Capsules (Ansel's Pharmaceutical Dosage Forms 11th edition)

capsules

are solid dosage forms in which medicinal agents or inert substances are enclosed in a small shell of gelatin

gelatin

it is obtained by the partial hydrolysis of collagen obtained from the skin, white connective tissue, and bones of animals. it is also stable in air when dry but is subject to microbial decomposition when it becomes moist

hard gelatin capsules and soft gelatin capsules

what are the two types of gelatin capsule shells?

hard gelatin capsules

it is a type of capsule that is composed of a body and a cap or more commonly known as two-piece capsules and are used in most commercial medicated capsules

13-16% of moisture

how much moisture does a hard gelatin capsule contain?

punch method

what method is used when filling a small number of capsules in the pharmacy?

soft gelatin capsules

a type of capsule that is made up of gelatin to which glycerin or polyhydric alcohol such as sorbitol has been added

soft gelatin capsules

it is used to encapsulate and hermetically seal liquids, suspensions, pasty materials, dry powders, and even preformed tablets

soft gelatin capsules

this capsule may be oblong, oval, or round, may be single-colored or two-toned, and may be imprinted with identifying markings

hard gelatin capsules

this capsule may be prepared with opaquants to render characteristic features to the capsule shell

through the plate process, the rotary die processes, and the reciprocating die process

how are softgel capsules prepared?

000

what is the largest capsule size?

5

what is the smallest capsule size?