Results for "Parathyroid Hormone"

Filters

Flashcards

1. Functions of Muscles: • Movement: Muscles contract to produce movement in the body, such as walking, running, or even facial expressions. • Posture and Stability: Muscles help maintain posture and stabilize joints, preventing falls or loss of balance. • Heat Production: Muscle contractions generate heat, which is vital for maintaining body temperature. • Protection of Internal Organs: Muscles, particularly in the abdominal region, protect internal organs from injury. • Circulation of Blood and Lymph: Cardiac and smooth muscles play roles in circulating blood and lymph throughout the body. 2. Characteristics of Muscles: • Excitability (Responsiveness): Muscles can respond to stimuli (like nerve signals). • Contractility: Muscles can contract or shorten when stimulated. • Extensibility: Muscles can be stretched without damage. • Elasticity: Muscles can return to their original shape after being stretched or contracted. 3. Locations of Smooth, Cardiac, and Skeletal Muscle: • Smooth Muscle: Found in walls of internal organs (e.g., stomach, intestines, blood vessels). • Cardiac Muscle: Found only in the heart. • Skeletal Muscle: Attached to bones and responsible for voluntary movements. 4. Events of Skeletal Muscle Contraction: 1. Nerve Impulse: A signal is sent from a motor neuron to the muscle. 2. Release of Acetylcholine: The neurotransmitter acetylcholine is released into the neuromuscular junction. 3. Muscle Fiber Activation: Acetylcholine stimulates muscle fibers, causing an action potential. 4. Calcium Release: The action potential triggers the release of calcium ions from the sarcoplasmic reticulum. 5. Cross-Bridge Formation: Calcium binds to troponin, moving tropomyosin, which allows myosin heads to attach to actin. 6. Power Stroke: Myosin heads pull actin filaments inward, causing the muscle to contract. 7. Relaxation: ATP breaks the cross-bridge, and the muscle relaxes when calcium is pumped back into the sarcoplasmic reticulum. 5. Isometric vs. Isotonic Contractions: • Isometric Contraction: The muscle generates tension without changing its length (e.g., holding a weight in a fixed position). • Isotonic Contraction: The muscle changes length while generating tension (e.g., lifting a weight). 6. Primary Functions of the Skeletal System: • Support: Provides structural support for the body. • Protection: Shields vital organs (e.g., brain, heart, lungs). • Movement: Works with muscles to allow movement. • Mineral Storage: Stores minerals like calcium and phosphorus. • Blood Cell Production: Bone marrow produces blood cells. • Energy Storage: Fat is stored in bone cavities. 7. Parts of a Long Bone: • Diaphysis: The shaft of the bone. • Epiphysis: The ends of the bone. • Metaphysis: Region between the diaphysis and epiphysis. • Medullary Cavity: Hollow cavity inside the diaphysis, containing bone marrow. • Periosteum: Outer membrane covering the bone. • Endosteum: Inner lining of the medullary cavity. 8. Inner and Outer Connective Tissue Linings of a Bone: • Outer: Periosteum. • Inner: Endosteum. 9. Structure of a Flat Bone: • Compact Bone: Dense bone found on the outside. • Spongy Bone: Lighter, less dense bone found inside, filled with red or yellow marrow. • No medullary cavity (unlike long bones). 10. Parts of the Osteon: • Central Canal (Haversian Canal): Contains blood vessels and nerves. • Lamellae: Concentric layers of bone matrix surrounding the central canal. • Lacunae: Small spaces containing osteocytes (bone cells). • Canaliculi: Small channels that connect lacunae and allow for nutrient exchange. 11. How Calcitonin, Calcitriol, and PTH Affect Blood Calcium: • Calcitonin: Lowers blood calcium levels by inhibiting osteoclast activity (bone resorption). • Calcitriol: Increases blood calcium by promoting calcium absorption in the intestines and bone resorption. • PTH (Parathyroid Hormone): Raises blood calcium by stimulating osteoclasts to break down bone and release calcium. 12. Two Forms of Ossification: • Intramembranous Ossification: Bone develops directly from mesenchymal tissue (e.g., flat bones of the skull). • Endochondral Ossification: Bone replaces a cartilage model (e.g., long bones). 13. Difference Between Appositional and Interstitial Growth: • Appositional Growth: Increase in bone diameter (growth at the surface). • Interstitial Growth: Increase in bone length (growth from within). 14. Different Joint Types: • Fibrous Joints: Connected by fibrous tissue (e.g., sutures of the skull). • Cartilaginous Joints: Connected by cartilage (e.g., intervertebral discs). • Synovial Joints: Have a fluid-filled joint cavity (e.g., knee, elbow). 15. Components of a Synovial Joint: • Articular Cartilage: Covers the ends of bones. • Synovial Membrane: Lines the joint capsule and produces synovial fluid. • Joint Capsule: Surrounds the joint, providing stability. • Ligaments: Connect bones to other bones. • Synovial Fluid: Lubricates the joint. 16. Hinge Joint Location: • Found in the elbow and knee. 17. Pivot Joint Location: • Found between the first and second cervical vertebrae (atlantoaxial joint). 18. Difference Between a Tendon and a Ligament: • Tendon: Connects muscle to bone. • Ligament: Connects bone to bone. 19. What is a Bursa? • A fluid-filled sac that reduces friction and cushions pressure points between the skin and bones or muscles and bones. 20. Three Types of Arthritis: • Osteoarthritis: Degeneration of joint cartilage and underlying bone, often due to wear and tear. • Rheumatoid Arthritis: Autoimmune disease causing inflammation in joints. • Gout: Caused by the accumulation of uric acid crystals in the joints. 21. Strain vs. Sprain: • A strain is damage to a muscle or tendon, whereas a sprain is damage to a ligament
Updated 53d ago
flashcards Flashcards (6)
PARATHYROID HORMONE
Updated 58d ago
flashcards Flashcards (140)
CT4-LECTURE 1- JAN 2025 OBJECTIVES Developmental Anatomy (Embryology): • Outline the stages of human growth and development, focusing on dental anatomy and root morphology. • Correlate developmental processes with hard and soft tissue formation in the oral cavity. Microscopic Anatomy: • Classify cells (cytology) and tissues (histology) based on their structure and specialization. • Evaluate the role of microscopic structures in maintaining oral health. GROSS Anatomy • Identify anatomical landmarks of the oral head and neck, including the TMJ, circulatory system, glands, and nervous system. • Describe the structures visible to the naked eye and their clinical relevance. Physiology: • Explain the functions of body systems and their integration in oral health. • Analyze the physiological processes affecting the oral cavity. 1/16/2025 3 Mitosis Meiosis One cell division Two cell division Produces two daughter cells Produces Four daughter cells Produces diploid cells Produces haploid cells Daughter cells are genetically identical Daughter cells are non- identical Produces body cells Produces sex cells • Mitosis and meiosis are both types of cell division. • Mitosis is how new body cells are produced, whereas meiosis is used to produce gametes (i.e. sperm and egg cells). first week Spermatozoa + Oocyte = Zygote (12-24hrs.) Cell division via mitosis = Cleavage 1st solid ball called Morulla Inside Morulla secretion of fluids becomes blastocyte (5days) Blastocyte has 2 regeions Trophoblast(peripheral cells) & Embryoblast layer(inner mass) CLINICAL CONSIDERATIONS FOR PREIMPLANTATION PERIOD •If any disturbances occur in meiosis during fertilization, major congenital malformations result from the chromosomal abnormality in around 10% of cases. •A syndrome is a group of specific signs and symptoms. PREIMPLANTATION PERIOD • After a week of cleavage, the blastocyst consists of a layer of peripheral cells, the trophoblast layer, and a small inner mass of embryonic cells or embryoblast layer. • The trophoblast layer later gives rise to important prenatal support tissue while the embryoblast layer later gives rise to the embryo. SECOND WEEK • A bilaminar embryonic disc • The superior epiblast layer is composed of high columnar cells. • The inferior hypoblast layer is composed of small cuboidal cells. THIRD WEEK • Primitive streak (rod shaped thickening) forms a bilateral symmetry within the bilaminar embryonic disc. • Some cells from the epiblast layer move or migrate toward the hypoblast layer only in the area of the primitive streak and become • Mesoderm, an embryonic connective tissue, and embryonic endoderm. END OF THIRD WEEK • With three layers present, the bilaminar disc has thickened into a trilaminar embryonic disc. • The epiblast layer is now considered ectoderm. • 3 germ layers • Ectoderm-becomes skin, nervous system, and neural crest cells. • Mesoderm-Becomes muscles, bones, blood, and connective tissues. • Endoderm-Forms internal organs like the digestive and respiratory systems. 1/16/2025 10 Neural Crest Cells & Mesenchymal Transition(dental tissue) • Neural crest cells are derived from the ectoderm during neurulation (around weeks 3-4). • NCC migrate and undergo epithelial-to-mesenchymal transition (EMT), becoming highly migratory mesenchymal cells. • They contribute to the formation of facial bones, cartilage, peripheral nerves, and parts of the heart. 1/16/2025 11 Embryonic Period: Physiological Process(changes in structure &function) • INDUCE, PROLIFERATE, DIFFERENTIATE AND MORPH, DON’T WAIT! MATURE AND GROW, IT’S YOUR FATE!" 1. Induction The process where one group of cells influences another to differentiate into a specific tissue or organ. 2. Proliferation Rapid cell division, increasing the number of cells. 3. Differentiation(Cyto, Histo, Morpho) Cells specialize to perform specific functions. 4. Morphogenesis The development of the overall shape and structure of tissues and organs. 5. Maturation The final stage where tissues and organs reach their fully functional form. 1/16/2025 12 Facial Development  The facial development that starts in the fourth week of the embryonic period will be completed later in the twelfth week within the fetal period.  At the fourth week, the developing brain, face, and heart are noted. 1/16/2025 13 • All three embryonic layers are involved in facial development: the ectoderm, mesoderm, and endoderm. • The upper part of the face is derived from the frontonasal process, the midface from the maxillary processes, and the lower from the mandibular processes. Early development of the face is also dominated by the proliferation and migration of ectomesenchyme, derived from neural crest cells (NCCs). Facial Development 1/16/2025 14 Stomodeum and Oral Cavity Formation With this disintegration of the membrane, the primitive mouth is increased in depth and enlarges in width across the surface of the midface. Nose and Paranasal Sinus Formation Apparatus Formation  First branchial/ pharyngeal arch also known as the mandibular arch and its associated tissue, includes Meckel cartilage.  Supplied by Trigeminal nerves Apparatus Formation  Second branchial/pharyngeal arch, which is also known as the hyoid arch, is cartilage like that of the mandibular arch, Reichert cartilage. Apparatus Formation  Third branchial/ pharyngeal arch  Has an unnamed cartilage associa ted with it. This cartilage will be responsible for forming parts of the hyoid bone. Apparatus Formation  Both the fourth and the sixth branchial /pharyngeal arch also have unnamed cartilage associated with them, they fuse and form most of the laryngeal cartilages. 1/16/2025 20 TOOTH DEVELOPMENT: INITIATION STAGE Stages of Tooth Development: I Bought Candy Bars After Midnight." I → Initiation Bought → Bud Candy → Cap Bars → Bell After → Apposition Midnight → Maturation 1/16/2025 23 1. Initiation Stage (Week 6-7): • Dental placodes form as localized thickenings of oral ectoderm. • Interaction with neural crest cells induces the formation of the tooth germ. 2. Bud Stage (Week 8): • The enamel organ invaginates into the underlying mesenchyme, creating a tooth bud. 3. Cap Stage (Week 9-10): • The enamel organ forms a cap-like structure over the dental papilla. 4. Bell Stage (Week 11-12): • Cells differentiate into ameloblasts (enamel-forming cells) and odontoblasts (dentin-forming cells). 5. Apposition and Maturation: • Enamel, dentin, and cementum are laid down and mineralized. 1/16/2025 25 • Dental Epithelium → Enamel Organ Enamel organ arises from the dental epithelium and forms ameloblasts, the cells responsible for producing enamel, the hardest substance in the body. Dental Mesenchyme → Dental Papilla Dental papilla forms from the mesenchyme and gives rise to: • Dentin -Odontoblasts: Cells that produce dentin (the layer beneath enamel). • Pulp: The soft, living core of the tooth, containing nerves and blood vessels. • Root Dentin: The dentin in the root of the tooth. Dental Follicle • Surrounds the developing tooth and forms: • Cementum: A calcified tissue covering the root of the tooth, anchoring it to the jaw. • Periodontal Ligament: Connective tissue fibers that hold the tooth in its socket and absorb chewing forces. Teeth w e a r c a n b e t r e a t e d A t t r i t i o n Abrasion Abfraction E r o s i o n Hunter-Schreger bands (HSB). • Hunter-Schreger bands (HSB): • Dark and light bands due to curvature or bends of the rods. • increasing the enamel’s strength. • Near the cusps or incisal ridges, where the enamel is the thickest Celiac Disease ˜ Dental enamel problems stemming from celiac disease involve permanent dentition and include tooth discoloration—white, yellow, or brown spots on the teeth—poor enamel formation, pitting or banding of teeth, and mottled or translucent-looking teeth. ˜ The imperfections are symmetrical and often appear on the incisors and molars. ˜ Tooth defects that result from celiac disease may resemble those caused by too much fluoride or a maternal or early childhood illness 1/16/2025 29 ROOT DEVELOPMENT  The process of root development takes place long after the crown is completely shaped, and the tooth is starting to erupt into the oral cavity.  The structure responsible for root development is the cervical loop.  The cervical loop is the most cervical part of the enamel organ, a bilayer rim that consists of only inner enamel epithelium (IEE) and outer enamel epithelium (OEE). ROOT DEVELOPMENT  To form the root region, the cervical loop begins to grow deeper into the surrounding ectomesenchyme of the dental sac, elongating and moving away from the newly completed crown area to enclose more of the dental papilla tissue, forming the Hertwig epithelial root sheath (HERS). Thus, HERS will determine if the root will be curved or straight, short or long as well as single or multiple. 1/16/2025 33 • Cervical Loop Formation ▪ The cervical loop, located at the junction of the enamel organ and the crown, elongates to form Hertwig’s Epithelial Root Sheath (HERS). ▪ HERS determines the shape, length, and number of roots. • Root Dentin Formation ▪ Inner cells of HERS induce adjacent dental papilla cells to differentiate into odontoblasts, which form root dentin. ▪ Once dentin is deposited, HERS disintegrates. • Epithelial Rests of Malassez ▪ After HERS disintegrates, remnants form clusters called epithelial rests of Malassez in the periodontal ligament. ▪ These remnants can sometimes form cysts later in life. PRIMARY DENTITION PROPERTIES  The actual dates are not as important as the eruption sequence, because there can be a great deal of variation in the actual dates of eruption.  However, the sequence tends to be uniform. Enamel Histology • Enamel tufts: Hypomineralized, Located at the dentino-enamel junction and filled with organic material. Forms between groups of enamel rods at the dentino-enamel junction. • Enamel lamellae are partially mineralized vertical sheets of enamel matrix that extend from the DEJ near the tooth’s cervix to the outer occlusal surface. Transverse section of enamel showing enamel tufts (white arrow) and enamel lamella (black arrow). Dentin Matrix Formation DENTINOGENESIS LPROCESS o$ CREATING DENTIN PRIMARY TEETH _ 14th WEEK of FETAL DEVELOPMENT PERMANENT TEETH L 3 MONTHS AFTER -PROCESS HAPPENS SLOWLY PERFORMED by ODONTOBLASTS —OUTSIDE INWARDS - BEGINS with MANTLE DENTIN ODONTOBLASTS -PREDENTIN -SOFT ORGANIC MATRIX -PROTEINS FIBROBLASTS -KORFF'S FIBERS -THICK COLLAGEN FIBERS -FRAMEWORK of DENTINOGENESIS 1/16/2025 39 Principal Fibers Protect, Gingival Fibers Guard." •Principal → Protection and anchorage of the tooth. •Gingival → Guard and stabilize gingiva. 1/16/2025 40 Principle Fibers "All Hungry Octopuses Appreciate Ice cream!" •All → Alveolar Crest •Hungry → Horizontal •Octopuses → Oblique •Appreciate → Apical •Ice cream → Interradicular 1/16/2025 41 Gingival Fiber : "Dentists Always Care Deeply for Teeth!" •Dentogingival •Alveologingival •Circular •Dentoperiosteal •Transseptal 1/16/2025 42 Primary (Deciduous) Teeth Eruption "Children Like Fruit Candy More" •C → Central Incisors •L → Lateral Incisors •F → First Molars •C → Canines •M → Second Molars CELL ORGANELLES SKIN ANATOMY COME, LET'S GET SOME BREAD" C ORNEUM (OUTER), L UCIDUM, G RANULOSUM, S PINOSUM, B ASALE. • Corneum - tough and protective. • Lucidum - clear layer (found only in thick skin like palms/soles). • Granulosum - cells with granules for keratinization. • Spinosum - "spiny" cells, providing strength and flexibility. • Basale - base layer where cell division happens. 1/16/2025 45 1/16/2025 46 Tooth Designation ∙ Commonly used in orthodontics, is the Palmer Notation Method, also known as the Military Tooth Numbering System. ∙ In this system, the teeth are designated from each other with a right-angle symbol indicating the quadrants and arch, with the tooth number placed inside. 1/16/2025 47 Mixed Dentition Period ∙ The mixed dentition period follows the primary dentition period. ∙ This period occurs between approximately 6 and 12 years of age. ∙ Both primary and permanent teeth are present during this transitional stage. ∙ The final dentition period is the permanent dentition period. ∙ This period begins with shedding of the last primary tooth. 1/16/2025 48 General Dental Terms •Each dental arch can be further divided into two quadrants, with four quadrants in the entire oral cavity. • The correct sequence of words when describing an individual tooth using a D-A-Q-T System is based on the tooth within its quadrant: D for dentition, A for arch, Q for quadrant, and T for tooth type. • Sextants: three parts according to the relationship to the midline: right posterior sextant, anterior sextant, and left posterior sextant. 1/16/2025 49 Root Axis Line (RAL) ∙ Root axis line (RAL), which is an imaginary line representing the long axis of a tooth, drawn in a way to bisect the root (and thus the crown) in the cervical area into two halves. 1/16/2025 50 Restorations: Biologic Width ∙ Biologic width is the distance established by the junctional epithelium and lamina propria attachment to the root surface of a tooth. ∙ This distance is important to consider when fabricating dental restorations, because they must respect the natural architecture of the gingival attachment if harmful consequences are to be avoided. ∙ Assessment for biologic width can be made clinically by measuring the distance between the bone and the restoration margin using a periodontal probe. 1/16/2025 51 PRIMARY DENTITION 1/16/2025 52 1/16/2025 53 Eruption 1/16/2025 54 1/16/2025 55 1/16/2025 56 Differences-(Enamel depth/pulp) 1/16/2025 57 Differences: Roots 1/16/2025 58 Importance of Primary teeth - PRIMATE Space 1/16/2025 59 Leeway Space 1/16/2025 Primary Occlusion 60 •Majority of children have Mesial step between distal of Primary 2nd molars. Mandibular 2nd molars are situated mesially than maxillary. •A smaller but still large group of children exhibit a flush terminal plane. The distal surfaces of the primary 2nd molars are even with each other. •A still smaller minority have a distal step. The mandibular 2nd molars are situated more distally than their maxillary counterparts. Thus, they form a distal step. 1/16/2025 Anatomy of Primary teeth 61 Incisors: resemble the outline of permanent counterpart except Primary do not have mamelons on the incisal ridge and there are no pits on the lingual surface. 1/16/2025 Primary Canines 62 Canines- resemble the outline of their permanent counterparts. The maxillary canine has a sharp cusp and appears especially wide and short. Maxillary Central and Lateral Incisors Central Incisors: • Larger overall; they are the widest teeth mesiodistally in the anterior maxillary arch. • Crown is more symmetrical and fan (mesiodistally wider compared to incisocervical length). • Lingual fossa is less pronounced. • Cingulum is well-developed and centered. • Root is shorter and more conical, with a blunt apex. • Rarely exhibit significant variation. Lateral Incisors: • Smaller and narrower mesiodistally than the central incisors. • Crown is less symmetrical and more rounded. • Lingual fossa is deeper, with more pronounced marginal ridges. • Cingulum is narrower and often slightly off-center to the distal. • Root is longer and thinner, with a more pointed apex. • Frequently display developmental variations (e.g., peg-shaped lateral incisors, congenitally missing). 1/16/2025 66 1/16/2025 67 1/16/2025 68 1/16/2025 69 CLASSIC TRAITS ➢ From the occlusal view, molar crowns taper from the buccal to the lingual EXCEPT for maxillary 1st molars. ➢ From the occlusal view, molar crowns taper distally; this allows more of the occlusal surface to be visible from the distal aspect than the mesial. ➢Maxillary molars have 3 roots: MB, DB, and lingual (palatal). The lingual root is usually the longest and the DB is the shortest. ➢ Mandibular molars have 2 roots: a long mesial root and a slightly shorter distal root. ➢ The root furcation on mandibular molars is close to the cervical line, making the root trunk shorter than on the maxillary molars. MAJOR AND MINOR CUSPS ➢In general, each cusp is formed from its own lobe. ➢Major cusps are large and well developed. ➢Minor cusps are less developed and have smaller proportions. They are less functional than the major cusps and may not always be present. ➢Supplementary cusp is very small and completely afunctional. They are rarely present. 1/16/2025 72 ➢First molars are the most highly developed and largest of the molars and more likely to have major, minor and supplementary cusps. ➢Both the 1st and 2nd maxillary molars have 4 major cusps but only 2 are visible from the buccal view. ➢The longest of the 4 major cusps are the ML, followed by the MB, DB, and the shortest DL (if present). 1/16/2025 73 • Molars (general: crowns larger, squarer, bear more cusps than any other tooth class, have multiple roots, 3rd molars sometimes mistaken for premolars) • Generally speaking, the maxilla molars go from largest to smallest (1st molar to 3rd molar) in size and morphology. The crowns generally have 4 cusps. • The 1st molar has three roots (two buccal and one lingual, which when seen from the buccal position the lingual root comes into view in the middle of the two buccal roots). The occlusal surface is described as a rhomboid in shape with 4 distinctive cusps. • Oblique ridge max molars only and transverse ridge one on max 2 on mandibular. • The 2nd molar has three roots but the two buccal roots are nearly parallel with each other and is described as heart shape in the occlusal view. • The 3rd molar has three roots present but the two buccal roots are often fused, and the outline of the occlusal surface is also described as a heart shape. The 3rd molar also shows greater developmental variation than either the 1st or • 3rd molars are often the tooth that is congenitally missing. All roots of the molars angle distally with respect to the major crown axes (White & Folkens 2005: 152). 1/16/2025 74 1/16/2025 75 Joint Movement ˜ Two basic types of movement of the mandible are performed by the TMJ and its associated muscles of mastication: ˜ a gliding movement and ˜ a rotational movement. 1/16/2025 76 • The muscles of mastication include the • Temporalis, • And Masseter, • Pterygoid muscles, medial and lateral. • These muscles are involved in mastication using these two movements. 1/16/2025 77 1/16/2025 78 TMD: Acute Episode • Trismus or the inability to normally open the mouth. • When the patient tries to close and elevate the mandible, the condylar heads cannot move posteriorly because both the bony relationships prevent this, and the muscles have become spastic. 1/16/2025 79 Overjet • Overjet is measured in millimeters with the tip of a periodontal probe, once a patient is in CO. • The probe is placed at 90°or at a right angle to the labial surface of a mandibular incisor at the base of the incisal ridge of a maxillary incisor. 1/16/2025 80 • Overbite is measured in millimeters with the tip of a periodontal probe after a patient is placed in CO. • The probe is placed on the incisal edge of the maxillary incisor at 90º or at a right angle to the mandibular incisor. • When the reverse is the case and the mandibular arch and its incisors extends beyond the maxillary arch and its incisors, it is causes an underbite. 1/16/2025 81 Lymph Nodes • The lymph flows (arrows) into the lymph node through many afferent vessels. (A is first comes in) • On one side of the node is a depression, or hilus, where the lymph through fewer vessels, or even a single efferent vessel. (E is Exit) • Primary or Secondary. • Region drains into primary nodes. • Primary nodes, in turn, drain into secondary nodes (or central nodes). Lymphatics: General Drainage pattern of body Right jugular trunk Left jugular trunk Enters venous system near junction of left subclavian vein and left internal jugular Thoracic duct Left side of head, neck, thorax, entire abdomen, pelvis, lower extremities Enters venous system near junction of right subclavian vein and right internal jugular Right side of head, neck, thorax *Lymphatic vessels are small and directly drain tissues and connect lymph nodes. *Lymphatic ducts are much larger, receive lymph from many lymphatic vessels, and drain into the venous system. 1/16/2025 83 Superficial Lymph Nodes of the Head (five categories) 1. Facial; lie along facial vein. 2 Superficial Parotid; superficial to parotid gland. 3. Anterior Auricular; anterior to external auditory meatus. 4. Posterior Auricular; posterior to external auditory meatus. 5. Occipital; lie in the occipital region. *Tissue drainage: buccal mucosa, skin of zygomatic and infraorbital regions, scalp, external ear, lacrimal gland Deep Lymph Nodes of Head (two categories) 1. Deep Parotid; lie deep in the parotid gland, superficial to the masseter muscle 2. Retropharyngeal; posterior to the pharynx at the level of the atlas (first cervical vertebrae). *Tissue drainage: parotid gland, paranasal sinuses, hard and soft palate, middle ear Superficial Cervical Lymph Nodes (4 categories) 1. Submental; inferior to the chin in the submental space. 2. Submandibular; along the inferior border of the mandible, superficial to the submandibular salivary gland 3. External Jugular; along the external jugular vein, superficial to the sternocleidomastoid muscle. 4. Anterior Jugular; along the anterior jugular vein, anterior to the sternocleidomastoid muscle. Tissue drainage: 1.Submental and submandibular; teeth and related tissues, apex and body of tongue, anterior hard palate, floor of mouth, lips, chin, sub- mandibular and sublingual glands, cheeks. 2. External and anterior jugular; superficial tissues in the anterior and posterior triangles. Deep Cervical Lymph Nodes (2 categories) 1. Superior Deep Cervical; lie along internal jugular vein, superior to the omohyoid muscle. *Jugulo-digastric- becomes enlarged when a palatine tonsil or the pharynx is involved in infection. 2. Inferior Deep Cervical; lie along internal jugular vein, inferior to the omohyoid muscle. *Jugulo-omohyoid-drains the submental region and base of the tongue. Additional Deep Cervical Nodes 1. Accessory; lie along accessory nerve 2. Subclavicular; lie along clavicle. *Tissue drainage: mostly secondary nodes 1/16/2025 88 Sequence of lymph nodes draining various tissues Most of face, scalp, ear, orbit, sinuses, nasal cavities Most maxillary and mandibular teeth and associated tissues, apex and body of tongue, floor of mouth, sublingual and submandibular glands, lips Maxillary third molars and associated tissues, base of tongue, pharynx, tonsils Tissue Primary nodes Secondary nodes Submental and submandibular nodes Facial, anterior auricular, retroauricular, occipital superficial and deep parotid, and retropharyngeal nodes Submandibular, deep cervical nodes Retropharyngeal, deep cervical nodes Neck and cervical viscera Superficial and deep cervical nodes Right jugular trunk Right subclavian vein Left jugular trunk Left subclavian vein Thoracic duct Endocrine-secrete substance into blood, examples-adrenal gland pituitary gland, thyroid gland Exocrine-secretes substance through a duct leading outside the body (digestive tract, skin). Examples- sweat glands, salivary glands, mucous glands, pancreas Where are the salivary ducts located intraorally? Parotid (Stensen) duct opening > Parotid Papilla. Submandibular (Wharton) duct opening Sublingual Caruncle. Plica Sublingualis Sublingual Caruncle Parotid Papilla Sublingual duct opening - Via Duct of Bartholin → Sublingual Caruncle. OR Via smaller Ducts of Rivinus > Plica Sublingualis. Thyroid and Parathyroid glands (endocrine) Thyroid: 1.Located inferior to the larynx along the sides of the trachea. 2. Has 2 lobes, connected by an isthmus. 3. Secrets thyroxin which influences metabolic rate Parathyroid: 1. Four small glands located on the posterior aspect of the thyroid gland. 2. Secrete parathyroid hormone, which regulates calcium and phosphate levels. Thymus 1. Located in the thorax and anterior region of the base of the neck, deep to the sternum and sternohyoid and sternothyroid muscles. 2. Involved in the maturation of T-cell lymphocytes 3. Shrinks in size with age Teeth and Periodontium Commonly Involved in Clinical Presentations of Abscesses and Fistulae 1. Abscess in maxillary vestibule or palate, 2. Penetration of nasal floor 3. Abscess in nasolabial skin region 4. Penetration into maxillary sinus 5. Abscess in buccal skin region 6. Abscess in mandibular vestibule 7. Abscess in submental skin region 8. Abscess in sublingual region → Any maxillary tooth (except maxillary canines for palate) • Maxillary central incisors → Maxillary canine → Maxillary molars • Maxillary or mandibular molars → Any mandibular tooth • Mandibular incisors → Mandibular molars with short roots superior to mylohyoid Teeth/Periodontium and Spaces Possibly Involved With Various Clinical Presentations of Cellulitus Location Space Involved Teeth/Periodontium Involved Infraorbital region Zygomatic region Buccal region Buccal space Maxillary premolars, and maxillary and mandibular molars Submental region Submental space Anterior mandibular teeth Submandibular region (unilateral) Submandibular space Posterior mandibular teeth Submandibular region (bilateral) Submental, sublingual Submandibular spaces Spread of mandibular dental infection Lateral cervical region Parapharyngeal space Spread of mandibular dental infection 4 major routes 1. Spread to the paranasal sinuses 2. Spread by the vascular system 3. Spread by the Lymphatic system 4. Spread by spaces Bacteria can spread through the blood from infected dental tissues to other areas. (1) An infected thrombus (blood clot) can travel as an embolus and spread infection. (2) Transient bacteremia (presence of bacteria in the blood) can occur during dental treatment. For example, a needle advanced too far during an attempt at PSA block can penetrate the pterygoid venous plexus after being inserted through infected tissue (needle track contamination). (3) The pterygoid venous plexus drains the dental tissues and communicates with the cavernous sinus via the inferior ophthalmic vein. (4) Infections in dental tissues can initiate an inflammatory response, which can result in thrombus formation, blood stasis, and increased extravascular pressure. (5) Veins in the head do not have valves, so backflow of blood carrying pathogens into the cavernous sinus can occur. Cranial Nerve Names & Function Names: "Only One Of The Two Athletes Felt Very Good, Victorious, And Healthy" Function: "Some Say Marry Money, But My Brother Says Big Brains Matter Most" 1. Only (Some) = Olfactory (S) 2. One (Say) = Optic (S) 3. Of (Marry) = Oculomotor (M) 4. The (Money) = Trochlear (M) 5. Two (But) = Trigeminal (B) 6. Athletes (My) = Abducens (M) 7. Felt (Brother) = Facial (B) 8. Very (Says) = Vestibulocochlear (S) 9. Good (Big) = Glossopharyngeal (B) 10. Victorious (Brains) = Vagus (B) 11. And (Matter) = Accessory (M) 12. Healthy (Most) = Hypoglossal (M) Blood Branching of Carotid Arteries from Aorta Common Carotid Arteries To upper limb Subclavian artery Subclavian artery Brachiocephalic trunk Aortic arch From heart To thorax, abdomen, legs Blood Flow LAB RAT LEFT ATRIUM=BICUSPID RIGHT ATRIUM= TRICUSPID Right ABC'S THE AORTIC ARCH GIVES RISE TO -BRACIOCHEPHALIC TRUNK COMMON COROTID ARTERY SUBCLAVIAN ARTERY Left: carotid & subclavian LUNG BAGHT PULMONARY ARTERY PILNONARY WEIN TRICUSPID VALVE L E F T LUNG S U P. VENA CAVA AORTIC ARCH LEFT PULMONARY ARTERY RIGHT ATRIUM PALMONART PULMONARY ARTERY LEFT ATRIUM PULMONARY VINN PELNONARY WEIN LEFT VENTRICLE RIGHT VENTRICLE B L O O D FLOW THROUGH THE HEART MITRAL VALVE I N 2 MINUTES INF. VENA CAVA Foramina, Canals, etc. Traversed by Various Blood Vessels Vertebral artery- transverse foramina in cervical vertebrae, foramen magnum Internal carotid artery-carotid canal, foramen lacerum, groove for the internal carotid artery Maxillary artery-terminates in pterygoid fossa Posterior superior alveolar artery-posterior superior alveolar foramina Infraorbital artery-inferior orbital fissure, infraorbital groove, infraorbital canal, infraorbital foramen Sphenopalatine artery-sphenopalatine foramen, incisive canal, incisive foramen Descending palatine artery-divides into greater and lesser palatine arteries which traverse same named foramina Inferior alveolar artery-mandibular foramen, mandibular canal Mental artery-mental foramen Mylohyoid artery-mylohyoid groove Ophthalmic artery-optic canal Anterior and posterior ethmoid arteries-anterior and posterior ethmoid foramina Middle menningeal artery-foramen spinosum Internal jugular-jugular foramen EXTERNAL CAROTID ARTERY LINGUAL- → SUPRAHYOID → DORSAL LINGUAL → SUBLINGUAL → DEEP LINGUAL - TONGUE - SOFT PALATE - SUBLINGUAL SALIVARY GLAND - MUSCLES ATTACHED to HYOID ARTERIAL SUPPLY: FACIAL- - MAXILLARY (3 PARTS) → ASCENDING MANDIBULAR PART: PALATINE → INFERIOR ALVEOLAR → TONSILAR - LOWER TEETH - CHEEK → SUBMENTAL - MYLOHYOID → GLANDULAR BRANCHES MUSCULAR PART: → SUPERIOR LABIAL → MASSETERIC → - MASSETER → INFERIOR LABIAL → DEEP TEMPORAL → - TEMPORALIS PTERYGOPALATINE PART: - SOFT PALATE - PALATINE TONSIL - ROOT of TONGUE - SUBMANDIBULAR & SUBLINGUAL SALIVARY GLANDS - LIPS → DESCENDING - HARD PALATE PALATINE - SOFT PALATE → POSTERIOR SUPERIOR ALVEOLAR - PALATINE TONSIL - UPPER PREMOLAR & M O L A R S → INFRAORBITAL → - UPPER TEETH It gives off six branches before it divides into two terminating branches. They are in ascending order: • superior thyroid, • ascending pharyngeal, • lingual, • facial, • occipital, and • posterior auricular. The two terminating branches are the • maxillary and • superficial temporal arteries. Lingual artery supplies the tongue, Floor of the mouth and suprahyoid muscles. FACIAL ARTERY 1) The facial artery runs anteriorly and superiorly near the labial commissure and along the lateral side of the naris of the nose. 2) The facial artery terminates at the medial canthus of the eye. 3) Supplies the face in the oral, buccal, zygomatic, nasal, infraorbital, and orbital regions. o Cervical – Ascending Palatine, submental and tonsillar o Facial branches – Glandular (submandibular), Angular, Superior Labial & Inferior labial *Face, palate, tonsils, submandibular, stylohyoid, digastric muscles Maxillary artery Acessory middle meningeal artery Masseteric artery Middle meningeal artery Deep temporal arteries Pharyngeal artery - Artery of pterygoid canal Sphenopalatine artery Infraorbital artery Anterior superior alveolar artery Deep auricular artery Anterior tympanic artery Inferior alveolar artery Mylohyoid artery Posterior superior alveolar artery Greater palatine artery Lesser palatine arteries Buccal artery Lingual branch Incisive branches Mental artery • 1st Mandibular part • 5 branches → Retromandibular foramen • 2nd Pterygoid part • 5 branches → Infratemporal foramen • 3rd Pterygopalatine part • 6 branches → Pterygopalatine foramen Epicranial Surprise Orbicularis oculi Closing eyelid and squinting Corrugator supercilii Frowning Orbicularis oris Closing and pursing lips as well as pouting and grimacing Buccinator Compresses the cheeks during chewing Risorius Stretching lips Levator labii superiori s Raising upper lip Levator labii superiori s alaeque nasi Raising upper lip and dilating nares with sneer Zygomaticus major Smiling Zygomaticus minor Raising upper lip to assist in smiling Levator anguli oris Smiling Depressor anguli oris Frowning Depressor labii inferi oris Lowering lower lip Mentalis Raising chin protruding lower lip Platysma Raising neck skin and grimacing Class I Malocclusion •The MB cusp of the maxillary first molar occludes with the MB groove of the mandibular first molar. Facial profile as described by many clinicians with the older term mesognathic. Class II Malocclusion Class II malocclusion (distoclusion) MB cusp of the maxillary first molar occluding (by more than the width of a premolar) mesial to the MB groove of the mandibular first molar. • The older term for describing the facial profile in Class II, division I, is retrognathic. Class II Malocclusion Division I Division II • Based on the • Position of the anterior teeth. • Shape of the palate • Resulting facial profile. Class II Malocclusion Division I maxillary incisors protrude facially from the mandibular incisors causing a severe over bite (or deep bite). Upper incisors are tilted outwards, creating significant overjet. Division II Protrusive maxillary incisors, the maxillary central incisors are either upright or retruded. Upper incisors are labially inclined. Class III Malocclusion The MB cusp of the maxillary first molar occludes (by more than the width of a premolar) distal to the MB groove of the mandibular first molar. • The older term that describes the facial profile with a Class III malocclusion is prognathic.
Updated 102d ago
flashcards Flashcards (7)
Negative and Positive Feedback Loops Control hormone levelsNegative feedback loopHormone release stops in response to decrease in stimulus- Stimulus (eating) raises blood glucose levels- Pancreas releases insulin in response to elevated blood   glucose- Blood glucose decreases as it is used by the body or  stored in the liver - Insulin release stops as blood glucose levels normalize Positive feedback loop As long as stimulus is present, action of hormone continues- Infant nursing at mother’s breast→stimulates  hypothalamus→stimulates posterior pituitary- Oxytocin released→stimulates milk production  and ejection from mammary glands- Milk release continues as long as infant  continues to nurse The Major Endocrine OrgansThe major endocrine organs of the body include: the pituitary, pineal, thyroid, parathyroid, thymus, and adrenal glands, pancreas, and gonads (ovaries and testes)Endocrine glands - Ductless - Release hormones - Directly into target tissues - Into bloodstream to be carried to target tissuesHormones(Greek word hormone – to set into motion)     Pituitary Gland and Hypothalamus o The pituitary gland is approximately the size of a pea. o It hangs by a stalk from the inferior surface of the hypothalamus of the brain, where it is snugly surrounded by the sella turcica of the sphenoid bone. o It has two functional lobes – the anterior pituitary (glandular tissue) and the posterior pituitary (nervous tissue). o The anterior pituitary gland controls the activity of so many other endocrine glands (“master endocrine gland”) o The release of each of its hormones is controlled by releasing hormones and inhibiting hormones produced by the hypothalamus. o The hypothalamus also makes two additional hormones, oxytocinand antidiuretic hormone, which are transported along the axons of the hypothalamic nuerosecretory cells to the posterior pituitary for storage. They are later released into the blood in response to nerve impulses from the hypothalamus. Oxytocin o Is released in significant amounts only during childbirth and nursing. o It stimulates powerful contractions of the uterine muscle during sexual relations, during labor, and during breastfeeding. o It also causes milk ejection (let-down reflex) in a nursing woman. Antidiuretic Hormone (ADH) o ADH is a chemical that inhibits or prevents urine production. o ADH causes the kidneys to reabsorb more water from the forming urine; as a result, urine volume decreases, and blood volume increases. o In larger amounts, ADH also increases blood pressure by causing constriction of the arterioles (small arteries). For this reason, it is sometimes referred to as vasopressin. Anterior Pituitary HormonesThe anterior pituitary produces several hormones that affect many body organs. Growth Hormone (GH) o Its major effects are directed to the growth of skeletal muscles and long bones of the body o At the same time, it causes fats to be broken down and used for energy while it spares glucose, helping to maintain blood sugar homeostasis. ProlactinIts only known target in humans is the breast.After childbirth, it stimulates and maintains milk production by the mother’s breasts.Gonadotropic Hormones (FSH and LH) o Regulate the hormonal activity of the gonads (ovaries and testes) o In women, the FSH stimulates follicle development in the ovaries. o In men, FSH stimulates sperm production by the testes. o LH triggers ovulation of an egg from the ovary and causes the ruptured follicle to produce progesterone and some estrogen. o LH stimulates testosterone production by the interstitial cells of the testes. Pineal Gland The pineal gland is a small, cone-shaped gland that hangs from the roof of the third ventricle of the brain. Melatonin o The only hormone secreted from pineal gland in substantial amounts o Believed to be a “sleep trigger” that plays an important role in establishing the body’s sleep-wake cycle. o The level of melatonin rises and falls during the course of the day and night. o The peak level occurs at night and makes us drowsy o The lowest level occurs during daylight around noon. Thyroid Gland • The thyroid gland is located at the base of the throat, just inferior to the Adam’s apple. • It is a fairly large gland consisting of two lobes joined by a central mass, or isthmus. • The thyroid gland makes two hormones, one called thyroid hormone, the other called calcitonin. Thyroid Hormone o Referred to as body’s major metabolic hormone o Contains two active iodine-containing hormones, thyroxine (T4)and thriiodothyronine (T3) o Most triiodothyronine is formed at the target tissues by conversion of thyronine to triiodothyronine o Thyroid hormone controls the rate at which glucose is “burned”, or oxidized, and converted to body heat and chemical energy (ATP). o Thyroid hormone is also important for normal tissue growth and development, especially in the reproductive and nervous systems. Homeostatic Imbalance ➢ Without iodine, functional thyroid hormones cannot be made. ➢ The source of iodine is our diet (seafoods) ➢ Goiter is an enlargement of the thyroid gland that results when the diet is deficient in iodine. Hyposecretion of thyroxine may indicate problems other than iodine deficiency. If it occurs in early childhood, the result is cretinism. ▪ Results in dwarfism and mental retardation (if discovered early, hormone replacement will prevent mental impairment) Hypothyroidism occurring in adults results in myxedema ▪ Characterized by both physical and mental sluggishness (no mental impairment) ▪ Other signs are puffiness of the face, fatigue, poor muscle tone, low body temperature, obesity, and dry skin (Oral thyroxine is prescribed to treat this condition)   ➢ Hyperthyroidism generally results from a tumor of the thyroid gland. ➢ Extreme overproduction of thyroxine results in a high basal metabolic rate, intolerance of heat, rapid heartbeat, weight loss, nervous and agitated behavior, and a general inability to relax. Graves’ disease o A form of hyperthyroidism o The thyroid gland enlarges, the eyes bulge (exophthalmos) Calcitonin ➢ Second important hormone product of the thyroid gland ➢ Decreases the blood calcium ion level by causing calcium to be deposited in the bones Parathyroid Glands ➢ The parathyroid glands are tiny masses of glandular tissue most often on the posterior surface of the thyroid gland. ➢ Parathyroid hormone (PTH) is the most important regulator of calcium ion homeostasis of the blood. ➢ Although the skeleton is the major PTH target, PTH also stimulates the kidneys and intestine to absorb more calcium ions. Homeostatic Imbalance o If blood calcium ion level falls too low, neurons become extremely irritable and overactive. They deliver impulses to the muscles so rapidly that the muscles go into uncontrollable spasms (tetany), which may be fatal. o Severe hyperparathyroidism causes massive bone destruction. The bones become very fragile, and spontaneous fractures begin to occur. Thymus o Is located in the upper thorax, posterior to the sternum. o Large in infants and children, it decreases in size throughout adulthood. o By old age, it is composed mostly of fibrous connective tissue and fat. o The thymus produces a hormone called thymosin and others that appear to be essential for normal development of a special group of white blood cells (T lymphocytes) and the immune response. Adrenal Glands o The two adrenal glands curve over the top of the kidneys like triangular hats. o It is structurally and functionally two endocrine organs in one.   • it has parts made of glandular (cortex) and neural tissue (medulla) • The central medulla region is enclosed by the adrenal cortex, which contains three separate layers of cells. Hormones of the Adrenal CortexThe adrenal cortex produces three major groups of steroid hormones, collectively called corticosteroids: 1. Mineralocorticoids (aldosterone) ➢ Are produced by the outermost adrenal cortex cell layer. ➢ Are important in regulating the mineral (salt) content of the blood, particularly the concentrations of sodium and potassium ions. ➢ These hormones target the kidney tubules(Distal Convulating Kidney Tubles) that selectively reabsorb the minerals or allow them to be flushed out of the body in urine. ➢ When the blood level of aldosterone rises, the kidney tubule cell reabsorb increasing amounts of sodium ions and secrete more potassium ions into the urine. ➢ When sodium is reabsorbed, water follows. Thus, the mineralocorticoids help regulate both water and electrolyte balance in body fluids. 2. Glucocorticoids (Cortisone and Cortisol)  ➢ Glucocorticoids promote normal cell metabolism and help the body to resist long-term stressors, primarily by increasing the blood glucose level. ➢ When blood levels of glucocorticoids are high, fats and even proteins are broken down by body cells and converted to glucose, which is released to the blood. ➢ For this reason, glucocorticoids are said to be hyperglycemic hormones. ➢ Glucocorticoids also seem to control the more unpleasant effects of inflammation by decreasing edema, and they reduce pain by inhibiting the pain-causing prostaglandins. ➢ Because of their anti-inflammatory properties, glucocorticoids are often prescribed as drugs to suppress inflammation for patients with rheumatoid arthritis. ➢ Glucocorticoids are released from the adrenal cortex in response to a rising blood level of ACTH (Adrenocorticotropic hormone). 3. Sex Hormones ➢ In both men and women, the adrenal cortex produces both male and female sex hormones throughout life in relatively small amounts. ➢ The bulk of the sex hormones produced by the innermost cortex layer are androgens (male sex hormones), but some estrogens (female sex hormones) are also formed. Homeostatic Imbalance1. Addisson’s disease (hyposecretion of all the adrenal cortex hormones) ✓ Bronze tone of the skin (suntan) ✓ Na (sodium) and water are lost from the body ✓ Muscles become weak and shock is a possibility ✓ Hypoglycemia (↓ glucocorticoids) ✓ Suppression of the immune system 2. Hyperaldosteronism (hyperactivity of the outermost cortical area) ✓ Excessive water and sodium ions retention ✓ High blood pressure ✓ Edema ✓ Low potassium ions level (hypokalemia) 3. Cushing’s Syndrome (Excessive glucocorticoids) ✓ Swollen “moon face” and “Buffalo hump” ✓ High blood pressure and hyperglycemia (steroid diabetes) ✓ Weakening of the bones (as protein is withdrawn to be converted to glucose) ✓ Severe depression of the immune system 4. Hypersecretion of the sex hormones leads to masculinization, regardless of sex. Hormones of the Adrenal Medulla ➢ When the medulla is stimulated by sympathetic nervous system neurons, its cells release two similar hormones, epinephrine(adrenaline) and norepinephrine (noradrenaline), into the bloodstream. ➢ Collectively, these hormones are called catecholamines. ➢ The catecholamines of the adrenal medulla prepare the body to cope with short-term stressful situations and cause the so-called alarm stage of the stress response. ➢ Glucocorticoids, by contrast, are produced by the adrenal cortex and are important when coping with prolonged or continuing stressors, such as dealing with the death of a family member or having a major operation (resistance stage). Pancreatic Islets ➢ The pancreas, located close to the stomach in the abdominal cavity, is a mixed gland. ➢ The pancreatic islets, also called the islets of Langerhans, are little masses of endocrine (hormone-producing) tissue of the pancreas. ➢ The exocrine, or acinar, part of the pancreas acts as part of the digestive system. ➢ Two important hormones produced by the islet cells are insulin and glucagon. Insulin ➢ Hormone released by the beta cells of the islets in response to a high level of blood glucose. ➢ Acts on all body cells, increasing their ability to import glucose across their plasma membranes. ➢ Insulin also speeds up these “use it” or “store it” activities. ➢ Because insulin sweeps the glucose out of the blood, its effect is said to be hypoglycemic. ➢ Without it, essentially no glucose can get into the cells to be used. Glucagon ➢ Acts as an antagonist of insulin ➢ Released by the alpha cells of the islets in response to a low blood glucose levels. ➢ Its action is basically hyperglycemic. ➢ Its primary target is the liver, which it stimulates to break down stored glycogen to glucose and to release the glucose into the blood. Gonads ➢ The female and male gonads produce sex cells. ➢ They also produce sex hormones that are identical to those produced by adrenal cortex cells. ➢ The major differences from the adrenal sex hormone production are the source and relative amounts of hormones produced. Hormones of the OvariesBesides producing female sex cells (ova, or eggs), ovaries produce two groups of steroid hormones, estrogens and progesterone. 1. Estrogen (Steroid Hormone) ➢ Responsible for the development of sex characteristics in women (primarily growth and maturation of the reproductive organs) and the appearance of secondary sex characteristics at puberty. ➢ Acting with progesterone, estrogens promote breast development and cyclic changes in the uterine lining (the menstrual cycle) 2. Progesterone (Steroid Hormone) ➢ Acts with estrogen to bring about the menstrual cycle. ➢ During pregnancy, it quiets the muscles of the uterus so that an implanted embryo will not be aborted and helps prepare breast tissue for lactation. Hormones of the TestesIn addition to male sex cells, or sperm, the testes also produce male sex hormones, or androgens, of which testosterone is the most important. 3. Testosterone ➢ Promotes the growth and maturation of the reproductive system organs to prepare the young man for reproduction. ➢ It also causes the male’s secondary sex characteristics to appear and stimulates the male sex drive. ➢ It is necessary for continuous production of sperm. ➢ Testosterone production is specifically stimulated by LH. Other Hormone-Producing Tissues and OrgansPlacenta ➢ During very early pregnancy, a hormone called human chorionic gonadotropin (hCG) is produced by the developing embryo and then by the fetal parts of the placenta. ➢ hCG stimulates the ovaries to continue producing estrogen and progesterone so that the lining of the uterus is not sloughed off in menses. ➢ In the third month, the placenta assumes the job of the ovaries of producing estrogen and progesterone, and the ovaries become inactive for the rest of the pregnancy. ➢ The high estrogen and progesterone blood levels maintain the lining of the uterus and prepare the breasts for producing milk. ➢ Human placental lactogen (hPL) works cooperatively with estrogen and progesterone in preparing the breasts for lactation. ➢ Relaxin, another placental hormone, causes the mother’s pelvic ligaments and the pubic symphysis to relax and become more flexible, which eases birth passage. Developmental Aspects of the Endocrine System ➢ In late middle age, the efficiency of the ovaries begins to decline, causing menopause. o Reproductive organs begin to atrophy o Ability to bear children ends o Problems associated with estrogen deficiency begin to occur (arteriosclerosis, osteoporosis, decreased skin elasticity, “hot flashes”) ➢ No such dramatic changes seem to happen in men. ➢ Elderly persons are less able to resist stress and infection. ➢ Exposure to pesticides, industrial chemicals, dioxin, and pother soil and water pollutants diminishes endocrine function, which may explain the higher cancer rates among older adults in certain areas of the country. ➢ All older people have some decline in insulin production, and type 2 diabetes mellitus is most common in this age group. BLOOD ➢ It is the only fluid tissue in the body. ➢ A homogenous liquid that has both solid and liquid components. ➢ Taste, Odor, 5x thicker than water ➢ Classified as a connective tissue ❖Living cells = formed elements ❖Non-living matrix = plasma (90% water) Components •Formed elements (blood cells)are suspended in plasma •The collagen and elastin fibers typical of other connective tissues are absent from blood; instead, dissolved proteins become visible as fibrin strands during blood clotting •If a sample of blood is separated, the plasma rises to the top, and the formed elements, being heavier, fall to the bottom. •Most of the erythrocytes (RBCs) settle at the bottom of the tube •There is a thin, whitish layer called the buffy coat at the junction between the erythrocytes and the plasma containing leukocytes (WBCs) and platelets   Physical Characteristics and Volume • Color range ➢ Oxygen-rich blood is scarlet red ➢ Oxygen-poor blood is dull red • pH must remain between 7.35–7.45 • Slightly alkaline • Blood temperature is slightly higher than body temperature • 5-6 Liters or about 6 quarts /body   Functions and Composition of Blood 1. Transport of gases, nutrients and waste products 2. Transport of processed molecules 3. Transport of regulatory molecules 4. Regulation of pH and osmosis 5. Maintenance of body temp 6. Protection against foreign substances 7. Clot formation   Plasma • The liquid part of the blood; 90 percent water • Over 100 different substances are dissolved in this straw-colored fluid: ➢ nutrients ➢ electrolytes ➢ respiratory gases ➢ hormones ➢ plasma proteins; and ➢ various wastes and products of cell metabolism   • Plasma proteins are the most abundant solutes in plasma (albumin and clotting proteins) • Plasma helps to distribute body heat, a by-product of cellular metabolism, evenly throughout the body. Formed Elements Erythrocytes (RBCs) • Function primarily to ferry oxygen to all cells of the body. • RBCs differ from other blood cells because they are anucleate (no nucleus) • Contain very few organelles (RBCs circulating in the blood are literally “bags” of hemoglobin molecules ) •Very efficient oxygen transporters (they lack mitochondria and make ATP by anaerobic mechanisms) • Their small size and peculiar shape provide a large surface area relative to their volume, making them suited for gas exchange • RBCs outnumber WBCs by about 1,000 to 1 and are the major factor contributing to blood viscosity. • There are normally about 5 million cells per cubic millimeter of blood. • The more hemoglobin molecules the RBCs contain, the more oxygen they will be able to carry. • A single RBC contains about 250 million hemoglobin molecules, each capable of binding 4 molecules of oxygen. • Normal hemoglobin count is 12-18 grams of hemoglobin per 100 ml of blood • Men: 13-18g/ml Women: 12-16 g/ml   Homeostatic Imbalance Anemia • a decrease in the oxygen-carrying ability of the blood, whatever the reason is. • May be the result of (1) a lower-than-normal number of RBCs or (2) abnormal or deficient hemoglobin content in the RBCs.   Polycythemia Vera • An excessive or abnormal increase in the number of erythrocytes; may result from bone marrow cancer or a normal physiologic response to living at high altitudes, where the air is thinner and less oxygen is available (secondary polycythemia)     Formed Elements Leukocytes (WBCs) • Are far less numerous than RBCs • They are crucial to body defense • On average, there are 4,800 to 10,800 WBCs/mm3 of blood • WBCs contain nuclei and the usual organelles, which makes them the only complete cells in the blood. • WBCs are able to slip into and out of the blood vessels – a process called diapedesis • WBCs can locate areas of tissue damage and infection in the body by responding to certain chemicals that diffuse from the damaged cells (positive chemostaxis) • Whenever WBCs mobilize for action, the body speeds up their production, and as many as twice the normal number of WBCs may appear in the blood within a few hours. • A total WBC count above 11,000 cells/mm3 is referred to as leukocytosis. • The opposite condition, leukopenia, is an abnormally low WBC count (commonly caused by certain drugs, such as corticosteroids and anti-cancer agents) • WBCs are classified into two major groups – granulocytes and agranulocytes – depending on whether or not they contain visible granules in their cytoplasm.   Granulocytes Neutrophils ➢ Are the most numerous WBCs. ➢ Neutrophils are avid phagocytes at sites of acute infection. Eosinophils ➢ Their number increases rapidly during infections by parasitic worms ingected in food such as raw fish or entering through the skin. Basophils ➢ The rarest of the WBCs, have large histamine-containing granules. Histamine ➢ is an inflammatory chemical that makes blood vessels leaky and attracts other WBCs to the inflamed site   Agranulocytes Lymphocytes ➢ Have a large, dark purple nucleus that occupies most of the cell volume. ➢ Lymphocytes tend to take up residence in lymphatic tissues, such as the tonsils, where they play an important role in the immune response. ➢ They are the second most numerous leukocytes in the blood Monocytes ➢ Are the largest of the WBCs. ➢ When they migrate into the tissues, they change into macrophages. ➢ Macrophages are important in fighting chronic infections, such as tuberculosis, and in activating lymphocytes Platelets   ➢ They are fragments of bizarre multinucleate cells called megakaryocytes, which pinch off thousands of anucleate platelet “pieces” that quickly seal themselves off from the surrounding fluids. ➢ Normal adult has 150,000 to 450,000 per cubic millimeter of blood ➢ Platelets are needed for the clotting process that stops blood loss from broken blood vessels. ➢ Average lifespan is 9 to 12 days   Hematopoiesis • Occurs in red bone marrow, or myeloid tissue. • In adults, this tissue is found chiefly in the axial skeleton, pectoral andpelvic girdles, and proximal epiphyses of the humerus and femur. • On average, the red marrow turns out an ounce of new bloodcontaining 100 billion new cells every day. • All the formed elements arise from a common stem cell, thehemocytoblast, which resides in red bone marrow. • Once a cell is committed to a specific blood pathway, it cannotchange. • The hemocytoblast forms two types of descendants – the lymphoidstem cell, which produces lymphocytes, and the myeloid stem cell,which can produce other classes of formed elements.   Formation of RBCs • Because they are anucleate, RBCs are unable to synthesizeproteins, grow, or divide. • As they age, RBCs become rigid and begin to fall apart in 100 to 120 days. • Their remains are eliminated by phagocytes in the spleen, liver, and other body tissues. • RBC components are salvaged. Iron is bound to protein as ferritin, and the balance of the heme group is degraded to bilirubin, which is then secreted into the intestine by liver cells where it becomes a brown pigment called stercobilin that leaves the body in feces. • Globin is broken down to amino acids which are released into the circulation.The rate of erythrocyte production is controlled by a hormone called erythropoietin (from the kidneys) • Erythropoietin targets the bone marrow prodding it into “high gear” to turn out more RBCs. • An overabundance of erythrocytes, or an excessive amount of oxygen in the bloodstream, depresses erythropoietin release and RBC production. • However, RBC production is controlled not by the relative number of RBCs in the blood, but by the ability of the available RBCs to transport enough oxygen to meet the body’s demands   Formation of WBCs and Platelets   • The formation of leukocytes and platelets is stimulated by hormones • These colony stimulating factors (CSFs) and interleukins not only prompt red bone marrow to turn out leukocytes, but also enhance the ability of mature leukocytes to protect the body. • The hormone thrombopoietin accelerates the production of platelets from megakaryocytes, but little is know about how process is regulated. • When bone marrow problems or disease condition is suspected, bone marrow biopsy is done.   Hemostasis If a blood vessel wall breaks, a series of reactions starts the process of hemostasis (stopping the bleeding). Phases of Hemostasis 1. Vascular spasms occur. 2. Platelet plug forms. 3. Coagulation events occur.       Human Blood Groups • An antigen is a substance that the body recognizes as foreign; it stimulates the immune system to mount a defense against it. • The “recognizers” are antibodies present in plasma that attach to RBCs bearing surface antigens different from those on the patient’s RBCs.   ABO and Rh Blood Types The blood group system recognizes four blood types: • Type A, B, AB, and O • They are distinguished from each other in part by their antigens and antibodies. • Specific antibodies are found in the serum based on the type of antigen on the surface of the RBC   ABO and Rh Blood Types BLOOD TYPE Can Accept From Can Donate To A A, O A, AB B B, O B, AB AB A, B, AB, O AB O O O, A, B, AB   The Rh Factor Rh-Positive Rh-Negative Contains the Rh antigen -No Rh antigen   -Will make antibodies if given Rh-positive blood   -Agglutination can occur if given Rh-positive blood     Summary • Blood is responsible for transporting oxygen, fluids, hormones, and antibodies and for eliminating waste materials. • The major components of blood include the formed elements and plasma. • RBCs transport oxygen and carbon dioxide; WBCs destroy foreign invaders. • WBCs include granulocytes and agranulocytes. • Plasma is the liquid portion of unclotted blood. Serum is the liquid portion of clotted blood • Hemostasis includes four stages: blood vessel spasm, platelet plug formation, blood clotting, and fibrinolysis. • ABO and Rh types are determined by the antigen found on the RBCs
Updated 177d ago
flashcards Flashcards (71)
PARATHYROID HORMONE
Updated 354d ago
flashcards Flashcards (82)
0.00
studied byStudied by 0 people