Summary of Solid Dosage Forms

Give examples of other routes of administration for solid dosage forms

buccal, sublingual, vaginal, ocular

Define palatability

the voluntarily uptake/ appreciation of a medicine by organoleptic properties; appearance, smell, taste, aftertaste and mouth feel and possibly also sound

What is the first-pass effect?

when drug metabolism occurs before the drug enters the systemic circulation

What is the effect of the first-pass effect on drugs?

Results in decreased bioavailability and therapeutic response

Describe sublingual administration

drug is dissolved under the tongue through mucous membranes

Sublingual/buccal administration bypasses the ...?

digestive system and liver's 1st pass metabolism

Glyceryl Trinitrate SL tablets, buprenorphine or buprenorphine and naloxone SL tablets, are administered...?

sublingually

Describe buccal administration

medication is placed or absorbed through the mucous membranes of the buccal mucosa (between cheek and gum)

give 4 advantages of sublingual and buccal administration

1) rapid onset of action

2) good option for drugs with poor absorption in GIT/degradation in stomach

3) bypasses first-pass metabolism

4) suitable for patients with difficulty swallowing or nausea

give 2 disadvantages of sublingual and buccal administration

1) not all medications can be administered effectively

2) requires patient to hold drug without swallowing/spitting

give 2 disadvantages of vaginal administration

1) limited drugs
2) discomfort/irritation

give 3 advantages of vaginal administration

1) targeted delivery

2) bypasses 1st pass metabolism

3) minimised systemic effects/ localised treatment

How many taste buds do we have?

9000

Define dysphagia

difficulty swallowing