ASPIRIN - uses

an odorless, white crystalline powder chemically known as 2-acetyloxybenzoic acid or ________________ (ASA)

acetylsalicylic acid (aspirin)

natural production: from ______ bark or _____________ flowers

willow (salix alba) or meadowsweet (filipendula ulmaria)

• synthetic production: salicylic acid +_________ in presence of acid catalyst

acetic anhydride

• Analgesic and anti-inflammatory

Aspirin is known to inhibit prostaglandin synthesis by irreversibly inactivating COX-1 and COX-2.

Antipyretic.

• Aspirin is said to inhibit thermoregulatory receptors in the hypothalamic center of the brain

• vasodilation and increased peripheral blood flow.

• exact MOA is unknown.

• Anti-thrombotic

inhibit aggregation by irreversibly acetylating serine 350 of COX-1.