Anti+Infective+Medications;Antifungals: Amphotericin B

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6 Terms

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mechanism of action

  • Has both fungistatic & fungicidal properties

  • Can slow or destroy depending on concentration by interrupting the integrity of the cell wall

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therapeutic use

Severe systemic infections

3
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complications

  • Infusion reactions

    • When giving 1st dose due a test dose

    • Pretreat with Benadryl & Tylenol

  • Thrombophlebitis

    • Administer in a large vein

  • Electrolyte Imbalance

  • Bone marrow suppression

  • Kidney toxicity

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contraindications/precautions

  • Impaired kidney function

  • Anemia, electrolyte imbalance, bone marrow suppression

  • Lactation

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drug to drug interactions

Aminoglycosides d/t increased risk of nephrotoxicity

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education

  • Infuse IV slowly over 4 -6 hours

    •  If given rapidly can cause cardiovascular collapse

  • Use a filter to prevent infusion of undissolved crystals