Innate Helper Cells

1

Defense against viruses and intracellularbacteria and parasites (protozoa).

1

Found under body surfaces such asintestinal mucosa- scattered through laminapropria.

intestinal mucosa

1: Found under body surfaces such as — - scattered through lamina propria.

under ; lamina propria

1: Found — body surfaces such as intestinal mucosa- scattered through —

1

Produces large amount of Th-1 associatedcytokines; interferon-y and TNF- a inresponse to activation by IL-12, -15 and -18from dendritic cells.

1: Produces large amount of Th-1 associated cytokines; interferon-y and TNF- a inresponse to activation by IL-12, -15 and -18from dendritic cells.

Th-1 ; interferyon-y and TNF-a

1: Produces large amount of — associated cytokines; — - a inresponse to activation by IL-12, -15 and -18 from dendritic cells.

IL-12, -15 and -18 ; Dendritic cells

1: Produces large amount of Th-1 associated cytokines; interferon-y and TNF- a in response to activation by — from —

1

Activates macrophages.

macrophages

1: Activates —

IL-23, IL-1B , retinoic acid.

1: ILC1- ILC3 on exposure to —

ILC1- ILC3

1: — on exposure to IL-23, IL-1B and retinoic acid.

IL-12, IL-15 and IL-18

1: ILC3-ILC1 through

ILC3-ILC1

1: — through IL-12, IL-15 and IL-18

1

NK cells are closely related to ILC

ILC

1: NK cells are closely related to —

2

Defense against helminths

2

Found in the lung, skin, bone marrow, liver,mesenteric fat and in the small intestine.

2

Produces large amount of Th2- associatedcytokines; IL-5 and IL-13 and smaller amountsof IL-4 and IL-9 in response to thymic stromallymphopoietin (TSLP).

Th2 ; thymic stromal lymphopoietin (TSLP)

Produces large amount of — associated cytokines; IL-5 and IL-13 and smaller amounts of IL-4 and IL-9 in response to —

IL-5 and IL-13 ; IL-4 and IL-9

2: Produces large amount of Th2- associatedcytokines; — and smaller amounts of — in response to thymic stromal lymphopoietin (TSLP).

2

IL-25 and IL-33 from epithelial cells.

epithelial cells

2: IL-25 and IL-33 from

IL-25 and IL-33

2: — from epithelial cells.

2

Required for the development of early innate immunity to parasitic helminths

2

Regulation of type 2 inflammatory response such as asthma and allergic disease.

2

Control eosinophil production by eosinophilia.

eosinophilia.

2: Control eosinophil production by

2

Mucus production by goblet cells

goblet cells

2: Mucus production by —

2

Alternative activation of macrophages

macrophages

2: Alternative activation of

2

Tissue repair

IL12

2: ILC2 – ILC1 by — , reversed by IL-4

ILC2 – ILC1

2: — by IL12, reversed by IL-4

IL-4

2: ILC2 – ILC1 by IL12, reversed by

3

Promotes immunity to extracellular bacteria.

3

Found in the GIT tract & lungs.

GIT tract & lungs.

3: Found in the

3

Produces IL-17 and IL-22 in response to stimulation by TSLP and IL-23 and thus resemble Th17 in their cytokine profile.

IL-17 ; IL-22

3: Produces — in response to stimulation by TSLP and IL-23 and thus resemble Th17 in their cytokine profile.

TSLP and IL-23 ; Th17

3: Produces IL-17 and IL-22 in response to stimulation by — and thus resemble — in their cytokine profile.

3

Immunity on mucosal surfaces by resisting extracellular bacteria and fungi.

mucosal surfaces

3: Immunity on — by resisting extracellular bacteria and fungi.

3

Require for the development of lymph nodes,peyer’s patches and isolated lymphoid follicles.

3

Also called lymphoid tissue inducer (LTI) cells.

lymphoid tissue inducer (LTI) cells.

3: Also called

3

Regulate differentiation of B cells.

B cells

3: Regulate differentiation of —