Pancreatic Cancer
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Facts about pancreatic cancer
3rd leading cause of cancer death (US)
more than 70% of patients die within 1 year
median survival rate is 4-6 months after diagnosis
5 year prognosis is less than 6%
Pancreatic Cancer
Few warning signs/symptoms
Most new cases have advanced tumor growth
3 warning signs of pancreatic cancer
Jaundice
Bloating
Fatigue
Why is pancreatic cancer resistant to chemo? (3)
Protein pump in membrane starts to pump drugs out
Creates a barrier around itself, chemo cannot reach tumor
Gene mutations create chemo resistant cells, develop mechanism to inactivate drugs
Pancreatic cancer cells and Vitamin D
Pancreatic cancer cells require Vitamin D for survival - if a drug could inhibit the Vitamin D receptor, chem works
Pancreatic cancer cells and glutamine
Pancreatic cancer cells are addicted to glutamine, leads to chemo resistance
preventing certain molecules from being used can make treatments
Note 
Flashcards (40)