L1 - GORD
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Last updated 12:25 PM on 3/13/25
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9 Terms
1
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What is the primary cause of GORD?
Dysfunction of the lower esophageal sphincter (LES).
2
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What are the common symptoms of GORD?
Heartburn, chest discomfort, difficulty swallowing.
3
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What is the role of gastric acid in the digestive system?
It aids in digestion, denatures proteins, activates digestive enzymes, and protects against pathogens.
4
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What are the three key receptors involved in gastric acid secretion?
H2 receptors, gastrin receptors, and M3 muscarinic receptors.
5
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How do H2 receptor antagonists work?
They competitively inhibit histamine at the H2 receptors, reducing acid secretion.
6
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Describe the mechanism of action of Proton Pump Inhibitors (PPIs).
They irreversibly bind to and inhibit the ATPase proton pump, reducing acid secretion.
7
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What is the definition of diarrhea?
The passage of loose or watery stools occurring more than three times per day.
8
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What type of receptors do prokinetic agents like metoclopramide act on?
Dopamine D2 receptors in the gastrointestinal tract.
9
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What is the mechanism of action of loperamide?
It acts on the mu opioid receptors in the gut to reduce intestinal motility and increase water absorption.
Flashcards (21)