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-multicellular organisms begin life as a single cell
-humans become trillions of cells because of cellular respiration
-replaces worn out or damaged tissues
overview of cellular respiration
asexual reproduction
doesnt require a sperm or egg cell it involves a single organism producing offspring genetically identical to itself. ex)binary fission
chromosomes part in cellular reproduction
DNA is copied and passed to each daughter cell, then DNA is packaged into chromosomes which ensures proper distribution during cell division.
chromosomes at the beginning of the cell cycle
chromatin are condensed into…
46 chromosomes
humans have…
mitotic phase
sequence of stages that take place between the time a new cell has arisen to the point where it gives rise to two daughter cells
distributes duplicated nuclear contents of parent cells to daughter cells
daughter chromosomes are then separated into sister chromatids
sister chromatids joined by a centromere and each has idential DNA
duplicated chromosomes are composed of….
interphase
G1- stage right before DNA replication, cell doubles organelles, accumulates materials for DNA synthesis, makes decision to divide or not
G0- prevents cell from dividing
S- DNA synthesis
G2- follows DNA synthesis and extends to onset of mitosis, synthesizes proteins needed for division
daughter nuclei
produced by mitosis and are genetically identical to parent cells
spindle
most eukaryotic cells require to pull the sister chromatids apart
made of microtubules
centrosomes
primary microtubule organizing center
-prophase-chromosomes are condensed into pairs, nucleolus disappears and the nuclear envelope breaks down, spindle fibers begin to form
-metaphase-chromosomes line up along equatorial plate, and spindles reach out to attach, unattached spindle fibers reach all the way around and overlap themselves
-anaphase-chromosomes are pulled to opposite sides of the cell-sister chromatids—>daughter chromosomes
-telephase and cytokinesis-spindles disappear and nuclear envelope reappears are daughter chromosomes, division of the cytoplasm begins, each cell has the exact same number of chromosomes two cells are fully visible under a microscope
mitosis divided into 4 phases in an animal cell
plant-have centrosomes but lack centrioles, cell membrane forms along cell plate
animal-have centrosomes and have two centrioles, cell membrane forms through a cleavage furrow
plant vs animal cell division
-prophase-nucleolus has disappeared and sister chromatids are visible, centrosomes begin moving apart and spindles begin to form. the kinetochore of each chromatid is attached to the spindle fibers to match
-metaphase-centromeres of duplicated chromosomes are aligned at metaphase plate, kinetochore spindle fibers attached to sister chromatids comes from diff poles
-anaphase-sister chromatids part, each pole receives the same number and kind of chromosomes
-telophase-daughter cells are forming as nuclear envelope and nucleoli come back, chromosomes will be come indistinct chromatin
mitosis divided into 4 phases in plant cells
cytokinesis in animal cells
cleavage furrow forms as anaphase ends, contractile ring forms a constriction and the two cells are separated
cytokinesis in plant cells
cell wall prevents furrowing so new plasma membrane is built between daughter cells, golgi appartus forms vesicles, new membrane releases molecules that form the new cell walls
cell cycle control system
ensures stages occur in the correct order and that the cycle only continues when the previous stage is done
G1-cell is committed to divide but can enter G0 if not passed. proper growth signals must be present and DNA integrity is checked
G2-verifies DNA replication and fixes damaged DNA
M- makes sure all chromosomes are attached to spindles
CCS checkpoints
signal
molecule that simulates or inhibits an event
kinases
remove phosphate from ATP to move to other molecules
cyclins
internal signals only present during certain phases
epidermal growth factor
stimulates skin to finish healing after injury
estrogen stimulates the lining of the uterus in preparation for egg implantation
cells stop dividing when they touch bc of contact inhibition
cells divide like 70 times and then die
fun facts
telomere
repeating DNA sequence at rhe end of chromosome
cancer
uncontrolled cell division
malignant
cancerous
benign
non cancerous
proto-oncogenes
code for proteins that promote the cell cycle and are linked to apoptosis
apoptosis
programmed cell death
tumor suppressor genes
code for proteins that inhibit the cell cycle and promote apoptosis
oncogenes
mutated proto-oncogenes that cause cancer
translocations
chromosomes can break off and attach to another
carcinogenesis
developement of cancer, lack differentiation and dont contribute to body function
undergo apoptosis so they never die
cancer cells never…
surgery
chemotherapy
radiation
cancer treatments
don’t smoke
avoid sun exposure
avoid heavy drinking
healthy diet
preventatives for cancer