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Enteral examples
Pill
Tablet
Capsule
Paste
Liquid
Pros of enteral drugs
Less risk of abscess forming
Cheaper
Can put it in food
Cons of enteral administration
Can be challenging to medicate animal
Can cause aspiration ulcers to esophagus
Drug that poses the largest risk for esophagitis
Doxycycline
Steps to pill a dog
Head tilted back slightly
Left hang grasps muzzle behind canine teeth
Right hand lowers jaw and places medication on back of tongue
Don’t let go until you see a swallow
Get pill back as far as you can to prevent spitting out
Steps to pill a cat
Thumb and index finger placed on either side of mouth and slight pressure will aid in opening mouth
Right middle finger used to depress mandible and medication placed on back of tongue
Don’t let go until they swallow
Rub throat
Give water [with syringe]
Keys for successful pilling a cat
Maintain good head control
Don’t let go until they swallow
Get pill as far back as you can
Pill guns
Helpful if animal is fractious
Will help prevent a bite
Maintain good head control
Fingers over mandible to keep mouth closed
Does help to get pill back farther in mouth
Can sometimes hold more than one pill
You can also use nylon muzzle a couple sizes too big and use pill gun to pill a dog you aren’t comfortable with
Hiding medication in food
Good option for dogs who have good appetite
Can make animals have aversion to the food you put it in, especially cats
Capsules
Same as pills but sometimes you can open capsule and sprinkle in food if medication is not bitter
If dry pilled, follow with water or treat to prevent esophageal damage
Liquids caution
Aspiration
Diastema
Space where there is no teeth
Orogastic
Tube passed from mouth to stomach or distal esophagus to deliver fluids and/or medications
Mouth to stomach measurement
Measure from canine tooth to 13th rib
Mouth to distal esophagus
Canine tooth to 8th or 9th rib
Topical: give liquid or ointment first?
Give liquid then ointment
Ointment creates a barrier
Must give liquid and ointment 5 minutes apart
Esophagostomy
Surgical procedure that must be done by a vet
Gastrostomy
Surgical placement that has to be done by a vet
Don’t need to wait for swallow
Jejunostomy
Surgical placement that must be done by a vet
Choose if there is blockage to anything cranial to the jejunum
Nebulizers
Commonly used for asthma and respiratory medications; has humidity and medication components
Metered Dose Inhaler (MDI)
Commonly used for asthma and respiratory medications; similar to normal inhalers— only has medication component
Transdermal gels’ uptake varies on…
Variable uptake depending on the skin; high blood flow areas absorb better than areas with lower blood flow areas
Patches uptake depends on…
Variable uptake depending on blood flow in area, temperature, etc
OH causes vasodilation, which increases absorption of patch
Scrubbing the area causes dilation, which increases absorption of patch
Cons of patches
Can be eaten, which causes animal to absorb full dose at once
Can fall off
Children can play with it
Orthopnea
Holding head forward to get a better breath
Parenteral
Introduction of drugs into the body by means other than the GIT
Pharmacokinetics
what the body does to a drug
Pharmacodynamics
What the drug does to a body
ADME stands for
Absorption
Distribution
Metabolism
Excretion
Absorption
Drug absorbed into bloodstream from injection of medicine
Distribution
Perfusion travels to target tissue
Metabolism
(Biotransformation) occurs in liver where enzymes break drug molecule down into metabolites
Metabolites are
less biologically active than the initial drug molecule
Parenteral excretion
Occurs in renal or urinary system
Enteral excretion
GIT; feces
Respiratory excretion
Exhalation