med 1 week up to 10 days, then restart). Deep brain stimulation (DBS) When meds aren't enough. Approved for **severe tremors**. - Electrodes go into the brain; wires run under the skin to a device in the **left chest** (like a pacemaker). - Sends pulses that **decrease involuntary movements** and block tremors. - **Not a cure.** Disease still progresses. - Same precautions as a pacemaker: avoid **electromagnetic fields and magnetic resonance imaging scans (MRIs)**. Nursing management (slides)Slides - **Injury prevention (falls)**: muscle strengthening, stretching, flexibility, balance and coordination. - Exercise, range of motion (ROM), walking; self-care; sleep problems. - Communication and speech help; emotional support; support groups. - **Nutrition:** **high protein, high calorie** (unless liver or kidney disease) · soft diet, thickened liquids · **weigh weekly** · swallow evaluation. Watch the trap: high-protein diet for weight, but keep protein away from the Sinemet dose. Captions mishear: `Echinacea` = bradykinesia · `pastoral` = postural · `cinnamon` = Sinemet · `bacteria` = nocturia Read in book Iggy Ch. 36, pp. 894–899 · crossed-out parts skipped (stages box, monoamine oxidase (MAO)-B/catechol-O-methyltransferase (COMT) drugs, imaging, other surgeries) Patho & early signs (book)Read in book **Primary (idiopathic)** is most common. **Secondary** parkinsonism: brain tumors, some **antipsychotics**. Substantia nigra degenerates → less dopamine. Protein **alpha-synuclein** is thought to drive it. Symptoms appear only after a big dopamine drop (book: 70–80%). **Non-motor signs can appear YEARS before TRAP:** constipation, soft voice, **micrographia** (tiny handwriting), **loss of smell**, sexual dysfunction, sleep problems. - **traumatic brain injury (TBI)** raises Parkinson's disease (PD) risk → teach contact-sport athletes to wear **helmets**. - Veterans: TBI, **Agent Orange** exposure. - **Lewy bodies** (abnormal proteins) → some get Lewy body dementia. - About **50% more men** than women. Assessment (book)Read in book - **Rigidity** = resistance to **passive** movement; present early. - Stage 4: needs a **walker** and help with activities of daily living (ADLs). Stage 5: trouble chewing and swallowing. - Late: dementia, psychosis (delusions, paranoia, hallucinations), depression, anxiety, apathy. - Autonomic: **excessive sweating**, orthostatic hypotension. - Speech: soft, slurred, monotone, halting, or rapid. - Bladder: incontinence **or** trouble urinating. Bowel: **constipation**. **No specific test.** Diagnosis is clinical, after ruling out other neuro diseases. **Priority problems:** 1) ↓mobility (self-care deficit) · 2) impaired cognition. **Priority of care: keep mobility and activities of daily living (ADL) independence as long as possible.** Box 36.7: best-practice careRead in book - Give patients **extra time** to answer and to do activities of daily living (ADLs); help only as needed. - Give meds **on time, on their individual schedule** (steady drug levels). - Fall Precautions; physical therapy (PT)/occupational therapy (OT). - Prevent immobility complications: constipation, pressure injuries, contractures. - Schedule activities **late morning** or at their best time of day. - Teach to speak slowly and clearly; communication board; refer to **speech-language pathologist (SLP)**. - Monitor swallowing and intake; **high-protein, high-calorie** foods. - Focus on strengths (self-esteem). Assess depression, anxiety, cognition, insomnia. Drug details (book)Read in book **Dopamine agonists** (apomorphine, pramipexole, ropinirole; **rotigotine patch**): best in the first **3–5 years**; fewer dyskinesias and less "wearing off." **Agonist Drug Alert:** orthostatic hypotension, hallucinations, **sleepiness** → no driving or heavy machinery · rise slowly · shouldn't be prescribed to older adults. **Carbidopa/levodopa:** nearly everyone takes it eventually. Cheaper and better for motor function than agonists. Comes as immediate-release (IR), controlled-release (CR), enteral infusion, and an **inhaled form for "off" periods**. **Safinamide** is an add-on. **Book says:** give levodopa **before meals** for better absorption. **Lecture says:** if it causes nausea, take with carbs, not protein. Both point the same way: **keep protein away from the dose**. **Toxicity** = delirium, hallucinations, less effect. Compare to the pre-drug baseline. **Tolerance** = effects wear off sooner. Drug holiday lasts up to 10 days; monitor and document Parkinson's disease (PD) symptoms during it. **Symptom helpers:** baclofen (spasms), **sublingual atropine** (drooling), zolpidem (insomnia). Medical cannabis: stay **nonjudgmental**. Freezing gait, sleep, eating & speechRead in book **Freezing gait tricks:** step **sideways, then forward** · shift weight side to side, then step · picture an object on the floor to **step over**. Yoga and tai chi help early. range of motion (ROM), stretching, out of bed. **Sleep:** poor nights + short naps they may not notice → risk of **falling asleep while driving**. - speech-language pathologist (SLP) swallowing evaluation. **Soft diet, thick cold fluids** (milkshakes), small frequent meals, thickener (Thick-It). - **Elevate the head** to prevent aspiration. Weigh **weekly**. - Speech: slow, deep breaths, exaggerate words; reduce background noise; listener watches lips. Cognition, home care & deep brain stimulation (DBS) (book)Read in book - About **50%** develop cognitive problems. Depression is common (venlafaxine may be used). - Don't force social events; emphasize strengths. - Teach to report **dizziness, falls, delirium, hallucinations**. - Constipation: fluids, high fiber, bowel program. Sleep hygiene: no alcohol or caffeine, dark room. - Impulse control problems: remind family the patient **can't control** them. Watch for caregiver strain. - Late disease → palliative or hospice care. - **DBS**: reduces the need for levodopa; usually **not offered while meds still work**. Book · Mastery Q2 An ambulatory client was recently diagnosed with **early** Parkinson's. What finding does the nurse expect? Resting tremor is an early sign. Dementia and swallowing problems come late. Book · NCLEX Challenge 36.3 · Select all Client prescribed **ropinirole**. Which teaching statements should the nurse include? Ropinirole is a dopamine agonist: orthostatic hypotension, sleepiness, possible dyskinesias. The patch is rotigotine, and the food rule is for monoamine oxidase inhibitors (MAOIs). Review class: Parkinson's meds + earliest sign Review class From the in-class exam review (Joline case study + NCLEX questions). - **Earliest (initial) sign: tremor.** All the classic signs are Parkinson's, but tremor usually comes first. - **Ropinirole = dopamine agonist** (mimics dopamine). **Caution in older adults:** orthostatic hypotension and drowsiness → falls. - **Carbidopa-levodopa** (Sinemet): levodopa is turned into dopamine. Causes **nausea** → take **with food, but NOT protein** (protein blocks absorption: no peanut butter, eggs). Quick recall · tap to flip NCLEX Which breakfast is best with the morning carbidopa-levodopa dose? Protein blocks levodopa. Carbs help nausea without blocking it. NCLEX Top safety concern for a client with Parkinson's? Low BP on standing + poor balance = high fall risk. NCLEX A family says their dad on a dopamine agonist is suddenly gambling a lot. The nurse knows: Dopamine drives pleasure and reward, so agonists can cause impulse control problems. The 60-second version ## Inherited disease: dementia + "dancing" movements - **Hereditary.** Symptoms start at **age 30–50**. - Brain cells die → **progressive dementia** + **chorea**. - Child of a parent with it: **50/50 chance**. - **No cure.** Control symptoms, prevent complications. "Chorea" is Greek for dance (like "choreography"). Picture fast, jerky dance moves the person can't stop. Chorea & treatment **Chorea** = rapid, jerky movements of the **arms, legs, and face**. The term is used only for Huntington's. - The movements have **no purpose**. - The patient **can't stop or control them**. Care is the same as for anyone with a movement or memory disorder (Parkinson's, Alzheimer's): - Assistive devices; physical therapy (PT), occupational therapy (OT), speech therapy. - **Keep familiar routines.** Break tasks into **small steps**. - **Avoid open-ended questions** (ask yes/no or simple choices). - To-do lists and calendars. Genetics & testing - Parent has it → each child has a **50% chance**. - Child **doesn't carry the gene** → won't get it and **can't pass it on**. - A test can show the gene. Hard question: is it better to know? - **Not done under age 18**: they may feel pressured and aren't mature enough for the results. - **Genetic counseling** is very important for the children (ethical dilemma). Quick recall · tap to flip NCLEX A 16-year-old whose father has Huntington's asks to be tested. Best response? No testing under 18. Risk is 50%, and it doesn't skip generations. NCLEX Which communication works best for a client with Huntington's? Avoid open-ended questions. Simple yes/no choices work better with cognitive decline. The 60-second version ## multiple sclerosis (MS): the immune system strips the wire coating - **Autoimmune.** Damages **myelin** in the brain and spinal cord → signals weak or blocked. - Comes in waves: **flare-ups** and **remissions**. - Top symptoms: **fatigue, mobility problems, vision changes**. - Avoid **heat, stress, fatigue**. No hot showers, no hard exercise. - amyotrophic lateral sclerosis (ALS): **movement only**. Mind and senses stay intact. Myelin is the plastic coating on a phone charger cord. Strip patches off and the signal flickers or cuts out. What multiple sclerosis (MS) is - Myelin **cushions and protects** nerves and helps signals travel between brain, cord, and body. - Demyelination → signals are **weaker**, or don't get through. - Progresses at **different speeds** in different people. **Why diagnosis takes so long** (frustrating for patient and family): - No single test confirms it. - Symptoms look like other neuro problems, which must be ruled out. - Symptoms go away for a while, so people don't seek care. Signs & symptoms - **Overwhelming fatigue.** - **Weak, stiff legs**: hard to move them, hesitant → **fall risk**. - **Vision** (optic nerve): **nystagmus**, **double vision**, blurry vision. - **Dysarthria**: slurred or **scanning speech** (long pauses between words; can sound like stuttering). - Spasticity, numbness/tingling, **intention tremor** (shakes when reaching), poor coordination, positive Babinski. - Trouble swallowing; bowel, bladder, and sexual problems; memory and focus problems. **Don't mix up tremors:** Parkinson's = shakes **at rest**. multiple sclerosis (MS) = shakes **when moving** (intention). Nursing care **Prevent flare-ups:** avoid **fatigue, stress, temperature extremes** (hot showers). **Keep them independent:** - Stay organized; keep often-used items **within reach** (saves energy). - Speech therapy for swallowing trouble. **Eye patch** for double vision. - **Strength and stretching** exercises (PT/occupational therapy (OT)) for balance and coordination. - **No rigorous exercise**: raises body temp → more fatigue, less movement. **Main goal = symptom control.** multiple sclerosis (MS) meds (only 2 to know) No cure. **Immunomodulators** slow the disease and make attacks fewer and milder. Your instructor said know only these: | Drug | Key points | | --- | --- | | **Interferon beta** | Shot under the skin (every other day or weekly). **Infection risk**, bone marrow suppression, **flu-like symptoms**. | | **Glatiramer** | Shot under the skin. **Fewer side effects.** | amyotrophic lateral sclerosis (ALS) (Lou Gehrig's disease) - **Motor neurons** die → weakness, muscle wasting, stiffness → **paralysis**. Cause unknown. - **Only movement is affected.** They can still see, hear, and feel, and **thinking stays intact**. - Starts in one area, then spreads. Lose the ability to talk, swallow, and breathe. - Signs: tired while talking, **tongue shrinking**, slurred speech, trouble swallowing, **face twitching** (fasciculations). - Death usually within **3 years**, from **respiratory failure**. - No cure. Meds treat pain, spasms, **extra secretions**, sleep problems. Communication aids. - May need a feeding tube and ventilator. Get **advance directives** early. **Hospice** supports the family. Read in book Iggy Ch. 37, pp. 913–920 · crossed-out parts left out (MS types except relapsing-remitting multiple sclerosis (RRMS), cerebrospinal fluid (CSF)/evoked potentials, other MS drugs) What happens in multiple sclerosis (MS)Read in book - Cause: **immune, genetic, and/or infectious** factors. - **Demyelination** slows or stops nerve signals → patchy **plaques** in white matter. - Early on, myelin repairs itself and symptoms fade. Over time, damage builds and **muscle atrophy** sets in. - Often hits the **optic nerves**, spinal tracts, brainstem, and the area around the ventricles. - A leading cause of neuro disability in **young and middle-age adults**. Types of multiple sclerosis (MS)Read in book | Type | Pattern | | --- | --- | | **relapsing-remitting multiple sclerosis (RRMS)** (relapsing-remitting) | **Most common.** Flares over weeks to months, then back to baseline. | RRMS is a roller coaster that returns to the station. Who gets itRead in book - **Women 2–3×** more than men (some studies say up to 4×). - Ages **20–50**. About 1 million people in the US. - More common in **colder climates** (Great Lakes, Pacific Northwest). - A **first-degree relative** with multiple sclerosis (MS) raises risk. multiple sclerosis (MS) vs. amyotrophic lateral sclerosis (ALS) (Table 37.1)Read in book | | MS | ALS | | --- | --- | --- | | Cause | Immune attack on myelin; remissions + flares | Unknown (genetic + environmental); progressive muscle wasting → **respiratory paralysis** | | Who | Common; women 2× men; ages 20–50 | Uncommon; **men** more; ages 40–60 | | Signs | Fatigue, spasticity, **diplopia**, scotomas, nystagmus, paresthesias, bladder problems, intention tremor | Fatigue, muscle atrophy (incl. tongue), twitching of face and tongue, dysarthria, dysphagia | | Outlook | Many disease-modifying drugs | **100% fatal**; no cure. Supportive + palliative care | Signs & symptoms (Box 37.1)Read in book **History:** early symptoms are **vague** and come and go, so diagnosis often takes years. Ask about vision, motor, and sensory changes. Ask what makes it worse: **fatigue, stress, temperature extremes, hot showers or baths**. **Common:** - Muscle **weakness and spasticity**; flexor spasms - **Fatigue**, worse with heat - **Paresthesia** (numbness, tingling) - Vision: **diplopia** (double vision), **nystagmus**, ↓acuity, **scotomas** (blind spots) - Bowel and bladder problems (flaccid or spastic); sexual dysfunction - Cognitive changes: memory, judgment, problem solving - Depression, emotional changes - **"MS hug"** (dysesthesia): squeezing feeling around the torso. Often an early sign. - Trouble walking, **dysmetria** (can't control movement range), vertigo, pain, itching **Less common:** **intention tremor** (shaking when reaching for something), hypalgesia, dysarthria, dysphagia, hearing loss, tinnitus, loss of taste, seizures. **Don't mix up the tremors:** Parkinson's = **resting** tremor (pill-rolling at rest). multiple sclerosis (MS) = **intention** tremor (during movement). PsychosocialRead in book - Long road to diagnosis → **anger and frustration**. Let them vent. - After diagnosis: anxiety. Later: apathy, emotional lability. - **Secondary depression** is the most common mental health problem in multiple sclerosis (MS). - Some are **euphoric** (from the disease or the drugs). - Cognition changes are usually **late**: memory, concentration, calculation, judgment. - Fatigue affects sexuality. Women: less sensation and orgasm. Men: erection and ejaculation problems. DiagnosisRead in book **No single test.** Results are put together. - **magnetic resonance imaging (MRI)** of brain and spinal cord showing plaques in **at least 2 areas** = diagnostic. Drug therapyRead in book Goal: slow the disease and reduce flares. Most drugs **suppress immunity** → infection risk. Teach: **avoid crowds and sick people**, wash hands. | Drug | Key nursing point | | --- | --- | | **Interferon beta**; **glatiramer** | Subcutaneous self-injections. **Rotate sites**. Flulike symptoms → acetaminophen/ibuprofen. Bone marrow suppression → report infection. | **Symptom drugs:** **baclofen** or tizanidine (spasticity; severe → intrathecal baclofen pump) · carbamazepine or tricyclic antidepressants (TCAs) (paresthesia) · propranolol, clonazepam (ataxia). Medical cannabis may ease pain and stiffness. Stem cell therapy is being studied. multiple sclerosis (MS) drugs are **very expensive** (health equity issue). Nursing care: mobility, vision, cognitionRead in book - physical therapy (PT)/occupational therapy (OT): **range of motion (ROM)**, stretching, strengthening. - **Avoid things that raise body temp** (worsen fatigue and vision). - Home safety: remove rugs and clutter; adapt for a wheelchair. Plan rest periods. - **Dysarthria / dysphagia** → speech-language pathologist (SLP); thickened liquids if needed; watch for aspiration. - **Diplopia:** **eye patch, switched eye to eye every few hours**. - Peripheral vision loss: teach **scanning** (turn the head side to side). - Cognition: single-date calendar, written lists, keep items in familiar places, phone reminders. Going homeRead in book **Teach to avoid triggers:** overexertion, stress, **temperature extremes** (fever, hot baths, saunas, hot tubs, overheating, getting chilled), humidity, people with infections. - Energy conservation: balance rest and activity. - Know every med: dose, time, route, side effects. - Personality changes: family can agree on a signal for inappropriate behavior. - Sexual dysfunction: phosphodiesterase (PDE)-5 inhibitors (sildenafil) for men; refer to counseling or urology. - Refer to the National multiple sclerosis (MS) Society. Book · NCLEX Challenge · Select all A client was recently diagnosed with MS. Which common findings does the nurse expect? Weakness, vision changes, spasticity, and fatigue are common early. Cognitive changes come later; hallucinations aren't typical. Book · Mastery Q2 · Select all A client will start **interferon beta-1a**. What should the nurse teach? Interferon = immune suppression, subcutaneous injections, flulike aches. The pulse and confusion options belong to other MS drugs that are crossed out of your reading. Quick recall · tap to flip NCLEX Which MS client statement needs more teaching? Heat worsens MS symptoms. NCLEX A client starting interferon beta asks what to watch for. Best answer? Interferon suppresses immunity and often causes flu-like symptoms. NCLEX The family of a client with late ALS asks if he still understands them. Best response? ALS spares thinking and senses. The 60-second version ## Spinal cord injury: protect the neck, watch the blood pressure (BP), find the trigger - Trauma = **safety first**, then **airway, breathing, circulation, disability, exposure (ABCDE)**, then head-to-toe. - Open the airway with a **jaw thrust** (protects the neck). - **Neurogenic shock** = low BP + **LOW heart rate**. - **Autonomic dysreflexia** = sudden **HIGH BP** → **sit up**, check the bladder. The spinal cord is the phone line between brain and body. Cut it, and messages can't get through either way. Below the cut, the body can panic, and the brain's "calm down" message never arrives. Basics - Top causes: **car crashes** and **falls**. About **80% are men**. - **Complete** = no messages below the injury. **Incomplete** = some movement or feeling left. - **Primary injury** = the trauma: bending forward too far (hyperflexion), back too far (hyperextension), crushed downward (axial loading), twisted, or stabbed/shot. - **Secondary injury** = makes it worse: bruising, **swelling** presses on the cord → low blood flow; bleeding; neurogenic shock. Trauma steps: safety, A & B 1. **Safety first**: scene and team. **personal protective equipment (PPE) on** (gloves, gown, eye protection, mask, cap, shoe covers). 2. **Primary survey (ABCDE)**: find and fix life threats. 3. **Secondary survey**: head-to-toe exam. **A = Airway.** Suction; check for face injuries blocking it. **Protect the neck:** **jaw thrust**, not head tilt. Keep the neck straight and in line. **"C3, 4, 5 keeps the diaphragm alive."** These nerves run the breathing muscle. A high neck injury can stop breathing. **Glasgow Coma Scale (GCS) under 8 → intubate.** **B = Breathing.** Breathing isn't enough; it must be **effective**. - Weak effort (gasping, respiratory rate (RR) about 6) → **bag-valve mask**. Oxygen alone won't help. - Breathing well on their own → **non-rebreather mask**. - Check **both sides of the chest rise equally** (collapsed lung?). C, D & E **C = Circulation.** - Outside bleeding: **direct pressure**, pack the wound, **tourniquet above** it. Log roll to check the back. - Inside bleeding shows as **shock**: low blood pressure (BP), fast heart rate (HR), weak pulse. Check the belly and **pelvis**. - **Two big intravenous lines (IVs) (16-gauge)** in the inner elbows. - **No BP cuff? Feel for pulses.** Systolic is at least: **radial 80 · femoral 70 · carotid 60**. **Exception:** **massive uncontrolled bleeding** → order becomes **C-A-B**. Stop the bleeding first. **D = Disability** (quick neuro): Glasgow Coma Scale (GCS), pupils, can they feel and move all 4 limbs? **E = Exposure.** Remove clothing to see everything. - Burns: clothing can melt into skin. - **Save evidence** (weapons, rape kits) for court. - Prevent **hypothermia**: blankets, warm room, warm intravenous (IV) fluids. Cover for dignity. **Secondary survey:** head-to-toe exam, splints, dressings, **nasogastric (NG) or orogastric (OG) tube** (empties stomach), **urinary catheter** (monitors kidneys). Neurogenic shock vs. spinal shock | | Neurogenic shock | Spinal shock | | --- | --- | --- | | What | Lost "fight or flight" tone → vessels go slack | Cord's reaction to injury and **swelling** (not a true shock) | | Signs | **Low blood pressure (BP)** (SBP \<90 or mean arterial pressure (MAP) \<65) + **LOW heart rate**, low temp, abnormal rhythms | Temporary loss of movement, feeling, reflexes, and automatic functions below the injury; **limp paralysis**; bowel stops (**paralytic ileus**) | | Care | **Emergency!** Fluids, vasopressors | Usually gone within **48 hrs** as swelling goes down | **The trick:** every other shock has a **fast** heart rate. Neurogenic shock has a **slow** one. Positioning, collars & halo - **Constant, detailed** movement and feeling checks catch problems early. - Keep the body **aligned**: log roll, turning sheet, slider board. - Thoracic or lumbar injury: may wear a **brace** out of bed. - Possible neck injury: **hard cervical collar** stays on until a **specific provider order** says remove. - Cord being squeezed → **surgery**: remove blood clot, bone pieces, or object; **spinal fusion**. **Halo device** (pins in skull, ring, vest), worn **8–12 weeks**: - **Never** tighten or loosen the screws. **Never** pull on it to move them. - **Wrench taped to the vest** for emergencies (CPR). - **Pin care**: watch for redness, drainage; clean them. Prevents skull bone infection. - Check skin under the vest. Itchy? **Nothing goes inside** (like a cast). - Drinks through a **straw**. Autonomic dysreflexia: emergency A huge, uncontrolled "fight or flight" surge. Usually after the acute phase (often first seen **3–6 months** after injury). **Cause:** something irritating below the injury. Most often a **full bladder** or **constipation**. Also pressure sores, pain, a wrinkled sheet. | Sign | Why | | --- | --- | | **Sudden severe high blood pressure (BP)** | Vessels below clamp down → risk of **stroke** | | **Slow heart rate** | Body tries to lower BP | | Severe **headache**, vision changes | High BP | | **Sweating + flushing ABOVE** injury | Vessels above open up | | **Cool, pale skin BELOW** injury | Vessels below stay tight | 1. **Sit them up** (High Fowler's) right away. 2. **Find and fix the cause.** Kinked Foley? Feel for a full bladder. No catheter → insert one. Check for constipation. 3. **Call the provider.** **Nifedipine** or a nitrate as ordered. 4. Check BP every **2–5 minutes**. Body systems after spinal cord injury (SCI) | System | Watch for / do | | --- | --- | | Lungs | Secretions build up → assisted coughing, incentive spirometer | | Heart | Low blood pressure (BP), low heart rate (HR), low temp, abnormal rhythms, **dizzy when sitting up**, autonomic dysreflexia, **blood clots** (compression devices, low molecular weight heparin) | | Gut | Belly bleeding, paralytic ileus, nutrition | | Bowel/bladder | Retention or incontinence; constipation (fluids, fiber, stool softeners); may learn self-cath | | Muscles/bones | Muscle wasting, spasticity → contractures; **osteoporosis** → fractures | | Skin | Turn **every 1–2 hrs** in bed. In a wheelchair, shift weight **more than every hour** (**wheelchair push-ups**, chair pad) | | Feelings | **Anger** (don't want to depend on others), depression. Check the home for safety and equipment. | Read in book Iggy Ch. 10 (trauma), pp. 208–210 Mechanism of injury (MOI)Read in book | Type | Examples | | --- | --- | | **Blunt** | Car crash, fall, assault (fists, kicks, bat), **blast effect** from a bomb | | **Acceleration-deceleration** (a blunt type) | High-speed crash, fall from a height → tearing, shearing, compression of tissues | | **Penetrating** | Knives, ice picks, gunshot wounds (GSW), shrapnel, falling onto a sharp object | A **GSW to the chest or abdomen** or a **stab wound to the neck** automatically calls the trauma team. Safety & primary survey (book)Read in book - **Scene safety** first, in the field and the emergency department (ED). Standard Precautions every time. - personal protective equipment (PPE): impervious gown, gloves, eye protection, facemask, surgical cap; shoe covers if heavy blood loss is expected. - Resuscitation happens **at the same time** as the survey. Fix airway, breathing, circulation, disability, exposure (ABCDE) problems before lower priorities like splints and dressings. **Airway Critical Rescue:** minutes without oxygen → anoxic brain injury. Clear the airway (suction or by hand), keep the neck **neutral and in line**, use a **jaw thrust**, give O₂. - Breathing on own → **non-rebreather**. Needs help → **bag-valve mask (BVM) with 100% O₂**. - **Glasgow Coma Scale (GCS) 3–8** → endotracheal tube + ventilator. - Breathing check: breath sounds, effort, chest expansion, chest trauma. **Circulation:** - Firm **direct pressure** with thick dry dressing first. Tourniquet if pressure fails. Wound packing, hemostatic dressings. - Suspect **internal bleeding** in any shock state. - **Hypotension is a late sign**: the body's compensation is already used up. - intravenous lines (IVs): two **16-gauge antecubital**; central line or **intraosseous** if veins can't be reached. - Fluids: **lactated Ringer's or 0.9% normal saline (NS)**; hypertonic saline for head trauma. **Warm** all fluids and blood. - Blood: packed red blood cells (PRBCs), fresh frozen plasma (FFP), platelets, or whole blood. But the priority is always to **stop the bleeding**. **Disability:** **AVPU** = Alert, responds to Voice, responds to Pain, Unresponsive. **GCS** 3 (totally unresponsive) to 15 (normal). Low blood sugar, hypoxia, drugs, or alcohol can lower level of consciousness (LOC). Reassess often. **Exposure:** **cut clothing off with scissors** (fast access, avoid moving injured limbs, burned fabric stuck to skin). Preserve **evidence** (clothing, weapons, bullets, drugs) for rape, abuse, assault, homicide, overdose. Nurses may testify in court. **Hypothermia** = 96.8°F (36°C) or lower. Secondary survey & after (book)Read in book - Gastric tube (prevent vomiting and aspiration), urinary catheter (urine output), diagnostic tests, head-to-toe exam, splints, temporary dressings. - **Disposition:** straight to operating room (OR) or interventional radiology, admit, or **transfer to a trauma center**. - Then assess **psychosocial needs**: social services, rehab, pastoral care, mental health, substance use counseling. Include the family. Book · NCLEX Challenge 10.3 Which mechanism of injury does the nurse document for a client with one gunshot entry point and two stab wounds? Bullets and knives both pierce the body = penetrating trauma. Read in book Iggy Ch. 37, pp. 920–929 · crossed-out parts left out (neuro level/dermatomes, clonidine) Types & mechanisms of injuryRead in book **Complete** spinal cord injury (SCI) = no function below the injury. **Incomplete** = some function left (more common). | Mechanism | Example | | --- | --- | | **Hyperflexion** | Head snaps forward: head-on crash, diving | | **Hyperextension** | Head snaps back: rear-end crash, fall hitting the chin | | **Axial loading** | Vertical compression: diving, landing on buttocks or feet | | **Excessive rotation** | Head turned past normal range | | **Penetrating** | Knife (low speed) or gunshot (high speed) | **Secondary injury** (worsens the first): hemorrhage, ischemia, hypovolemia, low perfusion from neurogenic shock, swelling. **Top causes of death:** **pneumonia** and **septicemia**. **Leading cause:** trauma (more than 1/3 vehicle crashes); falls in older adults; violence; sports. **Prevention:** helmets and padding, seat belts, no impaired driving, water at least **9 feet deep** before diving. Assessment termsRead in book | Term | Meaning | Injury level | | --- | --- | --- | | **Tetraplegia** (quadriplegia) | Paralysis of all 4 limbs | Cervical / upper thoracic | | **Quadriparesis** | Weakness of all 4 limbs | | | **Paraplegia** | Paralysis of legs only | Lower thoracic / lumbosacral | | **Paraparesis** | Weakness of legs only | | - Reflexes: biceps **C5**, triceps **C7**, patella **L3**, ankle **S1**. Absent during spinal shock. Autonomic dysreflexia: book detailsRead in book **Box 37.2 key features:** - Sudden big rise in blood pressure (BP) **+ bradycardia** - Profuse **sweating above** the injury (face, neck, shoulders) - **Flushing above** the injury; goose bumps - **Blurred vision, spots** in the visual field - **Nasal congestion** - Severe **throbbing headache** - Feeling of apprehension **Triggers:** bladder distention, urinary tract infection (UTI), scrotal compression, constipation/impaction, hemorrhoids, pain, **tight clothing**, hard or sharp objects, temperature changes. **Box 37.3: what to do** 1. **Sit them up** (first priority). 2. Check the bladder: retention, catheter **kinks**. No catheter → check for distention and catheterize (anesthetic ointment on the tip). 3. Check for UTI or bladder stones. 4. Check for **fecal impaction** using anesthetic ointment. 5. Check skin for pressure injuries. 6. BP every **10–15 minutes**. 7. **Nifedipine** or a nitrate as ordered. Lecture said BP every 2–5 min; the book says 10–15 min. Go with your instructor on exams, but know both. Airway & breathing (book)Read in book **Airway is the priority** for cervical spinal cord injury (SCI). Injuries at or above **T6**: risk of respiratory distress and **pulmonary embolism (PE) in the first 5 days**. - Breath sounds every **2–4 hrs** the first few days. Act if **oxygen saturation (SpO₂) drops below 95%**. - Incentive spirometer; suction as needed. - **Cough assist** ("quad cough"): hands on the upper abdomen below the ribs; push **inward and upward** as the patient coughs. Neurogenic shock: book detailsRead in book Usually within **24 hrs**, in injuries **above T6**. **Critical Rescue (check at least hourly):** warm, flushed skin (temp dysregulation) · symptomatic bradycardia · ↓level of consciousness (LOC) · ↓urine output · systolic blood pressure (SBP) \<90 or mean arterial pressure (MAP) \<65 → Rapid Response. - intravenous (IV) and oral fluids. **Dextran** (plasma expander). - **Atropine** if heart rate (HR) drops below 50–60. - Severe hypotension: IV vasopressors (phenylephrine, dopamine). Collar, surgery & halo (book)Read in book - Hard collar (**Miami J, Philadelphia**) until an order says remove. Pad pressure points, especially the **back of the head**. - Keep alignment; **log roll**. - After spinal fusion: neuro checks + vital signs (VS) **every hour for 4–6 hrs**, then every 4 hrs. - Thoracic/lumbar fusion: Harrington rods, molded plastic brace. **Halo:** 4 pins into the skull, worn **6–12 weeks** (lecture said 8–12). **Halo Action Alert:** never move the patient by the halo · never adjust screws · **one finger** should fit between the jacket and skin · **wrench taped to the vest** · nothing sharp under the vest · pin care per policy. Report fever or pus from pins. Serious complications: **osteomyelitis of the skull**, subdural abscess. Meds for spinal cord injury (SCI)Read in book | Drug | Why | | --- | --- | | **Pantoprazole** (PPI) | Prevent **stress ulcers** | | Anticoagulant (LMWH) | Prevent venous thromboembolism (VTE) | | Bulk laxatives, stool softeners | Prevent constipation | | Celecoxib | Prevent heterotopic ossification (↑myocardial infarction (MI) and stroke risk) | | Calcium, bisphosphonates | Prevent osteoporosis | | **Intrathecal baclofen (ITB)** | Spasticity. Sedation, fatigue, headache, hypotension. **Never stop suddenly** → seizures, hallucinations. | Long-term complicationsRead in book - **Paralytic ileus** within **72 hrs**; check bowel sounds. Stress ulcers. - **Heterotopic ossification (HO)**: bony overgrowth into muscle. Not visible on x-ray for several weeks. - Pressure injuries, venous thromboembolism (VTE), osteoporosis → fractures, contractures (splints, range of motion (ROM)). - **Orthostatic hypotension**: change position slowly. - Transfers: paraplegic patients often transfer alone; tetraplegic may use a **sliding board**. | Lesion | Bowel/bladder | Care | | --- | --- | --- | | **Upper motor neuron** (cervical, high thoracic) | **Spastic**; reflex emptying still works | Bladder/bowel training; rectal suppositories | | **Lower motor neuron** (lower thoracic, lumbosacral) | **Flaccid**; no reflex | Intermittent catheterization; manual disimpaction | All: **1.5–2 L fluid a day** + stool softeners. Psychosocial, sexuality & rehabRead in book - Often **young men**; may feel guilt (diving, racing). Many veterans (blast injuries). - Be realistic but offer hope. - Men with injuries **above T6** may have reflex erections. A vasodilator before sex can prevent autonomic dysreflexia (AD). - Women can still become pregnant. - Rehab goal: **live independently**. Functional electrical stimulation (FES), exoskeletons. - Older adults with spinal cord injury (SCI): vaccines (respiratory infections are the top cause of death), osteoporosis prevention, skin care. Book · NCLEX Challenge A client with a recent **T1** spinal cord injury (SCI) is flushed and sweating on the face and neck and reports "seeing spots." Which action first? Autonomic dysreflexia. Sitting up lowers blood pressure (BP) immediately. Then find the cause. Book · NCLEX Challenge 37.3 A client with SCI is in a halo fixator with vest. Which action is **most important** for safety? The wrench lets staff remove the vest fast for cardiopulmonary resuscitation (CPR). That's life-saving; the others are routine care. Book · Mastery Q1 A client with a **C6** fracture just got a halo device. Which statement needs **immediate** follow-up? A **new** change in sensation moving upward = possible worsening cord injury. Numb feet were already there. Book · NGN Challenge 37.1 (C7 SCI, halo + vest) **Case:** 21-year-old, C7 SCI. At 1435: new throbbing frontal headache, blurred vision, very sleepy, face and neck flushed with sweating. T 99°F, **heart rate (HR) 58**, **BP 184/95**, oxygen saturation (SpO₂) 95%. Foley draining. At 1450: BP 192/98, headache 8/10. Review class: spinal shock, autonomic dysreflexia, trauma priority Review class From the in-class exam review (Joline case study + NCLEX questions). - **Spinal shock:** swelling right after the injury knocks out movement, feeling, and reflexes. It does **not** mean permanent paralysis. The injury **can't be classified until spinal shock resolves** (about **48 hours**). - **Spinal shock is over when** things come back: they can urinate, reflexes return, they feel an itch or pain, they can move. - **Autonomic dysreflexia:** blood pressure shoots up + pounding headache. Caused by any irritating stimulus. Even a **fan's cool breeze** can trigger it. Find and remove the cause. - **Trauma (Ch. 10 pages):** normally airway, breathing, circulation, disability, exposure (ABCDE), but **massive uncontrolled external bleeding comes first**. No airway will help if they bleed out. Exception to the rule. Quick recall · tap to flip NCLEX A client with a T4 injury suddenly has BP 210/110, HR 48, a pounding headache, and a flushed face. First action? Autonomic dysreflexia. Sitting up lowers BP right away. Then check the bladder. NCLEX Which vital signs suggest neurogenic shock? Low BP with a LOW heart rate. Low BP + fast HR points to bleeding (hypovolemic shock). NCLEX A trauma client is gasping with a respiratory rate of 6. Priority? Weak breathing needs breaths given. Oxygen alone won't help. NCLEX A client in a halo vest says the skin under it itches. Best response? Nothing inside the vest. Never touch the screws or pull on the frame. The 60-second version ## Back pain: mostly a squished disc pressing a nerve - **Neck** and **low back** get hurt most (most flexible parts). - #1 cause of **workplace injury**. Protect your own back! - Comfort: **Williams position**, heat or ice, nonsteroidal anti-inflammatory drugs (NSAIDs). - After back surgery: **cerebrospinal fluid (CSF) leak** = lower head of bed (HOB), call. Must **void** before going home. - After neck surgery: **airway first**. A disc is a jelly donut between two bones. Squeeze it wrong and the jelly (nucleus pulposus) leaks out and presses on the nerve next to it. Protect your own back - **Bend at the knees**, not the back. - **Raise the bed** when repositioning a patient or giving a 2–3 minute intravenous (IV) push. - Good posture, proper shoes, weight control, ergonomics. - Use **ceiling lifts** and get help. No equipment? **Advocate** for it. Disc problems & nerve pain - Disc's jelly center = **shock absorber**. - **Bulging** disc = pushes out. **Herniated** disc = **much worse**, the wall breaks open. - Pressure on a nerve → **burning or stabbing** pain, spasms, numbness, tingling. - Low back → pain down the **leg** (sciatic nerve). Neck → pain down the **arm**. - Big herniation can press on the **spinal cord** → leg/arm weakness, bladder or bowel problems. - **Spinal stenosis** = narrowed spinal canal (from a disc, arthritis, infection, trauma, swelling). Tests | Test | Shows | | --- | --- | | **magnetic resonance imaging (MRI)** | Cord, bones, discs, and **nerve root compression** | | **electromyography (EMG)** | Needle in the muscle checks its electrical activity → nerve damage | | **Nerve conduction study** | **How fast** nerves send signals | Comfort & meds - **Williams position**: semi-Fowler's with a **pillow under the knees**. A recliner works too. - **Firm mattress.** Change positions often. - **Moist heat or ice: 20–30 min, 4 times a day** (whichever works for them). - physical therapy (PT), weight control, massage, chiropractor, acupuncture, **transcutaneous electrical nerve stimulation (TENS) unit**. | Med | Know this | | --- | --- | | **nonsteroidal anti-inflammatory drugs (NSAIDs)** (first choice) | Block prostaglandins (inflammation). Side effect: **gastrointestinal (GI) upset**. Adverse: **bleeding**. | | **Muscle relaxants** (baclofen, cyclobenzaprine) | **Drowsiness, fatigue** | | **Gabapentin** | Anti-seizure drug used for nerve pain | | **Tramadol (Ultram)** | If an opioid is needed: least potent, low dependency | | **Epidural injection** | Steroid + numbing med | Surgery | Minimally invasive | Open | | --- | --- | | Scope removes the piece pressing the nerve. Less pain and blood loss. **Home same or next day**. Walk daily. | Bigger incision. Used when the **spinal cord is compressed**. | - **Discectomy** = remove disc. **Laminectomy** = remove part of a vertebra. - Spine unstable → **spinal fusion**, often with bone from the **hip** → 2 painful sites that can get infected. After open back surgery - Vitals + neuro checks **every hour for 4–6 hrs**, then every 4 hrs. - Watch for fever, low blood pressure (BP), fast heart rate (HR). **cerebrospinal fluid (CSF) leak:** clear drainage, a **"halo"** ring on the dressing, bulging at the incision, or a sudden headache → **lower the head of the bed** and **call the provider**. - Check for a **hematoma**. Check the hip donor site. - Patient **must void before discharge**. - Turn **as a unit** (log roll). **No twisting. No overhead trapeze.** Neck (cervical) surgery - **Front of the neck** (anterior) is most common. Back (posterior) = more pain. **Priority = airway.** Swelling can press on the windpipe. Check **swallowing** and **hoarseness**. Read in book Iggy Ch. 37, pp. 929–937 · crossed-out parts left out (muscle relaxant list, ziconotide, failed back surgery syndrome) Nonsurgical care (book pp. 932–933)Read in book - **Non-drug measures come first.** A short period of bed rest with **heat** may help; heat gives short-term relief. - Start stretching and **resume normal activity as soon as possible**. Aerobic exercise has good evidence. - **Change position often**: long standing, sitting, or lying increases pain. Shoe insoles or floor pads can help. - **Williams position** for acute low back pain from a bulging or herniated disc. - Reassure patients: many fear the pain won't go away. Most won't have another episode with good care. - Chronic pain: stress reduction, mindfulness, progressive muscle relaxation, yoga. **cognitive behavioral therapy (CBT) + physical therapy (PT)** helps pain lasting over 12 months. - **McKenzie exercises** (extension and flexion) move pain toward the center of the back. Start only **after acute pain eases**. Water therapy builds muscle without strain. - **Weight loss** if more than 10% over ideal weight. Meds & muscle relaxant alert (book)Read in book - **nonsteroidal anti-inflammatory drugs (NSAIDs)** (aspirin, ibuprofen, naproxen) help. - Antidepressants and gabapentin are often prescribed, but national guidelines **don't recommend them** for low back pain (antidepressants OK if the patient is also depressed). - Opioids: very limited role, used sparingly and short-term for acute pain. - Topical **capsaicin**: short-term relief. Lidocaine patches: no real benefit. - **Ziconotide**: strong analgesic for severe persistent pain. **Drug Alert:** centrally acting muscle relaxants cause **sedation, dizziness, lightheadedness** and anticholinergic effects (dry mouth, urinary retention, blurred vision, constipation, tachycardia). **Avoid in older adults** (falls). No driving, alcohol, or other central nervous system (CNS) depressants. **Metaxalone** can damage the liver. Surgery details (book)Read in book Done when conservative care fails or **neuro deficits keep getting worse**. minimally invasive surgery (MIS) isn't used if the disc presses on the spinal cord. **Pre-op teaching:** getting in and out of bed, turning, **report new numbness, tingling, or weakness** in the legs, home restrictions. | Minimally invasive | Open | | --- | --- | | **Microdiskectomy** (1-inch incision, endoscope) · **PED** (percutaneous endoscopic diskectomy, may add laser) · **Laser-assisted laparoscopic** (belly-button incision; bulging discs only; risks: infection, nerve root injury) · robot-assisted. Home same day or in 23–48 hrs. | **Diskectomy** (remove disc) · **laminectomy** (remove part of the lamina) · **spinal fusion** (bone graft, metal rods/screws) · interbody cage fusion (titanium mesh) · artificial disc. Pain control may use intrathecal or epidural patient-controlled analgesia (PCA). | **Open-surgery complications:** nerve injury, **diskitis** (disc inflammation), **dural tears**. - Book: vital signs (VS) **at least every 4 hrs for 24 hrs** (fever, hypotension, severe pain); neuro checks every 4 hrs (movement, strength, sensation in legs). - Check ability to **void after catheter removal**. Pain and lying flat make voiding hard, **especially for men**. Lecture said VS every hour for the first 4–6 hrs, then every 4 hrs. The book only says "at least every 4 hrs." Use your instructor's version for exams. Causes & risk factorsRead in book - Muscle strain or spasm, ligament sprain, disk degeneration, **herniated nucleus pulposus (HNP)**. - **Spinal stenosis**: narrowing of the spinal canal, usually over age 50. - Most common in ages 30–60; women a bit more than men. - Risks: heavy lifting, falls, crashes, repetitive bending and twisting, **obesity**, **smoking** (less blood flow to disks), scoliosis. - Older adults: osteoporosis, vertebral fractures, arthritis. Prevention (Box 37.5)Read in book - Safe lifting; ask for help with heavy chores. - Regular exercise: swimming, walking, back strengthening. - No high heels; good posture; footstool and ergonomic chairs. - Avoid prolonged sitting or standing. - Weight within **10% of ideal**. Enough calcium and vitamin D. - **Stop smoking.** **Nurses:** avoid lifting patients by hand. Use the lift equipment. AssessmentRead in book - Main complaint: **continuous pain**. Stiff, flexed posture; limp; can't bend. - **Sciatic pain:** sharp, burning down the back of the thigh or calf, maybe to the ankle or toes. Worse with **sneezing, coughing, straining**. - Raising the straight leg causes severe pain (nerve compression). - Check both legs for sensation (cotton ball, paper clip) and strength. - Ask about **bladder or bowel changes** (new incontinence or retention). - Ask about sadness and suicidal thoughts with persistent pain. - Tests: imaging only if severe; **electromyography (EMG)** and nerve conduction studies. Treatment & meds (slides)Slides **Diagnosis:** magnetic resonance imaging (MRI), electromyography (EMG), nerve conduction study. **Interventions:** positioning · moist heat or cold · physical therapy · weight control · complementary therapies · meds (NSAIDs, muscle relaxants, gabapentin, tramadol, epidural injection). | Class | Examples | | --- | --- | | **NSAIDs** (block prostaglandins → less inflammation and nerve sensitivity) | over-the-counter (OTC): aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve). Rx: **celecoxib** (Celebrex), **meloxicam** (Mobic) | | **Muscle relaxants** | Baclofen, **cyclobenzaprine** (Flexeril), tizanidine (Zanaflex), methocarbamol (Robaxin) | **Surgery:** minimally invasive (microscopic or endoscopic discectomy: shorter stay, less blood loss and pain) or open (**discectomy, laminectomy, spinal fusion**). **Post-op (slide):** vital signs (VS) **hourly for 4–6 hrs**, then every 4 hrs (fever, ↓blood pressure (BP), tachycardia) · neuro checks (movement, strength, sensation) · cerebrospinal fluid (CSF) leak signs → **head of bed (HOB) flat** and call the provider · ability to void · log roll · pain control. After lumbar surgery (Table 37.2)Read in book | Complication | Watch for / do | | --- | --- | | **cerebrospinal fluid (CSF) leak** | Clear fluid on dressing; "halo" ring. **Lay flat**, report to surgeon now. | | Fluid deficit | I&O, hypotension, tachycardia | | **Urinary retention** | Get them to the bathroom early; men may stand to void | | Paralytic ileus | Flatus or stool, distention, N/V | | Fat embolism | Chest pain, dyspnea, anxiety, confusion; **petechiae** on neck, chest, mouth | | Nerve root pain | Pain not relieved by meds | | Infection | Temp spike after **day 2** post-op | **Critical Rescue:** a sudden headache + clear drainage = possible CSF leak. Keep on bed rest, lower the head of the bed, report right away. Bulging at the incision = CSF leak or hematoma. - **Log roll every 2 hrs**. **No overhead trapeze** (strains the back). - Sit in a straight-back chair, feet flat. - venous thromboembolism (VTE) prevention: early mobility, compression devices, anticoagulant. **Home (first 4–6 weeks):** limit stairs and driving · lift nothing over **5 lb** · no bending or twisting · walk daily. Clear drainage from incision → call the surgeon. **Spinal cord stimulation** may help persistent pain: check neuro status below the device and make sure they can void. Cervical neck painRead in book - Usually a herniated disk at **C5–C6** or **C6–C7**. - Pain radiates to the shoulder and arm with numbness or tingling; may disrupt sleep. - Conservative care: exercises (shoulder shrugs, squeezes); soft collar at night, **no longer than \~10 days**. - Surgery: anterior cervical discectomy and fusion (ACDF) (fusion with bone graft) or newer anterior interbody cervical fusion (AICF)/lateral interbody cervical fusion (LICF) (titanium device; shorter recovery). Collar for 2–3 weeks after ACDF. **After ACDF, priority = airway.** Neck swelling can narrow the trachea; the surgery can affect swallowing. Check **swallowing** and breathing; keep suction ready; sit upright; report changes now. **Box 37.6 discharge:** someone stays with them the first few days · no lifting · no driving until cleared · walk daily · call if pain, numbness, or swallowing get worse. Book · Mastery Q3 · Select all A nurse teaches a community group about preventing back injury. Which recommendations are correct? Log rolling is post-op care, not prevention. Everything else is in Box 37.5. Review class: after disc surgery Review class From the in-class exam review (Joline case study + NCLEX questions). - **Distended bladder = urinary retention** → possible spinal nerve damage. Priority finding. - **Reposition every 2 hours** (not every 4). - **Nothing by mouth (NPO) is based on sedation / gag reflex return**, not on whether they've voided or have nausea. - An indwelling catheter, echo, or dietary assessment isn't needed unless the story gives a reason. Quick recall · tap to flip NCLEX Best position for a client with low back pain? Bent knees take pressure off the nerve and relax back muscles. NCLEX After lumbar fusion, a client wants to use the overhead trapeze. Best response? No twisting after back surgery. NCLEX After a laminectomy, the dressing has a clear ring around blood and the client has a sudden headache. First action? Halo sign + headache = possible CSF leak. The 60-second version ## Problems in the wires outside the brain and cord - **Myasthenia gravis**: muscles get weak with use. Keep meds with them always. - **Peripheral nerve injury**: protect the numb area. - **Trigeminal neuralgia (CN V)**: lightning-bolt face pain. - **Bell's palsy (CN VII)**: one side of the face droops. Protect the eye. **Cranial nerves:** your instructor said **don't memorize all 12**. Know V (trigeminal) and VII (facial), plus the swallowing nerves **IX (glossopharyngeal) and X (vagus)** from the stroke lecture. Myasthenia gravis: what it is Acetylcholine is a key. The muscle has locks. In myasthenia gravis (MG), the immune system jams the locks, so the key can't make the muscle move. - **Autoimmune.** Attacks **acetylcholine receptors** where nerve meets muscle. - **Extreme fatigue**; muscles weaken very easily. - First: **eyes** (droopy eyelid = ptosis, double vision). Then **face**: hard to smile, chew, swallow, shave, brush teeth. - Advanced: all muscles, including bowel, bladder, and **breathing**. Edrophonium test & pyridostigmine **Edrophonium (Tensilon) test:** gives more acetylcholine. myasthenia gravis (MG) → muscles improve **within 1 minute**, lasting 4–5 min. **Can cause serious bradycardia.** **Atropine** (the antidote) must be at the bedside. **Pyridostigmine:** keeps more acetylcholine around. Controls symptoms; **doesn't cure**. - Dose can change day to day (weaker days = higher dose). - **Eat 45–60 min after** the dose: muscles strongest → **no aspiration**. Myasthenic vs. cholinergic crisis | | Myasthenic crisis | Cholinergic crisis | | --- | --- | --- | | Cause | **Not enough** medicine | **Too much** medicine | | Edrophonium test | Muscles **improve** | No improvement; may get **weaker** | | Clue | Worsening weakness, **breathing trouble** (may need ventilator) | **Extra secretions**: drooling, sweating, lung secretions | | Treat | More medicine | **Atropine** | Memory trick: **cholinergic = "too much choline" = too much fluid pouring out** (spit, sweat, secretions). Other myasthenia gravis (MG) treatments - **Steroids** (calm the immune system). - **Plasmapheresis & intravenous immunoglobulin (IVIG)**: **short-term only**, for emergencies like breathing distress. Work fast; last weeks to a couple of months. - **Plasmapheresis** = filters out the plasma carrying the bad antibodies; returns the blood cells. Watch for: **low blood pressure (BP)** (fluid loss), **electrolyte imbalance**, **hypothermia**, **access-site infection**. - **IVIG** = donor antibodies that block the bad antibodies. - **Thymectomy** = remove the thymus. MG is linked to a thymus tumor, and the bad antibodies are made there. myasthenia gravis (MG) nursing care - **Breathing support** first. - Plan activities around **peak medicine times**. - Keep pyridostigmine **with them always**: nightstand, car, work. - **Rest is essential.** Repetitive movement can trigger a myasthenic crisis. - Help with communication and nutrition (weak face muscles). - **Eye protection** at night (eyes may not close); **artificial tears** during the day. Peripheral nerve injury From a cut, burn, crush, stretch, and more. The nerve past the injury dies back → weakness, limp paralysis, burning, numbness. - Both nerve ends try to grow back together. **Lined up** → normal function. **Not lined up** → weakness, spasms, less feeling. - **Infection** or **older age** slows healing. - Some function can return early through **backup (collateral) nerves**. - Treatment: **splint or cast** to rest it; surgery to realign the ends. **Teach:** they can't feel the area well → **protect it**. Cover it in cold and heat. Keep skin moisturized. Trigeminal neuralgia (CN V) Irritated **cranial nerve 5** (one on each side of the face) → **one-sided**, excruciating, sharp, shooting bursts of pain. - Triggers: touch, chewing, **brushing teeth**, even **smiling**. Patients start avoiding these things. **Priority = pain management.** 1. **Antiepileptics**: carbamazepine (Tegretol), gabapentin, pregabalin. 2. **Nerve block.** 3. **Surgery** (see below). - **Rhizotomy**: heated needle destroys nerve fibers → that side is **permanently numb**. Teach to **look for injuries** (poked eye, cavity) they can't feel. - **Microvascular decompression**: moves an artery pressing on the nerve. More serious: needs a **craniotomy**. Bell's palsy (CN VII) Sudden paralysis of the **facial nerve (CN 7)**, triggered by the **herpes simplex virus** waking up (infection, cold exposure). - **One side** of the face: can't close the eye, smile, or wrinkle the forehead. Taste is affected. - Can hurt **body image**. - **Antivirals**: acyclovir, valacyclovir. - **Protect the eye** (can't blink or close it). - Nutrition, massage, warm moist heat, facial exercises, emotional support. - Most recover fully in **weeks to months**; a few keep some weakness. Review class: myasthenia gravis + trigeminal neuralgia Review class From the in-class exam review (Joline case study + NCLEX questions). **Pyridostigmine**: **cholinesterase inhibitor** for **myasthenia gravis**. Keeps more acetylcholine around so nerve signals reach the muscles. - **Never miss a dose.** - **Take it so it peaks before activities that need energy**, like **eating**. Eating at a low level → weak swallow → **aspiration**. - **Dose changes daily** based on symptoms and energy (like sliding-scale insulin). Exception to the rule! | Myasthenic crisis | Cholinergic crisis | | --- | --- | | **Not enough** pyridostigmine → weakness, poor oxygenation | **Too much** pyridostigmine ("cholin-" is in the name) | - **Plasmapheresis** (myasthenia gravis treatment) risks: fluid and electrolyte loss, blood pressure changes, site infection. - **Trigeminal neuralgia:** brushing teeth or shaving triggers intense pain, so patients may stop doing them. Address hygiene. Quick recall · tap to flip NCLEX A client with myasthenia gravis (MG) has severe weakness, drooling, sweating, and heavy lung secretions after extra pyridostigmine. The nurse suspects: Too much medicine → too much acetylcholine → secretions. Atropine reverses it. NCLEX Most important teaching for an MG client going home on pyridostigmine? Weakness can hit anytime. Eat 45–60 min after the dose, and rest often. NCLEX Priority teaching for a client with Bell's palsy? The eye can't close, so it can dry out and get hurt. NCLEX A client with a nerve injury to the hand is going outside in winter. Best teaching? Decreased sensation means they can't sense cold or heat injury. Cover it and keep skin hydrated. The 60-second version ## Every med from your lectures & slides, in one place - Only meds your instructor mentioned (no book-only drugs). - **★** = your instructor stressed it most. - Learn the **one big safety point** for each, not every detail. Think of each drug as having one "headline." Sinemet: no protein. Phenytoin: gums. Pyridostigmine: eat 45–60 min later. Mannitol: hourly urine. Migraine | Drug | Know this | | --- | --- | | Acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, naproxen), over-the-counter (OTC) + **caffeine** (Excedrin) | First try. Caffeine narrows vessels. Take at first sign/aura. | | **★ Triptans**: sumatriptan (Imitrex), rizatriptan (Maxalt) | Activate serotonin → narrow vessels. **NO** with heart disease, hypertension (HTN), **peripheral vascular disease (PVD)**. Report **chest pain**. No selective serotonin reuptake inhibitors (SSRIs) or St. John's wort (serotonin syndrome). | | Lasmiditan | Doesn't narrow body vessels. Causes sedation, dizziness. | | Prevention: NSAIDs, **beta blockers**, **topiramate** | For frequent or severe migraines | **Rebound headache** = taking meds too often or too much. Seizures | Drug | Know this | | --- | --- | | **★ Phenytoin (Dilantin)** | **Gingival hyperplasia** → soft toothbrush, dentist | | Carbamazepine (Tegretol), valproic acid (Depakote), topiramate (Topamax) | Same class rules below | **All anti-seizure meds:** drowsiness · depression/**suicidal thoughts** · liver damage · low white blood cells (WBCs) · **blood levels** (narrow range) · **never stop suddenly** (status epilepticus) · pregnancy category D · birth control less effective (use 2nd method) · watch **warfarin** · no **grapefruit**. **Status epilepticus:** 1. **★ Lorazepam (Ativan)** or diazepam (Valium) intravenous (IV) → **stops** the seizure 2. **Fosphenytoin** (preferred, safer) or phenytoin → **prevents** the next one Meningitis - **Broad-spectrum antibiotic** right away (after blood cultures) if ↑intracranial pressure (ICP) signs. Switch to **narrow-spectrum** once the germ is known. - **Vaccines**: meningococcal (age 11–12, booster 16), flu, pneumonia. Parkinson's | Drug | Know this | | --- | --- | | **★ Carbidopa-levodopa (Sinemet)** | Replaces dopamine. Nausea → take with **carbs, NOT protein**. Long-term: dyskinesia, "on-off." | | Dopamine agonists | **Impulse control** problems (gambling). Not for older adults. | **Tolerance** (stops working) or **toxicity** (delirium) → lower dose, change meds, or **drug holiday** (1 week–10 days). multiple sclerosis (MS) (only 2 to know) | Drug | Know this | | --- | --- | | **★ Interferon beta** | Shot under the skin. **Infection risk**, bone marrow suppression, **flu-like symptoms** | | **★ Glatiramer** | Shot under the skin. Fewer side effects | Both slow the disease and make attacks fewer and milder. **No cure.** Spinal cord injury - **Nifedipine** or a nitrate → autonomic dysreflexia (after sitting up and fixing the cause). - **Fluids, vasopressors** → neurogenic shock. - **Low molecular weight heparin** → prevent blood clots. - **Stool softeners** → constipation. Back & neck pain | Drug | Know this | | --- | --- | | **nonsteroidal anti-inflammatory drugs (NSAIDs)** (first choice): aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), meloxicam (Mobic) | Block prostaglandins. Side effect: **gastrointestinal (GI) upset**. Adverse: **bleeding** | | **Muscle relaxants**: baclofen, cyclobenzaprine (Flexeril), tizanidine (Zanaflex), methocarbamol (Robaxin) | **Drowsiness**, fatigue (act on central nervous system (CNS)) | | Gabapentin | Anti-seizure drug for **nerve pain** | | **★ Tramadol (Ultram)** | If an opioid is needed: least potent, low dependency | | Epidural injection | Steroid + numbing med | Myasthenia gravis | Drug | Know this | | --- | --- | | **★ Pyridostigmine** | Keeps more acetylcholine (ACh) around. **Eat 45–60 min after** (no aspiration). **Carry it always.** Dose changes daily. | | Edrophonium (Tensilon) | **Test** drug. myasthenia gravis (MG) improves within 1 min. Can cause **bradycardia**. | | **★ Atropine** | Antidote for edrophonium; treats **cholinergic crisis**. Keep at bedside. | | Corticosteroids, intravenous immunoglobulin (IVIG) | Calm the immune system; IVIG is short-term for crises | **Too little med** = myasthenic crisis. **Too much** = cholinergic crisis (secretions). Trigeminal neuralgia & Bell's palsy - **Trigeminal**: carbamazepine (Tegretol), gabapentin (Neurontin), pregabalin (Lyrica); nerve block. - **Bell's palsy**: antivirals **acyclovir**, **valacyclovir** (HSV-1). Stroke & transient ischemic attack (TIA) | Drug | Know this | | --- | --- | | **★ tissue plasminogen activator (tPA) (alteplase)** | Ischemic only. Within **3 (up to 4.5) hrs** of symptom onset. **computed tomography (CT) first.** Bleeding risk. Repeat CT after. | | **Antiplatelets**: aspirin, clopidogrel | Prevent clots. Both together = dual antiplatelet therapy | | **Anticoagulants**: heparin, warfarin, direct oral anticoagulants (DOACs) | For **A-fib** | | Aspirin 325 mg | 24–48 hrs after stroke. **Not within 24 hrs of tPA** | | Statin | Must be discharged on one (core measure) | | Enoxaparin / heparin | Prevent blood clots | | Anti-seizure meds | Hemorrhagic stroke (seizure ↑intracranial pressure (ICP)) | Head injury & intracranial pressure (ICP) | Drug | Know this | | --- | --- | | **★ Mannitol** | Pulls water out of the brain. Osmolality goal **310–320**. **Hourly urine** (Foley). Watch dehydration, electrolytes, kidney injury. | | Furosemide | Given with mannitol; removes fluid from the body | | Hypertonic saline (3% or 5%) | Works like mannitol. intensive care unit (ICU) only | | Acetaminophen | Concussion pain. **No nonsteroidal anti-inflammatory drugs (NSAIDs)** (bleeding) | Dialysis (kidney lecture) - **Hold** antihypertensives and antidysrhythmics until after (low blood pressure (BP)). - **Give after**: antibiotics, anticonvulsants, vitamins (dialyzed out). - **Heparin** during dialysis lasts **4–6 hrs**. Antidote: **protamine sulfate**. Review class: med "exceptions" she stressed Review class From the in-class exam review (Joline case study + NCLEX questions). - **Mannitol:** filter needle; dose by serum osmolality (goal 310–320); intake and output (I&O); sodium, potassium. - **Propranolol** prevents migraine; **triptans** abort it (avoid with hypertension, peripheral vascular disease, angina, selective serotonin reuptake inhibitors (SSRIs)). - **Diazepam/lorazepam** stop status epilepticus; **phenytoin/fosphenytoin** only prevent future seizures. - **Ropinirole**: careful in older adults (orthostatic hypotension). **Carbidopa-levodopa**: with food, not protein. - **Pyridostigmine**: don't miss doses, take before eating, dose changes daily. Quick recall · tap to flip NCLEX Which med should the nurse hold before a client's dialysis? Antihypertensives wait until after dialysis (low blood pressure (BP) risk). NCLEX A client on phenytoin says, "I feel fine, so I stopped my pills." Priority concern? Stopping anti-seizure meds suddenly can trigger status epilepticus. NCLEX Which client should NOT get sumatriptan? Triptans narrow vessels everywhere. NCLEX A client on a dopamine agonist starts gambling heavily. The nurse: Impulse control problems are a known adverse effect. The 60-second version ## Dialysis = an artificial kidney - Started based on **symptoms**, not lab numbers. - **Fistula/graft arm:** feel the **thrill**, hear the **bruit**. No blood pressure (BP), intravenous lines (IVs), or sticks in that arm. - **Hold** antihypertensives and dialyzable meds until **after** dialysis. - After: watch for **low BP** and **bleeding** (heparin lasts 4–6 hrs). - Peritoneal dialysis: biggest risk = **peritonitis**. The dialyzer is a coffee filter. Blood flows on one side, a clean solution (dialysate) on the other. Waste and extra fluid pass through the filter and get thrown away. **Note:** this is renal (kidney) content from a different lecture. It's here because you asked to add it. What dialysis is - **Kidney replacement therapy** = umbrella term for **dialysis or transplant**. Those are the only 2 options. - Used when kidneys fail (acute or chronic) to remove extra **fluid and waste**. - Blood passes through an artificial **semipermeable membrane** in the **dialyzer** (artificial kidney). - **Dialysate** = solution that looks like plasma. Fixes electrolytes and acid-base balance. Pause activity: added vs. removed during dialysis. The answer slide wasn't in your transcript; standard answer: **removed** = urea (BUN), creatinine, potassium, uric acid, extra fluid; **added** = bicarbonate (fixes acidosis). Check against your slide. When to start dialysis - Based on **signs and symptoms**, NOT labs (BUN, creatinine, glomerular filtration rate (GFR)). - chronic kidney disease (CKD): started when **uremic** symptoms appear. **Emergency dialysis:** - **Pulmonary edema** - Severe electrolyte or acid-base imbalance, e.g., **hyperkalemia with electrocardiogram (EKG) changes** - **Pericarditis** Pause question: why does pericarditis need emergency dialysis? Standard answer: it's caused by **uremic toxins** irritating the heart sac. Fluid can build up around the heart → **cardiac tamponade**. Dialysis removes the toxins. Check against your slide. Intermittent vs. continuous | | Intermittent hemodialysis | Continuous (CRRT) | | --- | --- | --- | | Schedule | **3×/week, 4 hrs** each | Over **24 hrs** | | Flow | \~300–500 mL/min → **big fluid shifts**, blood pressure (BP) changes | Only 10–80 mL/min (gentler) | | Who | Stable patients | **Unstable** (heart problems) · **intensive care unit (ICU) only** | | Also called | — | Hemofiltration, ultrafiltration | Access: dialysis catheter Regular veins can't handle the high flow, so special access is needed. - **Short-term** (a few sessions or weeks). - Tip in the **superior vena cava** (just above the right atrium); 2 ports: one out to the machine, one back. - Watch for **infection and bleeding** at the site. - **Sterile** dressing changes by the **dialysis nurse only**, not floor nurses. **Dialysis only.** Nothing else goes through it: no intravenous (IV) fluids, no meds. Access: arteriovenous (AV) fistula or graft - **Long-term** dialysis. - **Fistula** = artery and vein sewn together in the arm. **Graft** = synthetic tube connects them. - Needs time to **mature** (fistula \~**12 weeks**). Meanwhile, a catheter is used, so a patient may have **both**. **"Feel the thrill, hear the bruit."** **Thrill** = palpate (buzzing). **Bruit** = auscultate (whooshing, like a loud murmur). Check and document **every 4 hrs**. Also check circulation below the site to the fingertips. **Protect the arm (keep it from clotting):** - **No intravenous lines (IVs), no blood pressure (BP), no compression** on that arm. - No carrying heavy things with it. - Don't sleep on it. Caring for patients after hemodialysis **Meds:** - Most meds are **dialyzable** (removed by dialysis). Give **antibiotics, anticonvulsants, vitamins AFTER**. - **Hold antihypertensives and antidysrhythmics** until after (dialysis already drops blood pressure (BP)). - **Heparin** is used during dialysis and stays active **4–6 hrs** → **no invasive procedures**, watch for bleeding. Antidote = **protamine sulfate**. **Vital signs** for several hours: - **Hypotension** is the big risk. - Slightly **warm** temp is normal (dialysate is warmed: prevents hypothermia, vasodilation speeds toxin removal). **Ongoing fever** → infection or **sepsis**. **Weights** before and after. After = **dry weight**. **1 kg = 1 L** of fluid. Peritoneal dialysis (PD) The **peritoneum** (belly lining) is the filter. Done at home; more freedom (even on vacation). **Won't work** with belly scarring or adhesions from past surgery. 1. **Infuse**: 1–2 L dialysate flows in by gravity. 2. **Dwell**: stays 4–8 hrs. Patient disconnects and walks around. Extra weight can cause **back pain**. 3. **Drain**: fluid flows out by gravity into a bag. Outflow = **effluent**. Types: continuous ambulatory (CAPD), small machines, or overnight while sleeping. Depends on needs and insurance. peritoneal dialysis (PD) complications | Problem | Fix | | --- | --- | | **Peritonitis** (#1) | From contamination at the connection. **Sterile technique**: hand hygiene, sterile gloves, clean and assess site, **mask** when connecting/disconnecting. | | Pain with infusion | Common the first 1–2 weeks. **Warm** the dialysate (warmer or heating pad). **Never the microwave.** | | Poor flow | Kinks or clots. Top causes: **position** (turn to other side, supine or low Fowler's, align body) and **constipation** (high fiber, stool softeners). | | Leakage | Clear fluid around catheter, from too much volume at first. Builds up to a full \~**2 L** over a couple weeks. | Non-compliance (Carlos) - Dialysis for life, 3–4 hrs, 3 days a week. Many feel **denial**: "I feel better, I'll skip today." - Find the **reason** first: money, work, **no ride** to the clinic. - Don't just tell them what to do. Ask what they're **thinking and feeling**. Class prep: how will you bring up non-compliance with Carlos? Try an open question, like "Tell me what makes getting to dialysis hard." Quick recall · tap to flip NCLEX A client returns from hemodialysis. Which order should the nurse question? Never use the access arm for IVs, BP, or compression. NCLEX A client is scheduled for dialysis at 0900. Which 0800 med should the nurse hold? Dialysis already lowers BP. Antihypertensives wait until after. NCLEX A client on peritoneal dialysis has cloudy effluent and belly pain. The nurse suspects: Peritonitis is the major PD complication, from contamination at the connection. NCLEX A client weighed 82 kg before dialysis and 79.5 kg after. How much fluid was removed? 82 − 79.5 = 2.5 kg = 2.5 L.

fresh dropuce section

module 7 (HIV/AIDS, precautions for airborne, droplet, standard,ambulatory aids, gait patterns, W/C, AFOs, Cardiacpulm like ECG and abnormal and interventions)

Infectious Diseases and Droplet Precautions Vocabulary

Droplet Precautions (Spiderman)

Droplets

bio Genetics is the study of heredity and how traits are passed from parents to offspring. Gregor Mendel is known as the “Father of Genetics.” Why did Mendel use pea plants? * Easy to grow * Short generation time * Many visible traits * Can self-pollinate or cross-pollinate * Produce many offspring Examples of traits studied: * Flower colour * Seed shape * Plant height ⸻ VOCABULARY Gene * A segment of DNA that controls a trait. Allele * Different forms of the same gene. Example: P = purple flowers p = white flowers Dominant Allele * Expressed whenever it is present. * Represented by a capital letter. Example: P = purple Recessive Allele * Only expressed when two copies are present. * Represented by a lowercase letter. Example: p = white Genotype * Genetic makeup of an organism. Examples: PP Pp pp Phenotype * Physical appearance of an organism. Examples: Purple flower White flower Homozygous * Two identical alleles. Examples: PP pp Heterozygous * Two different alleles. Example: Pp Pure Breeding * Homozygous for a trait. Gamete * Sex cell (sperm or egg). ⸻ MENDEL’S LAWS Law of Dominance * A dominant allele masks a recessive allele. Example: Pp = Purple flower Law of Segregation * Alleles separate during gamete formation. * Each gamete receives only one allele. Example: Parent = Pp Gametes: P p Law of Independent Assortment * Different genes assort independently during meiosis. ⸻ MONOHYBRID CROSSES A monohybrid cross studies one trait. Example: P = Purple p = White Cross: Pp × Pp Punnett Square INCOMPLETE DOMINANCE Neither allele completely dominates. Example: Snapdragons RR = Red WW = White RW = Pink Cross: RW × RW Genotype Ratio: 1 RR : 2 RW : 1 WW Phenotype Ratio: 1 Red : 2 Pink : 1 White CODOMINANCE Both alleles are expressed equally. Example: AB Blood Type Genotype: IAIB Phenotype: AB MULTIPLE ALLELES More than two alleles exist in a population. Example: ABO Blood Group Alleles: IA IB i BLOOD TYPES Type A Genotypes: IAIA or IAi Type B Genotypes: IBIB or IBi Type AB Genotype: IAIB Type O Genotype: ii Can Type A and Type B Parents Have a Type O Child? Yes. If: Father = IAi Mother = IBi Possible Blood Types: AB A B O CELL CYCLE Purpose: * Growth * Repair * Replacement of cells Stages: G1 S G2 Mitosis Cytokinesis INTERPHASE G1 Phase Cell grows and carries out normal functions. S Phase DNA replication occurs. G2 Phase Cell prepares for division. MITOSIS Purpose: Growth and repair. Produces: 2 genetically identical diploid cells. PROPHASE Events: * Chromosomes condense * Nuclear membrane disappears * Nucleolus disappears * Spindle fibres form METAPHASE Events: * Chromosomes line up at the equator ANAPHASE Events: * Sister chromatids separate TELOPHASE Events: * Nuclear membranes reform * Chromosomes uncoil CYTOKINESIS Division of the cytoplasm. Animal Cells: Cleavage furrow forms. Plant Cells: Cell plate forms. CHROMOSOME STRUCTURE Chromosome consists of: * Two sister chromatids * One centromere DIPLOID VS HAPLOID Diploid (2n) * Two sets of chromosomes * Human body cells * 46 chromosomes Haploid (n) * One set of chromosomes * Human gametes * 23 chromosomes HOMOLOGOUS CHROMOSOMES Chromosome pairs that: * Carry the same genes * One comes from the mother * One comes from the father Humans have 23 homologous pairs. MEIOSIS Purpose: Produce gametes. Produces: 4 genetically unique haploid cells. MEIOSIS I Separates homologous chromosomes. CROSSING OVER Occurs during Prophase I. Definition: Exchange of DNA between homologous chromosomes. Importance: Creates genetic variation. RANDOM ASSORTMENT Occurs during Metaphase I. Definition: Homologous pairs line up randomly. Importance: Creates unique chromosome combinations. MEIOSIS II Separates sister chromatids. MITOSIS VS MEIOSIS Mitosis * 2 cells produced * Diploid * Genetically identical * Growth and repair Meiosis * 4 cells produced * Haploid * Genetically different * Produces gametes NONDISJUNCTION Failure of chromosomes to separate properly during meiosis. Can result in extra or missing chromosomes. DOWN SYNDROME Cause: Extra chromosome 21. Chromosome Number: 47 Usually caused by nondisjunction during meiosis. DNA DNA = Deoxyribonucleic Acid Shape: Double Helix Function: Stores genetic information. NUCLEOTIDE Three Components: * Phosphate Group * Deoxyribose Sugar * Nitrogenous Base NITROGENOUS BASES Adenine (A) Thymine (T) Cytosine (C) Guanine (G) COMPLEMENTARY BASE PAIRING A pairs with T C pairs with G DNA REPLICATION Purpose: Make identical copies of DNA. Location: Nucleus Result: Two identical DNA molecules. TRANSCRIPTION Purpose: Create mRNA from DNA. Location: Nucleus DNA → mRNA Remember: RNA uses Uracil (U) instead of Thymine (T). TRANSLATION Purpose: Make proteins. Location: Ribosome mRNA is read and amino acids are joined together to form a protein. MUTATIONS A mutation is a change in DNA sequence. Types: * Deletion * Duplication * Inversion * Translocation DELETION DNA segment removed. DUPLICATION DNA segment repeated. INVERSION DNA segment reversed. TRANSLOCATION DNA segment moves to another chromosome. SEX-LINKED TRAITS Traits located on sex chromosomes. Most are located on the X chromosome. RED-GREEN COLOUR BLINDNESS Inheritance: X-linked recessive. XC = Normal Vision Xc = Colour Blind Male: XcY Colour blind boys inherit the allele from their mother because fathers pass a Y chromosome to their sons. TAY-SACHS DISEASE Cause: Missing enzyme that breaks down lipids in nerve cells. Inheritance: Autosomal recessive. Treatment: No cure currently available. SICKLE CELL ANEMIA Cause: Mutation in hemoglobin gene. Effects: * Sickle-shaped red blood cells * Reduced oxygen transport * Blocked blood vessels Inheritance: Autosomal recessive. HUNTINGTON’S DISEASE Cause: Dominant mutation. Effects: * Nervous system degeneration * Loss of motor control * Cognitive decline Inheritance: Autosomal dominant. KARYOTYPE A photograph of chromosomes arranged in pairs. Used to: * Determine sex * Detect chromosome abnormalities * Diagnose genetic disorders PEDIGREE A family tree used to track inheritance patterns. Symbols: Square = Male Circle = Female Shaded = Has trait CLONING Producing genetically identical organisms. Uses: * Research * Agriculture * Medicine * Conservation GENETIC COUNSELLING Provides information about: * Inherited disorders * Family risk * Testing options AMNIOCENTESIS Prenatal test in which amniotic fluid is sampled and fetal cells are analyzed. Can detect: * Genetic disorders * Chromosomal disorders GMOs Genetically Modified Organisms. Definition: Organisms whose DNA has been altered through biotechnology. Advantages: * Increased crop yield * Disease resistance * Pest resistance Disadvantages: * Ethical concerns * Environmental concerns DNA REPLICATION → TRANSCRIPTION → TRANSLATION DNA (Nucleus) ↓ Replication DNA Copy DNA ↓ Transcription mRNA mRNA ↓ Translation Protein Final Product: Protein RESPIRATORY SYSTEM Function: * Brings oxygen into the body * Removes carbon dioxide * Works with the circulatory system to supply cells with oxygen Why do organisms require oxygen and produce carbon dioxide? Oxygen is required for cellular respiration. Cellular Respiration: Glucose + Oxygen → Energy (ATP) + Carbon Dioxide + Water Cells use oxygen to release energy from food. Carbon dioxide is produced as a waste product and must be removed. ⸻ PATHWAY OF AIR Nasal Cavity ↓ Pharynx ↓ Larynx ↓ Trachea ↓ Bronchi ↓ Bronchioles ↓ Alveoli ⸻ NASAL CAVITY Functions: * Warms air * Moistens air * Filters air Nasal Hairs: * Trap large particles Mucus: * Traps dust and microorganisms Blood Capillaries: * Warm incoming air ⸻ PHARYNX Common passageway for: * Air * Food Also called the throat. ⸻ UVULA Functions: * Prevents food from entering nasal cavity * Helps with speech ⸻ EPIGLOTTIS Functions: * Covers trachea during swallowing * Prevents choking ⸻ LARYNX Also called the voice box. Contains vocal cords. ⸻ TRACHEA Also called the windpipe. Contains cartilage rings that prevent collapse. Lined with: * Cilia * Mucus ⸻ CILIA Tiny hair-like structures. Function: * Sweep mucus upward toward throat ⸻ BRONCHI Two branches of the trachea leading to lungs. Right Bronchus → Right Lung Left Bronchus → Left Lung ⸻ BRONCHIOLES Smaller branches inside lungs. Lead to alveoli. ⸻ ALVEOLI Tiny air sacs. Site of gas exchange. Adaptations: * Thin walls * Moist surface * Large surface area * Rich blood supply Gas Exchange: Oxygen moves: Alveoli → Blood Carbon Dioxide moves: Blood → Alveoli By diffusion. ⸻ BREATHING MECHANICS Two main muscles: 1. Diaphragm 2. Intercostal Muscles ⸻ INHALATION (INSPIRATION) Diaphragm: * Contracts * Moves downward Intercostal Muscles: * Contract * Lift ribs upward Result: * Chest cavity volume increases * Pressure decreases * Air enters lungs ⸻ EXHALATION (EXPIRATION) Diaphragm: * Relaxes * Moves upward Intercostal Muscles: * Relax Result: * Chest cavity volume decreases * Pressure increases * Air leaves lungs ⸻ MEDULLA OBLONGATA Located in the brainstem. Function: * Controls breathing rate Responds to: * Carbon dioxide levels More CO₂: * Faster breathing Less CO₂: * Slower breathing ⸻ LUNG VOLUMES Tidal Volume * Normal amount of air breathed in and out Inspiratory Reserve Volume * Extra air inhaled after normal breath Expiratory Reserve Volume * Extra air exhaled after normal breath Residual Volume * Air remaining in lungs after maximum exhalation Vital Capacity * Maximum amount of air exhaled after deepest breath Total Lung Capacity * Total amount of air lungs can hold ⸻ CIRCULATORY SYSTEM Functions: * Transport oxygen * Transport nutrients * Remove wastes * Maintain homeostasis * Transport hormones Humans have a CLOSED circulatory system. Blood remains inside vessels. ⸻ BLOOD VESSELS ARTERIES Function: * Carry blood away from heart Characteristics: * Thick walls * High pressure * Small lumen * No valves Usually oxygen-rich Exception: Pulmonary artery ⸻ VEINS Function: * Carry blood toward heart Characteristics: * Thin walls * Low pressure * Large lumen * Valves present Usually oxygen-poor Exception: Pulmonary vein ⸻ CAPILLARIES Smallest blood vessels. Functions: * Gas exchange * Nutrient exchange * Waste exchange Walls are one cell thick. ⸻ HEART STRUCTURE Blood Flow: Body ↓ Vena Cava ↓ Right Atrium ↓ Right Ventricle ↓ Pulmonary Artery ↓ Lungs ↓ Pulmonary Vein ↓ Left Atrium ↓ Left Ventricle ↓ Aorta ↓ Body ⸻ HEART CHAMBERS Right Atrium * Receives deoxygenated blood Right Ventricle * Pumps blood to lungs Left Atrium * Receives oxygenated blood Left Ventricle * Pumps blood to body ⸻ SEPTUM Wall separating left and right sides of heart. Prevents mixing of blood. ⸻ HEART VALVES Function: * Prevent backflow of blood Types: Atrioventricular (AV) Valves Pulmonary Semilunar Valve Aortic Semilunar Valve ⸻ SA NODE Sinoatrial Node Known as: * Natural pacemaker Initiates heartbeat. ⸻ AV NODE Atrioventricular Node Receives signal from SA node. Delays impulse slightly. Allows ventricles to fill before contraction. ⸻ BLOOD Components: 1. Plasma 2. Red Blood Cells 3. White Blood Cells 4. Platelets ⸻ PLASMA Liquid component of blood. Functions: * Transport nutrients * Transport hormones * Transport wastes ⸻ RED BLOOD CELLS (ERYTHROCYTES) Function: * Carry oxygen Contain: * Hemoglobin ⸻ HEMOGLOBIN Protein in red blood cells. Function: * Binds oxygen Allows oxygen transport. ⸻ WHITE BLOOD CELLS (LEUKOCYTES) Function: * Fight infection * Defend body Part of immune system. ⸻ PLATELETS Function: * Blood clotting Prevent blood loss. ⸻ BLOOD PRESSURE Force of blood against artery walls. Measured using: Sphygmomanometer Example: 120/80 120 = Systolic Pressure 80 = Diastolic Pressure ⸻ SYSTOLIC PRESSURE Pressure when heart contracts. ⸻ DIASTOLIC PRESSURE Pressure when heart relaxes. ⸻ HYPERTENSION High blood pressure. Can increase risk of: * Stroke * Heart attack * Kidney disease ⸻ STROKE VOLUME Amount of blood pumped per heartbeat. ⸻ CARDIAC OUTPUT Amount of blood pumped per minute. Formula: Cardiac Output = Heart Rate × Stroke Volume ⸻ ECG Electrocardiogram Measures electrical activity of heart. Used to detect: * Irregular heartbeat * Heart damage ⸻ PULMONARY CIRCULATION Heart → Lungs → Heart Purpose: * Oxygenate blood ⸻ SYSTEMIC CIRCULATION Heart → Body → Heart Purpose: * Deliver oxygen to tissues ⸻ HOMEOSTASIS DURING EXERCISE Body responds by: * Increasing heart rate * Increasing breathing rate * Increasing cardiac output * Redirecting blood to muscles * Sweating to cool body Purpose: Maintain stable internal conditions. ⸻ DIGESTIVE SYSTEM Functions: * Break down food * Absorb nutrients * Eliminate waste ⸻ DIGESTIVE TRACT Mouth ↓ Pharynx ↓ Esophagus ↓ Stomach ↓ Small Intestine ↓ Large Intestine ↓ Rectum ↓ Anus ⸻ MECHANICAL DIGESTION Physical breakdown of food. Examples: * Chewing * Churning ⸻ CHEMICAL DIGESTION Chemical breakdown of food using enzymes. Examples: * Amylase * Pepsin ⸻ SALIVA Functions: 1. Moistens food 2. Contains amylase Amylase begins carbohydrate digestion. ⸻ TONGUE Functions: 1. Forms bolus 2. Pushes food for swallowing ⸻ ESOPHAGUS Moves food to stomach. Uses: Peristalsis ⸻ PERISTALSIS Wave-like muscular contractions. Move food through digestive tract. ⸻ STOMACH Functions: * Stores food * Mixes food * Begins protein digestion Produces: * HCl * Pepsin * Mucus ⸻ HCl Hydrochloric Acid Functions: * Kills bacteria * Activates pepsin ⸻ PEPSIN Function: * Digests proteins ⸻ MUCUS Function: * Protects stomach lining ⸻ CHYME Semi-liquid food mixture leaving stomach. ⸻ HEARTBURN Cause: Stomach acid enters esophagus. Usually caused by weakened cardiac sphincter. ⸻ SMALL INTESTINE Main site of: * Digestion * Absorption Adaptations: * Long length * Folds * Villi * Microvilli Large surface area increases absorption. ⸻ DUODENUM First section. Functions: * Receives bile * Receives pancreatic enzymes * Most chemical digestion ⸻ JEJUNUM Main nutrient absorption. ⸻ ILEUM Final nutrient absorption. ⸻ VILLI Finger-like projections. Function: Increase surface area. ⸻ LIVER Functions: * Produces bile * Processes nutrients * Detoxifies blood ⸻ GALL BLADDER Functions: * Stores bile * Releases bile into small intestine ⸻ PANCREAS Functions: * Produces digestive enzymes * Produces bicarbonate ⸻ BILE Function: Emulsifies fats. Breaks large fat droplets into smaller droplets. Makes fat digestion easier. ⸻ DIGESTION OF CARBOHYDRATES Mouth: * Amylase begins digestion Small Intestine: * Pancreatic amylase continues digestion End Product: Glucose ⸻ DIGESTION OF PROTEINS Stomach: * Pepsin begins digestion Small Intestine: * Trypsin continues digestion End Product: Amino Acids ⸻ DIGESTION OF LIPIDS Small Intestine: * Bile emulsifies fats * Lipase digests fats End Product: Fatty Acids + Glycerol ⸻ EVOLUTION Evolution: Change in populations over time. Individuals do NOT evolve. Populations evolve. ⸻ DARWIN Proposed: Natural Selection Book: On the Origin of Species ⸻ WALLACE Independently developed theory of natural selection. ⸻ LAMARCK Proposed: Inheritance of acquired characteristics Example: Giraffes stretch necks and pass longer necks to offspring. This theory is incorrect. ⸻ NATURAL SELECTION Requirements: 1. Variation 2. Overproduction 3. Competition 4. Differential Survival 5. Reproduction Result: Adaptation ⸻ ADAPTATION Inherited characteristic that increases survival and reproduction. ⸻ SELECTIVE ADVANTAGE A characteristic that improves survival or reproduction. Example: Antibiotic resistance ⸻ SELECTIVE PRESSURE Environmental factor that influences survival. Examples: * Predators * Disease * Climate * Competition ⸻ VARIATION Differences among individuals in a population. Sources: * Mutation * Crossing Over * Random Assortment ⸻ MUTATION Ultimate source of new alleles. Creates genetic variation. ⸻ FOSSIL Preserved remains or traces of organisms. ⸻ FOSSIL RECORD Collection of fossils showing evolutionary history. Provides evidence for evolution. ⸻ RADIOACTIVE DATING Uses radioactive isotopes to determine fossil age. ⸻ UNIFORMITARIANISM Proposed by Lyell. Earth changes gradually over long periods of time. ⸻ CATASTROPHISM Proposed by Cuvier. Earth shaped by sudden catastrophic events. ⸻ BIOGEOGRAPHY Study of species distribution around Earth. Provides evidence for evolution. ⸻ EMBRYOLOGY Study of embryos. Similar embryos suggest common ancestry. ⸻ HOMOLOGOUS STRUCTURES Same evolutionary origin. Different functions. Example: Human arm Whale flipper Bat wing Evidence of common ancestry. ⸻ ANALOGOUS STRUCTURES Different origins. Same function. Example: Bird wing Insect wing Not evidence of close ancestry. ⸻ VESTIGIAL STRUCTURES Structures with little or no function. Examples: * Human appendix * Whale pelvis Evidence of evolution. ⸻ MIMICRY One species resembles another. Example: Syrphid fly resembles wasp. Provides protection. ⸻ ARTIFICIAL SELECTION Humans select traits. Examples: * Dog breeding * Crop breeding ⸻ DIRECTIONAL SELECTION One extreme phenotype favored. Graph shifts in one direction. ⸻ STABILIZING SELECTION Average phenotype favored. Extremes selected against. ⸻ DISRUPTIVE SELECTION Both extremes favored. Middle selected against. ⸻ GENETIC DRIFT Random change in allele frequencies. Most significant in small populations. ⸻ FOUNDER EFFECT Small group starts new population. Different allele frequencies from original population. ⸻ BOTTLENECK EFFECT Population drastically reduced. Loss of genetic variation. ⸻ GENE FLOW Movement of alleles between populations. Occurs through migration. ⸻ NON-RANDOM MATING Individuals choose specific mates. Can reduce variation. ⸻ SPECIES A group of organisms that can interbreed in nature and produce fertile offspring. ⸻ SPECIATION Formation of new species. ⸻ ALLOPATRIC SPECIATION Requires: Geographic isolation Example: Mountain separates populations. ⸻ SYMPATRIC SPECIATION Occurs without geographic isolation. ⸻ PRE-ZYGOTIC ISOLATION Prevents fertilization. Examples: * Different mating seasons * Different mating songs * Different habitats ⸻ POST-ZYGOTIC ISOLATION Occurs after fertilization. Example: Sterile hybrids Example: Mule DIVERSITY Prokaryotes vs Eukaryotes PROKARYOTES * No nucleus * No membrane-bound organelles * Circular DNA * Smaller * Examples: Eubacteria, Archaebacteria EUKARYOTES * Nucleus present * Membrane-bound organelles * Linear chromosomes * Larger * Examples: Protists, Fungi, Plants, Animals Three Differences: 1. Nucleus vs no nucleus 2. Organelles vs no organelles 3. Larger vs smaller ⸻ Taxonomy Kingdom Phylum Class Order Family Genus Species Mnemonic: King Philip Came Over For Good Soup ⸻ Binomial Nomenclature Genus + Species Example: Homo sapiens Rules: * Genus capitalized * Species lowercase * Italicized Purpose: * Universal naming system * Avoids confusion * Shows relationships ⸻ Dichotomous Key Used to identify organisms using paired choices. Example: 1a Has wings → Step 2 1b No wings → Step 3 ⸻ Six Kingdoms 1. Archaebacteria 2. Eubacteria 3. Protista 4. Fungi 5. Plantae 6. Animalia ⸻ VIRUSES Virus Structure: * DNA or RNA * Capsid * Attachment proteins * Sometimes envelope Why Viruses Are Not Living: * Not made of cells * Cannot reproduce independently * No metabolism * Need host cell ⸻ DNA Virus vs RNA Virus DNA Virus: * Contains DNA * More stable RNA Virus: * Contains RNA * Mutates faster ⸻ Lytic Cycle Attachment ↓ Penetration ↓ Replication ↓ Assembly ↓ Lysis Host cell bursts. ⸻ Lysogenic Cycle Attachment ↓ Penetration ↓ Integration into host DNA ↓ Host reproduces ↓ Virus DNA copied Cell survives initially. ⸻ ARCHAEBACTERIA Characteristics: * Prokaryotic * Unicellular * Extreme environments Three Groups: Methanogens * Produce methane Halophiles * Salt-loving Thermoacidophiles * Hot acidic environments ⸻ EUBACTERIA Characteristics: * Prokaryotic * Peptidoglycan cell wall * Binary fission Examples: * E. coli * Streptococcus ⸻ Binary Fission DNA Replication ↓ Cell Growth ↓ Cell Division ↓ Two Identical Cells ⸻ Conjugation DNA transfer through pilus. Importance: * Genetic variation * Antibiotic resistance ⸻ Antibiotic Resistance Mutation ↓ Antibiotic kills susceptible bacteria ↓ Resistant bacteria survive ↓ Resistant bacteria reproduce Natural Selection ⸻ PROTISTS Characteristics: * Eukaryotic * Mostly unicellular * Aquatic Three Groups: Animal-like * Amoeba * Paramecium Plant-like * Algae * Euglena Fungus-like * Slime molds ⸻ Amoeba * Uses pseudopods * Phagocytosis ⸻ Algae * Photosynthetic * Oxygen producer ⸻ Euglena * Chloroplasts * Flagellum * Photosynthesis * Can also feed heterotrophically ⸻ Malaria Cause: Plasmodium Kingdom: Protista ⸻ FUNGI Characteristics: * Eukaryotic * Heterotrophic * Chitin cell walls * Reproduce with spores Examples: * Mushrooms * Mold * Yeast ⸻ External Digestion Release enzymes ↓ Digest food outside body ↓ Absorb nutrients ⸻ Fungi vs Plants FUNGI * Heterotrophic * Chitin * No chloroplasts PLANTS * Autotrophic * Cellulose * Chloroplasts ⸻ PLANTS Biodiversity vs Monoculture BIODIVERSITY * Many species * Stable ecosystem * Disease resistance MONOCULTURE * One crop species * Low diversity * Disease risk ⸻ Bryophytes Definition: Nonvascular plants Examples: * Mosses * Liverworts Characteristics: * No xylem * No phloem * Need water for reproduction ⸻ Vascular Plants Contain: * Xylem * Phloem ⸻ Xylem Function: Water and minerals Direction: Roots → Leaves ⸻ Phloem Function: Sugars Direction: Throughout plant ⸻ Alternation of Generations Sporophyte (2n) ↓ meiosis Spores (n) ↓ Gametophyte (n) ↓ Gametes ↓ fertilization Zygote (2n) ↓ Sporophyte ⸻ Moss Life Cycle Spores ↓ Gametophyte ↓ Egg + Sperm ↓ Zygote ↓ Sporophyte ↓ Capsule ↓ Spores Know: * Capsule * Sporophyte * Gametophyte * Spores ⸻ Fern Life Cycle Fern ↓ Sori ↓ Spores ↓ Prothallus ↓ Gametes ↓ Fertilization ↓ Young Fern Know: * Frond * Sori * Sporangia * Prothallus ⸻ Gymnosperms Characteristics: * Naked seeds * Cones * Wind pollination * Evergreen Examples: * Pine * Spruce * Fir ⸻ Angiosperms Characteristics: * Flowers * Fruit * Seeds enclosed Examples: * Apple tree * Rose * Maple ⸻ Flower Structure Anther * Produces pollen Pollen Grain * Male gamete Stigma * Receives pollen Style * Connects stigma and ovary Ovary * Contains ovules Ovule * Female gamete Petals * Attract pollinators ⸻ Plant Tissues Meristematic * Growth Dermal * Protection Ground * Photosynthesis * Storage Vascular * Transport ⸻ Leaf Structure Blade * Main leaf surface Petiole * Connects leaf to stem Cuticle * Reduces water loss Palisade Mesophyll * Photosynthesis Spongy Mesophyll * Gas exchange Veins * Xylem + Phloem ⸻ Stomata Openings in leaves. Functions: * Gas exchange * Water loss ⸻ Guard Cells Control opening and closing of stomata. ⸻ Transpiration Water loss from leaves. Functions: * Pulls water upward * Cools plant * Moves minerals ⸻ Simple vs Compound Leaves Simple: * One blade Compound: * Multiple leaflets ⸻ Monocots vs Dicots MONOCOTS * 1 cotyledon * Parallel veins * Fibrous roots * Flower parts in 3s Examples: Corn Grass DICOTS * 2 cotyledons * Net veins * Taproot * Flower parts in 4s or 5s Examples: Bean Maple ⸻ Seeds Contain: * Embryo * Stored food * Seed coat Functions: * Protection * Survival * Dispersal ⸻ Seed Dispersal Wind * Dandelion Water * Coconut Animals * Burrs Explosive * Touch-me-not ⸻ Fruit vs Vegetable Fruit: * Comes from ovary * Contains seeds Examples: Tomato Apple Pepper Vegetable: * Root, stem, leaf, or flower Examples: Carrot Celery Broccoli ⸻ Factors Affecting Plant Growth 1. Light 2. Water 3. Carbon dioxide 4. Temperature 5. Soil nutrients 6. Oxygen 7. Soil pH 8. Space 9. Pollinators 10. Disease and pests

Mode of Transmission: Droplet

MMiPeople Francesco Redi: scientist who tested spontaneous generation with rotting meat and maggot formation with an open container, sealed container, and gauze-covered container, and refuted spontaneous generation Needham: scientist who tested spontaneous generation with boiling chicken broth, sealing the container, and waiting a few days to assess for microbial growth, and supported spontaneous generation Spallanzani: scientist who tested spontaneous generation with further testing, Needham’s experiment, and tested with an open and closed container that was later opened, and refuted spontaneous generation Louis Pasteur: scientist who used swan-neck flasks in his experiment and definitively refuted spontaneous generation Anthony van Leeuwenhoek: scientist who was the first to observe eukaryotic microbes, calling them “wee animalcule” Robert Hooke: coined the term “cell” when looking at cork Matthias Schleiden: observed cells in plant tissue Theodor Schwann: observed cells in animal tissue Rudolf Virchow and Robert Remark: observed cells dividing to make new cells (not mitosis) Hippocrates: suggested disease has natural causes Thucydides: advocated for evidence-based analysis of cause and effect and suggested immunity after observing plague survivors didn't get sick again Marcus Terentius Varro: the first to propose that things we cannot see cause disease Ignaz Semmelweis: physician who observed the spread of disease among patients in different sides of the hospital and instituted hand washing between patients to reduce the spread of disease from patient to patient via healthcare workers Joseph Lister: surgeon who observed post-surgical infection and instituted hand washing and sterilization of medical equipment with 5% phenol solution for less disease Robert Koch: scientist who developed Koch’s postulates to determine the cause of disease and had a rivalry with Louis Pasteur John Snow: questioned the London cholera outbreak and asked questions to the people who had been infected about where they had been and what they had eaten or drank, and noticed that everyone who had cholera used one of two water pumps Classification of microbes What are the 2 domains that are composed of all microbes? Bacteria and Archaea What domain of life is composed only of some microbes? Eukarya What types of microbes do not fit into the domains of life? Viruses and Prions Prions: unicellular organisms in the domains Bacteria and Archaea with no nucleus and have cell walls Viruses: acellular and domainless (not alive) Eukaryotes: unicellular OR multicellular organisms, in domain Eukarya, have a nucleus, have membrane-bound organelles, and include fungi, algae, protazoa, and helminths How many times bigger are bacteria than viruses? 100x A cell is around how many times bigger than an individual bacteria? 10x Cell structures Know the function, general location, and whether they are shared with eukaryotes (if yes similarities/differences) of the following structures: 1. Nucleoid: contains chromosome(s) and nuclear-associated proteins that are usually haploid and circular near the center of the cell, which hold the DNA genetic information without a membrane Eukaryotes = have a nucleus, are diploid and linear Prokaryotes = have nucleoid, are haploid and circular 2. Ribosomes: work with mRNA protein synthesis, made up of proteins and RNA, found in cytoplasm Eukaryotes: 80S, 60 large, 40 small (18S sequencing) Prokaryotes: 70S, 50 large, 30 small (16S sequencing) 3. Cytoplasm: fluid inner layer 4. Fimbriae: short, bristle-like projections for attachment to surfaces 5. Endospores: not all bacteria have, protect bacteria in a dormant state/ harsh environment, found inside bacteria, sporulation = the process of becoming dormant, germination = process of becoming active 6. Plasma membrane: semipermeable, composed of lipids and proteins, controls transport into and out of cell, most inner layer before cytoplasm (ex: facilitated diffusion, active transport, diffusion, endocytosis (Eukaryotes), sterols (Eukaryotes), and cholesterol (Eukaryotes) Same for Eukaryotes 7. Cell wall: protects against harsh changing environments and osmotic stress, contains peptidoglycan in bacteria, contains Gram + and Gram - Steps of Gram stain: dye with crystal violet, iodine (mordant), alcohol (decolorizer), and safranin red If mycobacteria complete an acid-fast stain Gram + has LTA an TA and one membrane Gram - has LPS and 2 membranes 8. Capsule: protective protein shell, outermost layer 9. Pilus: medium projection, adheres to surfaces, does DNA gene transfer 10. Flagellum: long protein projections made of flagellin for movement (ex: 1= monotrichous, one at each end = amphitrichous, many at one end = lophotrichous, many flagella all over the cell = peritrichous 11. Plasmid: circular, double-stranded DNA not part of the chromosome, and can have 1-100 of the same or different plasmids to help with gene transfer, antibiotic resistance, and virulence factors, found anywhere in the cytoplasm Not part of Eukaryotes 12. Inclusion: not all bacteria have, helps with the storage of nutrients and other materials, has protein shell, and is found in cytoplasm (ex: lipid droplets store fats, volutin stores inorganic phosphates, sulfur inclusions store sulfur, gas bubbles store gas for buoyancy in water, magnetosomes store metals for movement) Not part of Eukaryotes; instead, they have vesicles for storage All cellular microbes have what four (4) components? Cell Membrane, Cytoplasm, Ribosomes, and DNA What is the only component of all cells that viruses have? Cytoplasm Know/ be able to identify the shapes of bacteria Round shape: coccus Rod shape: bacillus Vibrio: curved rod shape Short rods with combo of coccus and bacillus: coccobacillus Wavy spiral shape: Spirillum Coiled spiral shape: Spirochete Microbial growth Phases of growth Lag Phase: bacteria gear up for replication by increasing cell size, metabolism, and protein synthesis Log Phase: exponential growth phase, where bacteria actively replicate and are most susceptible to antibiotics Stationary Phase: growth curve flatlines bc bacteria are dying at same rate of growth, begin survival mode and sporulation, produce secondary metabolites, and produce virulence factors, and are low on space, nutrients, and oxygen Death Phase: bacteria die at exponential rate, increase amount of toxic waste, release spores, some spontaneously lyse to feed others, and persister cells refuse to die How do microbes replicate? Through binary fission, fragmentation, budding, and sexually What is a biofilm? Communities of bacteria (steps: colonization, attachment, replication, make EPS with antibiotic resistance, EPS kick bacteria out to replicate somewhere else) How does quorum sensing work? Bacteria want to work together, so they secrete autoinducers, and when you activate enough receptors, they activate a response Growth requirements – classifications and adaptations 1. Oxygen requirements Obligate Aerobes: need O2 to survive Obligate Anaerobes: die in presence of O2 Faculative: mostly need O2 but can survive without it Microaerophiles: need O2 for survival but not atmospheric O2 (low levels) Aerotolerant: can survive with or without oxygen Capnophiles: like high CO2 and low O2 2. pH requirements Acidophiles: low pH (2-4), high H+ environments, efflux pumps to remove H+ ions, changes membrane composition to withstand low pH Neutrophiles: neutral pH (7), found within body Alkaliphiles: basic pH (9-10), modified lipid protein structures, modified electron transport system that use Na+ instead of H+, high OH- environment 3. temperature requirements Psychrophiles: like freezing temperatures a below 0-15 degrees, die at or above 20 degrees, found in cold lakes or the ocean floor, have hydrophobic proteins to increase flexibility, have decreased secondary stabilizing bonds Psychrotolerant: cold not ideal but wont kill them, live between 4-25 degrees (fridge temperature) Mesophiles: moderate temperatures, 20-40 degrees, grow in body Thermophiles: hot environments 50-80 degrees, hot springs, geothermal soil Hyperthermophiles: very hot environments 80-110 degrees, found in hydrothermal vents, increased saturation in membranes, increased stabilizing bonds, alter amino acids to prevent denaturation 4. osmolarity requirements Hypertonic: more water out Hypotonic: more water in Isotonic: equal water in and out Halotolerant: dont require salt but can grow in high salt environments Halophiles: love salt, found in ocean and salt lakes, have increased cytoplasmic glycerol, have efflux pumps for salt 5. barometric requirements Barophile: survive high atmospheric environments like the bottom of the ocean (something at top of mountain has low atmospheric pressure) Microbial Metabolism Means of generating energy (do the processes require oxygen?, which gives the most energy?) Glycolysis: does not require O2 bc it can be used during fermentation, used 2 ATP, makes 4 ATP, NET 2 ATP Kreb’s cycle: requires O2; NET after 1 round= 1ATP, 1 NADH, 1FADH2 (x2 for second round) Electron transport: requires O2, biggest payout of ATP with NET 34 ATP Photosynthesis: does not require O2 as it is a waste product, can do oxygenic and anoxygenic Microbial genetics DNA Replication – enzymes and functions DNA gyrase: unwinds DNA (enzyme) Helicase: unzips DNA (enzyme) Single-stranded binding proteins: bind to DNA so doesnt close back up (protein) Single-stranded binding proteins: bind to DNA so doesnt close back up (protein) DNA polymerase III: lay down new DNA nucleotides, synthesizes leading and lagging strands 5’ →3’(enzyme) DNA polymerase I: removes RNA primers (enzyme) DNA Ligase: seals RNA primers (enzyme) Topoisomerase 4: separates 2 circular chromosomes Transcription and translation – enzymes and function 1. RNA polymerase: turns DNA→ mRNA (transcription) 2. Ribosomes: 30S small, 50S large, 70S total 3. tRNA: A,P, and E sites, bacteria links transcription and translation bc no nucleus, has anticodon at opposite long 3’ end, high energy bond, same active translation process as Eukaryotes Be able to do DNA base pairing, transcription, and translation (given codon table) Also know differences between prokaryotic and eukaryotic Replication, transcription, and translation Genetic Diversity – how does this work? 1. Transformation: uptake of plasmid into different bacteria and is incorporated into its genetic material 2. Transduction: bacteriophage inserts its plasmid into a bacteria (virus that infects a bacteria) 3. Conjugation: like plasmid transfer (ex: rolling circle replication), “bacterial sex” 4

Lipid droplets

Learning Rate and Overfitting/dropout

Week 5 Absolutely — here’s a condensed study guide that keeps the major concepts (the stuff most likely to be tested), without all the extra detail. Infection Control & Body Defenses — Condensed Study Guide (Major Concepts) Chain of Infection (6 Links + how to break them) 1. Infectious agent (bacteria, viruses, fungi, parasites, prions) ○ Break it: disinfect/sterilize/clean; antimicrobials as ordered 2. Reservoir (where it lives: people/animals/insects; soil, water, food, equipment, IV fluids, feces) ○ Break it: hand hygiene, pre-op skin prep, environmental cleaning 3. Portal of exit (blood/body fluids, respiratory/GI tract, mouth/nose/ears, skin) ○ Break it: contain drainage/secretions (dressings, drains) 4. Mode of transmission ○ Main: contact, droplet, airborne (also vehicle, vector) ○ Break it: hand hygiene + PPE + disinfect shared equipment 5. Portal of entry (orifices, mucous membranes, breaks in skin; invasive devices) ○ Break it: aseptic technique, protect skin, sterile technique when needed 6. Susceptible host (risk depends on immunity/health) ○ Break it: immunizations, nutrition, hygiene, blood sugar control Virulence: how efficient an organism is at making people ill. Modes of Transmission (what to recognize) Contact ● Direct: person-to-person (ex: blood to open abrasion) ● Indirect: contaminated objects/PPE/equipment (ex: bed rails, shared devices) Droplet ● From coughing/sneezing/singing/talking; some procedures (CPR, intubation) ● Examples: influenza, pertussis, RSV, adenovirus, rhinovirus ● Respiratory etiquette + masking when out of room Airborne ● Small particles remain suspended; travel farther ● Requires private room; negative pressure (AIIR) preferred ● Examples: TB, measles (rubeola), varicella Vehicle / Vector ● Vehicle: contaminated food/water (ex: E. coli produce) ● Vector: insects/rodents (mosquitoes, rats) Body Defenses (3 Types) 1. Physical & chemical barriers ○ Skin (primary defense), mucous membranes/mucus, tears/sweat, cilia + cough, stomach acid, normal flora 2. Nonspecific immunity ○ Neutrophils + macrophages (phagocytes “eat and destroy”) 3. Specific immunity ○ Antibodies (immunoglobulins) + lymphocytes Inflammatory Response (key steps + signs) Steps: ● Pattern receptors recognize harmful stimuli ● Inflammatory pathway activated ● Markers released (ex: CRP) ● Inflammatory cells recruited (leukocytes → monocytes/lymphocytes) Signs of inflammation (local tissue): ● heat, redness, swelling, pain, loss of function Triggers can be infectious (viruses/bacteria) or noninfectious (trauma, burns, irritants, toxins, radiation, etc.). Stages of Infection (in order) 1. Incubation (exposure → first symptom; may have lab changes) 2. Prodromal (vague symptoms: malaise, fever, aches) 3. Acute illness (most severe; specific symptoms) 4. Decline (symptoms decrease) 5. Convalescence (recover/return to baseline) Local vs Systemic Infection ● Local: confined to one area (often topical/oral treatment) ● Systemic: enters bloodstream, affects whole body (often IV antibiotics + monitoring) Diagnostic Tests (high-yield) ● UA for UTI symptoms → if WBCs present, culture & sensitivity ● CXR confirms pneumonia/atelectasis but doesn’t tell viral vs bacterial ● CBC + differential ○ Expected WBC: 5,000–10,000/mm³ ○ “Left shift” = increased bands (immature neutrophils) → infection ● Nonspecific markers: CRP, ESR, Procalcitonin Asepsis & Precautions Hand hygiene (most important) ● Soap/water when visibly soiled and for C. diff spores ● Alcohol sanitizer works unless hands visibly soiled Medical asepsis (clean technique) ● reduces microbes; includes isolation precautions Surgical asepsis (sterile technique) ● prevents introducing microbes during invasive procedures; uses sterile supplies/fields Isolation Precautions (major takeaways) Standard precautions ● For all clients ● Protect from blood/body fluids, secretions, excretions, nonintact skin, mucous membranes ● PPE based on expected exposure Contact precautions ● Gown + gloves ● Examples: C. diff, VRE, norovirus, RSV, large draining wounds ● Remove PPE inside room Droplet precautions ● Surgical mask ● Examples: influenza, pertussis, RSV Airborne precautions ● N95 or higher, private room; AIIR/negative pressure preferred ● Examples: TB, measles, varicella Protective isolation (protective environment) ● For severely immunocompromised (ex: post-allogenic HSCT) ● Positive airflow + HEPA (goal: protect the client) Health Care–Associated Infections (HAIs) — the “big 4” ● CLABSI ● CAUTI ● SSI ● VAP Devices/lines/wounds create portals of entry → strict asepsis reduces risk. MDROs (major concept) MDROs = resistant bacteria (hard to treat) Examples: MRSA, VRE, VRSA, VISA, ESBL, MDRSP Prevention: hand hygiene, contact precautions per policy. If you want, I can turn this condensed guide into a 20-question practice quiz (ATI/NCLEX-style) focusing on chain links, precautions, PPE, labs, and transmission. Week 6 Here is a more condensed study guide that keeps all main concepts from your content (no major topics removed), just simplified and streamlined for studying. Condensed Study Guide: Novice to Expert + Nursing Communication I. Novice to Expert Nursing (Benner Model) Lifelong Learning & Collaboration ● Learning occurs through study and working with others ● Nurses grow by: ○ observing experienced nurses ○ sharing knowledge and best practices ● Respect all experience levels (years ≠ only indicator of knowledge) ● Leaders promote: ○ collaboration ○ mutual respect ○ teamwork culture Benner’s 5 Stages of Competence 1. Novice – no experience; relies on rules; struggles to prioritize 2. Advanced Beginner – recognizes patterns; still rule-focused; needs help setting priorities 3. Competent – uses past experience to prioritize; more organized but slower than proficient 4. Proficient – sees the big picture; adapts to changing situations 5. Expert – intuitive, confident, and highly skilled with complex care II. Communication Foundations Definition Communication = transfer of information that is always occurring, even without speaking. Includes: verbal words, body language, emotions, and technology. Why Communication Matters ● Key to client safety (Joint Commission goal) ● Miscommunication → medical errors ● Nurses must detect when clients don’t understand III. Communication Models (Core Concepts) Shannon–Weaver Model (Linear) Sender → Encoder → Channel → Decoder → Receiver + Noise (distractions interfering with message) Schramm Model (Feedback) ● Sender and receiver exchange messages ● Feedback confirms understanding ● No feedback = communication incomplete Newcomb ABX Model (Social) ● A (sender), B (receiver), X (topic affecting interaction) ● Focus on relationships and shared topic Berlo S-M-C-R Model (One-way) ● Sender → Message → Channel → Receiver ● No feedback loop IV. Forms of Communication Verbal Spoken communication (face-to-face or phone) Nonverbal (Body Language) ● Eye contact, posture, facial expressions ● When verbal and nonverbal conflict → nonverbal dominates Auditory What the receiver hears (tone, speed, clarity) Emotional Speaker’s emotional state influences how message is received Energetic Speaker’s presence/empathy affects perception of message V. Modes of Communication (4 Types) 1. Verbal – spoken conversation 2. Nonverbal – gestures, posture, appearance 3. Electronic – email, text, video (must be secure/HIPAA compliant) 4. Written – letters, emails, documents (may lack tone/body language) HIPAA & Electronic Communication Must include: ● secure messaging ● unique logins ● auto logoff ● encrypted/indecipherable PHI VI. Communication Styles Most effective: Assertive ● Passive: avoids conflict; agrees despite concerns ● Assertive: clear, respectful, confident; uses “I” statements ● Aggressive: blaming, hostile, controlling ● Passive-aggressive: indirect expression (sarcasm, avoidance) VII. Therapeutic Communication Purpose Build trust and provide patient-centered, empathetic care Cornerstones ● Compassion ● Caring ● Empathy Peplau’s Nurse-Client Relationship Phases 1. Orientation – client seeks help 2. Identification – relationship forms 3. Exploitation – active teaching/working phase 4. Resolution – issue resolved; relationship ends Watson’s Theory of Human Caring ● Authentic presence ● Protect dignity ● Loving-kindness ● “Healing moment” interactions VIII. Therapeutic Communication Techniques (Must Know) ● Active listening – attend to verbal + nonverbal cues ● Open-ended questions – encourage discussion (“Tell me more…”) ● Silence – allows client to reflect and share more ● Restating / summarizing – repeat message to confirm understanding ● Reflection – mirror feelings (“What do you think you should do?”) ● Accepting – acknowledge message without judgment ● Giving recognition – note change without compliment ● Focusing – gently redirect to important topic ● Offering self – sit with client and be present IX. Nontherapeutic Communication (Avoid) ● Giving advice ● False reassurance (“You’ll be fine”) ● Criticizing or challenging ● Asking “Why” questions ● Rejecting or disagreeing ● Probing irrelevant topics ● Changing the subject Effects: ● increased stress ● damaged trust ● poor outcomes X. Interprofessional Communication Importance Effective teamwork improves: ● client outcomes ● safety ● efficiency ● reduces errors IPEC Core Competencies 1. Mutual respect among team members 2. Use shared knowledge collaboratively 3. Communicate effectively as a team 4. Support team values and client-centered care XI. Motivational Interviewing (MI) Purpose Encourage behavior change (diabetes, obesity, substance use) OARS Technique ● Open-ended questions ● Affirmations (positive encouragement) ● Reflective listening ● Summarizing XII. Group vs Individual Communication ● Individual: new diagnosis, personal teaching ● Group: ongoing education, support groups XIII. Communication Barriers (Major Categories) Cognitive/Developmental ● dementia, stroke, autism Physiological ● hearing loss, vision impairment Cultural & Language ● language differences, cultural beliefs, lack of cultural competence Environmental/Situational ● noise, lighting, temperature ● fear, anxiety, fatigue, stress Technological ● poor reception, distractions, electronic errors XIV. Strategies to Overcome Barriers Universal Strategies ● show empathy and respect ● avoid interrupting ● use simple, clear language ● confirm understanding (summarize/reflect) Language Barriers (CLAS Standards) ● Use qualified medical interpreter ● Do NOT use family members or translation apps ● Required for federally funded facilities Hearing Impairment Strategies ● face the client ● speak clearly/moderate pace ● reduce background noise ● use written info or visual aids ● ensure hearing aids in place ● speak to client (not interpreter) if interpreter present Vision Impairment Strategies ● introduce yourself ● give clear directions (“door at 10 o’clock”) ● allow client to hold your arm ● provide large print/audio/Braille materials Cognitive/Developmental Strategies ● use simple words ● avoid jargon/slang ● speak slowly and clearly ● reduce noise/bright distractions ● ensure glasses/hearing aids available Key Takeaways (Exam Focus) ● Benner’s stages: Novice → Advanced Beginner → Competent → Proficient → Expert ● Communication must include feedback to be effective ● Nonverbal cues often outweigh verbal messages ● Best communication style = Assertive ● Core therapeutic techniques = active listening, open-ended questions, silence, reflection, summarizing ● Use qualified interpreter for language barriers (CLAS standard) ● Barriers include cognitive, physical, cultural, environmental, and emotional factors ● Effective communication improves client safety and outcomes Here is a condensed but complete study guide that keeps all concepts from the Safety lesson while removing extra wording. SAFETY & PATIENT PROTECTION – CONDENSED STUDY GUIDE I. Joint Commission National Patient Safety Goals (NPSGs) Purpose Annual goals to improve: ● Client safety ● Safe, effective care ● Prevention of adverse outcomes 1. Identify Clients Correctly ● Use two identifiers (name, DOB, MRN, etc.) ● Confirm before meds, procedures, treatments ● Ask open-ended questions ● Verify ID band & EMR ● Use barcode scanning ● ❌ Never use room number 2. Improve Staff Communication ● Report critical results immediately ● Critical results = life-threatening abnormal labs/diagnostics ● Facility policies define: ○ critical result criteria ○ reporting timeframe ○ documentation requirements ● Communicate directly (in person/phone), not voicemail (HIPAA) 3. Use Medications Safely Label medications ● Label all syringes/containers with name, dose, date/time ● Discard unlabeled meds Anticoagulant safety ● Examples: warfarin, heparin, enoxaparin ● Monitor labs, weight, interactions, dosing ● Educate on risks, food interactions, follow-up labs Medication reconciliation ● Compare home meds with new prescriptions ● Done on admission, transfer, discharge ● Resolve discrepancies 4. Use Alarms Safely ● Clinical alarms warn of patient events or equipment malfunction ● Examples: IV pumps, ventilators, monitors, bed/chair alarms ● Risk: alarm fatigue ● Nurse role: ○ know alarm priorities ○ respond promptly ○ help develop alarm policies 5. Prevent Hospital-Acquired Infections (HAIs) Common HAIs: ● CLABSI ● CAUTI ● SSI ● VAP Concern: MDROs (MRSA, VRE, C. diff) ⭐ Hand hygiene = most important prevention Compliance required with monitoring and action plans. 6. Identify Safety Risks: Suicide Prevention ● Screen behavioral health clients ≥12 yrs ● Positive screen → detailed suicide assessment ● Implement: ○ constant observation ○ removal of harmful items ○ environmental safety checks ○ staff competency training 7. Universal Protocol (Surgery Safety) Prevent wrong-site/procedure/client: 1. Two identifiers 2. Mark surgical site (if applicable) 3. Time-out before procedure 4. Verify consent & procedure with client 8. Improve Health Care Equity (2024 Goal) Assess social determinants: ● literacy ● housing ● transportation ● food access Continue assessment throughout hospitalization and discharge planning. II. Standards of Compliance Former NPSGs now routine standards: ● Medical error prevention ● Staff competency verification ● Client rights & education ● Infection control ● Medication management ● Emergency preparedness III. Culture of Safety Promotes: ● open communication ● reporting of errors & near misses ● nonpunitive environment ● improved outcomes & staff satisfaction Nurses play key role due to frequent client contact. IV. Transforming Care at the Bedside Initiative 1. Spend 70% of time in direct bedside care 2. Leadership development 3. Rapid Response Team (RRT) 4. Standardized communication (ISBARR) Benefits: ● fewer falls, HAIs, med errors ● improved outcomes and satisfaction V. Rapid Response Team (RRT) Interdisciplinary team (ICU nurse, RT, provider) for sudden deterioration. Call RRT for: ● sudden vital sign changes ● low O₂ despite intervention ● chest pain after nitro ● seizure ● sudden mental status change ● serious clinical concern VI. ISBARR Communication Tool 1. Identity 2. Situation 3. Background 4. Assessment 5. Recommendation 6. Read-back VII. Types of Unexpected Events ● Near miss: error caught before harm ● Client safety event: event with potential harm ● Adverse event: unexpected harm occurred ● Sentinel event: severe harm/death (never event) Examples sentinel: ● wrong-site surgery ● suicide in facility ● serious fall injury VIII. Occurrence (Incident) Reporting Purpose: improve systems, prevent future errors (not punishment) Report: ● falls/injuries ● wrong meds ● adverse reactions ● blood/body fluid exposure ● property damage ● unsafe behaviors/events IX. Safety Assessment & Agencies Regulated by: ● TJC ● CMS ● OSHA ● State boards & local agencies Nursing safety focus: ● falls ● meds & allergies ● restraints ● pressure injury prevention ● infection control ● sharps & pathogen exposure ● body mechanics ● fire, chemical, radiation safety X. Electrical Safety Check: ● frayed cords ● grounded 3-prong plugs ● GFCI outlets ● no wet handling ● avoid extension cords ● tag/remove faulty equipment XI. Chemical Safety Exposure routes: ● inhalation ● skin/eyes ● ingestion ● injection (needlestick) Use: ● SDS sheets ● PPE (gloves, masks, gowns, goggles) ● ventilation systems ● emergency eye wash/showers XII. Radiation Safety Risk proportional to: ● exposure time ● distance from source Principles: 1. Reduce time 2. Increase distance 3. Shield (lead aprons, barriers) Types: ● Alpha (least risk, short travel) ● Beta (moderate risk, small distance) ● Gamma (highest risk, penetrates tissue) Initial symptoms: ● nausea, vomiting, diarrhea ● burns, alopecia ● immunocompromise ● psychological effects XIII. Age-Related Safety Risks Infants/Preschoolers ● burns, poisonings, choking, drowning ● car seat safety ● smoke detectors & safe storage of toxins School-Age ● sports injuries, firearm safety, internet risks Adolescents ● substance use, risky driving, violence, suicide risk Adults/Older Adults ● chronic illness, frailty, mobility decline ● ⭐ Major risk: falls ● frailty → poorer outcomes XIV. Hospital-Acquired Injuries Include: ● SSIs, CAUTIs, CLABSIs ● falls, trauma ● pressure injuries ● DVT ● insulin errors ● transfusion reactions ● burns/electrical shock High-risk clients: ● neurologic disorders (stroke, MS, Parkinson’s) ● cognitive impairment, dementia ● communication disabilities ● visual deficits ● behavioral disorders XV. Screening Tools Used to identify early risk: ● Morse Fall Scale (fall risk) ● Braden Scale (pressure injury risk) ● Tools must be valid/reliable Positive results → detailed assessment + individualized care plan. XVI. Home Hazard Safety Bathroom: ● grab bars, non-slip mats, raised toilet, step-free showers Bedroom: ● low bed, alarms, hospital bed if needed Kitchen: ● reachable items, automatic stove shut-off, secure chemicals General: ● good lighting, remove loose rugs, secure cords, install handrails ● cordless blinds for child safety ● emergency numbers accessible XVII. Fire Safety RACE ● Rescue ● Alarm ● Contain (close doors/windows) ● Extinguish PASS ● Pull pin ● Aim at base ● Squeeze ● Sweep Fire extinguisher types: ● A: paper/wood ● B: liquids/oils ● C: electrical ● D: metals ● K: kitchen grease ● ABC: multipurpose Evacuation: ● Lateral = same floor (preferred) ● Vertical = different floor XVIII. Workplace Safety Bullying ● Repeated harassment/belittlement ● Leads to burnout, errors, poor retention Workplace Violence Includes verbal abuse to homicide Risk factors: ● violent clients ● staff shortages ● long wait times ● lack of training/security Active Shooter Response 1. Run 2. Hide 3. Fight (last resort) XIX. Emergency Preparedness Facilities must have: ● disaster plans ● staff training & drills ● defined staff roles Types of mass exposure: ● Radiation ● Biological (anthrax, Ebola, COVID) ● Chemical toxins Response: ● PPE ● decontamination (remove clothing, shower) ● monitor vitals & mental status XX. Injury Prevention Strategies ● hourly rounding ● video monitoring ● bedside sitters ● individualized safety plans ● prompt call-light response XXI. Fall Prevention Risk factors: ● weakness, gait issues, vision problems ● confusion, dementia, impulsiveness ● clutter, poor lighting ● high-risk meds (antihypertensives, antidepressants) ● incontinence, age Universal precautions: ● nonskid footwear ● low bed & locked wheels ● clutter-free room ● call light within reach ● hourly rounding & quick response Movement alarms = warning device Siderails: ● 2 rails for safety ● 4 rails = restraint (intent matters) XXII. Restraints & Seclusion Types: ● Physical: manual holding ● Mechanical: mitts, wrist, vest, 4-point ● Chemical: sedatives/antipsychotics ● Barrier: enclosures, lapboards, 4 rails ● Seclusion: locked room Use ONLY as last resort when: ● danger to self/others ● removing life-saving devices ● severe aggression Care of restrained client: ● frequent circulation, skin, respiratory checks ● ROM, hygiene, fluids, elimination ● reevaluate every 24 hrs ● discontinue ASAP XXIII. Seizure Precautions Preseizure ● suction & oxygen ready ● padded rails ● IV access ● remove restrictive clothing/jewelry During seizure ● call for help ● side-lying position ● protect head ● do NOT restrain ● monitor duration & movements ● give benzodiazepine if ordered Postseizure ● assess gag reflex before oral intake ● reassure client ● labs, EEG, imaging as ordered XXIV. Musculoskeletal Injury Prevention (Nurse Safety) Use assistive devices: ● Hoyer lift (ground lift) ● ceiling lift ● slide sheets ● sit-to-stand lift Safe handling: ● clear area ● use correct sling size ● have 2 staff assist ● lock brakes ● never leave client unattended XXV. Patient-Centered Care Focus: ● client as center of care ● collaboration & shared decision-making ● respect cultural, spiritual, religious needs ● holistic & individualized care ● include pastoral care support FINAL MEMORY CHECK (High-Yield Core Concepts) ● Two identifiers before any care ● Hand hygiene prevents HAIs ● Time-out before surgery ● ISBARR improves communication ● RRT for sudden deterioration ● Fall prevention + restraints last resort ● RACE & PASS fire response ● Run–Hide–Fight for active shooter ● Time–distance–shielding for radiation safety ● Screening tools identify early risks Here is a fully condensed study guide that includes ALL major topics and concepts from your lesson (patient-centered care, caring theories, cultural care, spirituality, advocacy, sleep & rest) without leaving anything out. CONDENSED STUDY GUIDE: PATIENT-CENTERED CARE, CARING, CULTURE, ADVOCACY & SLEEP I. Patient-Centered Care Definition Patient-centered care = placing the client at the center of all care, focusing on preferences, culture, and holistic needs rather than just tasks or documentation. Key Concepts ● Improves client satisfaction and outcomes ● Involves caring, preferences, cultural respect, and shared decision-making ● Holistic care: physical, emotional, spiritual needs II. Caring in Nursing Definition Caring = nurturing another person with responsibility and commitment; core of professionalism. Holistic Caring Includes ● Healing environment ● Kindness, empathy, compassion ● Addressing physical, emotional, and spiritual needs III. Caring Theories A. Watson’s Theory of Human Caring Holistic model focusing on mind-body-spirit harmony through transpersonal (human-to-human) caring relationships. Core Ideas ● Caring moments foster healing and self-restoration ● Nurse must achieve inner balance and spirituality ● Establish trusting presence and relationships 10 Caritas Processes 1. Loving-kindness and compassion 2. Authentic presence and honoring beliefs 3. Sensitivity to self and others 4. Trusting caring relationships 5. Expression of feelings 6. Creative problem-solving through caring 7. Transpersonal teaching/learning 8. Healing environment (comfort, dignity, peace) 9. Reverent assistance with basic needs 10. Openness to spirituality and miracles B. Swanson’s Theory of Caring Caring improves well-being through empowerment, dignity, and respect. Five Caring Processes 1. Maintaining belief – instill hope and meaning 2. Knowing – understand client’s situation/perception 3. Being with – emotional and physical presence 4. Doing for – perform needed tasks for client 5. Enabling – guide and support through events/transitions IV. Caring Behaviors 1. Listening ● Active, empathetic listening ● Observe verbal and nonverbal cues ● Key for holistic assessment and trust 2. Touch ● Used for procedures and expressive caring ● Requires permission; consider culture, trauma, gender ● Can reduce anxiety and increase well-being 3. Being Present ● Physical and emotional availability ● Reduces loneliness and improves comfort ● Reflects “being with” (Swanson) 4. Providing Comfort ● Pharmacologic and nonpharmacologic comfort measures ● Examples: pillows, blankets, hygiene, music, temperature control ● Represents “doing for” 5. Showing Compassion ● Recognize suffering and act to relieve it ● View client as person, not diagnosis ● Requires self-awareness and adequate staffing V. Client Preferences in Care Clients are full members of the health care team and experts on their own experiences. Benefits ● Increased trust and satisfaction ● Improved healing and outcomes ● Greater sense of control Ways to Include Preferences 1. Endorsing participation – empower involvement 2. Promoting understanding – correct misinformation 3. Sharing information – two-way communication Barriers ● Power imbalance ● Medical jargon ● Weakness, fatigue, cognitive impairment ● Poor collaboration and language barriers VI. Cultural Competence Definition Evidence-based care aligned with client’s cultural values, beliefs, and practices. Influencing Factors ● Socioeconomic status ● Health literacy ● Racism experiences ● Sexual orientation ● Acculturation (adapting to another culture) Five Elements of Cultural Competence 1. Cultural awareness – self-examine biases 2. Cultural knowledge – learn client values/beliefs 3. Cultural skill – assess cultural needs accurately 4. Cultural encounters – interact with diverse cultures 5. Cultural desire – motivation to connect with cultures Cultural Assessment Includes ● Cultural/spiritual affiliation ● Health beliefs and practices ● Spiritual rituals ● Dietary preferences/prohibitions ● Care preferences to increase comfort VII. Age-Related (Generational) Care Preferences Generation Preferences Silent (1928–1945) Formal, face-to-face, written communication Baby Boomers Team-oriented, sincere, in-person communication Gen X Direct, independent, questions providers Millennials Tech-based communication, frequent feedback Gen Z Digital natives, prefer texting/email Gen Alpha Tech-savvy children; family-centered care VIII. Spiritual Nursing Care Spiritual Well-Being Feeling of meaning, purpose, and connection to higher power → improves quality of life. Spiritual Assessment Questions ● Source of spiritual strength? ● Meaning-of-life concerns? ● Relationship with higher power? ● Spiritual practices? ● Fear of dying? ● Relationship concerns? Assessment Tools FICA: ● Faith ● Importance ● Community ● Address in care HOPE: ● Hope sources ● Organized religion ● Personal spirituality/practices ● Effects on care/end-of-life issues IX. Spiritual Distress Definition Questioning life meaning or beliefs causing despair, anger, fear, uncertainty. Nursing Interventions ● Listen and be present ● Encourage spiritual expression ● Provide prayer, texts, pastoral referral ● Address emotional and spiritual needs X. Pastoral Care Provides: ● Ethical, religious, and spiritual support ● Counseling, prayer, rituals ● End-of-life and grief support ● Support for families and staff Chaplains assist all clients regardless of religion. XI. Access to Care Barriers ● Lack of insurance ● Transportation problems ● Limited providers/facilities (rural areas) ● Restricted clinic hours ● Medication cost barriers Solutions ● Telemedicine: remote diagnosis/testing ● Telehealth: broader remote clinical and nonclinical services ● Improves access, especially rural areas XII. Client Advocacy Definition Protect client autonomy, rights, and safety; act as client’s voice. Clients Needing Advocacy ● Unconscious ● Children ● Fearful/intimidated clients ● Uninformed about diagnosis/rights Advocacy Steps 1. Assess needs, values, cognition, resources 2. Verify client goals/preferences 3. Implement plan and communicate with team 4. Evaluate outcomes and self-determination Related Concepts ● Medically futile: treatment unlikely to cure or extend life ● Potentially inappropriate treatment: works but may not improve quality of life ● Palliative care: symptom relief + quality of life ● Quality of life: personal meaning, independence, relationships XIII. Sleep and Rest Importance of Sleep Supports: ● Memory, learning, concentration ● Immune system and tissue repair ● Hormone balance (ghrelin, leptin, cortisol) ● Mood, reaction time, coordination ● Prevention of obesity, diabetes, cardiovascular disease XIV. Physiology of Sleep Key Brain Structures ● Cerebral cortex: sensory processing & memory ● Brainstem: controls REM and muscle relaxation ● Hypothalamus: autonomic control, circadian rhythm (SCN) ● Thalamus: sensory filtering during sleep ● Pineal gland: produces melatonin XV. Sleep Regulation Mechanisms 1. Circadian rhythm – 24-hour internal sleep–wake cycle influenced by light and temperature 2. Sleep–wake homeostasis – pressure to sleep increases with sleep deprivation Factors affecting sleep: ● Light exposure ● Stress ● Medications ● Caffeine/food ● Environment XVI. Stages of Sleep NREM Sleep Stage 1: Light sleep; easily awakened (5%) Stage 2: Deeper sleep; decreased HR/temp; memory consolidation (50%) Stage 3: Deep sleep; delta waves; immune strengthening and tissue repair (15%) REM Sleep ● Dream stage ● Irregular breathing and increased HR ● Muscle atonia (prevents acting out dreams) ● Occurs ~90 minutes after sleep onset Sleep cycles repeat 4–6 times per night. XVII. Sleep Patterns by Age ● Newborns: multiple cycles, high REM ● Adults: 2–5% stage 1, 45–55% stage 2, 10–20% stage 3, 20–25% REM ● Older adults: less deep sleep, more awakenings XVIII. Sleep Deprivation Types ● Total: no sleep for extended period ● Partial: reduced sleep hours ● Chronic: ongoing insufficient sleep ● Selective: loss of specific sleep stage Effects ● Impaired judgment and memory ● Mood swings, depression ● Increased accidents and chronic illness risk ● Poor glucose control and obesity XIX. Promoting Sleep Nonpharmacologic Interventions ● Avoid caffeine, nicotine, alcohol before bed ● Keep room dark, quiet, cool ● Establish bedtime routine ● Consistent sleep schedule ● Exercise regularly (not right before bed) ● Limit naps (<30 minutes) ● Remove electronics/TV from bedroom XX. Sensory Overload in Hospital Definition: Excess stimuli beyond brain’s processing ability → sleep disruption. Nursing Interventions ● Lower noise and alarms ● Dim lights ● Provide earplugs/eye masks ● Cluster care tasks ● Control pain and medication effects XXI. Sleep Disorders Insomnia Difficulty falling/staying asleep → fatigue, poor concentration, mood changes Sleep Apnea ● Central: brain fails to signal breathing ● Obstructive: airway collapse; snoring; daytime sleepiness Treatment: CPAP, weight loss, avoid alcohol/smoking Narcolepsy Sudden sleep attacks; possible cataplexy (loss of muscle tone) Hypersomnia Excessive daytime sleepiness despite adequate sleep Restless Legs Syndrome (RLS) Urge to move legs; worsens at night; disrupts sleep Night Terrors Non-REM parasomnia causing panic and no recall; common in children XXII. Pharmacologic Sleep Therapies ● Benzodiazepines (GABA agonists): sedative but dependency risk ● Nonbenzodiazepine hypnotics (most common) ● Melatonin: low-risk first-line option ● Antihistamines: OTC but cause side effects XXIII. Nonpharmacologic Sleep Therapies ● Massage, acupuncture, thermotherapy ● Guided imagery, meditation, music therapy ● Yoga and relaxation techniques ● Sleep diaries to identify patterns and personalize care FINAL KEY POINT Patient-centered nursing integrates: ● Caring theories ● Cultural competence ● Spiritual support ● Client advocacy ● Sleep and comfort promotion Goal: provide holistic care that supports physical healing, emotional well-being, spiritual meaning, autonomy, and optimal quality of life. Week 7 Absolutely—here’s a more condensed study guide that still includes every concept you were given. CONDENSED STUDY GUIDE: ELIMINATION (ALL CONCEPTS) 1) Big Picture ● Elimination (urine + stool) is continuous and essential. Patterns vary, but changes require assessment + intervention to restore usual patterns or establish a new baseline. 2) Urinary System Basics Functions: excrete waste/fluid → urine, regulate electrolytes, support RBC production, help regulate BP, support bone health. Pathway: kidneys → ureters → bladder → urethra → urination. Control: internal sphincter + external sphincter + pelvic floor muscles prevent leakage. Urination: elimination of urine via urethra. 3) Urine Production & Assessment Normal: clear, light yellow, minimal odor. Typical daily amount: ~1–2 quarts/day (varies). Expected output by age: infant ~2 mL/kg/hr; toddler ~1.5; teen ~1; adult ~0.5. Color clues: ● Dark yellow/amber = need fluids ● Dark brown = dehydration/kidney/liver concern ● Red/pink = blood or foods (beets, blackberries, rhubarb) Diet/med effects: ● Fluids ↑ volume, lighter color ● Asparagus ↑ odor ● Dyes can turn blue/green ● Alcohol + caffeine ↑ urine output (can dehydrate if not balanced) Aging urinary changes: ↓ nephrons/kidney function, ↓ bladder tone → incontinence/retention risks. 4) GI System Basics Organs: mouth → esophagus → stomach → small intestine → large intestine → rectum → anus. Peristalsis: contractions that move contents through GI tract. Feces formation: digestion + absorption (small intestine), water absorption + stool formation (large intestine), bacteria help + make vitamin K, rectum stores stool until BM. Bristol Stool Chart: ● Types 1–2 = constipation ● Types 3–4 = expected ● Types 5–7 = diarrhea Aging GI changes: ↓ peristalsis/muscle tone → constipation; ↑ PUD risk (NSAIDs), ↓ elasticity/emptying changes, possible ↓ absorption/bacterial overgrowth, ↓ lactase → lactose intolerance; lifestyle factors (inactivity, low fiber/fluids, meds) contribute. 5) Expected Elimination ● Urine: clear, light yellow, varies with intake/activity/diuretics. ● Stool: frequency varies widely; should be soft/formed, easy to pass without straining. 6) Altered Urinary Elimination Urinary Incontinence (UI) Involuntary urine loss. Can cause skin breakdown + distress. Types: ● Stress: cough/sneeze/exertion ● Urge: sudden urge, leak before toilet ● Reflex: nerve damage, no warning ● Overflow: incomplete emptying → overfill/leak ● Functional: can’t reach toilet (mobility/dexterity issues) ● Nocturnal enuresis: nighttime (kids; adults w alcohol/caffeine/meds) Management: lifestyle changes (↓ caffeine/alcohol, smoking cessation, address constipation), pelvic floor exercises, bladder training, meds/devices/surgery; skin protection (pads/briefs, cleanser, barrier cream). Urinary Retention Incomplete bladder emptying (acute or chronic). Causes: BPH, cystocele/prolapse, obstruction (stones/lesions). Findings: hesitancy, weak stream, frequency, distention, pain, leakage. Risks: UTI, bladder/kidney damage. 7) Altered Bowel Elimination Constipation <3 BMs/week + hard/lumpy stools, difficult to pass. Risks: pregnancy/postpartum, older adults, low fiber/fluids, meds, GI disorders, immobility. Red flags: fever, GI bleeding, severe pain, vomiting, weight loss. Complication: fecal impaction/obstruction (liquid stool may leak around impaction). Tx: fiber + fluids + exercise + bowel training; meds; enema/manual removal; surgery if complete obstruction. Diarrhea Frequent loose/watery stools: acute (1–2d), persistent (>2w <4w), chronic (>4w). Risks: infection, meds, GI disorders, diet. Dangers: dehydration, malabsorption. Adult urgent follow-up: fever ≥102°F, >2 days, ≥6/day, severe pain, blood/black stool. Tx: rehydration; OTC (loperamide/bismuth) if appropriate; antibiotics/probiotics if infectious cause. Bowel Incontinence Urge (can’t reach toilet) most common; passive (unaware leakage). Leads to skin issues + reduced self-esteem. Children: encopresis. 8) Medications That Affect Elimination Constipation: antacids (Al/Ca), anticholinergics/antispasmodics, antiseizure meds, Ca-channel blockers, diuretics, iron, antiparkinsonian, opiates, antidepressants. Diarrhea: antibiotics, magnesium antacids; consider C. diff if severe/persistent after antibiotics. 9) Conditions Altering Urinary Patterns ● Dehydration: thirst, dry mouth, fatigue, dizziness, dark urine; severe needs IV fluids. ● UTI: dysuria, urgency/frequency; can progress to pyelonephritis (fever, flank pain, N/V, hematuria). Tx antibiotics + fluids. Higher risk: females, retention, obstruction, catheters, diabetes, menopause. ● Kidney stones: severe flank pain radiating to groin, hematuria, dysuria, fever/chills, N/V. Tx fluids, pain meds, strain urine, ESWL/surgery. ● Kidney failure: waste/fluid buildup → ↓ urine, HTN, anemia, itching; Tx dialysis or transplant. ● BPH: urethral constriction → retention, nocturia, weak stream; can cause UTIs/damage; Tx meds/surgery. 10) Conditions Altering Bowel Patterns ● Diverticulosis: pouches; Diverticulitis: inflamed/infected pouch → pain/bleeding; risk perforation → peritonitis. Prevent: fiber; nuts/seeds no longer restricted. Tx antibiotics + liquid/soft diet. ● IBS: pain + diarrhea/constipation (IBS-C, IBS-D, IBS-M); Tx diet (fiber/probiotics, avoid triggers), stress reduction, sleep/exercise, meds. ● Bowel obstruction: blockage → N/V, distention, severe constipation; NG decompression + surgical consult. ● Ileus: decreased/absent motility (often post-op/illness/meds) → absent bowel sounds, distention, N/V; Tx NPO, NG tube, IV fluids; consider TPN if prolonged. ● Ulcerative colitis: colon inflammation/ulcers → bloody diarrhea, fatigue, anemia; Tx meds; surgery if refractory/cancer risk. ● Crohn’s: inflammation anywhere (often small intestine) → diarrhea, weight loss, anemia; complications fistulas/abscess/obstruction; Tx meds + possible surgery. 11) Diversions & Ostomies Urinary Diversions ● Catheterization (temporary) ● Ureteral stent ● Ileal conduit/urostomy (stoma + pouch) ● Nephrostomy (kidney → external bag) ● Neobladder (internal reservoir, may need catheter) ● Continent cutaneous reservoir (internal pouch + valve; catheter to empty) ● Cystostomy (catheter directly into bladder) Complications: UTIs, kidney infection, skin breakdown; psychosocial concerns. Fecal Diversions ● Ileostomy ● Colostomy (+ irrigation option for some permanent colostomies) ● J-pouch (internal ileal reservoir connected to anus; often temporary ileostomy first) ● Kock pouch (continent ileostomy; catheter to empty) Complications: skin irritation, hernia/prolapse/stenosis, blockage, diarrhea, bleeding, electrolyte imbalance, infection, leakage. WOC nurse supports education + supplies + skin/stoma care. 12) Diagnostics & Specimen Collection Urinary ● Urodynamics: uroflowmetry, postvoid residual, cystometric test, leak point pressure, EMG, video urodynamics, pressure-flow study ● Scopes: cystoscopy, ureteroscopy ● Urinalysis: visual + dipstick + microscopic (WBC, RBC, bacteria, casts, crystals) ● Urine culture: clean catch midstream; grows organism + susceptibility testing (correct antibiotic; reduces resistance) ● 24-hour urine: collect all urine, refrigerate, avoid certain foods/meds Urine collection methods: clean catch vs catheter (sterile technique for intermittent/indwelling). GI ● Tests: celiac testing, colonoscopy, ERCP, sigmoidoscopy, upper/lower GI series, upper endoscopy ● FOBT: dietary/med restrictions to prevent false positives (ex: beets, red meat, some veggies; aspirin/ibuprofen/Vit C) ● Stool culture: for severe/persistent diarrhea (travel, contaminated food/water, antibiotics) 13) Nursing Interventions Promote Urinary Elimination ● Bedpan/urinal assistance + measure output + privacy + skin check ● Bladder irrigation (ordered; pain is NOT expected → report) ● Lifestyle: avoid bladder irritants; appropriate fluids; weight loss; stop smoking ● Bladder training + elimination journal ● Bladder scan to avoid unnecessary catheterization ● Catheters: intermittent, indwelling, external male condom, external female wick ● CAUTI prevention: sterile insertion for indwelling/intermittent; daily hygiene; handwashing; keep system clean Promote Bowel Elimination ● Fiber, hydration, activity, respond to urge, stress management ● Bowel training (may use laxatives) ● Enemas: cleansing vs retention; solutions hypotonic/isotonic/hypertonic (tap water can cause electrolyte shifts) ● Laxatives: ○ Bulk-forming ○ Surfactant (stool softener) ○ Stimulant ○ Osmotic ● Rectal tubes/fecal management systems for severe incontinence Skin Care for Incontinence ● Clean promptly, rinse, pat dry ● Moisturize (alcohol-free) ● Barrier ointments/pastes/sealants ● Assess for nonblanchable redness, blisters, wounds/ulcers NG Decompression (for obstruction/ileus) Measure nose → ear tragus → xiphoid, advance with swallowing, confirm placement (x-ray/capnography/pH per policy), secure + suction as ordered. If you want, I can also turn this into a 1-page “exam cram” sheet (still including every concept, just in ultra-compact bullets). Condensed Study Guide: Main Concepts (Elimination + Sensory Perception) 1) ELIMINATION (URINARY + BOWEL) Urinary system basics ● Organs: kidneys → ureters → bladder → urethra ● Kidneys: filter blood, remove waste/fluid, regulate electrolytes & BP hormones, support RBC production. ● Normal urine: clear, light yellow, minimal odor. ○ Dark yellow/amber: dehydration. ○ Red/pink: blood or foods (beets). ○ Brown: severe dehydration/liver/kidney issues or certain foods. Expected urine output (high-yield) ● Adults: ~0.5 mL/kg/hr ● Output generally decreases with age (↓ nephrons, ↓ renal blood flow). Urinary alterations Urinary incontinence = can’t control urination Types: ● Stress: cough/sneeze/exertion → leak ● Urge: sudden strong urge → can’t reach toilet ● Overflow: bladder overfills from incomplete emptying → dribbling/leak ● Reflex: nerve damage → unpredictable leakage ● Functional: can’t get to toilet in time (mobility/dexterity issues) ● Nocturnal enuresis: nighttime bedwetting Key nursing focus: skin protection (barrier creams, briefs/pads), reduce irritants, bladder training, pelvic floor exercises. Urinary retention = can’t empty bladder fully ● Causes: BPH, prolapse (cystocele), obstruction (stones), neuro issues. ● Findings: hesitancy, weak stream, frequency, distention, pain, leakage. ● Risks: UTI, bladder/kidney damage. ● Interventions: identify cause, drain bladder if needed, bladder scan, catheterization if ordered. Common urinary conditions ● Dehydration: thirst, dry mouth, dizziness, dark urine, low urine; severe → IV fluids. ● UTI: dysuria, urgency/frequency; untreated → pyelonephritis (fever, flank pain, N/V). Treat: antibiotics + fluids. ● Kidney stones: severe flank pain radiating to groin, hematuria, N/V; treat pain + fluids, strain urine, possible lithotripsy/surgery. ● Kidney failure: ↓ urine, HTN, anemia, itching; treat dialysis/transplant. ● BPH: frequency/nocturia, weak stream, retention/incontinence; treat meds/surgery. Bowel system basics ● GI tract: mouth → esophagus → stomach → small intestine → large intestine → rectum → anus ● Peristalsis moves contents forward. ● Stool: should be soft/formed, easy to pass (no straining). Bristol Stool Chart (quick) ● 1–2: constipation (hard/lumpy) ● 3–4: ideal/normal ● 5–7: diarrhea (loose/watery) Bowel alterations ● Constipation: <3 BMs/week + hard stool/straining ○ Risks: impaction/obstruction (esp immobile/neuro injury). ○ Tx: fiber, fluids, activity, bowel training, stool softeners/laxatives; impaction → enema/manual removal. ● Diarrhea: frequent loose watery stools ○ Danger: dehydration, electrolyte imbalance; red flags: blood/black stool, fever, severe pain, lasts >2 days. ○ Tx: rehydration, remove irritants; meds like loperamide (if appropriate); infection → meds/probiotics as ordered. ● Bowel incontinence: urge (can’t reach toilet) vs passive (leak without awareness). ○ Nursing: skin care, scheduled toileting, bowel training, protect dignity. Diversions (know names + purpose) Urinary diversions ● Catheterization: intermittent or indwelling ● Ureteral stent: keeps ureter open ● Urostomy/ileal conduit: urine exits through stoma into pouch ● Nephrostomy: kidney → external drainage ● Cystostomy (suprapubic): catheter directly into bladder ● Neobladder/continent reservoir: internal storage; may need catheter to empty Complications: infection, skin breakdown, psychosocial stress. Fecal diversions ● Ileostomy: ileum → stoma (often liquid stool) ● Colostomy: colon → stoma (more formed depending on location) ● J-pouch: internal ileal reservoir connected to anus ● Kock pouch: continent ileostomy; catheter to empty Complications: skin irritation, leaks, hernia/prolapse, blockage, diarrhea, electrolyte issues. Diagnostic tests/specimens (high-yield) Urinary ● Urinalysis: dipstick + microscopic ● Urine culture: clean catch; susceptibility testing picks the right antibiotic ● 24-hr urine: measures substances over time ● Urodynamics: bladder function (uroflowmetry, PVR, cystometrics, etc.) ● Cystoscopy/ureteroscopy: visualize urinary tract GI ● FOBT: check hidden blood (avoid foods/meds that cause false positives) ● Stool culture: severe/persistent diarrhea, travel, prolonged antibiotics ● Colonoscopy, sigmoidoscopy, upper GI endoscopy, ERCP, GI series as indicated Nursing priorities (elimination) ● Assess: amount, frequency, color/odor, pain, stool type. ● Prevent skin breakdown: cleanse, dry, barrier creams, frequent checks. ● Promote normal patterns: hydration, fiber, activity, timed toileting, privacy, proper equipment (bedpan/urinal). ● Reduce infection risk: sterile technique for invasive catheters; minimize indwelling catheter days (CAUTI prevention). 2) SENSORY PERCEPTION (ALL MAIN CONCEPTS) Big picture ● Stimulus → sensory organ → CNS/cranial nerves → brain interprets → response ● Problems can be in reception, perception, or response. Key terms ● Sensory deficit: reduced function (vision/hearing/touch/etc.) ● Sensory deprivation: too little stimulation ● Sensory overload: too much stimulation → anxiety/confusion ● SPD: detects stimuli but brain misprocesses → oversensitive/overwhelmed Cranial nerves (only what’s essential) ● I smell, II vision, III/IV/VI eye movement ● V facial sensation/jaw ● VII facial expression + taste (front tongue) ● VIII hearing/balance ● IX/X swallowing/gag/voice ● XI shoulder shrug/head turn ● XII tongue movement Vision: most tested disorders ● Refractive errors: myopia, hyperopia, astigmatism, presbyopia ● Cataracts: cloudy lens → blurry/hazy, ↓ color ● Diabetic retinopathy: retinal vessel damage → floaters/blur → blindness risk ● Glaucoma: ↑ intraocular pressure → loss of peripheral vision (irreversible) ● Macular degeneration: loss of central vision (older adults) Tests: Snellen/Tumbling E; slit lamp; fluorescein angiography; visual field test; intraocular pressure; Amsler grid. Hearing ● Anatomy: outer → middle (ossicles) → inner (cochlea) → CN VIII. ● Tinnitus: ringing/buzzing without sound. ● Types of loss: ○ Sensorineural: inner ear/nerve (aging = presbycusis, loud noise, ototoxic meds) ○ Conductive: sound can’t travel (wax, otitis media, perforation, otosclerosis) ○ Mixed: both Tests: Rinne, pure-tone audiometry; ABR/OAE (screening). Speech/Aphasia (stroke-related high yield) ● Broca/expressive: understands but can’t produce words well (“telegraphic” speech) ● Wernicke/fluent: lots of words, no meaning; poor comprehension ● Global: severe impairment of both Touch ● Hypersensitivity / defensiveness (painful to normal touch) vs hyposensitivity (reduced pain/temp). ● Major causes: peripheral neuropathy (diabetic), spinal cord injury. ● Testing: neuro exam, sensation checks, nerve conduction, EMG, MRI. Smell & taste (often linked) ● Taste disorders: hypogeusia (↓ taste), ageusia (no taste), dysgeusia (metallic/rancid), phantom taste ● Smell disorders: anosmia (no smell), hyposmia (reduced), parosmia (distorted), phantosmia (smell not real) ● Causes: URIs, sinus disease, head injury, smoking, meds, zinc deficiency, neuro disorders. Aging effects (must know) ● Vision & hearing decline most. ● Vision: smaller pupils, less lens flexibility, weaker extraocular muscles, ↓ tears/dry eyes. ● Hearing: high-frequency loss, cerumen impaction, tinnitus. ● Taste/smell: ↓ taste buds + ↓ saliva → ↓ appetite → malnutrition risk. ● Touch: ↓ circulation → ↓ temperature/pain sensitivity. Nursing priorities (sensory) ● Safety + independence + emotional support ● Vision: lighting, corrective lenses, remove clutter, orient to room, fall prevention. ● Hearing: face client, reduce background noise, check hearing aids, use written info/interpreter. ● Speech: allow time, don’t finish sentences, use boards/paper/tablet. ● Touch: injury prevention (diabetic foot care, protective footwear, daily inspection). ● Smell/taste: oral hygiene, season foods, smoke/CO detectors, avoid smoking. If you want, I can turn this into a one-page “test-ready” version (even shorter, like only definitions + red flags + key interventions). Condensed Study Guide: Complementary & Integrative Health (CIH) / CAM / Holistic Nursing 1) Key Terms (know the differences) ● Conventional (Western) medicine: Evidence-based diagnosis & treatment (meds, surgery, radiation). Also called mainstream, allopathic, biomedicine, orthodox. ● Complementary therapy: Used with conventional care (ex: aloe + NSAID for sunburn). ● Alternative therapy: Used instead of conventional care. ● Integrative health: Combines conventional + complementary + alternative in a coordinated plan (mind–body–spirit). ● Holistic nursing: Client-centered care treating the whole person (physical, emotional, spiritual, social, cultural, environment). Focus is healing + wellness, not just curing disease. 2) NCCIH Categories (how CIH is “delivered”) Nutritional approaches ● Herbs/botanicals, supplements, vitamins/minerals, probiotics, dietary therapies ● Usually OTC and labeled as dietary supplements Psychological (mind–body) approaches ● Relaxation, meditation, mindfulness/MBSR, guided imagery, biofeedback, hypnosis, prayer Physical approaches ● Hands-on body structures/systems: massage, chiropractic, osteopathy, spinal manipulation, heat/cold, reflexology Bioenergetic (energy) therapies ● Veritable energy = measurable EM fields/light/magnets ● Putative energy (biofields) = subtle energy concepts ● Examples: Healing Touch, Therapeutic Touch, Reiki, Tai Chi, qi gong, acupressure Whole medical systems ● Complete systems separate from Western medicine: ○ Ayurveda, Traditional Chinese Medicine (TCM), Unani, Kampo ○ Also: Homeopathy, Naturopathy, Functional medicine (root-cause focus) Combined approaches ● Blends multiple categories: yoga, mindfulness eating, dance/art/music therapy 3) Why it matters (nursing relevance) ● Many clients use CIH (often alongside prescriptions). Nurses must: ○ Assess what clients use ○ Prevent interactions/harms ○ Provide culturally congruent care ○ Support self-care + empowerment ● Holistic nursing priorities ○ Promote wellness, honor caring–healing relationship ○ Respect subjective experience of illness/healing ○ Encourage informed decisions + active participation ○ Incorporate cultural beliefs/folk practices safely 4) High-yield Mind–Body Therapies (what they do) ● Deep breathing: control rate/depth → ↓ anxiety/stress ● Meditation: quiet mind/focused attention → ↓ BP/HR, ↓ stress effects ● Mindfulness: present-moment awareness; can reduce stress and improve coping ● Guided imagery: mental visualization → relaxation, pain/anxiety reduction ● Prayer: spiritual coping/connection (client-defined) ● Progressive relaxation: systematically tense/relax muscle groups ● Yoga (meditative movement): poses + breathing ± meditation → stress, sleep, anxiety; also pain (back/neck) support ● Aromatherapy: essential oils (inhaled/topical) → relaxation, anxiety relief; some evidence for nausea (ex: ginger/lavender/peppermint blends) ● Acupuncture/acupressure: stimulates points/meridians → pain, nausea, fatigue, anxiety support ● Hypnotherapy: focused attention + suggestion → phobias, anxiety, pain, habits (smoking) ● Biofeedback: device-assisted control of body functions (HR, tension) → stress, headaches, rehab, pain 5) Manual Therapies (hands-on) ● Massage: manipulates soft tissues → pain/anxiety/insomnia support ○ Precautions: avoid over clots/tumors/prostheses; caution with anticoagulants/low platelets (bruising/bleeding); older adults risk (rare) fractures ● Reflexology: foot/hand zones thought to correspond to body functions ● Chiropractic: spinal manipulation + structural focus; no surgery/Rx meds ● Osteopathic medicine: structure-function relationship; osteopathic manipulation used by trained physicians 6) Bioenergetic / Movement Therapies ● Tai Chi / Qi gong: meditative movement; balance, function, stress reduction ● Alexander Technique: posture/neck-spine alignment awareness → chronic pain support ● Feldenkrais: mindful movement retraining → pain + mobility ● Rolfing/Structural integration: deep tissue/fascia work → posture/function ● Pilates: core/torso control, posture → balance, flexibility, pain relief ● Therapeutic Touch / Healing Touch / Reiki: energy-based touch; may support relaxation, pain reduction, agitation (ex: dementia) 7) Traditional / Indigenous Practices (cultural competence) ● Traditional medicine (WHO concept): culture-based knowledge/practices for prevention/diagnosis/treatment—often includes spirituality. ● Examples: Native healing practices (prayer, drumming, storytelling, sacred rituals), herbal use, cupping, etc. ● Nursing: respect beliefs, ask what practices are important, integrate safely. 8) Whole Medical Systems (quick ID) ● Ayurveda: balance mind–body–spirit; doshas; cleansing + diet + herbs + yoga/meditation ● TCM: acupuncture, Tai Chi/qi gong, herbs; balance yin/yang + qi flow ● Naturopathy: “body heals itself” supported by diet, lifestyle, herbs, supplements, homeopathy, etc. ● Homeopathy: “like cures like,” highly diluted remedies ● Functional medicine: root-cause, systems-based approach 9) Natural Products: BIG SAFETY POINTS (test favorites) FDA/supplements ● FDA regulates supplements, but manufacturers are responsible for quality/claims → variability exists. ● “Natural” ≠ safe. Must-do nursing action ● Always ask about herbs/supplements/vitamins OTC. ● Encourage a current med + supplement list shared with provider/pharmacist before starting anything new. Common interaction themes ● Bleeding risk (esp with anticoagulants like warfarin): ○ Garlic, ginger, ginkgo, cranberry (large amounts), evening primrose oil, etc. ● Serotonin syndrome risk when mixing certain herbs with antidepressants: ○ St. John’s wort + antidepressants (ex: duloxetine) ● CNS depression/sedation combos: ○ Valerian + sedatives/alcohol/antihistamines ● Vitamin K decreases warfarin effect: ○ Leafy greens (consistency matters) Specific high-yield herbal cautions ● Ephedra (ma huang): banned in U.S. supplements → serious CVA/MI risk (worse with caffeine) ● Kava: can cause liver damage ● Black cohosh: possible liver injury risk ● Tea tree oil: toxic if ingested ● Licorice root: ↑ BP, can lower K+ (esp with diuretics); avoid in pregnancy ● St. John’s wort: many interactions (reduces effectiveness of multiple meds) + photosensitivity Probiotics (basic) ● Support healthy gut flora; can help inhibit harmful bacteria (ex: Lactobacillus) 10) Vitamins & Minerals (core test facts) Vitamins ● Water-soluble: B-complex + C (not stored well → need regular intake) ● Fat-soluble: A, D, E, K (stored in fat/liver → toxicity risk if too much) Vitamin K newborn note: doesn’t cross placenta well; newborns get IM vitamin K to prevent bleeding. B-complex quick purpose (big picture) ● Mostly metabolism/energy, neuro function, RBC formation ● B12: neuro + RBCs (deficiency → anemia, fatigue, neuro changes) Minerals (core roles) ● Needed for: enzyme function, nerve/muscle contraction, fluid balance, bone/teeth ● Examples: ○ Calcium: bones + clotting + nerve impulses ○ Sodium: extracellular fluid, nerve/muscle ○ Potassium: nerve/muscle; high/low can cause arrhythmias ○ Magnesium: metabolic processes; low with alcohol use disorder/DM ○ Iron: oxygen transport; deficiency → anemia Food-drug/nutrient interactions (quick) ● Vitamin C ↑ non-heme iron absorption ● Coffee/tea/wine (polyphenols) + phytic acid (legumes/nuts) ↓ iron absorption Quick “Exam-Style” Reminders ● Complementary = with conventional; Alternative = instead; Integrative = coordinated blend. ● Nursing role: assess use, prevent interactions, educate, support self-care, respect culture. ● Biggest safety issue: herb/supplement interactions (bleeding, serotonin syndrome, sedation, warfarin/vit K). If you want, paste any practice questions from this lesson and I’ll answer them using only what’s in your notes

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