Type II Hypersensitivity REVISED

What are some examples of Type II hypersensitivity?

IMHA, transfusion reaction, myasthenia gravis

What is Type II hypersensitivity also known as?

Host cells are targets for destruction

What are the primary antibodies involved in type II hypersensitivity? 

IgG and IgM

Briefly describe Type II hypersensitivity

Antigens associated with the cell membrane.

What are intrinsic antigens and what are they involved in?

They are molecules synthesized by the cell and are involved in autoimmune disease and blood transfusion reactions.

What are extrinsic antigens and what are they involved with?

Extrinsic antigens are molecules that attach to the cell, and they are involved with microbial antigens and therapeutic drugs

What is the role of IgG in Type II Hypersensitivity?

IgG plays a role in target cell death, leading to opsonization/phagocytosis, complement activation and ADCC by NK cells

What is the result of antibody-mediated inactivation during Type II Hypersensitivity?

Myasthenia gravis

What is the result of antibody-mediated activation during Type II Hypersensitivity?

Grave’s disease (excess production of thyroid hormone, human only as of now)

What is the prominent blood group antigen in Dogs?

Dog erythrocyte antigen (DEA), specifically DEA 1

Are there any naturally occurring antibodies against blood group antigens?

No

What are the three blood group antigens present in cats?

A, B and AB

Briefly describe neonatal isoerythrolysis in newborns

It is when foals that gave a different blood group antigen from the mare (14%), they ingest antibodies through colostrum and sensitization through previous pregnancies

What are signs of isoerythrolysis in animals?

Depression, weakness, neurologic signs, icterus, hemoglobinuria