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EXTERNAL AND INTERNAL STRUCTURE OF THE BRAIN STEM DR A. A. NWAKANMA THE BRAINSTEM •The brainstem is made up of the medulla oblongata, pons and midbrain •It is stalklike in shape and connects the narrow spinal cord with the expanded forebrain •Occupies the posterior cranial fossa of the skull Loading… FUNCTIONS OF BRAINSTEM •It serves as a conduit for the ascending and descending tracts connecting the spinal cord to the different parts of the higher centers in the forebrain •It contains important reflex centers associated with the control of respiration and CVS. •It is also associated with the control of consciousness •It contains important nuclei of cranial nerves II through XII EXTERNAL FEATURES OF MEDULLA OBLONGATA • The medulla oblongata connects the pons superiorly with the SC inferiorly •The junction of the medulla and SC is at the origin of the anterior and posterior roots of the first cervical nerve which corresponds approximately to the level of the foramen magnum Loading… EXTERNAL FEATURES OF MEDULLA •The medulla oblongata is piriform in shape •It has a broad superior part – open part •And a lower closed part •The central canal of the SC continues upward into the lower half of the medulla •In the upper half of the medulla it expands as the cavity of the fourth ventricle EXTERNAL FEATURES OF MEDULLA •On the ant. Surface of the medulla is the anterior median fissure which is continous inferiorly with the ant. Median fissure of the SC •On each side of the median fissure is a swelling called the pyramid EXTERNAL FEATURES OF MEDULLA •The pyramids are composed of bundles of nerve fibers, corticospinal fibers which originate in large nerve cells in the precentral gyrus of the cerebral cortex •The pyramids tapers inferiorly and majority of the descending fibers cross over to the opposite side forming the decussation of the pyramids here •The ant. External arcuate fibers are a few nerve fibers that emerge from the ant. Median fissure above the decussation and pass laterally over the medulla oblongata to enter the cerebellum EXTERNAL FEATURES OF MEDULLA •Posterolateral to the pyramids are the OLIVES which are oval elevations produced by the underlying inf. Olivary nuclei •In the groove b/w the pyramid and olive emerges the rootlets of the hypoglossal nerve •Post. To the olives are the inf. Cerebellar peduncles which connect the medulla to the cerebellum EXTERNAL FEATURES OF MEDULLA •In the groove b/w the olive and the inf. Cerebellar peduncle emerges the roots of the glossopharyngeal and vagus nerves and the cranial roots of accessory nerve •The post. Surface of the sup. Half of the medulla forms the lower part of the floor of the 4th ventricle External features of medulla •The post surface of the inf. Half continues with the post. Aspect of the SC and possesses a post. Median sulcus •On each side of the median sulcus is an elongated swelling , the Gracile tubercle produced by the underlying gracile nu. •Lat. To the gracile tubercle is the cuneate tubercle produced by the underlying cuneate nu. Loading… INTERNAL STRUCTURE OF MEDULLA •The internal structure of the medulla oblongata is usually considered at 3 levels •Level of pyramidal decussation •Level of olive •Level of sensory or lemniscal decussation T/S OF MEDULLA AT THE LEVEL OF OLIVE •This level corresponds to the floor of the 4th ventricle and the cranial n. Nuclei seen include •Hypoglossal n. • Vestibular nuclei •Dorsal nu. Of vagus •Solitary tract and its nu. •Nu. Ambigus • dorsal and ventral cochlear nu. T/S OF MEDULLA AT THE LEVEL OF OLIVE •The other masses of gray matter seen at this level include •The medial and dorsal accessory olivary nu. •Lat. Reticular nu. •Arcuate nu. •The descending tracts seen include •Pyramid •Rubrospinal tract •Spinal nu. And •Tract of trigeminal n. T/S OF MEDULLA AT THE LEVEL OF OLIVE •The ascending tracts include •Medial lemniscus lying in the middle and is L shaped •Spinothalamic T •Spinocerbellar T. •Spinotectal T. •The reticular formation and the inf. Olivary nu. Are also prominent features found at this level T/S OF THE MEDULLA AT THE LEVEL OF LEMNISCAL DECUSSATION •The level represented by this section lies a little above the level of the pyramidal decussation •The structures found at this level include •Central canal surrounded by gray matter •Medial lemniscus •The pyramids the nu. And fasciculus cuneatus •Spinal nu. Of trigeminal n. •The reticular formation T/S OF THE MEDULLA AT THE LEVEL OF LEMNISCAL DECUSSATION •Internal arcuate fibers which arise from the nu. Gracilis and cuneatus and arch forward on the medial side of the gray matter crossing in the midline to form the lemniscal or sensory decussation •Accessory cuneate nu. Lying dorsolateral to the cuneate nu. T/S OF THE MEDULLA AT THE LEVEL OF LEMNISCAL DECUSSATION •The cranial nerve nuclei seen at this level include •Hypoglossal nu. •Dorsal motor nu. Of vagus •Arcuate nu. •Nu. Of solitary tract •Nu. Ambigus •Other structures include •Lower part of inf. Olivary nu. •Lat. Reticular nu. •Arcuate nu. •Lat. & ventral spinothalamic tr. •Doral and ventral spinocerebella tr. •Spino-olivary tr. •Pyramids •Vestibulospinal tr. •Corticospinal tr. •Medial longitudinal fasciculus Connections of the Inferior Olivary Complex • The main afferents of the inferior olivary nucleus are from the cerebral cortex and from the spinal cord • The main efferents are to the cerebellar cortex. • An olivospinal tract is traditionally described, but some authorities hold that the inferior olivary nuclei do not send any fibres to the spinal cord. •The nucleus may be regarded as a relay station on the cortico-olivo-cerebellar and spino-olivo-cerebellar pathways. • The accessory olivary nuclei are connected to the cerebellum by parolivo-cerebellar fibres. THE PONS •The pons is the middle part of the brainstem •Its continuous below with the medulla oblongata and above with the midbrain •It is seperated from the cerbellum by the 4th ventricle •Pons has two surfaces: •Ventral and dorsal External Features Of Ventral Surface Of Pons •The ventral surface of pons shows the following features •The ventral surface is convex and has a shallow groove in the midline called the basilar groove which lodges basillar artery •Transvesely running fibers connecting the pons to the cerebellum thru the middle cerebellar peduncle •The two roots of trigeminal nerve (sensory and motor) emerge at the jxn b/w the ventral surface of pons and middle cerebellar peduncle EXTERNAL FEATURES OF DORSAL PONS •The dorsal surface of pons shows the following features •Median sulcus in the median plane •Medial eminence – shows rounded elevation in the lower part called facial colliculus which overlies the nu. Of abducent n. •Sulcus limitans – is lat. To the medial eminence and seperates medial eminence from vestibular area T/S THROUGH CAUDAL PART OF PONS •The features seen at this level include •Medial lemniscus in the most ant. Part of the tegmentum •The facial nu. Lies post to the lat. Part of the medial lemniscus •The fibers of the facial nerve wind around the nu. Of the abducent nerve producing the facial colliculus T/S THROUGH CAUDAL PART OF PONS •The medial longitudinal fasciculus is situated beneath the floor of the 4th ventricle on either side of the midline •The medial longitudinal fasciculus is the main pathway that connects the vestibular and cochlear nuclei with the nuclei controlling the extraocular muscles (oculomotor, trochlear and abducent) •The medial vestibular nu. Is situated lat. To the abducent nu. And in close relationship to the inf. Cerebellar peduncle T/S THROUGH CAUDAL PART OF PONS •The sup. Part of the lat. And inf. Part of sup. Vestibular nu. Are found at this level •Post. And ant. Cochlear nu. Are also found at this level •The spinal nu.of trigeminal nerve and tract lie on the anteromedial aspect of the inf. Cerebellar peduncle T/S THROUGH CAUDAL PART OF PONS •The trapezoid body is made up of fibers derived from the cochlear nuclei and the nuclei of trapezoid body •They run transversely in the ant. Part of the tegmentum •The basilar part of the pons at this level contain masses of nervr cells called pontine nuclei T/S THROUGH CAUDAL PART OF PONS •The axons of these cells give origin to the transverse fibers of the pons which cross the midline and intersect the corticospinal and corticonuclear tracts breaking them up into small bundles Loading… INTERNAL STRUCTURE OF CRANIAL PART OF PONS •The internal structure of the cranial part of pons is similar to that seen at the caudal level but contains the motor and principal sensory nuclei of the trigeminal nerve •The motor nu. Of the trigeminal nerve is situated beneath the lat. Part of the 4th ventricle within the reticular formation INTERNAL STRUCTURE OF CRANIAL PART OF PONS •The principal sensory nu. Of the trigeminal nerve is situated lateral to the motor nu. •The sup. Cerebellar peduncle is situated posterolat. To the motor nu. Of trigeminal nerve EXTERNAL FEATURES OF MIDBRAIN •Midbrain measures about 2cm in length and connects the pons and cerebellum with the forebrain •The midbrain is traversed by a narrow channel – the cerebral aqueduct ( which is filled with CSF) •On the posterior surface are four rounded eminences that are divided into superior and inferior pairs •The sup. Colliculi are centers for visual reflexes while the inf. Are lower auditory centers •In the midline below the inf. Colliculi emerges the trochlear nerves EXTERNAL FEATURES OF MIDBRAIN •Each colliculi is related to a ridge called brachium •The sup. Brachium passes from the sup. Colliculus to the lat. Geniculate body and the optic tract •The inf. brachium connects the inf colliculus to the medial geniculate body EXTERNAL FEATURES OF MIDBRAIN •On the anterior aspect of the midbrain is a deep depression in the midline called the interpeduncular fossa which is bounded on either side by the crus cerebri •Many blood vessels perforate the floor of the interpeduncular fossa and this region is termed the post. Perforated substance INTERNAL STRUCTURE OF MIDBRAIN •The midbrain is divided into two parts – •An upper tectum and •A lower part called cerebral peduncles •The upper part (tectum) contains mainly the colliculi of the two sides and represents the dorsal part of the midbrain •The cerebral peduncles are subdivided by the substantia nigra into •The tegmentum and •Crus cerebri STRUCTURE OF MIDBRAIN AT OF INF. COLLICULUS •The structures seen at this level include •Crus cerebri- this contain descending fibers from different parts of the cerebral cortex •The medial 1/6 contain frontopontine fibers •The intemediate 2/3 contain corticospinal and corticonuclear fibers •The lat. 1/6 contain temporopontine fibers •Other structures include •Substantia nigra •Cerebral aqueduct : this is surrounded by the central gray matter. •Ventral to this aqueduct is the oculomotor and trochlear nerves STRUCTURE OF MIDBRAIN AT OF INF. COLLICULUS •Reticular formation b/w the substantia nigra and gray matter •Inferior colliculus •Mesocephalic nu. Of trigeminal nerve •Compact bundle of fibers lies in the tegmentum dorsomedial to the substantia nigra •This bundle consistsof the medial lemniscus, trigeminal lemniscus and spinal lemniscus •Medial longitudinal fasciculus •Superior cerebellar peduncle •Rubrospinal tract Structure of midbrain at the level of sup. colliculus •The following structures are seen at this level •Sup. Colliculus in the tectum •Red nu. In the tegmentum dorsomedial to the substantia nigra •Oculomotor nuclei near the central gray matter •Bundles of ascending fibers consisting of medial lemniscus, spinal lemniscus and trigeminal lemniscus Structure of midbrain at the level of sup. colliculus •Dorsal tegmental decussation : this consists of fibers originating in the sup. Colliculus, it crosses to the opp. Side and descend as the tectospinal tract •Ventral tegmental decussation : this originates in the red nu
Updated 25d ago
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Please wait outside until I let you in, and put all your stuff at the back just like we've done about 20 times already this semester. Okay? Or this semester and last, and you will be just fine. Now your lecture exam too is 90 marks big. It is 90 multiple choice questions. Okay. It is going to be on cardiovascular disorders, urinary system, fluid balance, Okay. So let's start talking about them. First of all, okay, you need to know the difference between a myocardial infarct, ischemic attack, a congestive heart failure, and angina pectorals. You need to know what a low level inflammatory response that develops over time where the endothelium is damaged due to the aging or prolonged hypertension, where LDLs accumulate, and the endothelium is repaired with collagen is called. That might take you a long time to read. Okay? But it is a good question. Okay? You need to know now be really, really clear on these. Okay? You absolutely need to know the difference between right ventricular hypertrophy and left ventricular hypertrophy and what they cause. Because there's two questions on here, and so far, this one hasn't been done very well. Okay? Make sure you understand what right ventricular hypertrophy leads to and you understand what left ventricular hypertrophy leads to. Now the original term, congestive heart failure, that refers to left ventricular hypertrophy leading to backup in the lungs. K? You need to know what arteries or vessels are used in bypass surgery. You need to know what a mini stroke is. Okay? You need to know the difference between thrombus and ballast occlusion and arthroma. You need to know what is a restriction in blood supply generally due to factors in the blood vessels with resultant damage or dysfunction of tissue. You need to know, what are the consequences of an aging cardiovascular system. And then I I've got a matching question for you. You need to match the basic function of the proximal convoluted tubule, the glomerulus, and the peri colic duct. And then two of my favorite questions. Are you ready? Okay. You have to find out which of the following is the best explanation for why the cells of the proximal convoluted tubule contain so many microclonary. Oh, isn't that lovely? Okay. And then the other one you need to know is you need to find the best explanation for the microvilli on the apical surface of the proximal convoluted tubules. So don't get that one wrong because we've talked about microvilli about a bazillion times. Okay? This picture is gonna be on there, folks. Okay? This is the picture of the of the nephron from your textbook. Okay. You need to label things like glomerulus glomerulus afferent arteriole collecting duct nephron move. Okay. Where do you find the granular cells? Okay. The difference between the medulla and the cortex. Make sure you know all of those things. I'll read you this one. This is a good question too. Hydrostatic pressure is the primary driving force of plasma through the filtration membrane into the capsular space. All the publicly following statements reflects why hydrostatic pressure is so high in the glomerular capillaries. Select the one statement that does not explain the high pressure within the glomerular capillaries. So you need to know why glomerular capillary pressure is higher than the rest of the capillaries in the body. You need to know how or why cells or transport proteins are prevented from moving through how yeah. What drives reabsorption of organic nutrients in the proximal condylated tubule? Who drives thus? You need to know the mechanism that establishes the medullary osmotic gradient the The functional and structural unit of the kidneys is what? The g force pushing the blood and solids out of the blood across the filtration membrane is what? Okay. The macular densities cells do what? Function in angiotensin two is to do what? What is, specific gravity or density? Okay. If you talk about the specific gravity or density of urine, how is it different from water? You need to actually, this is just one question, but it should be a pretty simple one. Okay? You need to place the following and correct sequence from the formation of a drop of urine to its elimination of the body. And so you have to go through from well, I'll just read it to you. Major calyx, minor calyx, nephron, urethra, ureter, and collecting that. So you need to put those in order from start to finish. Okay? What would happen if the capsular hydrostatic pressure were increased above normal? You need to know what would happen. Reabsorption of bilevels of glucose and amino acids in the filtrate is accomplished. The 44 more. Okay. So you need to match to their definition. All of your hypo and hypers. Make sure you have some under control. Okay? And then you need to match possible causes. So there's possible causes of respiratory alkalosis, metabolic alkalosis, metabolic acidosis, and respiratory acidosis. Respiratory alkalosis, metabolic alkalosis, metabolic acidosis, and respiratory acidosis. There are possible causes for those four things. You need to match the disorder to the cause. Okay? And then you need to know, the body's motor volume is mostly tied to the level of then I have a couple of clinical correlation questions for you, but they are multiple choice this time. So something happened to Jane. You have to tell me what's happening to Jane. Okay? Now whereas sodium is mainly found in the extracellular fluid, most is found in intracellular systems are. Okay. Which of the following is not a likely source of hydrogen ions in blood plasma, so there's a few types in the tablets, so make sure you know which ones are going to produce acids and which ones aren't. And then Annie had something happen to her as well. Across capillary walls is what? Regulation of potassium balance is what? Now Dave Dave did something silly. Okay? Dave ran a marathon. Okay? And then Dave did something even more silly afterwards. I want you to tell me what happened to Dave. And in addition to that, Nancy is having a panic attack. So I want you to tell me what's happening to Nancy in terms of respiratory aesophosis and respiratory aldosterone. Okay. If thyroid and parathyroid glands were surgically removed, which of the following would go out of balance without replacement therapy? Falling arterial blood pressure holds which? An illness, Doug. Doug has severe diarrhea. Okay. And, is accompanying the loss of bicarbonate or secretions. So how is Doug gonna compensate for that for Doug? Okay. You need to know what the medical term for kidney stones is. You need to know what happens, or what could cause the passage of proteins, red blood cells, and white blood cells into the urine. You need to know how to solve prostatic enlargement, and, you need to know what the presence of white blood cells in urine is called and what is causing it. Okay? And then there's a picture of the lymphatic of the lymph node. Okay. You need to label the lymph node picture. And then you there is going to be a matching question on lymphatic structures, so you need to know what happens in the spleen, the lymph nodes, the thoracic duct, the lymph, and the pyre patches. There's a list, a small short list. Okay? So in other words, you're going to need to know what is classified as a lymphoid organ and what does not. Okay? So make sure you know what your lymphoid organs are. You need to know the pathway of lymph. So it starts in lymph capillaries. Where does it end? Make sure you know all the steps along the way. And then you need to know the functions of the spleen. What did what does the spleen do? And that is it for an example
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CNS and Afferent PNS
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PNS Afferent
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CT4-LECTURE 1- JAN 2025 OBJECTIVES Developmental Anatomy (Embryology): • Outline the stages of human growth and development, focusing on dental anatomy and root morphology. • Correlate developmental processes with hard and soft tissue formation in the oral cavity. Microscopic Anatomy: • Classify cells (cytology) and tissues (histology) based on their structure and specialization. • Evaluate the role of microscopic structures in maintaining oral health. GROSS Anatomy • Identify anatomical landmarks of the oral head and neck, including the TMJ, circulatory system, glands, and nervous system. • Describe the structures visible to the naked eye and their clinical relevance. Physiology: • Explain the functions of body systems and their integration in oral health. • Analyze the physiological processes affecting the oral cavity. 1/16/2025 3 Mitosis Meiosis One cell division Two cell division Produces two daughter cells Produces Four daughter cells Produces diploid cells Produces haploid cells Daughter cells are genetically identical Daughter cells are non- identical Produces body cells Produces sex cells • Mitosis and meiosis are both types of cell division. • Mitosis is how new body cells are produced, whereas meiosis is used to produce gametes (i.e. sperm and egg cells). first week Spermatozoa + Oocyte = Zygote (12-24hrs.) Cell division via mitosis = Cleavage 1st solid ball called Morulla Inside Morulla secretion of fluids becomes blastocyte (5days) Blastocyte has 2 regeions Trophoblast(peripheral cells) & Embryoblast layer(inner mass) CLINICAL CONSIDERATIONS FOR PREIMPLANTATION PERIOD •If any disturbances occur in meiosis during fertilization, major congenital malformations result from the chromosomal abnormality in around 10% of cases. •A syndrome is a group of specific signs and symptoms. PREIMPLANTATION PERIOD • After a week of cleavage, the blastocyst consists of a layer of peripheral cells, the trophoblast layer, and a small inner mass of embryonic cells or embryoblast layer. • The trophoblast layer later gives rise to important prenatal support tissue while the embryoblast layer later gives rise to the embryo. SECOND WEEK • A bilaminar embryonic disc • The superior epiblast layer is composed of high columnar cells. • The inferior hypoblast layer is composed of small cuboidal cells. THIRD WEEK • Primitive streak (rod shaped thickening) forms a bilateral symmetry within the bilaminar embryonic disc. • Some cells from the epiblast layer move or migrate toward the hypoblast layer only in the area of the primitive streak and become • Mesoderm, an embryonic connective tissue, and embryonic endoderm. END OF THIRD WEEK • With three layers present, the bilaminar disc has thickened into a trilaminar embryonic disc. • The epiblast layer is now considered ectoderm. • 3 germ layers • Ectoderm-becomes skin, nervous system, and neural crest cells. • Mesoderm-Becomes muscles, bones, blood, and connective tissues. • Endoderm-Forms internal organs like the digestive and respiratory systems. 1/16/2025 10 Neural Crest Cells & Mesenchymal Transition(dental tissue) • Neural crest cells are derived from the ectoderm during neurulation (around weeks 3-4). • NCC migrate and undergo epithelial-to-mesenchymal transition (EMT), becoming highly migratory mesenchymal cells. • They contribute to the formation of facial bones, cartilage, peripheral nerves, and parts of the heart. 1/16/2025 11 Embryonic Period: Physiological Process(changes in structure &function) • INDUCE, PROLIFERATE, DIFFERENTIATE AND MORPH, DON’T WAIT! MATURE AND GROW, IT’S YOUR FATE!" 1. Induction The process where one group of cells influences another to differentiate into a specific tissue or organ. 2. Proliferation Rapid cell division, increasing the number of cells. 3. Differentiation(Cyto, Histo, Morpho) Cells specialize to perform specific functions. 4. Morphogenesis The development of the overall shape and structure of tissues and organs. 5. Maturation The final stage where tissues and organs reach their fully functional form. 1/16/2025 12 Facial Development  The facial development that starts in the fourth week of the embryonic period will be completed later in the twelfth week within the fetal period.  At the fourth week, the developing brain, face, and heart are noted. 1/16/2025 13 • All three embryonic layers are involved in facial development: the ectoderm, mesoderm, and endoderm. • The upper part of the face is derived from the frontonasal process, the midface from the maxillary processes, and the lower from the mandibular processes. Early development of the face is also dominated by the proliferation and migration of ectomesenchyme, derived from neural crest cells (NCCs). Facial Development 1/16/2025 14 Stomodeum and Oral Cavity Formation With this disintegration of the membrane, the primitive mouth is increased in depth and enlarges in width across the surface of the midface. Nose and Paranasal Sinus Formation Apparatus Formation  First branchial/ pharyngeal arch also known as the mandibular arch and its associated tissue, includes Meckel cartilage.  Supplied by Trigeminal nerves Apparatus Formation  Second branchial/pharyngeal arch, which is also known as the hyoid arch, is cartilage like that of the mandibular arch, Reichert cartilage. Apparatus Formation  Third branchial/ pharyngeal arch  Has an unnamed cartilage associa ted with it. This cartilage will be responsible for forming parts of the hyoid bone. Apparatus Formation  Both the fourth and the sixth branchial /pharyngeal arch also have unnamed cartilage associated with them, they fuse and form most of the laryngeal cartilages. 1/16/2025 20 TOOTH DEVELOPMENT: INITIATION STAGE Stages of Tooth Development: I Bought Candy Bars After Midnight." I → Initiation Bought → Bud Candy → Cap Bars → Bell After → Apposition Midnight → Maturation 1/16/2025 23 1. Initiation Stage (Week 6-7): • Dental placodes form as localized thickenings of oral ectoderm. • Interaction with neural crest cells induces the formation of the tooth germ. 2. Bud Stage (Week 8): • The enamel organ invaginates into the underlying mesenchyme, creating a tooth bud. 3. Cap Stage (Week 9-10): • The enamel organ forms a cap-like structure over the dental papilla. 4. Bell Stage (Week 11-12): • Cells differentiate into ameloblasts (enamel-forming cells) and odontoblasts (dentin-forming cells). 5. Apposition and Maturation: • Enamel, dentin, and cementum are laid down and mineralized. 1/16/2025 25 • Dental Epithelium → Enamel Organ Enamel organ arises from the dental epithelium and forms ameloblasts, the cells responsible for producing enamel, the hardest substance in the body. Dental Mesenchyme → Dental Papilla Dental papilla forms from the mesenchyme and gives rise to: • Dentin -Odontoblasts: Cells that produce dentin (the layer beneath enamel). • Pulp: The soft, living core of the tooth, containing nerves and blood vessels. • Root Dentin: The dentin in the root of the tooth. Dental Follicle • Surrounds the developing tooth and forms: • Cementum: A calcified tissue covering the root of the tooth, anchoring it to the jaw. • Periodontal Ligament: Connective tissue fibers that hold the tooth in its socket and absorb chewing forces. Teeth w e a r c a n b e t r e a t e d A t t r i t i o n Abrasion Abfraction E r o s i o n Hunter-Schreger bands (HSB). • Hunter-Schreger bands (HSB): • Dark and light bands due to curvature or bends of the rods. • increasing the enamel’s strength. • Near the cusps or incisal ridges, where the enamel is the thickest Celiac Disease ˜ Dental enamel problems stemming from celiac disease involve permanent dentition and include tooth discoloration—white, yellow, or brown spots on the teeth—poor enamel formation, pitting or banding of teeth, and mottled or translucent-looking teeth. ˜ The imperfections are symmetrical and often appear on the incisors and molars. ˜ Tooth defects that result from celiac disease may resemble those caused by too much fluoride or a maternal or early childhood illness 1/16/2025 29 ROOT DEVELOPMENT  The process of root development takes place long after the crown is completely shaped, and the tooth is starting to erupt into the oral cavity.  The structure responsible for root development is the cervical loop.  The cervical loop is the most cervical part of the enamel organ, a bilayer rim that consists of only inner enamel epithelium (IEE) and outer enamel epithelium (OEE). ROOT DEVELOPMENT  To form the root region, the cervical loop begins to grow deeper into the surrounding ectomesenchyme of the dental sac, elongating and moving away from the newly completed crown area to enclose more of the dental papilla tissue, forming the Hertwig epithelial root sheath (HERS). Thus, HERS will determine if the root will be curved or straight, short or long as well as single or multiple. 1/16/2025 33 • Cervical Loop Formation ▪ The cervical loop, located at the junction of the enamel organ and the crown, elongates to form Hertwig’s Epithelial Root Sheath (HERS). ▪ HERS determines the shape, length, and number of roots. • Root Dentin Formation ▪ Inner cells of HERS induce adjacent dental papilla cells to differentiate into odontoblasts, which form root dentin. ▪ Once dentin is deposited, HERS disintegrates. • Epithelial Rests of Malassez ▪ After HERS disintegrates, remnants form clusters called epithelial rests of Malassez in the periodontal ligament. ▪ These remnants can sometimes form cysts later in life. PRIMARY DENTITION PROPERTIES  The actual dates are not as important as the eruption sequence, because there can be a great deal of variation in the actual dates of eruption.  However, the sequence tends to be uniform. Enamel Histology • Enamel tufts: Hypomineralized, Located at the dentino-enamel junction and filled with organic material. Forms between groups of enamel rods at the dentino-enamel junction. • Enamel lamellae are partially mineralized vertical sheets of enamel matrix that extend from the DEJ near the tooth’s cervix to the outer occlusal surface. Transverse section of enamel showing enamel tufts (white arrow) and enamel lamella (black arrow). Dentin Matrix Formation DENTINOGENESIS LPROCESS o$ CREATING DENTIN PRIMARY TEETH _ 14th WEEK of FETAL DEVELOPMENT PERMANENT TEETH L 3 MONTHS AFTER -PROCESS HAPPENS SLOWLY PERFORMED by ODONTOBLASTS —OUTSIDE INWARDS - BEGINS with MANTLE DENTIN ODONTOBLASTS -PREDENTIN -SOFT ORGANIC MATRIX -PROTEINS FIBROBLASTS -KORFF'S FIBERS -THICK COLLAGEN FIBERS -FRAMEWORK of DENTINOGENESIS 1/16/2025 39 Principal Fibers Protect, Gingival Fibers Guard." •Principal → Protection and anchorage of the tooth. •Gingival → Guard and stabilize gingiva. 1/16/2025 40 Principle Fibers "All Hungry Octopuses Appreciate Ice cream!" •All → Alveolar Crest •Hungry → Horizontal •Octopuses → Oblique •Appreciate → Apical •Ice cream → Interradicular 1/16/2025 41 Gingival Fiber : "Dentists Always Care Deeply for Teeth!" •Dentogingival •Alveologingival •Circular •Dentoperiosteal •Transseptal 1/16/2025 42 Primary (Deciduous) Teeth Eruption "Children Like Fruit Candy More" •C → Central Incisors •L → Lateral Incisors •F → First Molars •C → Canines •M → Second Molars CELL ORGANELLES SKIN ANATOMY COME, LET'S GET SOME BREAD" C ORNEUM (OUTER), L UCIDUM, G RANULOSUM, S PINOSUM, B ASALE. • Corneum - tough and protective. • Lucidum - clear layer (found only in thick skin like palms/soles). • Granulosum - cells with granules for keratinization. • Spinosum - "spiny" cells, providing strength and flexibility. • Basale - base layer where cell division happens. 1/16/2025 45 1/16/2025 46 Tooth Designation ∙ Commonly used in orthodontics, is the Palmer Notation Method, also known as the Military Tooth Numbering System. ∙ In this system, the teeth are designated from each other with a right-angle symbol indicating the quadrants and arch, with the tooth number placed inside. 1/16/2025 47 Mixed Dentition Period ∙ The mixed dentition period follows the primary dentition period. ∙ This period occurs between approximately 6 and 12 years of age. ∙ Both primary and permanent teeth are present during this transitional stage. ∙ The final dentition period is the permanent dentition period. ∙ This period begins with shedding of the last primary tooth. 1/16/2025 48 General Dental Terms •Each dental arch can be further divided into two quadrants, with four quadrants in the entire oral cavity. • The correct sequence of words when describing an individual tooth using a D-A-Q-T System is based on the tooth within its quadrant: D for dentition, A for arch, Q for quadrant, and T for tooth type. • Sextants: three parts according to the relationship to the midline: right posterior sextant, anterior sextant, and left posterior sextant. 1/16/2025 49 Root Axis Line (RAL) ∙ Root axis line (RAL), which is an imaginary line representing the long axis of a tooth, drawn in a way to bisect the root (and thus the crown) in the cervical area into two halves. 1/16/2025 50 Restorations: Biologic Width ∙ Biologic width is the distance established by the junctional epithelium and lamina propria attachment to the root surface of a tooth. ∙ This distance is important to consider when fabricating dental restorations, because they must respect the natural architecture of the gingival attachment if harmful consequences are to be avoided. ∙ Assessment for biologic width can be made clinically by measuring the distance between the bone and the restoration margin using a periodontal probe. 1/16/2025 51 PRIMARY DENTITION 1/16/2025 52 1/16/2025 53 Eruption 1/16/2025 54 1/16/2025 55 1/16/2025 56 Differences-(Enamel depth/pulp) 1/16/2025 57 Differences: Roots 1/16/2025 58 Importance of Primary teeth - PRIMATE Space 1/16/2025 59 Leeway Space 1/16/2025 Primary Occlusion 60 •Majority of children have Mesial step between distal of Primary 2nd molars. Mandibular 2nd molars are situated mesially than maxillary. •A smaller but still large group of children exhibit a flush terminal plane. The distal surfaces of the primary 2nd molars are even with each other. •A still smaller minority have a distal step. The mandibular 2nd molars are situated more distally than their maxillary counterparts. Thus, they form a distal step. 1/16/2025 Anatomy of Primary teeth 61 Incisors: resemble the outline of permanent counterpart except Primary do not have mamelons on the incisal ridge and there are no pits on the lingual surface. 1/16/2025 Primary Canines 62 Canines- resemble the outline of their permanent counterparts. The maxillary canine has a sharp cusp and appears especially wide and short. Maxillary Central and Lateral Incisors Central Incisors: • Larger overall; they are the widest teeth mesiodistally in the anterior maxillary arch. • Crown is more symmetrical and fan (mesiodistally wider compared to incisocervical length). • Lingual fossa is less pronounced. • Cingulum is well-developed and centered. • Root is shorter and more conical, with a blunt apex. • Rarely exhibit significant variation. Lateral Incisors: • Smaller and narrower mesiodistally than the central incisors. • Crown is less symmetrical and more rounded. • Lingual fossa is deeper, with more pronounced marginal ridges. • Cingulum is narrower and often slightly off-center to the distal. • Root is longer and thinner, with a more pointed apex. • Frequently display developmental variations (e.g., peg-shaped lateral incisors, congenitally missing). 1/16/2025 66 1/16/2025 67 1/16/2025 68 1/16/2025 69 CLASSIC TRAITS ➢ From the occlusal view, molar crowns taper from the buccal to the lingual EXCEPT for maxillary 1st molars. ➢ From the occlusal view, molar crowns taper distally; this allows more of the occlusal surface to be visible from the distal aspect than the mesial. ➢Maxillary molars have 3 roots: MB, DB, and lingual (palatal). The lingual root is usually the longest and the DB is the shortest. ➢ Mandibular molars have 2 roots: a long mesial root and a slightly shorter distal root. ➢ The root furcation on mandibular molars is close to the cervical line, making the root trunk shorter than on the maxillary molars. MAJOR AND MINOR CUSPS ➢In general, each cusp is formed from its own lobe. ➢Major cusps are large and well developed. ➢Minor cusps are less developed and have smaller proportions. They are less functional than the major cusps and may not always be present. ➢Supplementary cusp is very small and completely afunctional. They are rarely present. 1/16/2025 72 ➢First molars are the most highly developed and largest of the molars and more likely to have major, minor and supplementary cusps. ➢Both the 1st and 2nd maxillary molars have 4 major cusps but only 2 are visible from the buccal view. ➢The longest of the 4 major cusps are the ML, followed by the MB, DB, and the shortest DL (if present). 1/16/2025 73 • Molars (general: crowns larger, squarer, bear more cusps than any other tooth class, have multiple roots, 3rd molars sometimes mistaken for premolars) • Generally speaking, the maxilla molars go from largest to smallest (1st molar to 3rd molar) in size and morphology. The crowns generally have 4 cusps. • The 1st molar has three roots (two buccal and one lingual, which when seen from the buccal position the lingual root comes into view in the middle of the two buccal roots). The occlusal surface is described as a rhomboid in shape with 4 distinctive cusps. • Oblique ridge max molars only and transverse ridge one on max 2 on mandibular. • The 2nd molar has three roots but the two buccal roots are nearly parallel with each other and is described as heart shape in the occlusal view. • The 3rd molar has three roots present but the two buccal roots are often fused, and the outline of the occlusal surface is also described as a heart shape. The 3rd molar also shows greater developmental variation than either the 1st or • 3rd molars are often the tooth that is congenitally missing. All roots of the molars angle distally with respect to the major crown axes (White & Folkens 2005: 152). 1/16/2025 74 1/16/2025 75 Joint Movement ˜ Two basic types of movement of the mandible are performed by the TMJ and its associated muscles of mastication: ˜ a gliding movement and ˜ a rotational movement. 1/16/2025 76 • The muscles of mastication include the • Temporalis, • And Masseter, • Pterygoid muscles, medial and lateral. • These muscles are involved in mastication using these two movements. 1/16/2025 77 1/16/2025 78 TMD: Acute Episode • Trismus or the inability to normally open the mouth. • When the patient tries to close and elevate the mandible, the condylar heads cannot move posteriorly because both the bony relationships prevent this, and the muscles have become spastic. 1/16/2025 79 Overjet • Overjet is measured in millimeters with the tip of a periodontal probe, once a patient is in CO. • The probe is placed at 90°or at a right angle to the labial surface of a mandibular incisor at the base of the incisal ridge of a maxillary incisor. 1/16/2025 80 • Overbite is measured in millimeters with the tip of a periodontal probe after a patient is placed in CO. • The probe is placed on the incisal edge of the maxillary incisor at 90º or at a right angle to the mandibular incisor. • When the reverse is the case and the mandibular arch and its incisors extends beyond the maxillary arch and its incisors, it is causes an underbite. 1/16/2025 81 Lymph Nodes • The lymph flows (arrows) into the lymph node through many afferent vessels. (A is first comes in) • On one side of the node is a depression, or hilus, where the lymph through fewer vessels, or even a single efferent vessel. (E is Exit) • Primary or Secondary. • Region drains into primary nodes. • Primary nodes, in turn, drain into secondary nodes (or central nodes). Lymphatics: General Drainage pattern of body Right jugular trunk Left jugular trunk Enters venous system near junction of left subclavian vein and left internal jugular Thoracic duct Left side of head, neck, thorax, entire abdomen, pelvis, lower extremities Enters venous system near junction of right subclavian vein and right internal jugular Right side of head, neck, thorax *Lymphatic vessels are small and directly drain tissues and connect lymph nodes. *Lymphatic ducts are much larger, receive lymph from many lymphatic vessels, and drain into the venous system. 1/16/2025 83 Superficial Lymph Nodes of the Head (five categories) 1. Facial; lie along facial vein. 2 Superficial Parotid; superficial to parotid gland. 3. Anterior Auricular; anterior to external auditory meatus. 4. Posterior Auricular; posterior to external auditory meatus. 5. Occipital; lie in the occipital region. *Tissue drainage: buccal mucosa, skin of zygomatic and infraorbital regions, scalp, external ear, lacrimal gland Deep Lymph Nodes of Head (two categories) 1. Deep Parotid; lie deep in the parotid gland, superficial to the masseter muscle 2. Retropharyngeal; posterior to the pharynx at the level of the atlas (first cervical vertebrae). *Tissue drainage: parotid gland, paranasal sinuses, hard and soft palate, middle ear Superficial Cervical Lymph Nodes (4 categories) 1. Submental; inferior to the chin in the submental space. 2. Submandibular; along the inferior border of the mandible, superficial to the submandibular salivary gland 3. External Jugular; along the external jugular vein, superficial to the sternocleidomastoid muscle. 4. Anterior Jugular; along the anterior jugular vein, anterior to the sternocleidomastoid muscle. Tissue drainage: 1.Submental and submandibular; teeth and related tissues, apex and body of tongue, anterior hard palate, floor of mouth, lips, chin, sub- mandibular and sublingual glands, cheeks. 2. External and anterior jugular; superficial tissues in the anterior and posterior triangles. Deep Cervical Lymph Nodes (2 categories) 1. Superior Deep Cervical; lie along internal jugular vein, superior to the omohyoid muscle. *Jugulo-digastric- becomes enlarged when a palatine tonsil or the pharynx is involved in infection. 2. Inferior Deep Cervical; lie along internal jugular vein, inferior to the omohyoid muscle. *Jugulo-omohyoid-drains the submental region and base of the tongue. Additional Deep Cervical Nodes 1. Accessory; lie along accessory nerve 2. Subclavicular; lie along clavicle. *Tissue drainage: mostly secondary nodes 1/16/2025 88 Sequence of lymph nodes draining various tissues Most of face, scalp, ear, orbit, sinuses, nasal cavities Most maxillary and mandibular teeth and associated tissues, apex and body of tongue, floor of mouth, sublingual and submandibular glands, lips Maxillary third molars and associated tissues, base of tongue, pharynx, tonsils Tissue Primary nodes Secondary nodes Submental and submandibular nodes Facial, anterior auricular, retroauricular, occipital superficial and deep parotid, and retropharyngeal nodes Submandibular, deep cervical nodes Retropharyngeal, deep cervical nodes Neck and cervical viscera Superficial and deep cervical nodes Right jugular trunk Right subclavian vein Left jugular trunk Left subclavian vein Thoracic duct Endocrine-secrete substance into blood, examples-adrenal gland pituitary gland, thyroid gland Exocrine-secretes substance through a duct leading outside the body (digestive tract, skin). Examples- sweat glands, salivary glands, mucous glands, pancreas Where are the salivary ducts located intraorally? Parotid (Stensen) duct opening > Parotid Papilla. Submandibular (Wharton) duct opening Sublingual Caruncle. Plica Sublingualis Sublingual Caruncle Parotid Papilla Sublingual duct opening - Via Duct of Bartholin → Sublingual Caruncle. OR Via smaller Ducts of Rivinus > Plica Sublingualis. Thyroid and Parathyroid glands (endocrine) Thyroid: 1.Located inferior to the larynx along the sides of the trachea. 2. Has 2 lobes, connected by an isthmus. 3. Secrets thyroxin which influences metabolic rate Parathyroid: 1. Four small glands located on the posterior aspect of the thyroid gland. 2. Secrete parathyroid hormone, which regulates calcium and phosphate levels. Thymus 1. Located in the thorax and anterior region of the base of the neck, deep to the sternum and sternohyoid and sternothyroid muscles. 2. Involved in the maturation of T-cell lymphocytes 3. Shrinks in size with age Teeth and Periodontium Commonly Involved in Clinical Presentations of Abscesses and Fistulae 1. Abscess in maxillary vestibule or palate, 2. Penetration of nasal floor 3. Abscess in nasolabial skin region 4. Penetration into maxillary sinus 5. Abscess in buccal skin region 6. Abscess in mandibular vestibule 7. Abscess in submental skin region 8. Abscess in sublingual region → Any maxillary tooth (except maxillary canines for palate) • Maxillary central incisors → Maxillary canine → Maxillary molars • Maxillary or mandibular molars → Any mandibular tooth • Mandibular incisors → Mandibular molars with short roots superior to mylohyoid Teeth/Periodontium and Spaces Possibly Involved With Various Clinical Presentations of Cellulitus Location Space Involved Teeth/Periodontium Involved Infraorbital region Zygomatic region Buccal region Buccal space Maxillary premolars, and maxillary and mandibular molars Submental region Submental space Anterior mandibular teeth Submandibular region (unilateral) Submandibular space Posterior mandibular teeth Submandibular region (bilateral) Submental, sublingual Submandibular spaces Spread of mandibular dental infection Lateral cervical region Parapharyngeal space Spread of mandibular dental infection 4 major routes 1. Spread to the paranasal sinuses 2. Spread by the vascular system 3. Spread by the Lymphatic system 4. Spread by spaces Bacteria can spread through the blood from infected dental tissues to other areas. (1) An infected thrombus (blood clot) can travel as an embolus and spread infection. (2) Transient bacteremia (presence of bacteria in the blood) can occur during dental treatment. For example, a needle advanced too far during an attempt at PSA block can penetrate the pterygoid venous plexus after being inserted through infected tissue (needle track contamination). (3) The pterygoid venous plexus drains the dental tissues and communicates with the cavernous sinus via the inferior ophthalmic vein. (4) Infections in dental tissues can initiate an inflammatory response, which can result in thrombus formation, blood stasis, and increased extravascular pressure. (5) Veins in the head do not have valves, so backflow of blood carrying pathogens into the cavernous sinus can occur. Cranial Nerve Names & Function Names: "Only One Of The Two Athletes Felt Very Good, Victorious, And Healthy" Function: "Some Say Marry Money, But My Brother Says Big Brains Matter Most" 1. Only (Some) = Olfactory (S) 2. One (Say) = Optic (S) 3. Of (Marry) = Oculomotor (M) 4. The (Money) = Trochlear (M) 5. Two (But) = Trigeminal (B) 6. Athletes (My) = Abducens (M) 7. Felt (Brother) = Facial (B) 8. Very (Says) = Vestibulocochlear (S) 9. Good (Big) = Glossopharyngeal (B) 10. Victorious (Brains) = Vagus (B) 11. And (Matter) = Accessory (M) 12. Healthy (Most) = Hypoglossal (M) Blood Branching of Carotid Arteries from Aorta Common Carotid Arteries To upper limb Subclavian artery Subclavian artery Brachiocephalic trunk Aortic arch From heart To thorax, abdomen, legs Blood Flow LAB RAT LEFT ATRIUM=BICUSPID RIGHT ATRIUM= TRICUSPID Right ABC'S THE AORTIC ARCH GIVES RISE TO -BRACIOCHEPHALIC TRUNK COMMON COROTID ARTERY SUBCLAVIAN ARTERY Left: carotid & subclavian LUNG BAGHT PULMONARY ARTERY PILNONARY WEIN TRICUSPID VALVE L E F T LUNG S U P. VENA CAVA AORTIC ARCH LEFT PULMONARY ARTERY RIGHT ATRIUM PALMONART PULMONARY ARTERY LEFT ATRIUM PULMONARY VINN PELNONARY WEIN LEFT VENTRICLE RIGHT VENTRICLE B L O O D FLOW THROUGH THE HEART MITRAL VALVE I N 2 MINUTES INF. VENA CAVA Foramina, Canals, etc. Traversed by Various Blood Vessels Vertebral artery- transverse foramina in cervical vertebrae, foramen magnum Internal carotid artery-carotid canal, foramen lacerum, groove for the internal carotid artery Maxillary artery-terminates in pterygoid fossa Posterior superior alveolar artery-posterior superior alveolar foramina Infraorbital artery-inferior orbital fissure, infraorbital groove, infraorbital canal, infraorbital foramen Sphenopalatine artery-sphenopalatine foramen, incisive canal, incisive foramen Descending palatine artery-divides into greater and lesser palatine arteries which traverse same named foramina Inferior alveolar artery-mandibular foramen, mandibular canal Mental artery-mental foramen Mylohyoid artery-mylohyoid groove Ophthalmic artery-optic canal Anterior and posterior ethmoid arteries-anterior and posterior ethmoid foramina Middle menningeal artery-foramen spinosum Internal jugular-jugular foramen EXTERNAL CAROTID ARTERY LINGUAL- → SUPRAHYOID → DORSAL LINGUAL → SUBLINGUAL → DEEP LINGUAL - TONGUE - SOFT PALATE - SUBLINGUAL SALIVARY GLAND - MUSCLES ATTACHED to HYOID ARTERIAL SUPPLY: FACIAL- - MAXILLARY (3 PARTS) → ASCENDING MANDIBULAR PART: PALATINE → INFERIOR ALVEOLAR → TONSILAR - LOWER TEETH - CHEEK → SUBMENTAL - MYLOHYOID → GLANDULAR BRANCHES MUSCULAR PART: → SUPERIOR LABIAL → MASSETERIC → - MASSETER → INFERIOR LABIAL → DEEP TEMPORAL → - TEMPORALIS PTERYGOPALATINE PART: - SOFT PALATE - PALATINE TONSIL - ROOT of TONGUE - SUBMANDIBULAR & SUBLINGUAL SALIVARY GLANDS - LIPS → DESCENDING - HARD PALATE PALATINE - SOFT PALATE → POSTERIOR SUPERIOR ALVEOLAR - PALATINE TONSIL - UPPER PREMOLAR & M O L A R S → INFRAORBITAL → - UPPER TEETH It gives off six branches before it divides into two terminating branches. They are in ascending order: • superior thyroid, • ascending pharyngeal, • lingual, • facial, • occipital, and • posterior auricular. The two terminating branches are the • maxillary and • superficial temporal arteries. Lingual artery supplies the tongue, Floor of the mouth and suprahyoid muscles. FACIAL ARTERY 1) The facial artery runs anteriorly and superiorly near the labial commissure and along the lateral side of the naris of the nose. 2) The facial artery terminates at the medial canthus of the eye. 3) Supplies the face in the oral, buccal, zygomatic, nasal, infraorbital, and orbital regions. o Cervical – Ascending Palatine, submental and tonsillar o Facial branches – Glandular (submandibular), Angular, Superior Labial & Inferior labial *Face, palate, tonsils, submandibular, stylohyoid, digastric muscles Maxillary artery Acessory middle meningeal artery Masseteric artery Middle meningeal artery Deep temporal arteries Pharyngeal artery - Artery of pterygoid canal Sphenopalatine artery Infraorbital artery Anterior superior alveolar artery Deep auricular artery Anterior tympanic artery Inferior alveolar artery Mylohyoid artery Posterior superior alveolar artery Greater palatine artery Lesser palatine arteries Buccal artery Lingual branch Incisive branches Mental artery • 1st Mandibular part • 5 branches → Retromandibular foramen • 2nd Pterygoid part • 5 branches → Infratemporal foramen • 3rd Pterygopalatine part • 6 branches → Pterygopalatine foramen Epicranial Surprise Orbicularis oculi Closing eyelid and squinting Corrugator supercilii Frowning Orbicularis oris Closing and pursing lips as well as pouting and grimacing Buccinator Compresses the cheeks during chewing Risorius Stretching lips Levator labii superiori s Raising upper lip Levator labii superiori s alaeque nasi Raising upper lip and dilating nares with sneer Zygomaticus major Smiling Zygomaticus minor Raising upper lip to assist in smiling Levator anguli oris Smiling Depressor anguli oris Frowning Depressor labii inferi oris Lowering lower lip Mentalis Raising chin protruding lower lip Platysma Raising neck skin and grimacing Class I Malocclusion •The MB cusp of the maxillary first molar occludes with the MB groove of the mandibular first molar. Facial profile as described by many clinicians with the older term mesognathic. Class II Malocclusion Class II malocclusion (distoclusion) MB cusp of the maxillary first molar occluding (by more than the width of a premolar) mesial to the MB groove of the mandibular first molar. • The older term for describing the facial profile in Class II, division I, is retrognathic. Class II Malocclusion Division I Division II • Based on the • Position of the anterior teeth. • Shape of the palate • Resulting facial profile. Class II Malocclusion Division I maxillary incisors protrude facially from the mandibular incisors causing a severe over bite (or deep bite). Upper incisors are tilted outwards, creating significant overjet. Division II Protrusive maxillary incisors, the maxillary central incisors are either upright or retruded. Upper incisors are labially inclined. Class III Malocclusion The MB cusp of the maxillary first molar occludes (by more than the width of a premolar) distal to the MB groove of the mandibular first molar. • The older term that describes the facial profile with a Class III malocclusion is prognathic.
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