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What is the Eternal Triangle (Paul Baker)?
The interaction between genotype phenotype and culture in shaping human biological variation
Why is describing human variation preferred over classifying it?
Because human variation is continuous overlapping and not divided into discrete races
What are the primate foundations of developmental plasticity?
Long growth periods high parental investment and flexible responses to environment
What is the Developmental Origins of Health and Disease (DOHaD)?
The idea that early life environments affect health outcomes later in life
What is biological programming (Barker Hypothesis)?
Environmental conditions during fetal development permanently shape physiology and disease risk
What are HOX genes?
Regulatory genes that control body patterning and development
What is mitochondrial DNA (mtDNA)?
Maternally inherited DNA useful for tracing ancestry and population history
What are classic genetic markers?
Protein polymorphisms used to study genetic variation
What is non-coding DNA?
DNA that does not code for proteins but regulates gene expression
What is HAR1?
A human accelerated region associated with brain development
What is FOXP2?
A gene linked to speech and language ability
What does mapping the human genome mean?
Identifying the location and function of genes across chromosomes
What does recent human origins refer to?
The emergence of anatomically modern humans in Africa about 200000 years ago
Why is genetic diversity highest in Africa?
Because African populations are older and closer to human origins
What is thermoregulation?
The process of maintaining internal body temperature
What is the difference between core and shell temperature?
Core refers to vital organs while shell refers to skin and extremities
How did humans adapt historically to heat stress?
Through hair loss increased sweating and changes in body proportions
What are hot dry cultural adaptations?
Loose clothing shade use activity timing and water conservation
What are hot dry biological adaptations?
Tall lean bodies that dissipate heat efficiently
What are warm humid physiological adaptations?
Efficient sweating and heat tolerance
What is acclimatization?
Short term physiological adjustment to environmental stress
How do native and non native heat responses differ?
Natives show more efficient sweating and cardiovascular responses
What are the main challenges of cold environments?
Heat loss frostbite and maintaining metabolism
What is cold buffering?
Cultural strategies such as clothing shelter and fire use
What is countercurrent heat exchange?
Heat transfer between adjacent blood vessels to conserve heat
What is cold induced vasodilation (CIVD)?
Periodic increased blood flow to extremities to prevent tissue damage
What is non shivering thermogenesis?
Heat production by brown adipose tissue without muscle contractions
Why do cold adapted populations have elevated BMR?
To increase internal heat production
What is hypobaric hypoxia?
Reduced oxygen availability due to low air pressure at high altitude
What is oxygen saturation?
The percentage of hemoglobin carrying oxygen
What is acute mountain sickness?
Short term illness caused by rapid ascent to high altitude
What is chronic mountain sickness?
Long term maladaptation involving excessive red blood cell production
What is the erythropoietic response?
Increased red blood cell production in response to low oxygen
How do Andean and Himalayan adaptations differ?
Andeans increase hemoglobin while Tibetans improve oxygen efficiency
Why is skin color a poor trait for racial classification?
Because it varies clinally and reflects environmental adaptation
What is Glogers Rule?
Darker pigmentation occurs in warmer more humid environments
What is melanin?
A pigment that protects the skin from UV radiation
What are advantages of dark skin?
Protection against UV damage and folate depletion
What are advantages of light skin?
Increased vitamin D synthesis in low UV environments
What is the Inuit anomaly?
Darker skin in low UV regions due to vitamin D rich diets
What is tanning?
Increased melanin production in response to UV exposure
What happened to skin color in early hominins?
Skin darkened as body hair decreased and sweat glands increased