protein turnover

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6 Terms

1
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what molecule is attached to proteins to mark them for degradation?

Ubiquitin

2
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what bond attaches ubiquitin to a protein?

isopeptide

3
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what provides the energy for the formation of the isopeptide bond?

ATP hydrolysis

4
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what are the three enzymes involved in the addition of a Ub molecule?

E1 - ubiquitin activating

E2 - ubiquitin conjugating

E3 - ubiquitin protein ligase

5
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what is the proteasome composed of?

19s regulatory unit + 20s catalytic unit

6
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what is the role of the 19s regulatory unit?

  • binds specifically to the Ub chain

  • isopeptide cleaves off the Ub molecules and allows for recycling

  • unfolds the protein and directs it to the 20s core