Pulmonary Hypertension: Dosing
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Last updated 2:48 AM on 3/24/26
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6 Terms
1
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Ambrisentan
Don’t use in moderate to severe hepatic impairment
2
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Macitentan
NO renal or hepatic adjustments
3
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Bosentan
Avoid initiating if moderate to severe hepatic impairment
4
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Tadalafil
CrCl < 30 mL/min: avoid use
Mild to moderate hepatic impairment: use with caution (initial dose 20 mg daily)
Severe hepatic impairment: avoid use
5
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Riociguat
CrCl < 15 mL/min or on dialysis: avoid use
Severe hepatic impairment: avoid use
6
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Treprostinil PO
Mild hepatic impairment: start 0.125 mg BID, increase every 3 to 4 days by 0.125 mg
Moderate hepatic impairment: avoid use
Severe hepatic impairment: CONTRAINDICATED
