protein turnover
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Last updated 7:03 PM on 1/15/26
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6 Terms
1
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what molecule is attached to proteins to mark them for degradation?
Ubiquitin
2
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what bond attaches ubiquitin to a protein?
isopeptide
3
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what provides the energy for the formation of the isopeptide bond?
ATP hydrolysis
4
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what are the three enzymes involved in the addition of a Ub molecule?
E1 - ubiquitin activating
E2 - ubiquitin conjugating
E3 - ubiquitin protein ligase
5
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what is the proteasome composed of?
19s regulatory unit + 20s catalytic unit
6
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what is the role of the 19s regulatory unit?
binds specifically to the Ub chain
isopeptide cleaves off the Ub molecules and allows for recycling
unfolds the protein and directs it to the 20s core
