324 exam 2: antipsychotics and mood stabilizers

first generation/typicals

- Haloperidol (Haldol
- Chlorpromazine (Thorazine)

second generation/atypicals

- Aripiprazole (Abilify)
- Clozapine (Clozaril)
- Olanzapine (Zyprexa)
- Quetiapine (Seroquel)
- Risperidone (Risperdal)
- Ziprasidone (Geodon)

1st generation antipsychotics: mechanism

- major function = dopamine antagonism
- block the D2 receptors, reducing positive symptoms
- clinical significance results from 70% occupancy
- blocking this receptor in the nigrostriatal pathway can cause problems that look like parkinson's disease

2nd generation antipsychotics: mechanism

- second-generatoin antipsychotics involve a lower D2 receptor blockage, reducing some side effects
- serotonin activity presents over-antagonism of DA receptors
- moderate-high 5HT2a receptor blockage