[ANAL-LAB-MID-01-PT2] TABLET HARDNESS / TABLET BREAKING FORCE

THIS FLASH CARDS IS ABOUT ANALYSIS; TABLET HARDNESS OR BREAKING FORCE.

Tablet Breaking Force

The force required to break a tablet under controlled conditions.

• Newton (N)

• Kilopond (KP)

Tablet Hardness are measured in?

9.8 N

How many in newton (N) is 1 kilopond (KP)?

Tablet Hardness

A key quality control parameter ensuring tablets can withstand handling, packaging, and transport.

• Handling

• Packaging

• Transport

Tablet Hardness is a key quality control parameter ensuring tablets can withstand?

• Prevents Breakage

• Consistent Dissolution

• Disintegration and Bioavailability

• Patient Compliance

What are the four (4) major importance of knowing the Tablet Hardness?

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Prevents Breakage

IMPORTANCE OF TABLET HARDNESS:

Hardness ensures tablets don’t crack or crumble during handling.

Consistent Dissolution

IMPORTANCE OF TABLET HARDNESS:

Proper hardness helps the tablet dissolve at the intended rate.

Disintegration and Bioavailability

IMPORTANCE OF TABLET HARDNESS:

Affects how quickly the tablet breaks down and releases the drug.

Patient Compliance

IMPORTANCE OF TABLET HARDNESS:

Tablets that are too hard or too soft may be difficult or unpleasant to take.

• Monsanto Hardness Tester

• Pfizer Hardness Tester

• Strong-Cobb Hardness Tester

• Erweka/Schleuniger Hardness Tester (Automated)

What are the four (4) Common Methods of the Measurement of Tablet Hardness?

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Monsanto Hardness Testes

METHODS OF THE MEASUREMENT OF TABLET HARDNESS:

Measures tablet hardness using a spring-loaded plunger; simple and widely used.

Pfizer Hardness Tester

METHODS OF THE MEASUREMENT OF TABLET HARDNESS:

Uses a compression mechanism to determine the force needed to break a tablet.

Strong-Cobb Hardness Tester

METHODS OF THE MEASUREMENT OF TABLET HARDNESS:

Measures tablet crushing strength with a dial gauge for accurate readings.

Erweka/Schleuniger Hardness Tester (Automated)

METHODS OF THE MEASUREMENT OF TABLET HARDNESS:

Electronic tester that automatically measures tablet hardness with high precision.

• Compressed Tablets

• Buccal Tablets

• Chewable/Sublingual Tablets

What are the three (3) criteria?

4-10 kg

It takes how many kilograms (kg) for compressed tablets to break?

7-10 kg

It takes how many kilograms (kg) for buccal tablets to break?

2-3 kg

It takes how many kilograms (kg) for chewable/sublingual tablets to break?

Saliva

This is the one that is responsible for a lot of breakdowns of our drugs with the help of its enzymes.

• Portable Hardness Tester

• Handheld Durometer

• Rockwell Hardness Tester

• Tablet Hardness Tester (Erweka Brand)

What are the four (4) devices/instruments to measure tablet hardness?

Portable Hardness Tester

This device often rebound or ultrasonic type, used for quick, non-destructive hardness checks on metals.

Handheld Durometer

This device is with a dial gauge, commonly used for rubber, plastics, and softer materilas.

Rockwell Hardness Tester

This is a bench-top device for precise hardness measurement of metals and alloys.

Tablet Hardness Tester (Erweka Brand)

This device is used in the pharmaceutical industry to measure the breaking strength of tablets.