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HS 8: purines
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1
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Nucleotide receptoren: welke, functie en type
P1 = adenosine
* G proteïne gekoppeld
* A1-2-3
P2X familie
* ionkanalen
* P2X1-7
* ATP = agonist
* activatie van bloedplaatjes
P2Y familie
* G proteïne gekoppeld
* 8 subtypen
* agonisten: ATP, ADP
* activatie van bloedplaatjes
2
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\
Effecten van A1
cAMP daling
* bronchoconstrictie
* atrioventriculaire geleiding remmen = anti-aritmisch
3
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Theofyline: werking en gebruik
* antagonist van A1
* bronchodilatatie bij astma
4
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Effecten van A2
cAMP stijging
* bloedvat dilatatie
* bloedplaatjesremmer
5
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Dipyridamol: werking en gebruik
* heropname adenosine remmen
* plaatjesremmer
* remt fosfodiesterase 5 (dus meer cGMP)
6
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Clopidogrel: werking en gebruik
* binding van ADP aan trombocytreceptor remmen
* bij atherotrombotische aandoeningen
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