Hematology Exam 2 Study questions

The following are compounds formed in the syntheses of heme:
​1. corproporphyrinogen
​2. porphobilinogen
​3. uroporphrinogen
​4. protoporphyrinogen

Which of the following responses lists these compounds in the order in which they are formed?

Porphobilinogen → Uroporphyrinogen → Coproporphyringen → Protoporphyrinogen
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What is the main function of the hexose-monophosphate shunt in the RBC?

Produce NADPH

A CLS finds evidence of Heinz bodies in the RBCs of a 30-year-old male. This is evidence of which of
the following?

Oxidative damage to hemoglobin (G6PD deficiency)
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Which situations are 6PD deficiency episodes related to?

Drugs

Fava bean ingestion

Infections

Severe illness

All of the above
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Heinz bodies may be seen in what hematologic disease?

G6PD

Unstable hemoglobinopathies

Oxidant drug exposure

All of the above

What can a deficiency in the hexose monophosphate shunt result in?

Oxidative hemolysis of RBCs due to accumulation of oxidized hemoglobin

G-6-P-D is found in which of the following pathway?

Hexose monophosphate shunt

Microcytic anemia histogram

Shift to the left, low MCV

Discuss the characteristics of Thalassemia. (Type)

A genetic disorder with decreased or absent glob in chain production. Presents as a microytic, hypochromic anemia with target cells and basophilic stippling, normal to elevated iron, low MCV, low MCH, and normal RDW

What is the number one cause of a Megaloblastic asynchronous development in the bone marrow?

Vitamin B12 or folate deficiency

From the standpoint of hematologic studies, what are the usual diagnostic criteria for anemia?

What might cause a microcytosis?

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What are the characteristic findings in a patient with iron deficiency anemia (IDA)? For example, what does the morphology look like? What are the platelet counts? What are the iron study values, what is happening with the portoporphyrin ring?

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Who can IDA be distinguished from anemia of chronic infection? (this should be in your chart you created)

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Which anemia has red cell morphology similar to that seen in IDA? (this should be in your chart you created)

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What are the iron study results and how can you characterize Iron deficiency anemia using the iron studies? (this should be in your chart you created)

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What are the characteristics associated with sideroblastic anemia? (this should be in your chart you created)

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Can a patient with polycythemia vera (very high RBC count) who is treated by phlebotomy is develop a anemia? If so, what type of deficiency would this patient develop?

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Which of the following parameters may be similar for the anemia of inflammation and IDA? (this should be in your chart you created)

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Where and in what form is the majority of iron in an adult found?

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What is the anemia of chronic infection characterized by? (this should be in your chart you created)

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What are the characteristic of lead poisoning? (this should be in your chart you created)

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Which of the following represent(s) an acquired sideroblastic anemia producing a microcytic hypochromic anemia, skin lesions, and neurological dysfunction?

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Hemosiderosis is the accumulation of excess __ in the macrophages of various tissues. (this should be in your chart you created)

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Which of the following is MOST closely associated with idiopathic hemochromatosis? (this should be in your chart you created)

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Which of the following blood findings does NOT correlate with the presence of ringed sideroblasts in the bone marrow? (this should be in your chart you created)

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What is the major mechanism responsible for the anemia of chronic disease? (this should be in your chart you created)

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What is an excessive accumulation of iron in body tissues called? (this should be in your chart you created)

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A platelet count is performed on an automated instrument from an EDTA blood sample. Smear evaluation reveals the presence of platelet clumps. The specimen is redrawn using sodium citrate as the anticoagulant, and a
count of xxxxx is obtained. What is the correct platelet count to report?

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Using one word for each cell, describe the size of cells 2 and 3. What would the MCV of these cells be (increased or decreased)? Grade the poikylocytosis and anisocytosis for this blood smear. List 3 names for the cell depicted by the white arrow. (10 points, level 3)

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Using 2 words describe the RBC morphology (size & color). Shown in the middle is a typical small lymphocyte. What possible Corpuscular Constants (MCV, MCH, MCHC) would you expect to correlate with this blood film? List 3 cause for seeing this type of blood film. Underline the most common cause. (10 points, level 3)

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What is Hepcidin and how does it work?

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What is the iron transport protein called?

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The term sideropenic is most closely associated with which anemia?

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Microcytic, hypochromic erythrocytes are most characteristic of which anemia?

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Which of the following individuals is most likely to require an increased intake of iron?

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The basic defect in sideroblastic anemia is:

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Anemia(s) characterized by defective heme syntheis includes:

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The most common cause of ID (iron deficiency) in middle-aged men is:

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Which of the following is most often associated with the presence of Pappenheimer bodies?

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Which of the following best describes hemochromatosis?

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A patient with anemia of chronic disease would be expected to have which set of laboratory test results?

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Why is a hematocrit not recommended to screen for iron deficiency in children?

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If a child with lead poisoning also had a significant microcytic, hypochromic anemia, what complicating pathology/pathologies should be considered?

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What laboratory test is best for screening for iron deficiency in a population of 1-to-3-year-old children who have a high incidence of elevated blood lead levels?

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A health maintenance organization (HMO) has a contract for laboratory testing services with your laboratory. The HMO has decided to screen its members for hereditary hemochromatosis. Which laboratory test will you recommend for this screening?

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A health maintenance organization (HMO) has a contract for laboratory testing services with your laboratory. The HMO has decided to screen its members for hereditary hemochromatosis. What test should you recommend be done reflexively on patients with an abnormal screening test? REMEMBER WAH A RELEX TEST IS.

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Which protein regulates iron absorption in the gut and transport of iron from cells to the plasma?

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What effect would a high degree of ineffective erythropoiesis have on iron metabolism?

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